Objective： To evaluate the therapeutic effects of Quyu Xiaoban Capsule （祛瘀消斑胶带）, QYXBC） on endothelial dependent vascular relaxation （EDVR） function in patients with atherosclerosis （AS） with ultrasonic ...Objective： To evaluate the therapeutic effects of Quyu Xiaoban Capsule （祛瘀消斑胶带）, QYXBC） on endothelial dependent vascular relaxation （EDVR） function in patients with atherosclerosis （AS） with ultrasonic technique. Methods： Tested were the endothelial function and blood lipids of 42 patients with AS in the treated group and 30 healthy volunteers in the control group. And re-examination of these parameters was carried out on the AS patients after they had been treated with QYXBC for 10 months. Results： Before treatment, the reactive hyperemia induced changes in artery diameter in the treated group was significantly lower than that in the control group （P〈0.01）, while insignificant difference was found between the two groups in response to nitroglycerin. In the treated group after treatment, with D%-R improved significantly （P〈0.01）, total cholesterol （TC）, triglyceride （TG） and low-density lipoprotein cholesterol （LDL-C） decreased by 16.3%, 5.6%, 10.2% respectively and high-density lipoprotein cholesterol （HDL-C） increased by 7.5%. EDVR was correlated negatively with the serum TC, LDL-C concentrations and the baseline brachial diameter （D0） （r = -0.41, -0.66, -0.59, respectively, all P〈0.01）, but correlated positively with HDL-C （r=0.62, P〈0.05）. The ameliorative extent of EDVR was correlated positively to the decreased magnitude of TC and LDL-C concentrations （r = 0.67,0.59, both P〈0.01）. Conclusion： QYXBC can lower the level of blood lipids and improve significantly EDVR function.展开更多
目的:应用高频超声显像技术观察动脉粥样硬化(AS)的自然消退及祛瘀消斑胶囊消退 AS 的作用。方法:20只兔喂以高胆固醇饲料,12周末16只造模兔随机分为自然消退组和中药组,每组8只。于实验开始、12周末和24周末分别进行血脂和高频超声检测...目的:应用高频超声显像技术观察动脉粥样硬化(AS)的自然消退及祛瘀消斑胶囊消退 AS 的作用。方法:20只兔喂以高胆固醇饲料,12周末16只造模兔随机分为自然消退组和中药组,每组8只。于实验开始、12周末和24周末分别进行血脂和高频超声检测,并和病理检测结果对比。结果:经过12周造模后,实验兔的血清总胆固醇(TC)、甘油三酯(TG)和低密度脂蛋白胆固醇(LDL-C)显著升高,腹主动脉内中膜厚度(IMT)显著增厚(P<0.05或 P<0.01)。24周末两组实验兔各项血脂指标均显著降低,中药组的 TC、TG 和 LDL-C 显著低于自然消退组(P<0.05或 P<0.01),IMT 显著小于自然消退组(P<0.05),腹主动脉超声图像平均回声强度的校正值(AIIc%)较造模后测量值显著增大(P<0.01)。造模后、自然消退组和中药组形态学检查有明显差异。结论:祛瘀消斑胶囊具有消退实验兔 AS 的作用,高频超声技术可作为定性和定量随访 AS 动态变化的可靠方法。展开更多
基金Supported by the 9th 5-year Key Project of Shandong Provincial Ministry of Health (No. 9711)
文摘Objective： To evaluate the therapeutic effects of Quyu Xiaoban Capsule （祛瘀消斑胶带）, QYXBC） on endothelial dependent vascular relaxation （EDVR） function in patients with atherosclerosis （AS） with ultrasonic technique. Methods： Tested were the endothelial function and blood lipids of 42 patients with AS in the treated group and 30 healthy volunteers in the control group. And re-examination of these parameters was carried out on the AS patients after they had been treated with QYXBC for 10 months. Results： Before treatment, the reactive hyperemia induced changes in artery diameter in the treated group was significantly lower than that in the control group （P〈0.01）, while insignificant difference was found between the two groups in response to nitroglycerin. In the treated group after treatment, with D%-R improved significantly （P〈0.01）, total cholesterol （TC）, triglyceride （TG） and low-density lipoprotein cholesterol （LDL-C） decreased by 16.3%, 5.6%, 10.2% respectively and high-density lipoprotein cholesterol （HDL-C） increased by 7.5%. EDVR was correlated negatively with the serum TC, LDL-C concentrations and the baseline brachial diameter （D0） （r = -0.41, -0.66, -0.59, respectively, all P〈0.01）, but correlated positively with HDL-C （r=0.62, P〈0.05）. The ameliorative extent of EDVR was correlated positively to the decreased magnitude of TC and LDL-C concentrations （r = 0.67,0.59, both P〈0.01）. Conclusion： QYXBC can lower the level of blood lipids and improve significantly EDVR function.
文摘目的:应用高频超声显像技术观察动脉粥样硬化(AS)的自然消退及祛瘀消斑胶囊消退 AS 的作用。方法:20只兔喂以高胆固醇饲料,12周末16只造模兔随机分为自然消退组和中药组,每组8只。于实验开始、12周末和24周末分别进行血脂和高频超声检测,并和病理检测结果对比。结果:经过12周造模后,实验兔的血清总胆固醇(TC)、甘油三酯(TG)和低密度脂蛋白胆固醇(LDL-C)显著升高,腹主动脉内中膜厚度(IMT)显著增厚(P<0.05或 P<0.01)。24周末两组实验兔各项血脂指标均显著降低,中药组的 TC、TG 和 LDL-C 显著低于自然消退组(P<0.05或 P<0.01),IMT 显著小于自然消退组(P<0.05),腹主动脉超声图像平均回声强度的校正值(AIIc%)较造模后测量值显著增大(P<0.01)。造模后、自然消退组和中药组形态学检查有明显差异。结论:祛瘀消斑胶囊具有消退实验兔 AS 的作用,高频超声技术可作为定性和定量随访 AS 动态变化的可靠方法。
