Description Journal of Integrative Agriculture(JIA),formerly Agricultural Sciences in China(ASC),founded in 2002,is sponsored by Chinese Academy of Agricultural Sciences(CAAS),co-sponsored by Chinese Association of Ag...Description Journal of Integrative Agriculture(JIA),formerly Agricultural Sciences in China(ASC),founded in 2002,is sponsored by Chinese Academy of Agricultural Sciences(CAAS),co-sponsored by Chinese Association of Agricultural Science Societies(CAASS).展开更多
Description Journal of Integrative Agriculture(JIA),formerly Agricultural Sciences in China(AsC),founded in 2002,is sponsored by Chinese Academy of Agricultural Sciences(CAAS),co-sponsored by Chinese Association of Ag...Description Journal of Integrative Agriculture(JIA),formerly Agricultural Sciences in China(AsC),founded in 2002,is sponsored by Chinese Academy of Agricultural Sciences(CAAS),co-sponsored by Chinese Association of Agricultural Science Societies(CAASS).JIAis a peer-reviewed and multi-disciplinary international journal and published monthly in English.JIA Editorial Board consists of 289 well-respected scholars of agricultural scientific fields.展开更多
Description Journal of Integrative Agriculture(JIA),formerly Agricultural Sciences in China(AsC),founded in 2002,is sponsored by Chinese Academy of Agricultural Sciences(CAAS),co-sponsored by Chinese Association of Ag...Description Journal of Integrative Agriculture(JIA),formerly Agricultural Sciences in China(AsC),founded in 2002,is sponsored by Chinese Academy of Agricultural Sciences(CAAS),co-sponsored by Chinese Association of Agricultural Science Societies(CAAss).JIA is a peer-reviewed and multi-disciplinary international journal and published monthly in English.JIA Editorial Board consists of 289 well-respected scholars of agricultural scientific fields.CAAs President,Academician WU Kong-ming is the Chairman of the Board,and CAAS Vice President,Academician CHEN Hua-lan is the Editor-in-Chief.JIA has been published by Elsevier B.V.since 2006 and is a leading academic journal in agricultural sciences in China.As released by JCR,the latest IF of the journal is 4.8.展开更多
Instruction to Authors Aims and Scope Journal of Integrative Agriculture(JIA),formerlyAgricultural Sciences in China(ASC),founded in 2002,is sponsored by Chinese Academy of Agricultural Sciences(CAAS),co-sponsored by ...Instruction to Authors Aims and Scope Journal of Integrative Agriculture(JIA),formerlyAgricultural Sciences in China(ASC),founded in 2002,is sponsored by Chinese Academy of Agricultural Sciences(CAAS),co-sponsored by Chinsese Association of Agricultural Science Societies(CAAsS).展开更多
Aims and Scope Journal of IntegrativeAgriculture(JIA),formerly Agricuiltural Sciences in China(ASC),founded in 2002,is sponsored by Chinese Academy of Agricultural Sciences(CAAS),co-sponsored by Chinsese Association o...Aims and Scope Journal of IntegrativeAgriculture(JIA),formerly Agricuiltural Sciences in China(ASC),founded in 2002,is sponsored by Chinese Academy of Agricultural Sciences(CAAS),co-sponsored by Chinsese Association of Agricultural Science Societies(CAAsS).The latest IF is 4.8.JIA seeks to publish those papers that are influential and will significantly advance scientific understanding in agriculture fields worldwide.JIA publishes manuscripts in the categories of Commentary,Review,Research Article,Letter and Short Communication,focusing on the core subjects:Crop Science Horticulture·Plant ProtectionAnimal Science·Veterinary Medicine·Agro-ecosystem&Environment·Food Science·Agricultural Economics and Management·Agricultural Information Science.展开更多
Description Journal of Integrative Agriculture(JIA),formerly Agricultural Sciences in China(AsC),founded in 2002,is sponsored by Chinese Academy of Agricultural Sciences(CAAS),co-sponsored by Chinese Association of Ag...Description Journal of Integrative Agriculture(JIA),formerly Agricultural Sciences in China(AsC),founded in 2002,is sponsored by Chinese Academy of Agricultural Sciences(CAAS),co-sponsored by Chinese Association of Agricultural Science Societies(CAAsS).JIA is a peer-reviewed and multi-disciplinary international journal and published monthly in English.JIA'Editorial Board consists of 289 well-respected scholars of agricultural scientific fields.CAAs President,Academician WU Kong-ming is the Chairman of the Board,and CAAS Vice President,Academician CHEN Hua-lan is the Editor-in-Chief.JIA has been published by Elsevier B.V.since 2006 and is a leading academic journal in agricultural sciences in China.As released by JCR,the latest IF of the journal is 4.8.展开更多
Description Journal of Integrative Agriculture(JIA),formerly Agricultural Sciences in China(AsC),founded in 2002,is sponsored by Chinese Academy of Agricultural Sciences(CAAS),co-sponsored by Chinese Association of Ag...Description Journal of Integrative Agriculture(JIA),formerly Agricultural Sciences in China(AsC),founded in 2002,is sponsored by Chinese Academy of Agricultural Sciences(CAAS),co-sponsored by Chinese Association of Agricultural Science Societies(CAAsS).JIAis a peer-reviewed and multi-disciplinary international journal and published monthly in English.JIA Editorial Board consists of 289 well-respected scholars of agricultural scientific fields.CAAS President,Academician WU Kong-ming is the Chairman of the Board,and CAAS Vice President,Academician CHEN Hua-lan is the Editor-in-Chief.JIA has been published by Elsevier B.V.since 2006 and is a leading academic journal in agricultural sciences in China.As released by JCR,the latest IF of the journal is 4.8.展开更多
试验选用初始体重为(44.34±1.58)g的津新鲤1 260尾,随机分为6组,每组3个重复,每个重复70尾鱼。6组饲料分别含有豆油、鸡油、玉米油、棕榈油、菜籽油、棉籽油。饲养8周后探讨饲料中不同脂肪源对津新鲤生长、相关脂代谢酶活性及脂肪...试验选用初始体重为(44.34±1.58)g的津新鲤1 260尾,随机分为6组,每组3个重复,每个重复70尾鱼。6组饲料分别含有豆油、鸡油、玉米油、棕榈油、菜籽油、棉籽油。饲养8周后探讨饲料中不同脂肪源对津新鲤生长、相关脂代谢酶活性及脂肪酸合成酶(FAS)、脂蛋白脂酶(LPL)基因表达的影响。结果表明:玉米油组的相对增重率、特定生长率及蛋白质效率显著高于其它5组(P<0.05),但玉米油组饵料系数则最低。不同脂肪源饲料对肝胰脏及肾脏中LPL、肝脂酶(HL)、总脂酶(GE)、脂肪代谢酶活性影响很大(P<0.05),且玉米油组酶活性均最高;各组肝胰脏及肾脏FAS变化不大(P>0.05)。从基因表达来看,玉米油组更容易诱导和调节肝胰脏和肾脏中FAS及LPL m RNA的表达(P<0.05),再次投喂后6 h,肝胰脏和肾脏中LPL m RNA表达丰度均达到峰值,而肝胰脏中FASm RNA表达丰度达到最低值,肾脏中FAS m RNA表达丰度逐渐下降。总之,玉米油可作为津新鲤优质脂肪源。展开更多
We report the genetic linkage map of Jian carp(C yprinus carpio var. Jian). An F1 population comprising 94 Jian carp individuals was mapped using 254 microsatellite markers. The genetic map spanned 1 381.592 c M and c...We report the genetic linkage map of Jian carp(C yprinus carpio var. Jian). An F1 population comprising 94 Jian carp individuals was mapped using 254 microsatellite markers. The genetic map spanned 1 381.592 c M and comprised 44 linkage groups,with an average marker distance of 6.58 c M. We identified eight quantitative trait loci(QTLs) for body weight(BW) in seven linkage groups,explaining 12.6% to 17.3% of the phenotypic variance. Comparative mapping was performed between Jian carp and mirror carp( Cyprinus carpio L.),which both have 50 chromosomes. One hundred and ninety-eight Jian carp marker loci were found in common with the mirror carp map,with 186(93.94%) showing synteny. All 44 Jian carp linkage groups could be one-to-one aligned to the 44 mirror carp linkage groups,mostly sharing two or more common loci. Three QTLs for BW in Jian carp were conserved in mirror carp. QTL comparison suggested that the QTL confidence interval in mirror carp was more precise than the homologous interval in Jian carp,which was contained within the QTL interval in Jian carp. The syntenic relationship and consensus QTLs between the two varieties provide a foundation for genomic research and genetic breeding in common carp.展开更多
Summary： Evidence-based medicine is advocated by WHO and adopted by developed countries for many years. In China, however, the selection of essential medicine and various medical insurance reimbursement schemes medic...Summary： Evidence-based medicine is advocated by WHO and adopted by developed countries for many years. In China, however, the selection of essential medicine and various medical insurance reimbursement schemes medicine is usually based on experts＇ experience of prescription practice which is under heavy critics resulting from the lack of related comparative efficacy and evidence-based research. The efficacy of Jian＇ganle in prevention of drug-induced liver injury （DILI） caused by antituberculotics was evaluated in this study by comparison with Hugan Pian, glucuronolactone and reduced glutathione. Evidence was provided for relevant sectors such as Ministry for Human Resources and Social Security of the People＇s Republic of China and National Health and Family Planning Commission of the Peo- ple＇s Republic of China to select and renew the Essential Medicine List （EML）, the new rural cooperative medical scheme in China （NRCMS） list or the reimbursement list of industrial injury insurance. A total of 189 patients with initial pulmonary tuberculosis were divided into four groups who took antituberculotics combined with Jian＇ganle, Hugan Pian, glucuronolactone and reduced glutathione respectively. Their liver function profile including alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, total bilirubin （TBIL）, direct bilirubin （DBIL）, total protein （TP）, albumin （A） and globulin （G） were detected at admission as baseline and after treatment. The Jian＇ganle group was compared with the three others by chi-square tests. In an aspect of maintaining bilirubin indexes normal, Jian＇ganle was more efficacious than glucuronolactone. And Jian＇ganle had a little more efficacy than reduced glutathione to maintain protein indexes normal as well. And the therapeutic regimen of antituberculotics combined with Jian＇ganle was the best in treating tuberculosis and preventing DILI at the same time. The study showed that among the four hepatinicas which demonstrated similar prevention of DILI caused by antituberculotics, Jian＇ganle has more advantages over the three others to some extent, which provides a reliable basis for health sectors to select and renew the EML, NRCMS List or the reimbursement list of industrial injury insurance.展开更多
BACKGROUND Given the complex pathogenesis of ulcerative colitis (UC), the conventional therapeutic methods are not fully curative. As a sort of systematic complementary and alternative medicine, traditional Chinese me...BACKGROUND Given the complex pathogenesis of ulcerative colitis (UC), the conventional therapeutic methods are not fully curative. As a sort of systematic complementary and alternative medicine, traditional Chinese medicine (TCM) provides new options for the standard therapy. Nevertheless, there are still numerous problems with the promotion of TCM attributed to its complexity, and consequently, new research approaches are urgently needed. Thus, we explored the protective effects of Jian-Pi Qing-Chang (JPQC) decoction on UC based on systems pharmacology approach, which might fill the current innovation gap in drug discovery and clinical practice pertaining to TCM. AIM To investigate the protective mechanisms of JPQC decoction on UC based on systems pharmacology approach. METHODS We performed systems pharmacology to predict the active ingredients, the matched targets, and the potential pharmacological mechanism of JPQC on UC. In vivo, we explored the effects of JPQC in a colitis model induced by dextran sulfate sodium. In vitro, we adopted the bone marrow-derived macrophages (BMDMs) as well as BMDMs co-cultured with Caco2 cells to verify the underlying mechanisms and effects of JPQC on UC under TNF-α stimulation. RESULTS Systems pharmacology revealed 170 targets for the 107 active ingredients of JPQC and 112 candidate targets of UC. Protein-protein interaction networks were established to identify the underlying therapeutic targets of JPQC on UC. Based on enrichment analyses, we proposed our hypothesis that JPQC might have a protective effect on UC via the NF-κB/HIF-1α signalling pathway. Subsequent experimental validation revealed that treatment with TNFα activated the NF-κB/HIF-1α signalling pathway in BMDMs, thereby damaging the epithelial barrier permeability in co-cultured Caco2 cells, while JPQC rescued this situation. The findings were also confirmed in a dextran sulfate sodium-induced colitis model. CONCLUSION JPQC could improve the mucosal inflammatory response and intestinal epithelial barrier function via the NF-κB/HIF-1α signalling pathway, which provides new perspectives on the pharmaceutical development and clinical practice of TCM.展开更多
According to the method of water balance,the parameters of groundwater resouce of Jian San Jiang area have been calculated in the paper.At the same time,the quality of water supplying and water mining can be calculate...According to the method of water balance,the parameters of groundwater resouce of Jian San Jiang area have been calculated in the paper.At the same time,the quality of water supplying and water mining can be calculated.Furthermore,the groundwater resource have been evaluated.Thus,the paper provides the important references for managers to using groundwater reasonable.展开更多
文摘Description Journal of Integrative Agriculture(JIA),formerly Agricultural Sciences in China(ASC),founded in 2002,is sponsored by Chinese Academy of Agricultural Sciences(CAAS),co-sponsored by Chinese Association of Agricultural Science Societies(CAASS).
文摘Description Journal of Integrative Agriculture(JIA),formerly Agricultural Sciences in China(AsC),founded in 2002,is sponsored by Chinese Academy of Agricultural Sciences(CAAS),co-sponsored by Chinese Association of Agricultural Science Societies(CAASS).JIAis a peer-reviewed and multi-disciplinary international journal and published monthly in English.JIA Editorial Board consists of 289 well-respected scholars of agricultural scientific fields.
文摘Description Journal of Integrative Agriculture(JIA),formerly Agricultural Sciences in China(AsC),founded in 2002,is sponsored by Chinese Academy of Agricultural Sciences(CAAS),co-sponsored by Chinese Association of Agricultural Science Societies(CAAss).JIA is a peer-reviewed and multi-disciplinary international journal and published monthly in English.JIA Editorial Board consists of 289 well-respected scholars of agricultural scientific fields.CAAs President,Academician WU Kong-ming is the Chairman of the Board,and CAAS Vice President,Academician CHEN Hua-lan is the Editor-in-Chief.JIA has been published by Elsevier B.V.since 2006 and is a leading academic journal in agricultural sciences in China.As released by JCR,the latest IF of the journal is 4.8.
文摘Instruction to Authors Aims and Scope Journal of Integrative Agriculture(JIA),formerlyAgricultural Sciences in China(ASC),founded in 2002,is sponsored by Chinese Academy of Agricultural Sciences(CAAS),co-sponsored by Chinsese Association of Agricultural Science Societies(CAAsS).
文摘Aims and Scope Journal of IntegrativeAgriculture(JIA),formerly Agricuiltural Sciences in China(ASC),founded in 2002,is sponsored by Chinese Academy of Agricultural Sciences(CAAS),co-sponsored by Chinsese Association of Agricultural Science Societies(CAAsS).The latest IF is 4.8.JIA seeks to publish those papers that are influential and will significantly advance scientific understanding in agriculture fields worldwide.JIA publishes manuscripts in the categories of Commentary,Review,Research Article,Letter and Short Communication,focusing on the core subjects:Crop Science Horticulture·Plant ProtectionAnimal Science·Veterinary Medicine·Agro-ecosystem&Environment·Food Science·Agricultural Economics and Management·Agricultural Information Science.
文摘Description Journal of Integrative Agriculture(JIA),formerly Agricultural Sciences in China(AsC),founded in 2002,is sponsored by Chinese Academy of Agricultural Sciences(CAAS),co-sponsored by Chinese Association of Agricultural Science Societies(CAAsS).JIA is a peer-reviewed and multi-disciplinary international journal and published monthly in English.JIA'Editorial Board consists of 289 well-respected scholars of agricultural scientific fields.CAAs President,Academician WU Kong-ming is the Chairman of the Board,and CAAS Vice President,Academician CHEN Hua-lan is the Editor-in-Chief.JIA has been published by Elsevier B.V.since 2006 and is a leading academic journal in agricultural sciences in China.As released by JCR,the latest IF of the journal is 4.8.
文摘Description Journal of Integrative Agriculture(JIA),formerly Agricultural Sciences in China(AsC),founded in 2002,is sponsored by Chinese Academy of Agricultural Sciences(CAAS),co-sponsored by Chinese Association of Agricultural Science Societies(CAAsS).JIAis a peer-reviewed and multi-disciplinary international journal and published monthly in English.JIA Editorial Board consists of 289 well-respected scholars of agricultural scientific fields.CAAS President,Academician WU Kong-ming is the Chairman of the Board,and CAAS Vice President,Academician CHEN Hua-lan is the Editor-in-Chief.JIA has been published by Elsevier B.V.since 2006 and is a leading academic journal in agricultural sciences in China.As released by JCR,the latest IF of the journal is 4.8.
文摘试验选用初始体重为(44.34±1.58)g的津新鲤1 260尾,随机分为6组,每组3个重复,每个重复70尾鱼。6组饲料分别含有豆油、鸡油、玉米油、棕榈油、菜籽油、棉籽油。饲养8周后探讨饲料中不同脂肪源对津新鲤生长、相关脂代谢酶活性及脂肪酸合成酶(FAS)、脂蛋白脂酶(LPL)基因表达的影响。结果表明:玉米油组的相对增重率、特定生长率及蛋白质效率显著高于其它5组(P<0.05),但玉米油组饵料系数则最低。不同脂肪源饲料对肝胰脏及肾脏中LPL、肝脂酶(HL)、总脂酶(GE)、脂肪代谢酶活性影响很大(P<0.05),且玉米油组酶活性均最高;各组肝胰脏及肾脏FAS变化不大(P>0.05)。从基因表达来看,玉米油组更容易诱导和调节肝胰脏和肾脏中FAS及LPL m RNA的表达(P<0.05),再次投喂后6 h,肝胰脏和肾脏中LPL m RNA表达丰度均达到峰值,而肝胰脏中FASm RNA表达丰度达到最低值,肾脏中FAS m RNA表达丰度逐渐下降。总之,玉米油可作为津新鲤优质脂肪源。
基金Supported by the Special Scientific Research Funds for Central Non-Profit Institutes,Chinese Academy of Fishery Sciences(No.2014A05CG01)the National High Technology Research and Development Program of China(No.2011AA100402-5)the China Ministry of Agriculture "948" Program(No.2011-G12)
文摘We report the genetic linkage map of Jian carp(C yprinus carpio var. Jian). An F1 population comprising 94 Jian carp individuals was mapped using 254 microsatellite markers. The genetic map spanned 1 381.592 c M and comprised 44 linkage groups,with an average marker distance of 6.58 c M. We identified eight quantitative trait loci(QTLs) for body weight(BW) in seven linkage groups,explaining 12.6% to 17.3% of the phenotypic variance. Comparative mapping was performed between Jian carp and mirror carp( Cyprinus carpio L.),which both have 50 chromosomes. One hundred and ninety-eight Jian carp marker loci were found in common with the mirror carp map,with 186(93.94%) showing synteny. All 44 Jian carp linkage groups could be one-to-one aligned to the 44 mirror carp linkage groups,mostly sharing two or more common loci. Three QTLs for BW in Jian carp were conserved in mirror carp. QTL comparison suggested that the QTL confidence interval in mirror carp was more precise than the homologous interval in Jian carp,which was contained within the QTL interval in Jian carp. The syntenic relationship and consensus QTLs between the two varieties provide a foundation for genomic research and genetic breeding in common carp.
基金supported by Health and Family Planning Commission of Hubei Province(No.02-16-516052)
文摘Summary： Evidence-based medicine is advocated by WHO and adopted by developed countries for many years. In China, however, the selection of essential medicine and various medical insurance reimbursement schemes medicine is usually based on experts＇ experience of prescription practice which is under heavy critics resulting from the lack of related comparative efficacy and evidence-based research. The efficacy of Jian＇ganle in prevention of drug-induced liver injury （DILI） caused by antituberculotics was evaluated in this study by comparison with Hugan Pian, glucuronolactone and reduced glutathione. Evidence was provided for relevant sectors such as Ministry for Human Resources and Social Security of the People＇s Republic of China and National Health and Family Planning Commission of the Peo- ple＇s Republic of China to select and renew the Essential Medicine List （EML）, the new rural cooperative medical scheme in China （NRCMS） list or the reimbursement list of industrial injury insurance. A total of 189 patients with initial pulmonary tuberculosis were divided into four groups who took antituberculotics combined with Jian＇ganle, Hugan Pian, glucuronolactone and reduced glutathione respectively. Their liver function profile including alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, total bilirubin （TBIL）, direct bilirubin （DBIL）, total protein （TP）, albumin （A） and globulin （G） were detected at admission as baseline and after treatment. The Jian＇ganle group was compared with the three others by chi-square tests. In an aspect of maintaining bilirubin indexes normal, Jian＇ganle was more efficacious than glucuronolactone. And Jian＇ganle had a little more efficacy than reduced glutathione to maintain protein indexes normal as well. And the therapeutic regimen of antituberculotics combined with Jian＇ganle was the best in treating tuberculosis and preventing DILI at the same time. The study showed that among the four hepatinicas which demonstrated similar prevention of DILI caused by antituberculotics, Jian＇ganle has more advantages over the three others to some extent, which provides a reliable basis for health sectors to select and renew the EML, NRCMS List or the reimbursement list of industrial injury insurance.
基金Supported by the National Natural Science Funds of China,No.81573892,No.81873253,and No.81704009
文摘BACKGROUND Given the complex pathogenesis of ulcerative colitis (UC), the conventional therapeutic methods are not fully curative. As a sort of systematic complementary and alternative medicine, traditional Chinese medicine (TCM) provides new options for the standard therapy. Nevertheless, there are still numerous problems with the promotion of TCM attributed to its complexity, and consequently, new research approaches are urgently needed. Thus, we explored the protective effects of Jian-Pi Qing-Chang (JPQC) decoction on UC based on systems pharmacology approach, which might fill the current innovation gap in drug discovery and clinical practice pertaining to TCM. AIM To investigate the protective mechanisms of JPQC decoction on UC based on systems pharmacology approach. METHODS We performed systems pharmacology to predict the active ingredients, the matched targets, and the potential pharmacological mechanism of JPQC on UC. In vivo, we explored the effects of JPQC in a colitis model induced by dextran sulfate sodium. In vitro, we adopted the bone marrow-derived macrophages (BMDMs) as well as BMDMs co-cultured with Caco2 cells to verify the underlying mechanisms and effects of JPQC on UC under TNF-α stimulation. RESULTS Systems pharmacology revealed 170 targets for the 107 active ingredients of JPQC and 112 candidate targets of UC. Protein-protein interaction networks were established to identify the underlying therapeutic targets of JPQC on UC. Based on enrichment analyses, we proposed our hypothesis that JPQC might have a protective effect on UC via the NF-κB/HIF-1α signalling pathway. Subsequent experimental validation revealed that treatment with TNFα activated the NF-κB/HIF-1α signalling pathway in BMDMs, thereby damaging the epithelial barrier permeability in co-cultured Caco2 cells, while JPQC rescued this situation. The findings were also confirmed in a dextran sulfate sodium-induced colitis model. CONCLUSION JPQC could improve the mucosal inflammatory response and intestinal epithelial barrier function via the NF-κB/HIF-1α signalling pathway, which provides new perspectives on the pharmaceutical development and clinical practice of TCM.
基金Chinese Postdctoral Science Fund and Youngth Science Fund of Si Chuan U niversity.
文摘According to the method of water balance,the parameters of groundwater resouce of Jian San Jiang area have been calculated in the paper.At the same time,the quality of water supplying and water mining can be calculated.Furthermore,the groundwater resource have been evaluated.Thus,the paper provides the important references for managers to using groundwater reasonable.
