Clinical Study of Shentong Zhuyu Decoction Combined with Massage Therapy in the Treatment of Exertional Chronic Lumbar Muscle Strain

[Objectives]To explore the effects of Shentong Zhuyu decoction combined with massage therapy in the treatment of exertional chronic lumbar muscle strain.[Methods]Sixty-four cases of exertional chronic lumbar muscle strain were randomly divided into two groups(32 cases each group).The patients in the control group only took celecoxib capsules,and those in the treatment group additionally took Shentong Zhuyu decoction combined with massage therapy.TCM syndrome score,lumbar function,hemorrheology index and clinical effect were compared between the two groups before and after treatment.[Results]After treatment,the TCM syndrome scores of lumbar distension/dull pain,tingling-like lumbago,adverse lateral turn,body weight loss,dark purple tongue,slow or astringent pulse,and Oswestry disability index(ODI)score in the treatment group were lower than those in the control group,and the levels of plasma viscosity,red blood cell aggregation index,platelet aggregation rate(PAG)and fibrinogen(Fib)were lower than those in the control group,showing statistical significance(P<0.05).The overall clinical effect distribution of the treatment group was better than that of the control group,and the difference was statistically significant(P<0.05).[Conclusions]Shentong Zhuyu decoction combined with massage therapy can effectively relieve the symptoms of patients with lumbago and improve the lumbar mobility function and hemorrheology,with obvious therapeutic effects in the treatment of exertional chronic lumbar muscle strain.

Clinical intervention effect of Xuefu Zhuyu decoction on chronic heart failure complicated with depression

BACKGROUND The diagnosis and treatment of depression in patients with chronic heart failure(CHF)is challenging,with no ideal treatment at present.AIM To analyze the clinical intervention effect of Xuefu Zhuyu decoction(XFZYD)on CHF complicated with depression.METHODS The study cohort comprised 116 patients with CHF complicated with depression who received treatment from July 2020 to July 2023,of which 55 received Western medicine(control group)and 61 received XFZYD(research group).Data on clinical effectiveness,traditional Chinese medicine(TCM)syndrome score,cardiac function,negative emotions,and serum inflammatory factors,were collected for comparative analyses.RESULTS Compared with the control group,the research group had an evidently higher total effective rate.Furthermore,there were marked reductions in TCM symptom score,left ventricular end-diastolic diameter,left ventricular end-systolic diameter,Self-Rating Depression Scale,Hamilton Depression Scale,high-sensitivity C-reactive protein,monocyte chemoattractant protein-1,and matrix metalloproteinase-9 in the research group after treatment,and these were lower than the corresponding values in the control group.Left ventricular ejection fraction was increased and higher in the research group compared with the control group after treatment.CONCLUSION Our findings conclusively proved that XFZYD was considerably superior to Western medicine for treating CHF complicated with depression because it significantly alleviated patients’symptoms,improved cardiac function,relieved negative emotions,and reduced the levels of serum inflammatory factors.

Analyzing the pharmacological substances and targets of Xuefu Zhuyu decoction in hypertensive vascular endothelial cells

Background:Xuefu Zhuyu decoction(XFZY)could significantly improve the function of hypertensive vascular endothelial cells,but the targets and mechanism are not clear.This study is to analyze the pharmacological substances and targets of Xuefu Zhuyu decoction in hypertensive vascular endothelial cells.Methods:This study used Xuefu Zhuyu decoction to intervene human umbilical vein endothelial cells incubated by hypertensive patients’serum,then detected the function of vascular endothelial cells.The aqueous extract of XFZY was analyzed and validated by liquid chromatography-mass spectrometry technology;Finally,macromolecular docking technology was used to analyze the potential active substances and targets of XFZY in the prevention and treatment of hypertension.Results:Compared with the model group,the XFZY group showed a significant increase in NO expression(P<0.01)and a significant decrease in ET-1 expression(P<0.001);and the expression of BIP,P-JNK,CHOP,and BAX in XFZY group cells was significantly decreased(P<0.001),while the expression of JNK and BCL2 was significantly increased(P<0.001).19 main compounds were identified in XFZY and there were 3 pairs of molecular complexes with high affinity for markers of the endoplasmic reticulum stress,including BIP-Hesperidin complex,BIP-HSYA complex and JNK-Naringin complex.Conclusion:This study analyzed the potential pharmacodynamic substance and targets of Xuefu Zhuyu decoction in improving the function of hypertensive vascular endothelial cells,which could provide a scientific basis for the future molecular mechanism of XFZY in treating hypertension.

Mechanism of the Xuefu Zhuyu decoction in treating diabetes mellitus erectile dysfunction based on the CaSR/Gq-PLC-PKC pathway

Background:To investigate the mechanism of Xuefu Zhuyu decoction in the treatment of diabetes mellitus erectile dysfunction.Methods:Rats with diabetes mellitus erectile dysfunction were developed using streptozocin and randomly assigned into model,low-dose herbal,and high-dose herbal groups.All rats were administered normal saline or the corresponding drugs by oral gavage for 4 weeks.The related indices were detected using enzyme-linked immunosorbent assays,immunohistochemistry,western blotting,and transmission electron microscopy.Results:The levels of lectin-like oxidized low-density protein receptor-1,endothelin-1,NADH oxidase,vascular cell adhesion molecule-1,and intercellular adhesion molecule-1 in the model group were significantly higher than they were in the mock group but lower than they were in the herbal treatment group.The level of nitric oxide was lower in the model group than was in the mock group but higher than the level in the herbal treatment group.The calcium-sensitive receptor,phospho-protein kinase Cδ/protein kinase Cδ,phosphorylated c-Jun amino-terminal kinase/c-Jun amino-terminal kinase,and phospho-P38 mitogen-activated protein kinase/P38 mitogen-activated protein kinase expression levels in the model group were higher than were in the mock group but lower than were in the herbal treatment group.The structures of the Corpus cavernosum penis endothelial cells were significantly improved in the herbal treatment group than they did in the model group.Conclusion:Xuefu Zhuyu decoction can decrease injury to the endothelium,improve vascular endothelial diastolic and contractive function,and inhibit vascular fibrosis in rats with diabetes mellitus erectile dysfunction.This mechanism may be related to the CaSR/Gq-PLC-PKC pathway.

Systematic review and meta-analysis of efficacy of Gexia Zhuyu Decoction in the treatment of nonalcoholic fatty liver disease

Objective:To evaluate the efficacy of Gexia Zhuyu Decoction in the treatment of nonalcoholic fatty liver disease(NAFLD).Methods:Four Chinese databases(CNKI,CMB,Wanfang,VIP)and four English databases(PubMed,Embase,Cochrane Library,Medline)were searched to screen randomized controlled trials(RCTs)of Gexia Zhuyu Decoction in the treatment of NAFLD.The enrollment of RCTs is from the starting date of database establishment till November 2,2022.and clinical registration tests and grey literatures were also searched.RCTs screening and relevant data exreacting were based on preset criteria.RevMan5.4.1 software was used for risk of bias assessment and Meta analysis of the included studies.Results:Eleven RCTs were included finally having 963 patients with NAFLD,including 499 in experimental group and 494 in control group.Meta-analysis results showed that GexiaZhuyu Decoction alone or combining with other medications for the treatment of NFALD was superior to that in control group in terms of total effective rate[RR=1.23,95%CI[1.16,1.31],Z=6.58(P<0.05)].Improve liver function index significantly:ALT[subgroup①WMD=-14.93,95%CI[-18.66,-9.42],Z=7.84(P<0.01);subgroup②WMD=-3.97,95%CI[-8.01,0.07],AST[subgroup①WMD=-13.25,95%CI[-18.10,-8.41],Z=5.36(P<0.05);subgroup②WMD=-2.70,95%CI[-6.94,1.54],Z=1.25(P>0.05)];GGT[WMD=-9.30,95%CI[-15.78,-2.81],Z=2.81(P<0.05)].Moreover,patients with therapy obviously decreased hepatic fibrosis index:桇-C[SMD=-1.15,95CI%[-1.48,-0.81],Z=6.77(P<0.05)],LN[SMD=-1.49,95CI%[-2.23,-0.75],Z=3.97(P<0.05)].Effectively reduce the level of LDL-C[WMD=-0.30,95CI%[-0.54,-0.06],Z=2.48(P<0.05)]and improve the rate of ultrasound renormalization[RR=1.94,95%CI[1.45,2.60],Z=4.48(P<0.05)].However,existing data cannot prove that the effect of reducing TC,TG and BMI in the treatment group is better than that in the control group:TC[WMD=-0.88,95CI%[-1.88,0.11],Z=1.74(P>0.05)],TG[WMD=-0.50,95CI%[-1.05,0.06],Z=1.76(P>0.05)],BMI[WMD=-1.61,95CI%[-4.77,1.54],Z=1.00(P>0.05)].Descriptive analysis results showed that the levels of LDL,HA and PCIII were significantly reduced in the treatment group,and the differences were statistically significant(P<0.05).In addition,no adverse drug reactions related to Gexia Zhuyu Decoction have been reported.Conclusion:Gexia Zhuyu Decoction can significantly improve the liver function,liver fibrosis,and hepatic steatosis in NAFLD patients,thereby improving the clinical efficacy.

Xuefu Zhuyu decoction improves neurological dysfunction by increasing synapsin expression after traumatic brain injury

Xuefu Zhuyu decoction has been used for treating traumatic brain injury and improving post-traumatic dysfunction, but its mechanism of action needs further investigation. This study established rat models of traumatic brain injury by controlled cortical impact. Rat models were intragastrically administered 9 and 18 g/kg Xuefu Zhuyu decoction once a day for 14 or 21 days. Changes in neurological function were assessed by modified neurological severity scores and the Morris water maze. Immunohistochemistry, western blot assay, and re- verse-transcription polymerase chain reaction were used to analyze synapsin protein and mRNA expression at the injury site of rats. Our results showed that Xuefu Zhuyu decoction visibly improved neurological function of rats with traumatic brain injury. These changes were accompanied by increased expression of synaptophysin, synapsin I, and postsynaptic density protein-95 protein and mRNA in a dose-de- pendent manner. These findings indicate that Xuefu Zhuyu decoction increases synapsin expression and improves neurological deficits alder traumatic brain injury.

The mechanism of Xuefu Zhuyu decoction in treating erectile dysfunction based on Arrowsmith tool

Arrowsmith,a literature retrieval tool,was used to explore the theoretical pharmacological mechanism of action of Xuefu Zhuyu decoction and its single herb against erectile dysfunction.Cytoscape 3.6.1 software was used to analyze the correlation between the components of Xuefu Zhuyu decoction and the identified mechanism of action.Different herbs in Xuefu Zhuyu decoction may play a therapeutic role by regulating iNOS,COX-2,mTOR,Wnt,AMPK,Nrf2,TLR4,CYP2D6,BDNF,MAPK,Akt,STAT3,PI3K,ERK1,P38MAPK,JNK,VEGF,and other targets.The treatment of erectile dysfunction with Xuefu Zhuyu decoction embodied the multicomponent,multitarget,and multipathway.The Arrowsmith tool retrieval and analysis provided a scientific basis for further elucidation of the mechanism of Xuefu Zhuyu decoction against erectile dysfunction.

Research on the Mechanism of the treatment of non‑alcoholic fatty liver by Jianwei Gexia Zhuyu Decoction based on network pharmacology and molecular docking

Objective:To analyse the key compounds,targets and pathways of the treatment of non‑alcoholic fatty liver disease(NAFLD)by Jianwei Gexia Zhuyu Decoction based on network pharmacology,in order to explore the molecular mechanism of its therapeutic effects.Methods:The differential genes between sick and normal conditions were screened by GEO‑Datasets,and the heat map and volcano map were drawn.The active compounds in Jianwei Gexia Zhuyu Decoction were searched by TCMSP platform and Drugbank database.OB≥30%and DL≥0.18 were set as thresholds to screen potential active compounds and action targets.The molecular target maps of Jianwei Gexia Zhuyu Decoction and NAFLD differential genes were constructed,and the PPI network and network topology parameters were obtained by STRING database.The PPI network and network topology parameters were visually analyzed by Cytoscape,and the core regulatory genes were screened.At the same time,the SwissDock platform was used to dock the main active components with the target.The main pathways were determined by GO biological function enrichment analysis and KEGG metabolic pathway enrichment analysis by DAVID.Results:After screening,377 differential genes(127 up‑regulated genes and 250 down‑regulated genes),225 active compounds of Jianwei Gexia Zhuyu Decoction,308 corresponding targets were obtained;14 key targets were screened,corresponding to 168 compounds,and the key targets involved MYC,FOSL2,FOS,etc.The results of GO functional enrichment analysis showed that Jianwei Gexia Zhuyu Decoction mainly regulated the activity expression of DNA binding transcriptional activator and the specific transcription of RNA polymeraseⅡ;The results of molecular docking showed that the main active components quercetin and baicalein had good binding activity with VCAM1,HSPB1,MYC,JUN and so on;The results of KEGG enrichment analysis showed that it was mainly involved in IL‑17 signal pathway,Wnt receptor signal pathway,NF‑κB signal pathway,TNF signal pathway and AGE‑RAGE signal pathway in diabetic complications.Conclusion:Through the interaction of multi‑components and multi‑targets,Jianwei Gexia Zhuyu Decoction has achieved the goal of overall treatment of NAFLD from many ways.The application of network pharmacology provides a new research approach and scientific basis for further study on the mechanism of Jianwei Gexia Zhuyu Decoction in the treatment of NAFLD.

Effects of Xuefu Zhuyu Decoction combined with conventional therapy on inflammatory response, oxidative stress, endothelium and related factors in patients with acute cerebral infarction

Objective: To explore the effects of Xuefu Zhuyu Decoction combined with conventional therapy on inflammatory response, oxidative stress, endothelium and related factors in patients with acute cerebral infarction. Methods: A total of 162 patients with acute cerebral infarction admitted to our hospital from November 2016 to January 1818 were selected as subjects. According to the random sampling method, the subjects were divided into 81 cases in the control group and 81 cases in the observation group. The control group was treated with conventional intracranial pressure, anticoagulation, anti-oxidation and lipid-lowering treatment. The observation group was treated with Xuefu Zhuyu Decoction on the basis of the control group. The changes of inflammatory response, oxidative stress, endothelium and related factors were compared and analyzed. Results:Before treatment, the levels of TNF-α, CRP, SOD, MDA, AOPPS, NO, ET-1, MMP-9, PAF and IGF-1 in the two groups were not significantly different, and there was no statistical significance. After treatment, the levels of TNF-α and CRP in the two groups were significantly lower than those before treatment, and the levels of TNF-α and CRP in the observation group were significantly lower than control group;the levels of MDA and AOPPS in the two groups were significantly lower than those before treatment, while the level of SOD was significantly higher than before treatment, and the levels of MDA and AOPPS in the observation group were significantly lower than control group, while the level of SOD was significantly higher. In the control group;the level of ET-1 in the two groups was significantly lower than that before treatment, while the level of NO was significantly higher than that before the treatment, and in the observation group the level of ET-1 was significantly lower than the control group, while the level of NO was significantly higher. In the control group;the levels of MMP-9 and PAF in the two groups were significantly lower than those before treatment, while the level of IGF-1 was significantly higher than before treatment, and the levels of MMP-9 and PAF in the observation group were significantly lower than control group, while the level of IGF-1 was significantly higher than control group. Conclusions: Xuefu Zhuyu Decoction combined with conventional treatment of acute cerebral infarction can effectively reduce inflammation and oxidative stress, improve vascular endothelial function and nerve function, and significantly reduce the degree of brain injury, which has clinical significance.

The Efficacy of Banxia Baizhu Tianma Decoction(半夏白术天麻汤)Combined with Xuefu Zhuyu Decoction(血府逐瘀汤)for Essential Hypertension and the Effects on Endothelial Function:A Systematic Review and Meta-analysis

Objective:Banxia Baizhu Tianma Decoction(半夏白术天麻汤,BBTD)combined with Xuefu Zhuyu Decoction(血府逐瘀汤,XFZYD)is widely used to treat essential hypertension in China,but its efficacy remains largely unexplored.We systemically summarized relevant evidence from randomized controlled trials(RCTs)to assess the therapeutic efficacy of BBTD+XFZYD.Methods:This review retrieved 6 databases like Pubmed,Cochrane Library,Embase,CNKI,et al.RCTs of BBTD+XFZYD plus conventional Western drugs(experimental group)and conventional Western drugs alone(control group)for hypertension was collected from the database establishment to August 5,2020.And the outcomes included clinical total effective rate,systolic blood pressure(SBP),diastolic blood pressure(DBP),nitric oxide(NO)and endothelin-1(ET-1).All studies’risk of bias were assessed by the Cochrane Collaboration tool 5.1.0.The data was statistically analyzed by RevMan5.3 Software.Results:Six studies with 608 participants were identified.About duration of treatment,4 studies were 1 month,2 studies were 2 months.The quality presented a high risk of bias.The experimental group showed that clinical total effective rate of the 1-month and 2-month was higher(P<0.00001),the systolic pressure was significantly lower(P<0.05),the NO increased(P<0.00001),and the ET-1 decreased(P<0.00001)compared with the conventional Western drugs used alone.However,DBP was significantly lower(P<0.05)at 2 months of treatment.Conclusion:BBTD+XFZYD plus conventional Western drugs might reduce blood pressure,improve clinical efficacy,repair endothelial function,but still need high-quality RCTs to better assess the outcomes.

身痛逐瘀汤加味联合盐酸普拉克索片治疗痰瘀痹阻型不宁腿综合征的临床观察

目的观察身痛逐瘀汤加味联合盐酸普拉克索片治疗痰瘀痹阻型不宁腿综合征(RLS)患者的临床疗效。方法将50名痰瘀痹阻型RLS患者按照随机数字表法分为2组,对照组25例予盐酸普拉克索片治疗,治疗组25例在对照组基础上联合身痛逐瘀汤加味治疗。2组均治疗1周为1个疗程,治疗2个疗程后统计疗效,比较2组治疗前后国际RLS严重程度评分量表(IRLS)评分、匹兹堡睡眠质量指数量表(PSQI)评分及中医症状评分变化情况。结果治疗组总有效率92.00%(23/25),对照组总有效率60.00%(15/25),治疗组总有效率高于对照组(P<0.05)。与本组治疗前比较,2组治疗后IRLS评分、PSQI评分及中医症状评分均降低(P<0.05),且治疗组治疗后IRLS评分、PSQI评分及中医症状评分均低于对照组(P<0.05)。结论身痛逐瘀汤加味联合盐酸普拉克索片治疗痰瘀痹阻型RLS疗效确切,可有效改善患者临床症状及中医症状,改善患者睡眠质量,操作简便,临床疗效显著,安全性良好。

血府逐瘀汤治疗冠心病研究进展

冠心病是临床常见的心血管疾病之一,其发病率和病死率呈上升趋势,严重危害居民健康,加重国家经济负担。血府逐瘀汤有活血化瘀、理气止痛的功效,主治胸中血瘀证。临床上根据其功效常用于治疗血瘀证冠心病,并取得良好疗效。此文旨在对血府逐瘀汤治疗冠心病的临床运用、作用机制及研究进展展开探讨,为深入挖掘血府逐瘀汤临床及实验研究提供新思路。

真武汤联合血府逐瘀方治疗老年冠心病伴慢性心力衰竭患者的疗效观察

目的探讨真武汤联合血府逐瘀方治疗老年冠心病伴慢性心力衰竭(Chronic heart failure,CHF)患者的临床疗效。方法选取2020年5月—2023年6月期间六安市中医院收治的老年冠心病伴CHF患者106例作为研究对象,依据简单随机数字表法分为对照组和研究组,每组各53例。对照组采取常规治疗,研究组在对照组基础上采取真武汤合血府逐瘀方,均治疗4周。观察比较两组患者临床疗效、不良反应发生情况,治疗前后中医证候积分、心功能[左心室射血分数(Left ventricular ejection fraction,LVEF)、心输出量(Cardiac output,CO)、左心室舒张末期内径(Left ventricular end-diastolic diameter,LVEDD)、左心室收缩末期内径(Left ventricular end-systolic diameter,LVESD)]、血流动力学[肺动脉平均压(Mean pulmonary artery pressure,MPAP)、左心房平均压(Mean left atrial pressure,MLAP)、平均二尖瓣跨瓣压差(Mean mitral valve intervalve pressure difference,MMPG)]、心力衰竭标记物[血管内皮生长因子(Vascular endothelial growth factor,VEGF)、可溶性生长刺激表达基因2蛋白(Soluble growth stimulation expressed gene2,sST2)、脑钠肽(Brain natriuretic peptide,BNP)]水平。结果治疗后研究组临床总有效率94.34%(50/53)明显高于对照组81.13%(43/53),差异有统计学意义(P<0.05)。治疗后两组患者肢冷、心悸、气短、喘促及肢体浮肿、胸闷、盗汗、乏力分值均较治疗前降低,差异有统计学意义(P<0.05);且研究组中医证候积分明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者LVEF、CO指标均较治疗前升高,LVEDD、LVESD指标均较治疗前降低,差异有统计学意义(P<0.05);且研究组LVEF、CO指标明显高于对照组,LVEDD、LVESD指标明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者血流动力学MPAP、MLAP、MMPG水平均较治疗前降低,差异有统计学意义(P<0.05);且研究组血流动力学MPAP、MLAP、MMPG水平明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者VEGF指标均较治疗前升高,sST2、BNP指标均较治疗前降低,差异有统计学意义(P<0.05);且研究组VEGF指标明显高于对照组,sST2、BNP指标均明显低于对照组,差异有统计学意义(P<0.05)。治疗期间,研究组不良反应发生率7.55%(4/53)与对照组3.77%(2/53)比较,差异无统计学意义(P>0.05)。结论常规基础上采取真武汤合血府逐瘀方治疗老年冠心病合并CHF可改善患者心功能,调节血流动力学状态及心力衰竭标记物水平,缓解临床症状,提升整体治疗效果,且具有安全性。

基于AMPK/PGC1α信号通路探究降脂逐瘀汤对动脉粥样硬化大鼠脂代谢的影响

目的:基于AMPK/PGC1α信号通路探究降脂逐瘀汤对动脉粥样硬化(AS)大鼠脂代谢的影响。方法:高脂饲料喂养及腹腔注射维生素D3诱导建立AS大鼠模型,随机分为模型组、降脂逐瘀汤(3.75 g/kg)低剂量组、降脂逐瘀汤(7.5 g/kg)中剂量组、降脂逐瘀汤(15 g/kg)高剂量组、降脂逐瘀汤(15 g/kg)高剂量+盐酸多索啡(AMPK抑制剂,0.2 mg/kg)组,每组12只,另取12只正常SD大鼠喂养普通饮食及腹腔注射生理盐水作为对照组。经降脂逐瘀汤和盐酸多索啡分组干预处理各组大鼠后,检测大鼠甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)水平;HE染色检测大鼠主动脉组织病理变化;油红O染色检测各组大鼠主动脉和肝脏脂质沉积;酶标仪测定大鼠血清炎症因子IL-8、IL-1β、IL-18水平;免疫印迹法检测大鼠主动脉组织AMPK/PGC1α通路蛋白表达。结果:与对照组相比,模型组大鼠主动脉组织发生严重病理损伤,主动脉和肝脏组织中有大量脂质沉积,肝脏脂肪变性严重,血清LDL-C、TC、TG、IL-8、IL-1β、IL-18水平显著升高(P<0.05),血清HDL-C水平、主动脉组织p-AMPK/AMPK与PGC1α蛋白表达显著降低(P<0.05)。与模型组相比,降脂逐瘀汤各剂量组大鼠主动脉组织病理损伤、主动脉脂质沉积和肝脏脂肪变性症状均减轻,血清LDL-C、TC、TG、IL-8、IL-1β、IL-18水平均降低(P<0.05),血清HDL-C水平、主动脉组织p-AMPK/AMPK与PGC1α蛋白表达均升高(P<0.05),且呈剂量依赖性(P<0.05);与降脂逐瘀汤高剂量组相比,降脂逐瘀汤高剂量+盐酸多索啡组大鼠主动脉组织病理损伤、主动脉脂质沉积和肝脏脂肪变性症状加重,血清LDL-C、TC、TG、IL-8、IL-1β、IL-18水平升高(P<0.05),血清HDL-C水平、主动脉组织p-AMPK/AMPK与PGC1α蛋白表达降低(P<0.05)。结论:降脂逐瘀汤可通过激活AMPK/PGC1α信号抵抗炎症发生发展,减轻大鼠主动脉组织病理损伤、主动脉脂质沉积和肝脏脂肪变性症状,改善AS大鼠脂代谢。

暖宫灸联合补肾逐瘀汤对卵巢子宫内膜异位症术后患者卵巢储备功能和子宫内膜容受性的影响

目的探析暖宫灸联合补肾逐瘀汤对卵巢子宫内膜异位症(EMS)术后患者卵巢储备功能和子宫内膜容受性的影响。方法选取2020年8月至2022年8月江西省妇幼保健院住院部收治的腹腔镜手术治疗的60例EMS患者作为研究对象,采用随机数字表法分为对照组和观察组,每组各30例。对照组给予亮丙瑞林治疗+补肾逐瘀汤,观察组于对照组基础上加用暖宫灸,持续治疗3个月。比较两组患者临床疗效、卵巢储备功能[血清抗米勒管激素(AMH)及抑制素B(INHB)、窦卵泡计数(AFC)]、子宫受容性相关指标(子宫内膜厚度、子宫内膜容积)以及不良反应发生情况。结果观察组总有效率高于对照组,差异有统计学意义(P<0.05);治疗3个月后,两组患者AMH、INHB及AFC水平高于本组治疗前,且观察组各指标高于对照组,差异有统计学意义(P<0.05);治疗3个月后,两组患者子宫内膜容积、厚度均高于本组治疗前,且观察组各指标高于对照组,差异有统计学意义(P<0.05);治疗期间,两组不良反应发生情况比较,差异无统计学意义(P>0.05)。结论暖宫灸联合补肾逐瘀汤治疗卵巢EMS术后患者效果显著,可改善卵巢储备功能,提高子宫容受性。

血府逐瘀汤联合胸腔镜手术治疗创伤性血气胸的临床疗效及对应激反应和凝血功能的影响

目的:探讨血府逐瘀汤联合胸腔镜手术治疗创伤性血气胸的临床疗效及对应激反应和凝血功能的影响。方法:将72例创伤性血气胸患者按照随机数字表法分为对照组和观察组,各36例。对照组采用胸腔镜进行手术并给予机械通气,观察组在对照组基础上联合血府逐瘀汤进行治疗。比较两组临床治疗总有效率、气滞血瘀症状评分、肺功能指标[第1秒用力呼气量(FEV1)、肺活量(VC)、最大通气量(MVV)、用力肺活量(FVC)]、应激反应指标[皮质醇(Cor)、去甲肾上腺素(NE)、胰岛素(Ins)、血管紧张素Ⅱ(AT-Ⅱ)]、凝血功能指标[凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)和D-二聚体(D-D)],以及术后并发症发生率。结果:观察组患者临床治疗总有效率为97.22%,高于对照组的83.33%,有统计学意义(P<0.05);治疗后,对照组及观察组患者气滞血瘀症状评分、Cor、NE、Ins、AT-Ⅱ、FIB水平均降低,FEV1、VC、MVV、FVC、PT、APTT、TT和D-D均升高,有统计学意义(P<0.05);与对照组比较,观察组患者气滞血瘀症状评分、Cor、NE、Ins、AT-Ⅱ、FIB水平均降低,FEV1、VC、MVV和FVC显著升高,有统计学意义(P<0.05)。结论:血府逐瘀汤联合胸腔镜手术治疗创伤性血气胸效果理想,可显著改善患者肺功能和凝血功能,减少应激反应。

益肾逐瘀汤联合中药外敷治疗前列腺增生伴膀胱过度活动症的疗效及机制研究

目的研究益肾逐瘀汤联合中药外敷治疗前列腺增生伴膀胱过度活动症的疗效及机制。方法选取2022年7月—2023年4月广西中医药大学第一附属医院泌尿外科收治的前列腺增生伴膀胱过度活动症患者90例,随机分为常规药物组、中药外敷组与益肾逐瘀汤组,每组30例。3组均给予常规药物(托特罗定)治疗,中药外敷组在托特罗定治疗的基础上给予中药敷贴于神阙关元穴,益肾逐瘀汤组在托特罗定治疗的基础上给予中药外敷联合益肾逐瘀汤浓缩丸剂口服治疗。治疗2周后比较3组患者治疗有效率,治疗前后的最大尿流率(maximum flow rate,Qmax)、尿量(urine volume,VV),国际前列腺症状评分(international prostate symptom score,IPSS)、膀胱活动过度症评分(overactive bladder syndrome score,OABSS),前列腺小体外泄蛋白(prostatic exosomal potein,PSEP)、血液流变学[全血高切黏度(high blood viscosity,HBV)、全血低切黏度(low blood viscosity,LBV)]和血清性激素[促黄体生成素(Luteinizing hormone,LH)、睾酮(testosterone,T)]的水平。结果常规药物组、中药外敷组与益肾逐瘀汤组治疗总有效率分别为73.33%(22/30)、90.00%(27/30)、96.67%(29/30),益肾逐瘀汤组显著高于常规药物组(P<0.05)。治疗后3组患者Qmax、VV均显著升高,并且益肾逐瘀汤组显著高于常规药物组、中药外敷组(P<0.05)。治疗后3组患者IPS、OABSS评分均显著降低,并且益肾逐瘀汤组显著低于常规药物组、中药外敷组(P<0.05)。治疗后3组患者PSEP、HBV、LBV、LH水平均显著下降,T水平显著升高,益肾逐瘀汤组PSEP、HBV、LBV、LH水平显著低于常规药物组、中药外敷组,T水平显著高于常规药物组、中药外敷组,差异均有统计学意义(P<0.05)。结论益肾逐瘀汤联合中药外敷治疗前列腺增生伴膀胱过度活动症效果满意,可提高治疗总有效率,并改善患者血流流变学、促进性激素水平处于平衡状态,促进患者康复。

血府逐瘀汤联合恩替卡韦治疗瘀血阻络型乙型肝炎肝硬化代偿期患者的临床效果

目的 探讨血府逐瘀汤联合恩替卡韦治疗瘀血阻络型乙型肝炎肝硬化代偿期患者的临床效果。方法 选取80例瘀血阻络型乙型肝炎肝硬化代偿期患者,随机分为观察组和对照组,每组40例。给予观察组血府逐瘀汤联合恩替卡韦治疗,给予对照组恩替卡韦治疗,疗程均为24周。比较两组患者治疗前后失代偿期肝硬化发生率,HBV-DNA载量、肝功能[ALT、AST、总胆红素(TBIL)]、血清炎症因子[肿瘤坏死因子α(TNF-α)、白细胞介素(IL)-6、IL-22]、肝脏超声相关指标(门静脉主干内径、脾静脉内径、脾脏厚度、脾脏长度)、中医证候积分和中医证候疗效的变化情况,以及治疗期间不良反应发生情况。结果 治疗后12周、治疗后24周,两组患者失代偿期肝硬化发生率及门静脉主干内径、脾静脉内径、脾脏厚度、脾脏长度差异无统计学意义(P>0.05)。两组患者的血清ALT、AST、TBIL、TNF-α、IL-6、IL-22水平,以及HBV-DNA载量、中医证候积分随治疗时间延长而降低,且治疗后12周、治疗后24周,观察组的上述指标均低于对照组(P<0.05)。治疗后,观察组的中医证候疗效的总有效率高于对照组(P<0.05)。治疗期间两组患者的不良反应发生率差异无统计学意义(P>0.05)。结论 血府逐瘀汤联合恩替卡韦治疗瘀血阻络型乙型肝炎肝硬化代偿期患者的临床疗效优于单纯恩替卡韦治疗,可有效降低炎症细胞因子的表达水平,改善肝功能,且安全性较好。

血府逐瘀汤对狼疮性肾炎患者胸腺肽β4及Ea-RFC的影响

目的探讨血府逐瘀汤辅助治疗狼疮性肾炎(LN)的效果及对患者胸腺肽β4及Ea花环细胞(Ea-RFC)形成率的影响。方法选取河北北方学院附属第二医院2020年1月至2021年6月收治的60例狼疮性肾炎患者,按随机数字表法分为观察组(行血府逐瘀汤联合泼尼松与环磷酰胺治疗)30例与对照组(行泼尼松与环磷酰胺治疗)30例,治疗18个月。观察组治疗后临床效果、中医症状、胸腺肽β4表达、Ea-RFC形成率、肾功能及不良反应。结果观察组治疗总有效率为96.67%,高于对照组的80.00%,差异有统计学意义(P<0.05)。治疗后,观察组纳少腹胀、腰膝酸软、面色不华、口黏口苦等中医症状积分低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组红细胞沉降率、血清肌酐及胸腺肽β4表达低于对照组,Ea-RFC形成率高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组不良反应发生率与对照组比较差异无统计学意义(P>0.05)。结论血府逐瘀汤辅助治疗LN患者疗效确切,能减少患者体内胸腺肽β4表达,提高Ea-RFC,改善肾功能,安全性较高。

膈下逐瘀汤联合地奥司明对大隐静脉曲张术后凝血机制的影响

目的探讨大隐静脉曲张手术患者应用膈下逐瘀汤联合地奥司明治疗对凝血机制的影响。方法选取2019年1月至2022年4月于绍兴市中医院接受大隐静脉曲张手术的60例患者,根据随机数字表法将纳入患者分为对照组和观察组,每组各30例,对照组患者予地奥司明治疗,观察组患者予地奥司明+膈下逐瘀汤治疗。比较两组患者的凝血指标、血管内皮功能、炎症因子水平。结果治疗后,观察组患者的Krüppel样转录因子、活化部分凝血活酶时间、凝血酶时间、凝血酶原时间、一氧化氮、白细胞介素(interleukin,IL)-10均显著高于对照组,纤溶酶原激活物抑制剂1型、血管性血友病因子、内皮素-1、超敏C反应蛋白、IL-2、IL-6均显著低于对照组(P<0.05)。结论膈下逐瘀汤联合地奥司明用于大隐静脉曲张术后患者可改善机体高凝状态和血管内皮功能,降低机体炎症因子水平,值得临床推广应用。