Objective:To investigate the impact of the endogamous marriage culture on the prevalence of the hemoglobin E(HbE) recessive variant.Methods:The prevalence of the hemoglobin E(HbE)recessive variant was determined by do...Objective:To investigate the impact of the endogamous marriage culture on the prevalence of the hemoglobin E(HbE) recessive variant.Methods:The prevalence of the hemoglobin E(HbE)recessive variant was determined by dot-blot hybridization in 4 endogamous villages(1 Mlabri and 3 Htin ethnic groups) in comparison with 9 other nearby non-endogamous populations.Results:Although the overall HbE prevalence in the population studied(8.44%,33/391)was not significantly different from that of the general southeast Asian population,a high prevalence and individuals with homozygous HbE were observed in two villages,the Mlabri from Wiang Sa district and the Htin from Thung Chang district of Nan province(26.3%and26.9%,respectively).The low HbE allelic frequency noticed in some endogamous populations suggests that not only endogamy but also other evolutionary forces,such as founder effect and HbE/β-thalassemia negative selection may have an effect on the distribution of the HbE trait.Conclusion:Our study strongly documents that cultural impact has to be considered in the extensive prevalence studies for genetic disorders in the ethnic groups of northern Thailand.展开更多
Marriage and family remain a universal and eternal subject of study. It covers law, ethics, sociology, psychology and even economics. Law and ethics play the most outstanding role in it. Family ethics and moral standa...Marriage and family remain a universal and eternal subject of study. It covers law, ethics, sociology, psychology and even economics. Law and ethics play the most outstanding role in it. Family ethics and moral standards constitute an important part of social ethical system while marriage and family constitute part of the legal system nearest to the life of the common people. Since the founding of New China, the Party and the State have paid full attention to the marriage and family system. Compared with other laws, the law about marriage and family was the first to be legislated. On May 1, 1950, New China’s first law, the 1950 version of Marriage Law, was promulgated. Commenting on the legal document, Chairman Mao Zedong had this to say: Marriage law concerns展开更多
基金supported by CMU Short Term Research Fellowships in Overseasfunded by a Junior Researcher Fellowship 2013,Faculty of Science,Chiang Mai University, Thailand
文摘Objective:To investigate the impact of the endogamous marriage culture on the prevalence of the hemoglobin E(HbE) recessive variant.Methods:The prevalence of the hemoglobin E(HbE)recessive variant was determined by dot-blot hybridization in 4 endogamous villages(1 Mlabri and 3 Htin ethnic groups) in comparison with 9 other nearby non-endogamous populations.Results:Although the overall HbE prevalence in the population studied(8.44%,33/391)was not significantly different from that of the general southeast Asian population,a high prevalence and individuals with homozygous HbE were observed in two villages,the Mlabri from Wiang Sa district and the Htin from Thung Chang district of Nan province(26.3%and26.9%,respectively).The low HbE allelic frequency noticed in some endogamous populations suggests that not only endogamy but also other evolutionary forces,such as founder effect and HbE/β-thalassemia negative selection may have an effect on the distribution of the HbE trait.Conclusion:Our study strongly documents that cultural impact has to be considered in the extensive prevalence studies for genetic disorders in the ethnic groups of northern Thailand.
文摘Marriage and family remain a universal and eternal subject of study. It covers law, ethics, sociology, psychology and even economics. Law and ethics play the most outstanding role in it. Family ethics and moral standards constitute an important part of social ethical system while marriage and family constitute part of the legal system nearest to the life of the common people. Since the founding of New China, the Party and the State have paid full attention to the marriage and family system. Compared with other laws, the law about marriage and family was the first to be legislated. On May 1, 1950, New China’s first law, the 1950 version of Marriage Law, was promulgated. Commenting on the legal document, Chairman Mao Zedong had this to say: Marriage law concerns
