In bidding farewell to 2023,Chinese President Xi Jinping’s New Year message,with its commitment to advance Chinese modernization,deliver a better life for the people,and build a community with a shared future for man...In bidding farewell to 2023,Chinese President Xi Jinping’s New Year message,with its commitment to advance Chinese modernization,deliver a better life for the people,and build a community with a shared future for mankind,effectively ushered in a new year brimming with hope.展开更多
objective:Two cycles of induction chemotherapy(IC)followed by 2 cycles of platinum-based concurrent chemoradiotherapy(CCRT)(2IC+2CCRT)for locoregionally advanced nasopharyngeal carcinoma(LA-NPC)is widely adopted but n...objective:Two cycles of induction chemotherapy(IC)followed by 2 cycles of platinum-based concurrent chemoradiotherapy(CCRT)(2IC+2CCRT)for locoregionally advanced nasopharyngeal carcinoma(LA-NPC)is widely adopted but not evidence-confirmed.This study aimed to determine the clinical value of 2IC+2CCRT regarding efficacy,toxicity and cost-effectiveness.Methods:This real-world study from two epidemic centers used propensity score matching(PSM)and inverse probability of treatment weighting(IPTW)analyses.The enrolled patients were divided into three groups based on treatment modality:Group A(2IC+2CCRT),Group B(3IC+2CCRT or 2IC+3CCRT)and Group C(3IC+3CCRT).Long-term survival,acute toxicities and cost-effectiveness were compared among the groups.We developed a prognostic model dividing the population into high-and low-risk cohorts,and survivals including overall survival(OS),progression-free survival(PFS),distant metastasis-free survival(DMFS)and locoregional relapse-free survival(LRRFS)were compared among the three groups according to certain risk stratifications.Results:Of 4,042 patients,1,175 were enrolled,with 660,419,and 96 included in Groups A,B and C,respectively.Five-year survivals were similar among the three groups after PSM and confirmed by IPTW.Grade 3-4 neutropenia and leukocytopenia were significantly higher in Groups C and B than in Group A(52.1%vs.41.5%vs.25.2%;41.7%vs.32.7%vs.25.0%)as were grade 3-4 nausea/vomiting and oral mucositis(29.2%vs.15.0%vs.6.1%;32.3%vs.25.3%vs.18.0%).Cost-effective analysis suggested that 2IC+2CCRT was the least expensive,while the health benefits were similar to those of the other groups.Further exploration showed that 2IC+2CCRT tended to be associated with a shorter PFS in high-risk patients,while 3IC+3CCRT potentially contributed to poor PFS in low-risk individuals,mainly reflected by LRRFS.Conclusions:In LA-NPC patients,2IC+2CCRT was the optimal choice regarding efficacy,toxicity and costeffectiveness;however,2IC+2CCRT and 3IC+3CCRT probably shortened LRRFS in high-and low-risk populations,respectively.展开更多
Kensuke's Kingdom is a highly readable British survival novel written by Michael Morourgo. It is not only a survival novel, but also a realistic novel for the children. By the two disparate characters, the writer ...Kensuke's Kingdom is a highly readable British survival novel written by Michael Morourgo. It is not only a survival novel, but also a realistic novel for the children. By the two disparate characters, the writer wants to discuss the effects of the war, which is the deeper meaning of this novel. Writing war and the effects of the war is a heavy but necessary topic for children's literature. Books like Kensuke's Kingdom can be woven into young readers' developing senses of themselves, extending their imaginations and helping them to understand the world from unaccustomed points of view.展开更多
World Heritage belongs to all the peoples of the world, irrespective of the territory on which they are living. The world heritage list draws attention to the wealth and diversity of the Earth's cultural and natur...World Heritage belongs to all the peoples of the world, irrespective of the territory on which they are living. The world heritage list draws attention to the wealth and diversity of the Earth's cultural and natural heritage. Historic cities in world heritage list agglomerates the elite of the noblest stage in human civilization history, whose outstanding historic, artistic and scientific values make them the living fossils of urban historic study.展开更多
World famous colour TVs,such asSony,National and Toshiba,usedto monopolize China’s large-screencolour TV market.But recently the KingBrand colour TV made by the TCL ElectronicsGroup has begun to challenge them.In1995...World famous colour TVs,such asSony,National and Toshiba,usedto monopolize China’s large-screencolour TV market.But recently the KingBrand colour TV made by the TCL ElectronicsGroup has begun to challenge them.In1995,the TCL King Brand colour TV notonly ranked first for its sales volume on theChinese market among the domestically-produced TVs of its kind,but also展开更多
Globally, any country in the world either exporting or importing country need to look at international market signals. Agriculture is one of the most contorted sectors in international trade. The study is basically ba...Globally, any country in the world either exporting or importing country need to look at international market signals. Agriculture is one of the most contorted sectors in international trade. The study is basically based on estimation and identification of various international trading signals to advocate their usefulness in decision making to multi-stake holders. Study period is 1990-91 to 2015-16 and the study employed is the Foreign Trade Philosophy to analyze the international market signals, trends, growth rates, elasticity’s, instability index, AOI, meta-analysis and the vision. It was observed that the export and import price elasticity’s for all the crops shown are positive except the wheat export price elasticity (-0.3%) and import price elasticity of soybean (-0.45%). Among cereals, pulses, oilseeds and fiber crops, rice (1.24%), peas (2.36%), mustard (0.97%) and cotton (0.75%) have high export elasticity’s respectively. These trade price elasticity’s are the important signals for the policy makers to layout the future trade. Study observed that the domestic support offered in the agricultural sector in Russia, India, China and New Zealand is more compared to other WTO member countries. Technical Barriers to Trade, Sanitary and Phytosanitary and Anti-dumping were found to be the most prominent in world and the highest imposed in Asia, Europe and North America. Study concluded, India has a comparative advantage in pulses, oilseeds and wheat and terms of trade of India’s cereals (except rice, maize), pulses (except pigeon pea, peas), cotton and jute which were found to be increased. The poor treatment towards the agriculture sector by the governments and World Bank Funding was observed. India’s import basket majorly consists of oilseeds and rice is the major exported product. Present study adds to the research directed at the impacts of domestic support and measures policies for WTO negotiations.展开更多
Current rates of mental illness are worrisome.Mental illness mainly affects females and younger age groups.The use of the internet to deliver mental health care has been growing since 2020 and includes the implementat...Current rates of mental illness are worrisome.Mental illness mainly affects females and younger age groups.The use of the internet to deliver mental health care has been growing since 2020 and includes the implementation of novel mental health treatments using virtual reality,augmented reality,and artificial intelligence.A new three dimensional digital environment,known as the metaverse,has emerged as the next version of the Internet.Artificial intelligence,augmented reality,and virtual reality will create fully immersive,experiential,and interactive online environments in the metaverse.People will use a unique avatar to do anything they do in their“real”lives,including seeking and receiving mental health care.In this opinion review,we reflect on how the metaverse could reshape how we deliver mental health treatment,its opportunities,and its challenges.展开更多
Music from a piano embodies widetechniques of expression, so thepiano is reputed as the king of musicalinstruments. China’s piano production datesback four decades. At present, there are 20piano production enterprise...Music from a piano embodies widetechniques of expression, so thepiano is reputed as the king of musicalinstruments. China’s piano production datesback four decades. At present, there are 20piano production enterprises in the county,including such backbone enterprises as theGuangzhou Pearl River Piano IndustrialCorporation, the Beijing Xinghai MusicalInstruments Corporation Ltd., the ShanghaiPiano Corporation, the Yingkou NortheastPiano(Group) Corporation and the展开更多
In the 21st Century,the native culture of Thailand has become a major inspiration for production of Thai movies,which have boomed,especially in four distinct genres:Thai epics,Muay Thai,horror,and teen movies.The firs...In the 21st Century,the native culture of Thailand has become a major inspiration for production of Thai movies,which have boomed,especially in four distinct genres:Thai epics,Muay Thai,horror,and teen movies.The first three genres are introspective and focus on the local characteristics of the nation by telling stories of Thai history,elaborating on the techniques of Muay Thai,and highlighting local spiritual beliefs.However,Thai teen movies are different because the genre tends to deploy internationalized narratives as part of the country’s efforts to build a Thai cultural identity that permeates global screens.展开更多
ZTE Corporation has launched its world-leadingGoTa Digital Trunking Communication System inBeijing—a CDMA-based new generation digitaltrunking technology for Chinese and internationalmarkets.It is the first digital t...ZTE Corporation has launched its world-leadingGoTa Digital Trunking Communication System inBeijing—a CDMA-based new generation digitaltrunking technology for Chinese and internationalmarkets.It is the first digital trunking productdeveloped by a Chinese enterprise with anindependent intellectual property right.“This is a product that the global public展开更多
The theme of this year' s World Metrology Day is 'Metrology and Energy'. Theenergy problem is an important issue for the whole world and has received great attention in Chinasince China is both a big energ...The theme of this year' s World Metrology Day is 'Metrology and Energy'. Theenergy problem is an important issue for the whole world and has received great attention in Chinasince China is both a big energy-consuming country and a country severely short of energy. Under theenergy and environmental pressure, China will take measures in the following four respects in orderto solve the problem of energy shortage: China will stick to the self-reliance principle for energysupply, since China has abundant coal resources, which have formed the mainstream of its energysupply. The coal resources account for 67 percent of energy supply and the self-reliant supply rateof coal has reached as high as 94 percent. China will take action to tap more resources and saveenergy consumption. China will attach greater importance to the development and exploitation ofrenewable energy resources. China will conduct international cooperation at an appropriate level.展开更多
文摘In bidding farewell to 2023,Chinese President Xi Jinping’s New Year message,with its commitment to advance Chinese modernization,deliver a better life for the people,and build a community with a shared future for mankind,effectively ushered in a new year brimming with hope.
基金supported by grants from the National Natural Science Foundation of China(No.81872375 and 82172863)the Natural Science Foundation of Guangdong Province(No.2021A1515010118).
文摘objective:Two cycles of induction chemotherapy(IC)followed by 2 cycles of platinum-based concurrent chemoradiotherapy(CCRT)(2IC+2CCRT)for locoregionally advanced nasopharyngeal carcinoma(LA-NPC)is widely adopted but not evidence-confirmed.This study aimed to determine the clinical value of 2IC+2CCRT regarding efficacy,toxicity and cost-effectiveness.Methods:This real-world study from two epidemic centers used propensity score matching(PSM)and inverse probability of treatment weighting(IPTW)analyses.The enrolled patients were divided into three groups based on treatment modality:Group A(2IC+2CCRT),Group B(3IC+2CCRT or 2IC+3CCRT)and Group C(3IC+3CCRT).Long-term survival,acute toxicities and cost-effectiveness were compared among the groups.We developed a prognostic model dividing the population into high-and low-risk cohorts,and survivals including overall survival(OS),progression-free survival(PFS),distant metastasis-free survival(DMFS)and locoregional relapse-free survival(LRRFS)were compared among the three groups according to certain risk stratifications.Results:Of 4,042 patients,1,175 were enrolled,with 660,419,and 96 included in Groups A,B and C,respectively.Five-year survivals were similar among the three groups after PSM and confirmed by IPTW.Grade 3-4 neutropenia and leukocytopenia were significantly higher in Groups C and B than in Group A(52.1%vs.41.5%vs.25.2%;41.7%vs.32.7%vs.25.0%)as were grade 3-4 nausea/vomiting and oral mucositis(29.2%vs.15.0%vs.6.1%;32.3%vs.25.3%vs.18.0%).Cost-effective analysis suggested that 2IC+2CCRT was the least expensive,while the health benefits were similar to those of the other groups.Further exploration showed that 2IC+2CCRT tended to be associated with a shorter PFS in high-risk patients,while 3IC+3CCRT potentially contributed to poor PFS in low-risk individuals,mainly reflected by LRRFS.Conclusions:In LA-NPC patients,2IC+2CCRT was the optimal choice regarding efficacy,toxicity and costeffectiveness;however,2IC+2CCRT and 3IC+3CCRT probably shortened LRRFS in high-and low-risk populations,respectively.
文摘Kensuke's Kingdom is a highly readable British survival novel written by Michael Morourgo. It is not only a survival novel, but also a realistic novel for the children. By the two disparate characters, the writer wants to discuss the effects of the war, which is the deeper meaning of this novel. Writing war and the effects of the war is a heavy but necessary topic for children's literature. Books like Kensuke's Kingdom can be woven into young readers' developing senses of themselves, extending their imaginations and helping them to understand the world from unaccustomed points of view.
基金Sub-program of the "Ninth Five-Year Plan Period" Key Research Program supported by the National Natural Science Foundation of Ch
文摘World Heritage belongs to all the peoples of the world, irrespective of the territory on which they are living. The world heritage list draws attention to the wealth and diversity of the Earth's cultural and natural heritage. Historic cities in world heritage list agglomerates the elite of the noblest stage in human civilization history, whose outstanding historic, artistic and scientific values make them the living fossils of urban historic study.
文摘World famous colour TVs,such asSony,National and Toshiba,usedto monopolize China’s large-screencolour TV market.But recently the KingBrand colour TV made by the TCL ElectronicsGroup has begun to challenge them.In1995,the TCL King Brand colour TV notonly ranked first for its sales volume on theChinese market among the domestically-produced TVs of its kind,but also
文摘Globally, any country in the world either exporting or importing country need to look at international market signals. Agriculture is one of the most contorted sectors in international trade. The study is basically based on estimation and identification of various international trading signals to advocate their usefulness in decision making to multi-stake holders. Study period is 1990-91 to 2015-16 and the study employed is the Foreign Trade Philosophy to analyze the international market signals, trends, growth rates, elasticity’s, instability index, AOI, meta-analysis and the vision. It was observed that the export and import price elasticity’s for all the crops shown are positive except the wheat export price elasticity (-0.3%) and import price elasticity of soybean (-0.45%). Among cereals, pulses, oilseeds and fiber crops, rice (1.24%), peas (2.36%), mustard (0.97%) and cotton (0.75%) have high export elasticity’s respectively. These trade price elasticity’s are the important signals for the policy makers to layout the future trade. Study observed that the domestic support offered in the agricultural sector in Russia, India, China and New Zealand is more compared to other WTO member countries. Technical Barriers to Trade, Sanitary and Phytosanitary and Anti-dumping were found to be the most prominent in world and the highest imposed in Asia, Europe and North America. Study concluded, India has a comparative advantage in pulses, oilseeds and wheat and terms of trade of India’s cereals (except rice, maize), pulses (except pigeon pea, peas), cotton and jute which were found to be increased. The poor treatment towards the agriculture sector by the governments and World Bank Funding was observed. India’s import basket majorly consists of oilseeds and rice is the major exported product. Present study adds to the research directed at the impacts of domestic support and measures policies for WTO negotiations.
基金Supported by Instituto de Salud CarlosⅢ(ISCⅢ),with group funds the Research Network on Chronicity,Primary Care and Health Promotion(RICAPPS,RD21/0016/0005)that is part of the Results-Oriented Cooperative Research Networks in Health(RICORS)(CarlosⅢHealth Institute),co-funded by the European Union“NextGeneration EU/PRTR”funds and with group funds Mental health research group in Primary Care(B17_23R),which is part of the Department of Innovation,Research,and University in the Government of Aragón(Spain).
文摘Current rates of mental illness are worrisome.Mental illness mainly affects females and younger age groups.The use of the internet to deliver mental health care has been growing since 2020 and includes the implementation of novel mental health treatments using virtual reality,augmented reality,and artificial intelligence.A new three dimensional digital environment,known as the metaverse,has emerged as the next version of the Internet.Artificial intelligence,augmented reality,and virtual reality will create fully immersive,experiential,and interactive online environments in the metaverse.People will use a unique avatar to do anything they do in their“real”lives,including seeking and receiving mental health care.In this opinion review,we reflect on how the metaverse could reshape how we deliver mental health treatment,its opportunities,and its challenges.
文摘Music from a piano embodies widetechniques of expression, so thepiano is reputed as the king of musicalinstruments. China’s piano production datesback four decades. At present, there are 20piano production enterprises in the county,including such backbone enterprises as theGuangzhou Pearl River Piano IndustrialCorporation, the Beijing Xinghai MusicalInstruments Corporation Ltd., the ShanghaiPiano Corporation, the Yingkou NortheastPiano(Group) Corporation and the
文摘In the 21st Century,the native culture of Thailand has become a major inspiration for production of Thai movies,which have boomed,especially in four distinct genres:Thai epics,Muay Thai,horror,and teen movies.The first three genres are introspective and focus on the local characteristics of the nation by telling stories of Thai history,elaborating on the techniques of Muay Thai,and highlighting local spiritual beliefs.However,Thai teen movies are different because the genre tends to deploy internationalized narratives as part of the country’s efforts to build a Thai cultural identity that permeates global screens.
文摘ZTE Corporation has launched its world-leadingGoTa Digital Trunking Communication System inBeijing—a CDMA-based new generation digitaltrunking technology for Chinese and internationalmarkets.It is the first digital trunking productdeveloped by a Chinese enterprise with anindependent intellectual property right.“This is a product that the global public
文摘The theme of this year' s World Metrology Day is 'Metrology and Energy'. Theenergy problem is an important issue for the whole world and has received great attention in Chinasince China is both a big energy-consuming country and a country severely short of energy. Under theenergy and environmental pressure, China will take measures in the following four respects in orderto solve the problem of energy shortage: China will stick to the self-reliance principle for energysupply, since China has abundant coal resources, which have formed the mainstream of its energysupply. The coal resources account for 67 percent of energy supply and the self-reliant supply rateof coal has reached as high as 94 percent. China will take action to tap more resources and saveenergy consumption. China will attach greater importance to the development and exploitation ofrenewable energy resources. China will conduct international cooperation at an appropriate level.