Mature While Growing up, Innovative While Inheriting——Exclusive Interview with Zhao Xinli, the Associate Dean of the Advertising School of Communication University of China

As the Chinese proverb goes,a man of his thirties should be independent.For a person,it s time to shoulder the responsibility he or she longs for.For a major and a School,it s time to root deep,to take responsibility and to fulfill its dream of 'a School stands for a hundred years as a tree for a thousand years'.As the Advertising School of Communication University of China embraces its 30th 'birthday',Zhao Xinli,the Associate Dean of the School,was exclusively interviewed by China’s Foreign Trade.

Inheriting Good Tradition and Expanding Cooperation Fields for New Stage of Friendship:on FES President Beck 's Visit to China

At the invitation of the Chinese Association for International Understanding(CAFIU),a delegation headed by Mr.Kurt Beck,President of FriedrichEbert-Stiftung(FES),visited China from 17 to 20,October 2013.As his first visit to China since taking the office of FES President,President Beck aimed at keeping abreast of China’s political,economic and social development since the 18th National Congress of the CPC as well as renewing the Memorandum of Understanding between CAFIU and FES.

The occurrence,inheritance,and segregation of complex genomic structural variation in synthetic Brassica napus

"Synthetic"allopolyploids recreated by interspecific hybridization play an important role in providing novel genomic variation for crop improvement.Such synthetic allopolyploids often undergo rapid genomic structural variation(SV).However,how such SV arises,is inherited and fixed,and how it affects important traits,has rarely been comprehensively and quantitively studied in advanced generation synthetic lines.A better understanding of these processes will aid breeders in knowing how to best utilize synthetic allopolyploids in breeding programs.Here,we analyzed three genetic mapping populations(735 DH lines)derived from crosses between advanced synthetic and conventional Brassica napus(rapeseed)lines,using whole-genome sequencing to determine genome composition.We observed high tolerance of large structural variants,particularly toward the telomeres,and preferential selection for balanced homoeologous exchanges(duplication/deletion events between the A and C genomes resulting in retention of gene/chromosome dosage between homoeologous chromosome pairs),including stable events involving whole chromosomes("pseudoeuploidy").Given the experimental design(all three populations shared a common parent),we were able to observe that parental SV was regularly inherited,showed genetic hitchhiking effects on segregation,and was one of the major factors inducing adjacent novel and larger SV.Surprisingly,novel SV occurred at low frequencies with no significant impacts on observed fertility and yield-related traits in the advanced generation synthetic lines.However,incorporating genome-wide SV in linkage mapping explained significantly more genetic variance for traits.Our results provide a framework for detecting and understanding the occurrence and inheritance of genomic SV in breeding programs,and support the use of synthetic parents as an important source of novel trait variation.

Facing ethical concerns in the age of precise gene therapy:Outlook on inherited arrhythmias

This editorial,comments on the article by Spartalis et al published in the recent issue of the World Journal of Cardiology.We here provide an outlook on potential ethical concerns related to the future application of gene therapy in the field of inherited arrhythmias.As monogenic diseases with no or few therapeutic options available through standard care,inherited arrhythmias are ideal candidates to gene therapy in their treatment.Patients with inherited arrhythmias typically have a poor quality of life,especially young people engaged in agonistic sports.While genome editing for treatment of inherited arrhythmias still has theoretical application,advances in CRISPR/Cas9 technology now allows the generation of knock-in animal models of the disease.However,clinical translation is somehow expected soon and this make consistent discussing about ethical concerns related to gene editing in inherited arrhythmias.Genomic off-target activity is a known technical issue,but its relationship with ethnical and individual genetical diversity raises concerns about an equitable accessibility.Meanwhile,the costeffectiveness may further limit an equal distribution of gene therapies.The economic burden of gene therapies on healthcare systems is is increasingly recognized as a pressing concern.A growing body of studies are reporting uncertainty in payback periods with intuitive short-term effects for insurance-based healthcare systems,but potential concerns for universal healthcare systems in the long term as well.Altogether,those aspects strongly indicate a need of regulatory entities to manage those issues.

Construction of the Demonstration Area for the Inheritance and Development of Yimeng Red Culture Based on Digital Empowerment

Yimeng red culture is an important part of the excellent culture of the Chinese nation.It is of great practical significance and long-term strategic significance to build the demonstration area for the inheritance and development of Yimeng red culture.Combining digital empowerment with the inheritance and development of Yimeng red culture is a new idea that conforms to the development of the times.In this paper,on the basis of combing Yimeng red cultural resources and combining with the current situation of inheritance and development of Yimeng red culture,the strategic layout and implementation approach of the demonstration area for the inheritance and development of Yimeng red culture were put forward from the perspective of digital empowerment.

Immune remodulation in pediatric inherited metabolic liver diseases

Inherited metabolic liver diseases arise from genetic mutations that lead to dis-ruptions in liver metabolic pathways and are predominantly observed in pedia-tric populations.The spectrum of genetic metabolic liver disorders is diverse,encompassing a range of conditions associated with aberrations in iron,copper,carbohydrate,lipid,protein,and amino acid metabolism.Historically,research in the domain of genetic metabolic liver diseases has predominantly concentrated on hepatic parenchymal cell alterations.Nevertheless,emerging studies suggest that inherited metabolic liver diseases exert significant influences on the immune microenvironment,both within the liver and systemically.This review endeavors to encapsulate the immunological features of genetic metabolic liver diseases,aiming to expand the horizons of researchers in this discipline,and to elucidate the underlying pathophysiological mechanisms pertinent to hereditary metabolic liver diseases and to propose innovative therapeutic approaches.

Protection and Inheritance of the Architectural Cultural Heritage of the Longevity Pagoda in Jingzhou

With the ongoing advancement of human civilization,China is increasingly prioritizing the preservation and transmission of its architectural heritage.This study examines the historical development of the Longevity Pagoda in Jingzhou,synthesizing its architectural and artistic characteristics as well as its cultural heritage value.In light of contemporary challenges,the paper proposes strategies for the protection and preservation of the Longevity Pagoda.The aim is to ensure that the Longevity Pagoda continues to realize its distinctive historical,cultural,and social significance in the future.

Utilization and Living Inheritance of Red Tourism Resources in Nanxiong City under the Background of"Baiqianwan Project"

Under the work deployment of"Double Hundred Action",Huizhou Engineering Vocational College,Nanxiong Municipal People's Government and Shaoguan College have formulated a series of plans and projects to promote the local development of Nanxiong through cooperation and in-depth research,which strengthens the role of vocational education in rural revitalization,and promotes the effective use of red tourism resources in Nanxiong City,promoted the development of local tourism and economy,provides new impetus and direction for rural revitalization,and demonstrates the positive prospects and vitality of rural revitalization,as well as the important value and potential of vocational education in rural revitalization.

Genetic variation features of neonatal hyperbilirubinemia caused by inherited diseases

BACKGROUND Genetic factors play an important role in neonatal hyperbilirubinemia(NH)caused by genetic diseases.AIM To explore the characteristics of genetic mutations associated with NH and analyze the correlation with genetic diseases.METHODS This was a retrospective cohort study.One hundred and five newborn patients diagnosed with NH caused by genetic diseases were enrolled in this study between September 2020 and June 2023 at the Second Affiliated Hospital of Xiamen Medical College.A 24-gene panel was used for gene sequencing to analyze gene mutations in patients.The data were analyzed via Statistical Package for the Social Sciences 20.0 software.RESULTS Seventeen frequently mutated genes were found in the 105 patients.Uridine 5'-diphospho-glucuronosyltransferase 1A1(UGT1A1)variants were identified among the 68 cases of neonatal Gilbert syndrome.In patients with sodium taurocholate cotransporting polypeptide deficiency,the primary mutation identified was Na+/taurocholate cotransporting polypeptide Ntcp(SLC10A1).Adenosine triphosphatase 7B(ATP7B)mutations primarily occur in patients with hepatolenticular degeneration(Wilson's disease).In addition,we found that UGT1A1 and glucose-6-phosphate dehydrogenase mutations were more common in the high-risk group than in the low-risk group,whereas mutations in SLC10A1,ATP7B,and heterozygous 851del4 mutation were more common in the low-risk group.CONCLUSION Genetic mutations are associated with NH and significantly increase the risk of disease in affected newborns.

Inheritance and Innovation of Chinese Filial Piety Culture Restated

Chinese traditional filial piety culture has gained widespread acceptance in contemporary social life and has been inherited and carried forward in a variety of ways instead of fading away with the development of economy and society.Meanwhile,under the background of urbanization,industrialization,and modernization,traditional filial piety also faces many new challenges.This paper puts forward the reflections and countermeasures concerning the inheritance and innovation of filial piety culture in the new era from perspectives of concept connotation,publicity and education,institutional guarantee,funding source,and social organizations.

Research on the Innovation of Traditional Music Cultural Inheritance

Traditional music is an important source of Chinese civilization and has a profound impact on the origin,enrichment,leap forward,and sublimation of Chinese culture.Starting from the three dimensions of history,people,and integration,it is important to inherit,carry forward,and spread the contemporary value of traditional music culture.We should focus on the inheritance of historical dimension,reposition the unique function of traditional music culture,strengthen the ecological protection of traditional music culture,and advocate excavation protection,purification protection,and promotion protection.Additionally,we focus on the development of the people dimension,adhere to the people-centered creative orientation,grasp the needs of the people,reflect their aspirations,and strive to enhance the timeliness and attraction of national music.We also focus on the communication of integration dimension,leverage the characteristic advantages of emerging media communication,promote the cross-border integration of the traditional music industry and related fields,respond to the focus and interaction of music audience services,and promote the construction of a modern three-dimensional communication system of traditional music.

Exploration of the Inheritance and Innovation Carrier of National Culture in the Teaching Model of Art Design Major in Higher Vocational Colleges:Integrating Lijiang Baisha Murals into Higher Vocational Art Design Curriculum System

This study aims to further promote the inheritance and innovative development of intangible cultural heritage in Yunnan Province,promote the protection,inheritance,integration,and innovation of ethnic culture in Lijiang,strengthen the protection and inheritance of Baisha murals in Lijiang,and change the teaching of art design majors in vocational colleges in Yunnan.Given the lack of traditional Chinese culture and local ethnic culture,this article focuses on the teaching of art design majors in Yunnan vocational colleges.It explores the construction model of the cultural inheritance and innovation carrier of Lijiang Baisha murals to meet the spiritual and cultural needs of the local people,and efforts will be made to promote the high-quality development of the Baisha ethnic area in Lijiang.

On Inheriting and Preserving the Cultural Heritage of Nuo in Jiangxi Province

There is a great necessity to inherit and preserve the cultural heritage of Nuo in Jiangxi Province for its artistic value,economic value and social value.In reality,however,the disappearance of culture-inheriting carriers and the failure to protect relevant resources all conspire against the task of inheriting and preserving this unique inheritance.Government needs to put its weight behind this work by establishing institutions and providing funds to restore the culture of Nuo in Jiangxi.

Studies on the Inheritance of Locule Formation in Tomatoes (Lycopersicon esculentum Mill.)

To fully understand the tomato ovary locule formation of inheritance, two varieties, ovary multi-locule （MLK1） and few-locule （FL1）, were used in these studies. Using reciprocal cross, self-cross, and backcross, we have constructed various groups to seek the genetic law and mechanisms of tomato locule formation, for modifying the tomato breeding theory. The parental and the resulting FI and F2 generations have been used to examine the heredity of the locule number. The results showed that few-locule was incompletely dominant. The data from backcross demonstrated a significant effect on the locule number, whereas, the reciprocal cross showed an insignificant effect. Not surprisingly, the locule number was controlled by nuclear genomes, not by exogenous substances. The model that inherited the locule number belonged to the additive-dominant model： additive effects played a very important role and were partially dominant. In addition, the results revealed that the locule number in tomato was mainly controlled by a single gene, whereas, it was modulated by a number of other genes. Finally, the general inheritability and narrow inheritability of the locule number were 69.44% and 52.98%, respectively.

Inheritance of Fat and Fatty Acid Compositions in Peanut (Arachis hypogaea L.)

[Objective] The aim was to explore the inheritance of fat and fatty acid compositions in peanut.[Method] Genetic and correlation analyses were performed using a mixed genetic model of major gene plus polygene with 215 F9 RILs and their parents ZHENG 8903 and YUHUA No.4.[Result] The optimal genetic model of the fat content was two linked complementary major gene plus polygene inheritance model.The heritability of major genes was 22.88%.Oleic,linoleic,and palmitic acid content were controlled by two major genes and the heritability was 75.11%,75.00% and 60.95%,respectively.Stearic and arachidic acid content were controlled by two major genes plus polygenes,the heritability of major genes was 26.43% and 33.17%,respectively.O/L ratio and behenic acid content were controlled by three major genes,the heritability was 70.65% and 30.70%,respectively.[Conclusion] The result in this study was that accumulating polygenes should be emphasized in the improvement of fat content,while utilization of major genes is enhanced in improvement of oleic and linoleic acids.

Inheritance of Chloroplast and Mitochondrial DNA in Chinese Fir (Cunninghamia lanceolata)

The inheritance of mitochondrial (mt) DNA and chloroplast (cp) DNA was investigated in intergeneric hybrids from crossing between Cunninghamia lanceolata (Lamb.) Hook. and Cryptomeria fortunei Hooibrenk. The chloroplast trnL trnF region and one intra genic segment of the mitochondrial gene, Cox Ⅲ, were amplified from those of the parents and hybrids by PCR using gene specific primers. Cp and mtDNA polymorphisms of the amplified regions were detected between the parents after restriction digestions. Restriction fragment length polymorphism (RFLP) analysis revealed that all the F 1 individuals possessed Cox Ⅲ restriction fragment patterns (characteristic of the paternal parent Cryptomeria fortunei ) and the trnL trnF region (identical to the maternal parent Cunninghamia lanceolata ) showing that a different mode of inheritance for organelle DNA has occurred in the hybrids. Furthermore, the maternal inheritance of chloroplast DNA is reported here for the first time in coniferophyta.

PATERNAL INHERITANCE OF PLASTID DNA IN GENUS PHARBITIS

The inheritance of plastid DNA in Pharbitis was studied by the method of restriction fragment length polymorphisms (RFLP).Experimental results showed that plastid DNA from Pharbitis was paternally inherited in reciprocal crosses,P. nil ×P. limbata and P. limbata×P. nil hybrids.But,in the cross of P. limbata×P. nil,the possibility of biparental inheritance of plastid DNA could not be roled out in our preliminary experiment.Thus Pharbitis became the third genus among angiosperms characterized with male plastid transmission.The mechanisms of paternal plastids DNA inheritance in Pharbitis is unclear.The authors proposed that dilution,exclusion and/or degeneration of maternal plastid,including their DNA,after fertilization should be considered.

Study on Inheritance Mechanism of Tomato Fruit Firmness

[Objective] This study aimed to investigate the inheritance mechanism of tomato fruit firmness.[Method] Two tomato cultivars significantly different in fruit firmness were selected for investigation of the inheritance mechanism of tomato fruit firmness using combination analysis of six generations （P1,P2,F1,F2,B1 and B2）.[Result] The results indicated that the heredity of tomato fruit firmness was consistent with the additive-dominant model controlled by one pair of major genes; the additive effect （d）,dominant effect （h） and degree of dominance （h/d） of major genes were 17.37,-7.96 and-0.46,respectively,showing positive additive effect and incompletely dominant-negative effect; the hereditability of major gene effect in B1,B2 and F2 generation was 88.59％,45.81％ and 85.62％,respectively.[Conclusion] The heredity of fruit firmness was controlled by one pair of major gene,showing significant additive effect and dominant effect.

Plastid Inheritance in Sweet Potato as Revealed by DNA Restriction Fingerprinting

The inheritance of chloroplast DNA (cpDNA) in sweet potato (Ipomoea batatas Lain.) was analyzed using DNA restriction fingerprinting. The cpDNA fingerprints of hybrids from reciprocal crosses between Xushu18 and AB78-1 were found to be identical to those of their female parents, which reveals that cpDNA of sweet potato is maternally inherited in this intervarietal crossing. This maternal cpDNA transmission pattern does not accord with the putative one based on former cytological studies. The plastid inheritance in Convolvulaceae has been briefly reviewed in this study, and the utility of DNA restriction fingerprinting analysis in the study of plastid inheritance is also discussed.

Protective Renovation and Cultural Inheritance of Ancient Villages——A Case Study of Hanjiaxiang Village in Chenggu County,Shaanxi Province of China

Cultural characteristics of the traditional architectural environment and places of traditional cultural activities in Hanjiaxiang Village,an immigrant village of the Ming Dynasty located in the present Yuangong Township,Chenggu County of Shaanxi Province,were studied to analyze influence of geographical environment,history and culture,and social environment on the village cultures.Specifically,cultural characteristics of traditional architectural environment in this village were elaborated from spatial layout,architectural structure,architectural style and village landscapes.In terms of places for traditional cultural activities,layouts and cultural characteristics of places for the clan's sacrifice and community's fire,traditional sacrifice activities,and local opera performances were introduced.On this basis,cultural inheritance means for the protective renovation and construction of overall village spaces,village buildings,village landscapes and cultural characteristics were proposed.