BACKGROUND Lung cancer is a common disease with high mortality,and psychological support is very important in the diagnosis and treatment of postoperative patients with cancer pain.AIM To explore the application effec...BACKGROUND Lung cancer is a common disease with high mortality,and psychological support is very important in the diagnosis and treatment of postoperative patients with cancer pain.AIM To explore the application effect of the narrative nursing method in postoperative lung cancer patients in the intensive care unit.METHODS A total of 120 patients diagnosed with lung cancer and experiencing cancer-related pain were randomly allocated into two groups:an observation group and a control group,each consisting of 60 cases.The control group was given routine analgesic and psychological care,while the research group applied the five-step narrative nursing method based on routine care,comparing the visual analogue scale scores,sleep status,anxiety and depression status,and quality of life of the two groups of patients before and after the intervention.RESULTS The pain scores,anxiety scores,and depression scores of the study group were lower than those of the control group after the intervention using the narrative nursing method,and the difference was statistically significant(P<0.05).CONCLUSION Using narrative nursing methods to intervene in patients with lung cancer combined with cancerous pain can help patients to correctly recognize their disease,adjust their mentality,establish confidence,alleviate patients'subjective pain feelings,and improve their adverse emotions.展开更多
Cultural symbols,a manifestation of cities’cultural resources,are not only signs that frame concepts but also forms that express meanings.Exploring the international communication of cities from the perspective of sy...Cultural symbols,a manifestation of cities’cultural resources,are not only signs that frame concepts but also forms that express meanings.Exploring the international communication of cities from the perspective of symbols,this paper analyzes in depth how cities create their cultural symbols in the dynamic process of international communication in an era of symbol-based digital media,and how they develop their narratives and explain meanings through the dissemination of symbols when telling their stories to international audiences,thus enhancing the efficiency and effectiveness of their international communication efforts.展开更多
In the context of the cultural development of the new era and the burgeoning spiritual demands of the people,there has been a remarkable surge in the proliferation of traditional Chinese cultural programs.The“Chinese...In the context of the cultural development of the new era and the burgeoning spiritual demands of the people,there has been a remarkable surge in the proliferation of traditional Chinese cultural programs.The“Chinese Festivals”series,produced by Henan TV,standing out as an engaging TV program that showcases traditional Chinese culture,has rapidly captivated a diverse audience across different age groups,creating a rich,multi-dimensional,and cross-media cultural communication ecosystem.The program strategically selects symbolic elements by systematically categorizing and organizing traditional Chinese cultural symbols to create a rich cultural space.It employs cutting-edge scientific and technological methods to enrich viewer immersion,crafting media rituals with both temporal significance and a profound sense of media ritual.This approach boosts the program’s popularity and sets a benchmark for industry innovation.By fostering an interactive narrative between mainstream media and the public,the program continuously broadens the scope of the“story world,”fostering a harmonious and structured national cultural community through the creative interpretation of traditional Chinese culture and the evocative crafting of the aesthetic sensibilities inherent in Chinese art.It is worth noting that the phenomenon of aesthetic fatigue besets the development of this serial program.To address this issue and further improve the appeal of the program,a comprehensive approach is required to develop a cohesive narrative mode for the“story world.”This involves harmonizing the interplay between artistic endeavors and technological advancements,synchronizing sensory experiences with the foundational ritualistic elements,and enhancing the effectiveness of the media communication matrix to construct a brand of media culture that has social significance,aesthetic value,and economic profits in the new era.展开更多
BACKGROUND Acute pancreatitis(AP),as a common acute abdomen disease,has a high incidence rate worldwide and is often accompanied by severe complications.Negative emotions lead to increased secretion of stress hormones...BACKGROUND Acute pancreatitis(AP),as a common acute abdomen disease,has a high incidence rate worldwide and is often accompanied by severe complications.Negative emotions lead to increased secretion of stress hormones,elevated blood sugar levels,and enhanced insulin resistance,which in turn increases the risk of AP and significantly affects the patient's quality of life.Therefore,exploring the intervention effects of narrative nursing programs on the negative emotions of patients with AP is not only helpful in alleviating psychological stress and improving quality of life but also has significant implications for improving disease outcomes and prognosis.AIM To construct a narrative nursing model for negative emotions in patients with AP and verify its efficacy in application.METHODS Through Delphi expert consultation,a narrative nursing model for negative emotions in patients with AP was constructed.A non-randomized quasi-experimental study design was used in this study.A total of 92 patients with AP with negative emotions admitted to a tertiary hospital in Nantong City of Jiangsu Province,China from September 2022 to August 2023 were recruited by convenience sampling,among whom 46 patients admitted from September 2022 to February 2023 were included in the observation group,and 46 patients from March to August 2023 were selected as control group.The observation group received narrative nursing plan,while the control group was given with routine nursing.Self-rating anxiety scale(SAS),self-rating depression scale(SDS),positive and negative affect scale(PANAS),caring behavior scale,patient satisfaction scale and 36-item short form health survey questionnaire(SF-36)were used to evaluate their emotions,satisfaction and caring behaviors in the two groups on the day of discharge,1-and 3-month following discharge.RESULTS According to the inclusion and exclusion criteria,a total of 45 cases in the intervention group and 44 cases in the control group eventually recruited and completed in the study.On the day of discharge,the intervention group showed significantly lower scores of SAS,SDS and negative emotion(28.57±4.52 vs 17.4±4.44,P<0.001),whereas evidently higher outcomes in the positive emotion score,Caring behavior scale score and satisfaction score compared to the control group(P<0.05).Repeated measurement analysis of variance showed that significant between-group differences were found in time effect,inter-group effect and interaction effect of SAS and PANAS scores as well as in time effect and inter-group effect of SF-36 scores(P<0.05);the SF-36 scores of two groups at 3 months after discharge were higher than those at 1 month after discharge(P<0.05).CONCLUSION The application of narrative nursing protocols has demonstrated significant effectiveness in alleviating anxiety,ameliorating negative emotions,and enhancing satisfaction among patients with AP.展开更多
Süskind’s “Perfume” constructs the story frame of the text through three sets of contradictory narratives, exploring the process of Grenouille, who is regarded as an alien by others, trying to find and constru...Süskind’s “Perfume” constructs the story frame of the text through three sets of contradictory narratives, exploring the process of Grenouille, who is regarded as an alien by others, trying to find and construct true meaning of being a human being from three aspects: human smell, emotion, and discourse. This process constantly encounters deconstruction from its own smelllessness, senselessness and aphasia, thereby implying the lack of human subjectivity and value through Grenouille’s failure to find identity. It also uses the image of perfume to express the author’s deep concerns about the loss of subjectivity, the disillusionment of classical morality, and the violence of industrial civilization in France and even Europe in the eighteenth century.展开更多
“The Law of Life”is one of Jack London’s representative works,depicting the story of an elderly Native American abandoned by his family,alone and waiting for life to fade away.This paper,based on narrative theory,a...“The Law of Life”is one of Jack London’s representative works,depicting the story of an elderly Native American abandoned by his family,alone and waiting for life to fade away.This paper,based on narrative theory,aims to explore how the author employs narrative techniques to present the image of the old man in the short story.The narrative techniques of dual focalization and dual narrative timelines in the text demonstrate the abandonment of the old man’s homeland and his inescapable death under a naturalistic view of life and reflect a desolate life picture of resignation towards death under naturalistic determinism,depicting a grim elderly world under the naturalistic concept of“survival of the fittest.”Studying this short story helps us reflect on the living conditions of the elderly and provides insights into how to better care for the elderly population amid the global trend of aging.展开更多
Wharton’s novels serve as compelling cases for understanding the complexities of late 19th-century American society.The paper uses The Age of Innocence as an example to examine detailed depiction of the era’s social...Wharton’s novels serve as compelling cases for understanding the complexities of late 19th-century American society.The paper uses The Age of Innocence as an example to examine detailed depiction of the era’s social hierarchy,fashion,architecture,and the intricate social rituals that defined New York’s upper class.It explores the constraints and dilemmas women faced within a patriarchal society,highlighting Wharton’s personal experiences and her critical stance on the social norms of her time.The characters of Newland Archer,May Welland,and Ellen Olenska are analyzed to reveal the pressures of societal expectations and the struggles for individual desires within a rigid social structure.Additionally,the paper proposes various teaching methods,including contextual understanding,literary analysis with a historical focus,and historical research projects,to enhance students’comprehension of the cultural and historical context of the novel.These methods aim to immerse students in the narrative and promote their understanding of the Gilded Age’s social dynamics.展开更多
Narrative empathy is a relatively new theory and it can guide researchers in the studies of main-melody films so as to promote the communication of the core values of the society.The rhetorical mechanism of narrative ...Narrative empathy is a relatively new theory and it can guide researchers in the studies of main-melody films so as to promote the communication of the core values of the society.The rhetorical mechanism of narrative empathy can be illustrated from five rhetorical elements,including rhetor,rhetorical goal,rhetorical situation,rhetorical strategy and audience.The theory of narrative empathy can be applied to the case study of the film My People,My Country.In the production of this film,the directors are the rhetors.The rhetors uphold the tenet of closeness,choose the right rhetorical situation as the 70th birthday of the People’s Republic of China,and use appropriate rhetorical strategies in order to realize the rhetorical goals of evoking empathy and inspiring patriotic feelings in the audience’s minds.An exploration and application of narrative empathy can be conducive to the empathic communication of Chinese main-melody films in order to achieve better communication effect.展开更多
David’s Story by Zoë Wicomb addresses the complexities of representing female suffering and the limitations of traditional historical narratives in capturing the experiences of marginalized bodies.It challenges ...David’s Story by Zoë Wicomb addresses the complexities of representing female suffering and the limitations of traditional historical narratives in capturing the experiences of marginalized bodies.It challenges the grand narratives of national history by emphasizing the indispensable role of women’s experiences.Through characters like Dulcie and Rachael,Wicomb portrays the female body as a site of resistance and resilience,highlighting the need for more nuanced and inclusive ways of documenting history.Underscoring the inexpressibility of trauma and the limitations of language and representation,the novel self-reflexively acknowledges its own aporia of completing the narrative,embodying the ongoing struggle to capture the full breadth of human experience.展开更多
Dharamvir Bharati’s Suraj Ka Satvan Ghoda connects the text with the social reality,through the multiple narrative perspectives of the“Panchatantra”Narrative Structure and the love stories,and narrates the survival...Dharamvir Bharati’s Suraj Ka Satvan Ghoda connects the text with the social reality,through the multiple narrative perspectives of the“Panchatantra”Narrative Structure and the love stories,and narrates the survival and spiritual dilemma of Indian women in the transformation of India’s modernization.The novel depicts in both content and form the plight of Indian women’s physical and spiritual dependence under the traditional concepts of arranged marriages,caste marriages,dowry system and patriarchal will,and shows the process of women’s body and self-consciousness gradually moving from vitality to extinction.展开更多
In the Heart of the Country,the second novel by J.M.Coetzee,has been traditionally read as a disembodied writing that focuses on the problem of writing per se instead of the reality.This paper contends that the work i...In the Heart of the Country,the second novel by J.M.Coetzee,has been traditionally read as a disembodied writing that focuses on the problem of writing per se instead of the reality.This paper contends that the work is actually a body narrative that explores the visceral pain suffered by Magda whose infertile body impedes her being a qualified subject.As the heroine in a postcolonial novel,Magda is not just a body that is restricted and constructed by the politics of the body,but also a thinking and writing body that consciously questions and resists the gendered bodily norms under whose yardstick her subjecthood is barred.Written in the metafictional manner,Magda’s narrative of the body is not just a record of her corporeal experience,but also a self-conscious negotiation with,and challenge of,the bodily norms under whose yardstick her body has been debased or,in terms of Judith Butler,abjected.Taking her female bodily experience as the starting point,Magda writes a feminine text that values passion,fluidity and non-linearity to disrupt the patriarchal discourse underpinned with logical reasoning.The feminine body narrative endeavors to achieve a new way of communication through which a reciprocal cross race/gender relationship might be established.展开更多
Objective:To explore the role of narrative medicine in cultivating the humanistic spirit of respiratory medicine interns.Methods:Thirty interns were selected,all of whom were received by the respiratory department of ...Objective:To explore the role of narrative medicine in cultivating the humanistic spirit of respiratory medicine interns.Methods:Thirty interns were selected,all of whom were received by the respiratory department of our hospital from September 2023 to June 2024 and underwent narrative medicine teaching.Scores on narrative medicine knowledge,empathy ability,humanistic care ability,and teaching recognition were compared before and after the internship.Results:Compared to before the internship,the interns’scores on narrative medicine knowledge were significantly higher after the internship,as were their empathy and humanistic care scores(P<0.05).Among the 30 interns,25 expressed interest in narrative medicine,and 29 were willing to continue with the narrative medicine teaching model.Conclusion:The application of narrative medicine in respiratory medicine internship teaching is highly effective.It cultivates the humanistic spirit of interns,improves their empathy and humanistic care abilities,and is worthy of wider implementation.展开更多
The research explored the ways and means of narrative design in which regional cultural elements are integrated into cultural and creative products.It also researched a new way of thinking and methods of creative prod...The research explored the ways and means of narrative design in which regional cultural elements are integrated into cultural and creative products.It also researched a new way of thinking and methods of creative product design based on regional cultural elements in order to satisfy consumers’emotional and cultural experiences.Narrative theory takes the perspective of narrative expression in the design of cultural and creative products.The regional cultural elements were used for better interactive communication with consumers in the form of cultural and creative products.In the narrative of cultural and creative product design,intervening in the development of regional cultural and creative design from the perspective of narratology can better exert and create the cultural value of the region itself,with cultural and creative products playing an important role in“local cultural stories.”This research adopted a qualitative approach and provided ideas and guidance for the narrative design and expression of regional cultural elements in creative products through comparative analysis of case studies.The research highlighted the role of narrative design in creating multi-layered experiences,weaving regional cultural stories into products,and the importance of deep understanding and effective use of regional cultural elements in design.展开更多
Objective:To explore the impact of narrative nursing on anxiety,depression,and quality of life in middle-aged and young dialysis patients.Method:Eighty-six middle-aged and young dialysis patients admitted from January...Objective:To explore the impact of narrative nursing on anxiety,depression,and quality of life in middle-aged and young dialysis patients.Method:Eighty-six middle-aged and young dialysis patients admitted from January 2023 to December 2023 were selected and divided into a control group and a study group,with 43 patients in each group.The control group received general nursing interventions,while the study group received narrative nursing in addition to the general interventions.The levels of anxiety and depression before and after the intervention were compared,and the quality-of-life scores of the two groups were analyzed.Results:After comprehensive intervention,the scores of both groups significantly decreased(P<0.05).After intervention,the scores of the study group were more significant compared to the control group(P<0.05).Compared with the control group,the quality-of-life score of the study group showed a significant upward trend,and this difference was statistically significant(P<0.05).Conclusion:Comprehensive narrative nursing can effectively reduce anxiety in middle-aged and young dialysis patients,further enhance their quality of life,and is worth promoting in clinical practice.展开更多
Putin’s forceful,almost contemptuous dismissal of warnings from U. S. and European leaders about the dangerous path he was pursuing led to anxious speclation about what lay behind it. After years of pursuing a pragma...Putin’s forceful,almost contemptuous dismissal of warnings from U. S. and European leaders about the dangerous path he was pursuing led to anxious speclation about what lay behind it. After years of pursuing a pragmatic geopolitical game that was understandable,though not always appreciated by the West,Putin seemed to be operating in a different world. He had spent years courting acceptance in organizations like the G8,whose meeting he had planned on hosting in the new Sochi Winter Olympics setting,but in 2014 he seemed to be throwing everything away in pursuit of some sort of mission that few in the west understood.展开更多
N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis a...N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be attributed to the timespecific nature of m^(6)A and its varying effects on distinct brain regions and in different environments.展开更多
Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug therapy.Physical exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitatio...Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug therapy.Physical exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after stroke.In this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral ischemia.We also examined the role of exercise-induced circulating factors in these effects.Adult mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery occlusion.We found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory function.Further analysis showed that circulating adiponectin plays a critical role in these preventive effects of exercise.Agonist activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise effects.In summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.展开更多
Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life ...Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of patients.To date,there are no viable treatment options for postoperative cognitive dysfunction.The identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future research.To identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial fracture.The dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub gene.Therefore,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re surgery.Mice were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning tests.In addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western blotting.Treatment with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expression compared with vehicle treatment.Intraperitoneal administration of the specific ERK inhibitor PD98059 diminished the effects of recombinant chitinase-3-like protein 1.Collectively,our findings suggest that recombinant chitinase-3-like protein 1 ameliorates surgery-induced cognitive decline by attenuating neuroinflammation via M2 microglial polarization in the hippocampus.Therefore,recombinant chitinase-3-like protein1 may have therapeutic potential fo r postoperative cognitive dysfunction.展开更多
Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s disease.Adult hippocampal neurogenesis is reduced in patients with Alzheimer’s disease.Exercise stimulates adult hippocampal neurogenesis in rode...Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s disease.Adult hippocampal neurogenesis is reduced in patients with Alzheimer’s disease.Exercise stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s disease.However,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly understood.Recently,regulator of G protein signaling 6(RGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in mice.Here,we generated novel RGS6fl/fl;APP_(SWE) mice and used retroviral approaches to examine the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse model.We found that voluntary running in APP_(SWE) mice restored their hippocampal cognitive impairments to that of control mice.This cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal neurogenesis.Adult hippocampal neurogenesis was reduced in sedentary APP_(SWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor cells.RGS6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGS6-expressing neurons.Thus,RGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWE) mice,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.展开更多
This paper rethinks critically the Italian serial production of fiction, in recent years, placing it in relation to the dynamics of collective memory. The analysis starts from two Italian fiction: Raccontami, the his...This paper rethinks critically the Italian serial production of fiction, in recent years, placing it in relation to the dynamics of collective memory. The analysis starts from two Italian fiction: Raccontami, the history of a family returns the great changes of the 60s'; I Medici dedicated to the biography of the great Florentine Renaissance banker family, exemplified by similar international productions (including the Borgia) and subject to strong promotion by Rai 1. Around these two lines of address is also the analysis of some miniseries among these biopics dedicated to figures of the national imagination such as pontiffs, doctors, partisans, entrepreneurs. If the twentieth century was defined as the "century of testimony" this is also due to the massive and pervasive presence of media that are often at the center of the processes of transformation and transition of the public and cultural life of societies. Television, in particular, confirms itself as the real, symbolic and rhetorical place in which historical events unfold, to be, on some occasions, a substitute simulacrum. Fiction, as a form of popular narrative and reworking, is an intermediary and central element in the processes of building the social imagery and collective memory, responding to the need for a typical tale of every society.展开更多
文摘BACKGROUND Lung cancer is a common disease with high mortality,and psychological support is very important in the diagnosis and treatment of postoperative patients with cancer pain.AIM To explore the application effect of the narrative nursing method in postoperative lung cancer patients in the intensive care unit.METHODS A total of 120 patients diagnosed with lung cancer and experiencing cancer-related pain were randomly allocated into two groups:an observation group and a control group,each consisting of 60 cases.The control group was given routine analgesic and psychological care,while the research group applied the five-step narrative nursing method based on routine care,comparing the visual analogue scale scores,sleep status,anxiety and depression status,and quality of life of the two groups of patients before and after the intervention.RESULTS The pain scores,anxiety scores,and depression scores of the study group were lower than those of the control group after the intervention using the narrative nursing method,and the difference was statistically significant(P<0.05).CONCLUSION Using narrative nursing methods to intervene in patients with lung cancer combined with cancerous pain can help patients to correctly recognize their disease,adjust their mentality,establish confidence,alleviate patients'subjective pain feelings,and improve their adverse emotions.
文摘Cultural symbols,a manifestation of cities’cultural resources,are not only signs that frame concepts but also forms that express meanings.Exploring the international communication of cities from the perspective of symbols,this paper analyzes in depth how cities create their cultural symbols in the dynamic process of international communication in an era of symbol-based digital media,and how they develop their narratives and explain meanings through the dissemination of symbols when telling their stories to international audiences,thus enhancing the efficiency and effectiveness of their international communication efforts.
基金the project“Research on the Digitalized Living Inheritance and Development of the Yellow River Cultural Gene,”a project of Humanities and Social Sciences Research of Higher Education Institutes in Henan Province(Project No.2024-ZDJH-770).
文摘In the context of the cultural development of the new era and the burgeoning spiritual demands of the people,there has been a remarkable surge in the proliferation of traditional Chinese cultural programs.The“Chinese Festivals”series,produced by Henan TV,standing out as an engaging TV program that showcases traditional Chinese culture,has rapidly captivated a diverse audience across different age groups,creating a rich,multi-dimensional,and cross-media cultural communication ecosystem.The program strategically selects symbolic elements by systematically categorizing and organizing traditional Chinese cultural symbols to create a rich cultural space.It employs cutting-edge scientific and technological methods to enrich viewer immersion,crafting media rituals with both temporal significance and a profound sense of media ritual.This approach boosts the program’s popularity and sets a benchmark for industry innovation.By fostering an interactive narrative between mainstream media and the public,the program continuously broadens the scope of the“story world,”fostering a harmonious and structured national cultural community through the creative interpretation of traditional Chinese culture and the evocative crafting of the aesthetic sensibilities inherent in Chinese art.It is worth noting that the phenomenon of aesthetic fatigue besets the development of this serial program.To address this issue and further improve the appeal of the program,a comprehensive approach is required to develop a cohesive narrative mode for the“story world.”This involves harmonizing the interplay between artistic endeavors and technological advancements,synchronizing sensory experiences with the foundational ritualistic elements,and enhancing the effectiveness of the media communication matrix to construct a brand of media culture that has social significance,aesthetic value,and economic profits in the new era.
文摘BACKGROUND Acute pancreatitis(AP),as a common acute abdomen disease,has a high incidence rate worldwide and is often accompanied by severe complications.Negative emotions lead to increased secretion of stress hormones,elevated blood sugar levels,and enhanced insulin resistance,which in turn increases the risk of AP and significantly affects the patient's quality of life.Therefore,exploring the intervention effects of narrative nursing programs on the negative emotions of patients with AP is not only helpful in alleviating psychological stress and improving quality of life but also has significant implications for improving disease outcomes and prognosis.AIM To construct a narrative nursing model for negative emotions in patients with AP and verify its efficacy in application.METHODS Through Delphi expert consultation,a narrative nursing model for negative emotions in patients with AP was constructed.A non-randomized quasi-experimental study design was used in this study.A total of 92 patients with AP with negative emotions admitted to a tertiary hospital in Nantong City of Jiangsu Province,China from September 2022 to August 2023 were recruited by convenience sampling,among whom 46 patients admitted from September 2022 to February 2023 were included in the observation group,and 46 patients from March to August 2023 were selected as control group.The observation group received narrative nursing plan,while the control group was given with routine nursing.Self-rating anxiety scale(SAS),self-rating depression scale(SDS),positive and negative affect scale(PANAS),caring behavior scale,patient satisfaction scale and 36-item short form health survey questionnaire(SF-36)were used to evaluate their emotions,satisfaction and caring behaviors in the two groups on the day of discharge,1-and 3-month following discharge.RESULTS According to the inclusion and exclusion criteria,a total of 45 cases in the intervention group and 44 cases in the control group eventually recruited and completed in the study.On the day of discharge,the intervention group showed significantly lower scores of SAS,SDS and negative emotion(28.57±4.52 vs 17.4±4.44,P<0.001),whereas evidently higher outcomes in the positive emotion score,Caring behavior scale score and satisfaction score compared to the control group(P<0.05).Repeated measurement analysis of variance showed that significant between-group differences were found in time effect,inter-group effect and interaction effect of SAS and PANAS scores as well as in time effect and inter-group effect of SF-36 scores(P<0.05);the SF-36 scores of two groups at 3 months after discharge were higher than those at 1 month after discharge(P<0.05).CONCLUSION The application of narrative nursing protocols has demonstrated significant effectiveness in alleviating anxiety,ameliorating negative emotions,and enhancing satisfaction among patients with AP.
文摘Süskind’s “Perfume” constructs the story frame of the text through three sets of contradictory narratives, exploring the process of Grenouille, who is regarded as an alien by others, trying to find and construct true meaning of being a human being from three aspects: human smell, emotion, and discourse. This process constantly encounters deconstruction from its own smelllessness, senselessness and aphasia, thereby implying the lack of human subjectivity and value through Grenouille’s failure to find identity. It also uses the image of perfume to express the author’s deep concerns about the loss of subjectivity, the disillusionment of classical morality, and the violence of industrial civilization in France and even Europe in the eighteenth century.
文摘“The Law of Life”is one of Jack London’s representative works,depicting the story of an elderly Native American abandoned by his family,alone and waiting for life to fade away.This paper,based on narrative theory,aims to explore how the author employs narrative techniques to present the image of the old man in the short story.The narrative techniques of dual focalization and dual narrative timelines in the text demonstrate the abandonment of the old man’s homeland and his inescapable death under a naturalistic view of life and reflect a desolate life picture of resignation towards death under naturalistic determinism,depicting a grim elderly world under the naturalistic concept of“survival of the fittest.”Studying this short story helps us reflect on the living conditions of the elderly and provides insights into how to better care for the elderly population amid the global trend of aging.
文摘Wharton’s novels serve as compelling cases for understanding the complexities of late 19th-century American society.The paper uses The Age of Innocence as an example to examine detailed depiction of the era’s social hierarchy,fashion,architecture,and the intricate social rituals that defined New York’s upper class.It explores the constraints and dilemmas women faced within a patriarchal society,highlighting Wharton’s personal experiences and her critical stance on the social norms of her time.The characters of Newland Archer,May Welland,and Ellen Olenska are analyzed to reveal the pressures of societal expectations and the struggles for individual desires within a rigid social structure.Additionally,the paper proposes various teaching methods,including contextual understanding,literary analysis with a historical focus,and historical research projects,to enhance students’comprehension of the cultural and historical context of the novel.These methods aim to immerse students in the narrative and promote their understanding of the Gilded Age’s social dynamics.
文摘Narrative empathy is a relatively new theory and it can guide researchers in the studies of main-melody films so as to promote the communication of the core values of the society.The rhetorical mechanism of narrative empathy can be illustrated from five rhetorical elements,including rhetor,rhetorical goal,rhetorical situation,rhetorical strategy and audience.The theory of narrative empathy can be applied to the case study of the film My People,My Country.In the production of this film,the directors are the rhetors.The rhetors uphold the tenet of closeness,choose the right rhetorical situation as the 70th birthday of the People’s Republic of China,and use appropriate rhetorical strategies in order to realize the rhetorical goals of evoking empathy and inspiring patriotic feelings in the audience’s minds.An exploration and application of narrative empathy can be conducive to the empathic communication of Chinese main-melody films in order to achieve better communication effect.
基金This work was supported by Humanities and Social Sciences Fund of Ministry of Education of China(No.19XJA7520012020)by National Social Science Fund of China(No.20BWW069).
文摘David’s Story by Zoë Wicomb addresses the complexities of representing female suffering and the limitations of traditional historical narratives in capturing the experiences of marginalized bodies.It challenges the grand narratives of national history by emphasizing the indispensable role of women’s experiences.Through characters like Dulcie and Rachael,Wicomb portrays the female body as a site of resistance and resilience,highlighting the need for more nuanced and inclusive ways of documenting history.Underscoring the inexpressibility of trauma and the limitations of language and representation,the novel self-reflexively acknowledges its own aporia of completing the narrative,embodying the ongoing struggle to capture the full breadth of human experience.
文摘Dharamvir Bharati’s Suraj Ka Satvan Ghoda connects the text with the social reality,through the multiple narrative perspectives of the“Panchatantra”Narrative Structure and the love stories,and narrates the survival and spiritual dilemma of Indian women in the transformation of India’s modernization.The novel depicts in both content and form the plight of Indian women’s physical and spiritual dependence under the traditional concepts of arranged marriages,caste marriages,dowry system and patriarchal will,and shows the process of women’s body and self-consciousness gradually moving from vitality to extinction.
基金supported by Humanities and Social Sciences Fund of Ministry of Education of China (No.19XJA7520012020)supported by National Social Science Fund of China (No.20BWW069).
文摘In the Heart of the Country,the second novel by J.M.Coetzee,has been traditionally read as a disembodied writing that focuses on the problem of writing per se instead of the reality.This paper contends that the work is actually a body narrative that explores the visceral pain suffered by Magda whose infertile body impedes her being a qualified subject.As the heroine in a postcolonial novel,Magda is not just a body that is restricted and constructed by the politics of the body,but also a thinking and writing body that consciously questions and resists the gendered bodily norms under whose yardstick her subjecthood is barred.Written in the metafictional manner,Magda’s narrative of the body is not just a record of her corporeal experience,but also a self-conscious negotiation with,and challenge of,the bodily norms under whose yardstick her body has been debased or,in terms of Judith Butler,abjected.Taking her female bodily experience as the starting point,Magda writes a feminine text that values passion,fluidity and non-linearity to disrupt the patriarchal discourse underpinned with logical reasoning.The feminine body narrative endeavors to achieve a new way of communication through which a reciprocal cross race/gender relationship might be established.
文摘Objective:To explore the role of narrative medicine in cultivating the humanistic spirit of respiratory medicine interns.Methods:Thirty interns were selected,all of whom were received by the respiratory department of our hospital from September 2023 to June 2024 and underwent narrative medicine teaching.Scores on narrative medicine knowledge,empathy ability,humanistic care ability,and teaching recognition were compared before and after the internship.Results:Compared to before the internship,the interns’scores on narrative medicine knowledge were significantly higher after the internship,as were their empathy and humanistic care scores(P<0.05).Among the 30 interns,25 expressed interest in narrative medicine,and 29 were willing to continue with the narrative medicine teaching model.Conclusion:The application of narrative medicine in respiratory medicine internship teaching is highly effective.It cultivates the humanistic spirit of interns,improves their empathy and humanistic care abilities,and is worthy of wider implementation.
文摘The research explored the ways and means of narrative design in which regional cultural elements are integrated into cultural and creative products.It also researched a new way of thinking and methods of creative product design based on regional cultural elements in order to satisfy consumers’emotional and cultural experiences.Narrative theory takes the perspective of narrative expression in the design of cultural and creative products.The regional cultural elements were used for better interactive communication with consumers in the form of cultural and creative products.In the narrative of cultural and creative product design,intervening in the development of regional cultural and creative design from the perspective of narratology can better exert and create the cultural value of the region itself,with cultural and creative products playing an important role in“local cultural stories.”This research adopted a qualitative approach and provided ideas and guidance for the narrative design and expression of regional cultural elements in creative products through comparative analysis of case studies.The research highlighted the role of narrative design in creating multi-layered experiences,weaving regional cultural stories into products,and the importance of deep understanding and effective use of regional cultural elements in design.
文摘Objective:To explore the impact of narrative nursing on anxiety,depression,and quality of life in middle-aged and young dialysis patients.Method:Eighty-six middle-aged and young dialysis patients admitted from January 2023 to December 2023 were selected and divided into a control group and a study group,with 43 patients in each group.The control group received general nursing interventions,while the study group received narrative nursing in addition to the general interventions.The levels of anxiety and depression before and after the intervention were compared,and the quality-of-life scores of the two groups were analyzed.Results:After comprehensive intervention,the scores of both groups significantly decreased(P<0.05).After intervention,the scores of the study group were more significant compared to the control group(P<0.05).Compared with the control group,the quality-of-life score of the study group showed a significant upward trend,and this difference was statistically significant(P<0.05).Conclusion:Comprehensive narrative nursing can effectively reduce anxiety in middle-aged and young dialysis patients,further enhance their quality of life,and is worth promoting in clinical practice.
文摘Putin’s forceful,almost contemptuous dismissal of warnings from U. S. and European leaders about the dangerous path he was pursuing led to anxious speclation about what lay behind it. After years of pursuing a pragmatic geopolitical game that was understandable,though not always appreciated by the West,Putin seemed to be operating in a different world. He had spent years courting acceptance in organizations like the G8,whose meeting he had planned on hosting in the new Sochi Winter Olympics setting,but in 2014 he seemed to be throwing everything away in pursuit of some sort of mission that few in the west understood.
基金supported by the Natural Science Foundation of Heilongjiang Province of China,Outstanding Youth Foundation,No.YQ2022H003 (to DW)。
文摘N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be attributed to the timespecific nature of m^(6)A and its varying effects on distinct brain regions and in different environments.
基金supported by STI2030-Major Projects,No.2022ZD0207600(to LZ)the National Natural Science Foundation of China,Nos.32070955(to LZ),U22A20301(to KFS)+3 种基金the Natural Science Foundation of Guangdong Province,No.2021A1515012197(to HO)Guangzhou Core Medical Disciplines Project,No.2021-2023(to HO)Key Research and Development Plan of Ningxia Hui Automomous Region,No.2022BEG01004(to KFS)Science and Technology Program of Guangzhou,China,No.202007030012(to KFS and LZ)。
文摘Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug therapy.Physical exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after stroke.In this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral ischemia.We also examined the role of exercise-induced circulating factors in these effects.Adult mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery occlusion.We found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory function.Further analysis showed that circulating adiponectin plays a critical role in these preventive effects of exercise.Agonist activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise effects.In summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.
基金supported by the National Natural Science Foundation of China,Nos.81730033,82171193(to XG)the Key Talent Project for Strengthening Health during the 13^(th)Five-Year Plan Period,No.ZDRCA2016069(to XG)+1 种基金the National Key R&D Program of China,No.2018YFC2001901(to XG)Jiangsu Provincial Medical Key Discipline,No.ZDXK202232(to XG)。
文摘Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of patients.To date,there are no viable treatment options for postoperative cognitive dysfunction.The identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future research.To identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial fracture.The dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub gene.Therefore,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re surgery.Mice were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning tests.In addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western blotting.Treatment with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expression compared with vehicle treatment.Intraperitoneal administration of the specific ERK inhibitor PD98059 diminished the effects of recombinant chitinase-3-like protein 1.Collectively,our findings suggest that recombinant chitinase-3-like protein 1 ameliorates surgery-induced cognitive decline by attenuating neuroinflammation via M2 microglial polarization in the hippocampus.Therefore,recombinant chitinase-3-like protein1 may have therapeutic potential fo r postoperative cognitive dysfunction.
基金supported by the National Institutes of Health,Nos.AA025919,AA025919-03S1,and AA025919-05S1(all to RAF).
文摘Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s disease.Adult hippocampal neurogenesis is reduced in patients with Alzheimer’s disease.Exercise stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s disease.However,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly understood.Recently,regulator of G protein signaling 6(RGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in mice.Here,we generated novel RGS6fl/fl;APP_(SWE) mice and used retroviral approaches to examine the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse model.We found that voluntary running in APP_(SWE) mice restored their hippocampal cognitive impairments to that of control mice.This cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal neurogenesis.Adult hippocampal neurogenesis was reduced in sedentary APP_(SWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor cells.RGS6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGS6-expressing neurons.Thus,RGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWE) mice,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.
文摘This paper rethinks critically the Italian serial production of fiction, in recent years, placing it in relation to the dynamics of collective memory. The analysis starts from two Italian fiction: Raccontami, the history of a family returns the great changes of the 60s'; I Medici dedicated to the biography of the great Florentine Renaissance banker family, exemplified by similar international productions (including the Borgia) and subject to strong promotion by Rai 1. Around these two lines of address is also the analysis of some miniseries among these biopics dedicated to figures of the national imagination such as pontiffs, doctors, partisans, entrepreneurs. If the twentieth century was defined as the "century of testimony" this is also due to the massive and pervasive presence of media that are often at the center of the processes of transformation and transition of the public and cultural life of societies. Television, in particular, confirms itself as the real, symbolic and rhetorical place in which historical events unfold, to be, on some occasions, a substitute simulacrum. Fiction, as a form of popular narrative and reworking, is an intermediary and central element in the processes of building the social imagery and collective memory, responding to the need for a typical tale of every society.