Effects of serum inflammatory factors,health index and disease activity scores on ankylosing spondylitis patients with sleep disorder

BACKGROUND Patients with ankylosing spondylitis(AS)frequently suffer from comorbid sleep disorders,exacerbating the burden of the disease and affecting their quality of life.AIM To investigate the clinical significance of serum inflammatory factors,health index and disease activity scores in patients with AS complicated by sleep disorders.METHODS A total of 106 AS patients with comorbid sleep disorders were included in the study.The patients were grouped into the desirable and undesirable prognosis groups in accordance with their clinical outcomes.The serum levels of inflammatory factors,including C-reactive protein,erythrocyte sedimentation rate,interleukin(IL)-6,tumour necrosis factor-αand IL-1β,were measured.Disease activity scores,such as the Bath AS functional index,Bath AS disease activity index,Bath AS metrology index and AS disease activity score,were assessed.The health index was obtained through the Short Form-36 questionnaire.RESULTS The study found significant associations amongst serum inflammatory factors,health index and disease activity scores in AS patients with comorbid sleep disorders.Positive correlations were found between serum inflammatory factors and disease activity scores,indicating the influence of heightened systemic inflammation on disease severity and functional impairment.Conversely,negative correlations were found between disease activity scores and health index parameters,highlighting the effect of disease activity on various aspects of healthrelated quality of life.Logistic regression analysis further confirmed the predictive value of these factors on patient outcomes,underscoring their potential utility in risk assessment and prognostication.CONCLUSION The findings demonstrate the intricate interplay amongst disease activity,systemic inflammation and patientreported health outcomes in AS patients complicated by sleep disorders.The results emphasise the need for comprehensive care strategies that address the diverse needs and challenges faced by these patients and underscore the potential relevance of serum inflammatory factors,health index and disease activity scores as prognostic markers in this patient population.

Hypertension Associated with Atherosclerosis Risk Factors in Patients of Family Health Strategy Highlighting the Framingham Risk Score

The Systemic Arterial Hypertension (SAH) stands out among the chronic non-transmissible pathologies that impact the cause and/or aggravation of cardiovascular diseases (CVD) on a global level, as the disease is an underestimated disorder due to non-perceptive symptoms and associated with factors and risk markers of another CVD. Therefore, establishing the risk of progression and aggravation of the SAH, according the Framingham Risk Score (FRS), allows to reducing morbidity and improving preventative measures for DCVs. This observational and transversal study approaches the data collection of patient records at the Health Family Strategy of Senhor do Bonfim, BA, which established differences by descriptive and inferential statistical analysis (correlation and regression). The aspects of hypertension associated with risk factors for atherosclerosis were analyzed, determining the risk of developing cardiovascular events in 10 years by FRS. From 432 families, 746 patients were selected, of which 340 are hypertensive individuals (SAH = 45.57%) and 406 (NSAH = 54.42%) non-hypertensives. Among the SAH the majority (31.17%) was in the age range of 63 - 77, but, in both groups, women were in stronger number. There was greater prevalence in SAH for all the characteristics analyzed, smoking (13.20%), sedentary (29.41%) and cardiovascular accident (22.60%). The SAH group is more susceptive to the CVD progress in 10 years by FRS (P < 0.0001 ANOVA). In the NSAH group, there were significant associations among all the variables analyzed as was expected, without differences between the linear correlation and regression, indicating the physio-metabolic equilibrium of the factors and markers evaluated by FRS. Already in SAH group, despite the correlations have been significant too, the regression analysis revealed that only Total Cholesterol (P = 0.0086);LDL (P < 0.0001), Glucose (P < 0.0006) and Age (P < 0.0001) have significative association with FRS. So, these factors and markers deserve more attention upon the health staff of Health Family Strategy, in the SAH course at studied population, attempt the highest cardiovascular risk by FRS (2.5 to 2.8 times) to SAH. The monitoring of high-risk patients should prioritize the lifestyle changes, employing preventive measures to SAH and CVD and atherosclerosis.

Ecological civilization health quotient index and its empirical analysis

The ecological civilization health quotient index is put forward combined with the "health quotient" concept to evaluate the health state of ecological civilization. This paper has constructed the index system of ecological civilization health quotient and quantitatively got each index proportion of the system with application of analytic hierarchy process(AHP). The value of ecological civilization health quotient index is calculated with the fuzzy analysis method. The health state of ecological civilization is judged by the positive and negative ecological civilization health quotient index. This paper has selected the data from 2009 to 2013 to calculate the whole health status of ecological civilization of our country. The conclusion is that our country had transformed from the unhealthy status(ecological civilization health quotient index is-0.133) into the sub-health state(ecological civilization health quotient index is 0.191, but its internal rule layers are negative) during the fi ve years. We should construct the ecological civilization mainly from two aspects of resource conservation and ecological behavior civilization in the future to build a beautiful China.

Association between Self-Rated Health and Depressive Symptoms in Rural Chinese Adults:A Cohort Study Based on Propensity Score Matching

Health status is widely regarded as a correlate of depressive symptoms.However,health assessments based on clinical diagnosis in rural areas with poor medical conditions are very limited.Self-rated health(SRH)serves as a simple and convenient evaluation indicator,which may be used as an independent predictor of depressive symptoms.To confirm the relationship between SRH and depressive symptoms in rural adults,a longitudinal survey of rural households in China was conducted using the China Family Panel Studies(CFPS)from 2012 to 2016.Propensity score matching and logistic regression analysis were used to explore the association.After data cleansing,3,127 pairs(6,254 participants)aged 16 and older followed for 4 years were enrolled,of which the average age was(50.02±14.19)years old,and the proportions of male and female were 48.64%and 51.36%,respectively.The incidence rate of depressive symptoms within 4 years was 30.86%(95%CI:29.24–32.48)in the group with fair or poor SRH,and 21.59%(95%CI:20.14–23.03)in the group with good SRH.The difference between the two groups was statistically significant(χ^(2)=69.51,P<0.001).The results of univariate unconditional logistic regression analysis showed that there was a correlation between SRH and depressive symptoms in rural adults aged 30 and above(OR=1.65,95%CI:1.46–1.85,P<0.001).Thus,a simple and practical assessment tool based on SRH and other indicators should be established for early prevention and intervention in rural primary mental health care.

A Theoretical Study on Health Quotient Promotion-based Physical Education Reform at the University Level

This study maintains that university-level physical education does not currently include or implement health education.? As a consequence of this, college and university students have a very weak theoretical understanding of health.? This study maintains that university-level physical education should focus on the state of students’ health, using the principles of the health quotient.? Of particular importance are problems related to mental health, social adaptive ability, and lifestyle.? Physical education should incorporate instruction based on health quotient-related theories and techniques;doing so will lay a strong foundation for students’ lifelong physical education.? In addition to opening up new paths and methods in research related to the all-around health education of college students, this can also enrich and perfect the theoretical system of modern sports science, as well as provide a new line of thinking and perspective to university-level physical education reform.

Effects of Health Record Computerization in the Context of the COVID-19 Pandemic in Burundi’ Hospitals: Propensity Score Matching

Introduction: A great number of software are currently used to digitalize the patient records in order to optimize the quality of services offered to patients. The objective of this study was to evaluate the effects of Electronic Health Records use in Burundi’s hospitals, taking into account the COVID-19 pandemic context. Methods: This was a quasi-experimental study based on difference in difference method. Ten district hospitals were included in the study, five of them had the Electronic Health Records and five of which did not yet have the Electronic Health Records. The hospital’s control group were chosen using the propensity score matching method. The period before the project’s implementation was 2014 and the period after were 2019 and 2020. Results: After 5 years of the Electronic Health Record’s implementation, the results showed an increase in outpatient consultation (70%), deliveries (more than 100%), caesarean sections (56%) and major surgeries (43%) indicators. The overall quality score of hospitals’ care had a regressive effect of 37% and the income from performance-based funding had an increase by 31%. The indicators which were affected by the context of the COVID-19 pandemic were especially outpatient consultation, caesarian section, income from performance-based funding decreased by 3%, 5% and 20% respectively. Conclusion: The effects of Electronic Health Records use are effective. As the COVID-19 pandemic impacted the hospital’s indicators negatively, the resilient strategies alongside the potential shocks are recommended.

Identification of Health and Welfare Parameters for Rabbit Production and Definition of an Evaluation Score

The knowledge on rabbit welfare may be improved by the use of correct tools for monitoring the different aspects of rabbit industrial farming. Therefore, the aim of this study was to define parameters related to health and welfare of animals in industrial farms with intensive husbandry. Health, management, environmental and productive parameters were firstly characterized and then a protocol to assess welfare of rabbits was define. The research was conducted on 8 industrial farms from 2004 to 2007 and around 30 inspections were done in each farm. At each visit, the health conditions were established by： （1） necropsy on animals of different productive category; （2） specific laboratory investigations based on the lesions observed; （3） checking the presence of parasites in environmental faecal samples; （4） bacteriological examination of vaginal, nasal and rectal swabs of rabbit of different age. The immune conditions and the efficacy of vaccinations were measured by determining anti-Myxomatosis and anti-Rabbit Haemorrhagic Disease antibodies using competitive ELISAs, and anti-Encephalitozoon cunicoli antibodies by immunocarbonassay. The environmental conditions were evaluated by measuring air temperature, relative humidity, ammonia concentration and bacterial/fungal count. Finally the productive parameters were also recorded and elaborated. All the entered values were then utilized for defining a score system to establish health and welfare conditions.

Contamination assessment,source apportionment and associated health risks of PTEs in agricultural soil under five land-use patterns in Sanya,China

To understand the levels of potentially toxic elements(PTEs)contamination in soils and their effects on human health from different agricultural land use in Sanya,China.128 soil samples(64 topsoil samples and corresponding subsoil samples)were collected from the five representative land-use patterns.Inductively coupled plasma mass spectrometry(ICP-MS),Atomic fluorescence spectrometry(AFS),and Inductively coupled plasma optical emission spectrometry(ICP-OES)were used to determine the content of PTEs(As,Cd,Hg,Cu,Cr,Ni,Pb,Zn,Co,Mo,Sb,and V).Correlation analysis and factor analysis were used to determine the source of PTEs.Geo-accumulation index(I_(geo)),hazard quotient(HQ),and total carcinogenic risk index(TR)were used to measure the PTEs contamination and its relative health impacts.Results showed that the average values of 12 PTEs in topsoil were higher than the Hainan soil geochemical baseline,showing different degrees of PTEs accumulation effect.The concentration of PTEs in the topsoil was lower than those in the subsoil except for Cd and Hg.The I_(geo)revealed that the major accumulated element in soils was As followed by Mo.Source apportionment suggested that parent materials and agricultural practices were the dominant factors for PTEs accumulation in the topsoil.Noncarcinogenic risks of soil samples from five land-use patterns presented a trend of paddy field>dry field>woodland>orchard>garden plot.However,the HQ values of 12 PTEs were less than the recommended limit of HQ=1,representing that there are no non-carcinogenic risks of PTEs for children and adults in the study area.The TR values are within 6.95×10^(-6)-1.38×10^(-5),which corresponds to the low level.Therefore the PTEs in the agricultural soil of the study area show little influence on the health status of the local population.

Work Ability Index and Work Ability Score: A Comparation between both Scores in a Persistent COVID-19 Cohort

Aims: The present study aims to compare the assessment of work ability based on the use of the Work Ability Index (WAI) with another questionnaire base only on the use of WAI’s first item, termed as the “Work Ability Score” (WAS). Study design: A cohort of 384 Spanish workers included in a Post COVID-19 condition or persistent COVID-19 multicenter research was utilized. Place and Duration of Study: This cohort was enlisted in four hospitals (Hospital Universitario 12 de Octubre, Madrid;Hospital Universitario Virgen Macarena, Sevilla, Andalucía;Hospital Universitario Gregorio Marañón, Madrid and Complejo Asistencial Universitario de Salamanca, Castilla y León), since 2021 until 2022. Methodology: 384 Spanish workers (176 men and 208 women;aged 20 to 70 years) with Post COVID-19 condition or persistent COVID-19 were included. Descriptive analysis of primary scores was conducted. Given the non-normal distribution of data, the Mann-Whitney and Kruskal-Wallis tests were employed. Spearman and Kendall correlations were employed to assess the relationship between WAI and WAS, also used weighted Kappa to estimate the degree agreement between WAI and WAS. Logistic regression models were utilized to study determinants influencing WAI and WAS, categorized as poor or moderate. Results: WAI had an average score of 32.98 (SD = 10.28), whereas WAS had an average of 5.95 (SD = 2.77). Significant differences were observed in both WAI and WAS across the same variables. Strong and statistically significant correlations were evident between WAI and WAS (rs = 0.83, p < 0.001). All the variables used in the logistic regression model (gender, the sector employment, and previous chronic diseases) were statistically significant in both questionnaires. Conclusion: WAS questionnaire could be used as a tool for reliable assessment of work ability among Spanish workers with Post COVID-19 condition or Persistent CO-VID-19.

Predictors of short-term outcome in patients with acute middle cerebral artery occlusion: unsuitability of fluid-attenuated inversion recovery vascular hyperintensity scores

Fluid-attenuated inversion recovery （FLAIR） vascular hyperintensity （FVH） is used to assess leptomeningeal collateral circulation, but clinical outcomes of patients with FVH can be very different. The aim of the present study was to assess a FVH score and explore its relationship with clinical outcomes. Patients with acute ischemic stroke due to middle cerebral artery M1 occlusion underwent magnetic resonance imaging and were followed up at 10 days （National Institutes of Health Stroke Scale） and 90 days （modified Rankin Scale） to determine short-term clinical outcomes. Effective collateral circulation indirectly improved recovery of neurological function and short-term clinical outcome by extending the size of the pial penumbra and reducing infarct lesions. FVH score showed no correlation with 90-day functional clinical outcome and was not sufficient as an independent predictor of short-term clinical outcome.

Assessment of disease specific knowledge and health-relatedquality of life among United States military veterans withinflammatory bowel disease

AIM To evaluate the association between patientdisease knowledge of inflammatory bowel disease （IBD）and health related quality of life （HRQoL） and identifypatient and disease related predictors of patientknowledge of IBD.METHODS： We performed a cross-sectional study ofIBD patients with an established diagnosis of IBD longerthan 3 mo prior to enrollment. The Crohn＇s and colitisknowledge score （CCKNOW） and short inflammatorybowel disease questionnaire （SIBDQ） were selfadministeredto assess patient knowledge of IBDand HRQoL, respectively. Demographic and diseasecharacteristics were abstracted from the electronicmedical record. The correlation between CCKNOWand SIBDQ scores was assessed by a linear regressionmodel. Associations of patient knowledge and thevariables of interest were calculated using ANOVA.RESULTS： A total of 101 patients were recruited.Caucasian race, younger age at diagnosis, and having a college or post-graduate degree were significantlyassociated with higher CCKNOW scores. Patients withCD had higher CCKNOW scores compared to patientswith ulcerative colitis and inflammatory bowel diseasetype unclassified, P 〈 0.01. There was no significantcorrelation between overall CCKNOW and SIBDQ scores（r^2 = 0.34, P = 0.13）. The knowledge sub-domain ofdiet in CCKNOW was negatively correlated with HRQoL（r^2 = 0.69, P 〈 0.01）.CONCLUSION： IBD diagnosis at a younger age inaddition to Caucasian race and higher education weresignificantly associated with higher knowledge aboutIBD. However, patient knowledge of IBD was notcorrelated with HRQoL. Further studies are required tostudy the effect of patient knowledge of IBD on otherclinical outcomes.

Poverty and Nutritional Health of the Child: Some Evidence from 2005 Demographic and Health Survey of Congo

The objective of this study is to identify the ways in which poverty could affect the nutritional health of the child and to analyze the strength of these links. On the whole, it appears that the relationship between poverty (measured by the wealth index) and health of the child (measured by an anthropometric index) is positive and highly significant.

Assessment of Metal Accumulation in the Vegetables and Associated Health Risk in the Upper-Most Ganga-Yamuna Doab Region, India

The present study indicates the status of metal contamination in the vegetables/crops grown in the upper most Ganga-Yamuna doab region of India and associated health risk. Commonly grown vegetables and crops were sampled and analyzed for the metal contamination. Maximum concentration (mg/kg) of Cd and Cr, was observed in Radish (7.6) and Cabbage (56.24) respectively, whereas maximum concentration of Pb, Ni and Zn was observed in the edible parts of Mustard plant (95.4, 58.6, 756.43 respectively). Bio-concentration factor (BCF) value indicated the transfer level of metal from soil to crop;indicated high transfer value of Cd in Radish followed by cabbage and spinach. Considerably high BCF value was observed in the Mustard (8.13), Cabbage (4.18) and radish (3.07) for Zn contamination. Estimated daily intake (EDI) and Hazard quotient (HQ) or Non-carcinogenic health risk was calculated using the USEPA method. The result revealed that the metal intake and associated health risk were considerably high in the children population in comparison to the adult population.

Health Risk Assessment of Heavy Metals in Groundwater： The Effect of Evaporation Ponds of Distillery Spent Wash

The current study was carried out to examine the heavy metals （Cd, Co, Cr, Cu, Mn, Ni, Pb, Zn and As） concentration in GW （groundwater） samples in the vicinity of distillery spent wash evaporation ponds and RGW （reference groundwater） samples collected 2 km to 3 km away from the source. The study examines the potential health risk caused by consumption of heavy metals to local inhabitants living around distillery spent wash evaporation ponds. HM （heavy metals） concentration was determined by AAS （atomic absorption） and the results were compared with permissible limits of PEPA （pakistan environmental Protection Agency） and WHO （World Health Organization）, set for industria effluents and drinking water. The health risk assessment such as CDI （chronic daily intake） and HQ （hazard quotient） were determined on the sources ofHM concentration. The cm of heavy metals in GW were found in following decreasing order Fe, Zn, Mn, Ni, Co, Cu, Cr, Cd, Pb and As. The HQ indexes of HM in the GW samples near the distillery spent wash evaporation ponds was in the order As, C, Ni, Cu, Mn, Zn, Pb and Cr. The results showed that the distillery spent wash is the cause for the change in HM contents of the study area.

Mineral Uptake of Heavy Metals by Some Marine Organisms along the Limbe Coastline in Cameroon and Health Risk Assessment

This study aimed at investigating the content of heavy metals in some marine organisms of the Cameroon Atlantic coast and assessing the health risk due to their consumption by the population. Nine fish and one shrimp species were collected for this study. These fish species were Ethmolosa fimbriata, Drepane africana, Dentex moroccanus, Arius latiscotatus, Scarus hoefleri, Cynoglossus browni, Sardinella madorensis, Pseudotolithus elongatus, Pseudotolithus typus. The shrimp species was Macrobranchium macrobranchium. The elements investigated in this study were: Fe, Co, Cu, Cd and Pb. For seven fish species it was found that the concentration of heavy metals followed the order Fe > Co > Cd > Cu > Pb. For most fish species the Target Hazard Quotient (THQ) value calculated showed the following trend Cd > Co > Pb > Fe ≥ Cu. Cadmium was found to be the main contributor to health risk that may result from the consumption of the fish species under study. The THQ for this element was in the range 0.7 - 1.2 while the Target Cancer Risk (TR) due to ingestion of this metal was in the range (3 × 10-4 - 6 × 10-4). These values are slightly above the threshold limits established for both carcinogenic and non carcinogenic risks by the United States, Environmental Protection Agency. The estimated weekly intake of cadmium due to consumption of some fishes under study was greater or equal to the Provisional Tolerable Weekly Intake (PTWI) determined by Food and Agriculture Organization/World Health Organization.

Spatial Investigation of Nilüfer Stream Arsenic Pollution in Previous and Post COVID-19 Pandemic and Evaluation of Health Risks for Adult People

This study was carried out in Nilüfer Stream in Bursa City,where intensive industrial,agricultural and mining activities are existed.The temporal and spatial variation of arsenic was evaluated by examining its concentrations between March 2015 and December 2021.Values between March 2015 and December 2019 were evaluated as pre-pandemic,and values between March 2020 and December 2021 were evaluated as post-pandemic.The results were compared with national and international standards and the chronic and cancer risks were calculated for adults.When the 7-year general averages were examined,it was seen that the highest concentration was 0.0256 mg/L at the 8th Station,and the lowest concentration was 0.0182 mg/L at the 1st Station.The reason why the highest value is at the 8th station was that the wastewater of Nilüfer and Bursa Organized Industrial Zones was discharged to Bursa West Wastewater Treatment Plant before this station.After the pandemic the raises in concentrations were observed at all stations,except for the 3rd Station.This shows that the pollution load had increased in general during the pandemic.However,it was estimated that there was a decrease in the pollution load of the industrial wastewater coming to the 3rd Station,which was located after the Eastern Wastewater Treatment Plant of the City.It was observed that all stations examined were higher than drinking water standards and lower than irrigation water standards according to WHO and Turkish National Standards.All measuring stations were greater than 1 of the hazard quotient(HQ)values.In terms of human consumption risk,all stations had a chronic and carcinogenic risk according to the values before and after the pandemic.After the pandemic conditions,the HQ order of the stations was 8>10>7>9>2>6>4>1>3.In general,post-pandemic HQ values had generally increased and the risk of cancer had increased.

Effect of sharing health messages on antenatal care behavior among women involved in microfinance-based self-help groups in Bihar India

Background:Bihar state in India has one of the highest rates of maternal and infant mortality in South Asia.Microfinance-based self-help groups(SHGs),involving rural women,are being utilized to improve maternal and child health practice and reduce mortality.SHG members receive information on key maternal and child health practices as well as encouragement for their practice.This study measures the association of health messaging to SHG members with their antenatal care(ANC)behaviors.Methods:The study was conducted in eight districts of Bihar in 2016.A three-stage cluster sampling design(with a random selection of blocks,villages,and SHGs)selected the sample of 1204 SHG members who had an infant child;of these,597 women were members of SHGs that received dedicated sessions on health messages,while 607 women belonged to SHGs that did not.To examine the impact of the health intervention on ANC practice,radius caliper method of propensity score matching controlled for various socio-demographic characteristics between the two groups.Results:Most of the interviewed women(91.5%)belonged to a scheduled caste or tribe.Nearly 44%of SHG members exposed to the health intervention were engaged in some occupation,compared to 35%of those not exposed to the intervention.After matching unexposed SHG women with exposed SHG women,no significant differences were found in their socio-demographic characteristics.Findings suggest that exposure to a health intervention is associated with increased likelihood of at least four ANC visits by SHG women(ATE=7.2,95%CI:0.76-13.7,p<0.05),consumption of iron-folic acid for at least 100 days(ATE=8.7,95%CI:5.0-12.5,p<0.001)and complete ANC(ATE=3.6,95%CI:2.3-4.9,p<0.001),when compared to women not exposed to the health intervention.Conclusions:The study shows that sharing health messages in microfinance-based SHGs is associated with significant increase in ANC practice.While the results suggest the potential of microfinance-based SHGs for improved maternal health services,the approach’s sustainability needs to be further examined.

《国家学生体质健康标准(2014年修订)》测试项目调整对学生测试成绩影响的实证研究——以小初衔接阶段学生为例

目的:探究《国家学生体质健康标准(2014年修订)》(以下简称“《标准》”)测试项目调整对学生成绩的影响,为《标准》测试项目优化发展提供理论参考与实践支持。方法:3000名小学六年级和初中一年级学生分别进行《标准》(小学六)和《标准》(初中一)测试(有效测试人数2870人),对比两次测试成绩差异。结果:(1)学生《标准》(小学六)非共性项目得分、总得分显著高于《标准》(初中一)非共性项目得分、总得分;(2)女生《标准》(初中一)非共性项目得分、总得分显著高于男生《标准》(初中一)非共性项目得分;(3)学生《标准》成绩在组别性别上存在交叉效应,男生得分的下降幅度高于女生。结论:(1)《标准》测试项目调整显著影响小初衔接阶段学生测试成绩;(2)《标准》测试项目调整后,男生成绩的下降幅度显著大于女生。为有效应对《标准》测试项目调整带来的影响,应统一男女《标准》非共性项目数量,同时降低男生《标准》非共性项目难度。

严重少弱精子症患者卵胞质内单精子注射失败后使用供精助孕对其心理健康与勃起功能的影响

目的探究严重少弱精子症患者卵胞质内单精子注射(ICSI)失败后使用供精助孕对其心理健康和勃起功能的影响,为该类人群针对性心理干预的实施提供参考。方法选取2020年12月至2022年12月于同济大学附属妇产科医院行助孕治疗的严重少弱精子症患者作为研究对象。其中ICSI失败后使用供精助孕的68例设为研究组,采用倾向性评分1∶1匹配ICSI失败后继续行ICSI助孕的68例设为对照组。采用一般资料调查表、焦虑自评量表(SAS)、抑郁自评量表(SDS)、中文版知觉压力量表(CPSS)和国际勃起功能指数-5(IIEF-5)进行横断面调查,比较两组血清总睾酮水平、心理健康和勃起功能状况。结果倾向性评分匹配后,两组社会人口学资料、血清总睾酮水平比较,差异无统计学意义(P>0.05);研究组焦虑、抑郁、高压力人群占比高于对照组,勃起功能障碍发生率高于对照组,差异具有统计学意义(P<0.05)。结论严重少弱精子症患者ICSI失败后使用供精助孕对其心理健康和勃起功能影响较大,医护人员应关注此类患者的心理健康和勃起功能状况,制定针对性措施帮助此类患者积极应对。

针对连续暴露因素的广义倾向评分方法在环境健康领域中的应用

目的介绍针对连续暴露因素的广义倾向评分(GPS)方法原理,探索其在环境健康领域中的应用,为测量环境健康风险提供有效工具。方法利用北京市“空气污染与人群健康队列研究”基线调查数据(2017—2018年),评价针对连续暴露因素的GPS方法在大气污染对健康效应估计中的应用效果。结果应用针对连续暴露水平的GPS方法后,不同暴露水平人群的混杂因素均衡性得到明显改善。PM_(2.5)暴露每增加10μg/m^(3),高血压患病的风险增加比例从原来的10.3%上升到11.9%。结论针对连续暴露水平的GPS方法在一定程度上为大气污染与健康的关联研究提供更准确的流行病学证据。