Background:Insomnia is a sleep disorder,which seriously affects people's physical and mental health.Our experimental study will further explain the efficacy and mechanism of the traditional Chinese medicine prescr...Background:Insomnia is a sleep disorder,which seriously affects people's physical and mental health.Our experimental study will further explain the efficacy and mechanism of the traditional Chinese medicine prescription Sanwei Anmian Decoction as well as the single drug treatment for insomnia,and provide scientific basis for TCM decoction to cure more insomnia patients.Methods:42 mices,half male and half female,were randomly divided into 7 groups,6 in each group,Blank group,Model group,Positive group,Sanwei Anmian Decoction group(abbreviated as Sanwei group),Suanzaoren group,Maidong group,Yuanzhi group.Intraperitoneal injection(ip)of PCPA 350 mg·kg^-1 in other groups except Blank group to establish a mice model of insomnia.On the next day after the successful modeling,10ml·kg^-1 corresponding decoction was given to Sanwei group,Suanzaoren group,Yuanzhi group and Maidong group respectively,0.8mg·kg^-1 estazolam for Positive group,Blank group and the Model group with the same amount of normal saline,three times a day for two days.The body weight and the number of autonomous activities of mice were observed.The sleep rate,sleep latency and sleep time were recorded after the last administration,and the contents of serum 5-hydroxytryptamine(5-HT)and dopamine(DA)were detected.Results:The changes of hair yellowing,alarm,food loss and weight loss in mice showed that the model was successful.After the last administration,compared with the Model group and the Blank group,the weight of mice in Sanwei Anmian Decoction and each disassembled prescription group increased,the autonomous activity decreased,the number of mice fell asleep increased,the concentration of 5-HT in serum increased and the concentration of DA decreased,P<0.01,which was statistically significant.Conclusions:Sanwei Anmian Decoction can effectively improve the symptoms of PCPA insomnia mice model.For single drug,Suanzaoren Decoction has the most obvious effect on the treatment of insomnia.展开更多
目的:观察曲直汤加味联合塞来昔布治疗肝肾亏虚型膝骨关节炎的临床效果。方法:将60例膝骨关节炎患者按随机数字表法分为对照组和观察组,每组各30例,分别给予塞来昔布和曲直汤加味联合塞来昔布治疗,疗程均为4周。观察西安大略和麦克马斯...目的:观察曲直汤加味联合塞来昔布治疗肝肾亏虚型膝骨关节炎的临床效果。方法:将60例膝骨关节炎患者按随机数字表法分为对照组和观察组,每组各30例,分别给予塞来昔布和曲直汤加味联合塞来昔布治疗,疗程均为4周。观察西安大略和麦克马斯特大学骨关节炎指数值(Western Ontario and Mc Master University osteoarthritis index,WOMAC)、膝关节功能量表(Lysholm)和视觉模拟疼痛量表(visual analogue scale,VAS)治疗前后的数值变化及临床疗效。结果:治疗后,两组患者WOMAC指数、VAS评分显著下降,Lysholm评分明显提高,且观察组显著优于对照组(P<0.05);观察组总有效率为96.67%,明显高于对照组的73.33%(P<0.05)。结论:与单用塞来昔布相比,曲直汤加味联合塞来昔布可进一步减轻患者的临床症状,提高膝关节的功能,显著改善患者的生活质量。展开更多
基金This work was supported by the National College Students Innovation and Entrepreneurship Training Program(Grant No:201610471013).
文摘Background:Insomnia is a sleep disorder,which seriously affects people's physical and mental health.Our experimental study will further explain the efficacy and mechanism of the traditional Chinese medicine prescription Sanwei Anmian Decoction as well as the single drug treatment for insomnia,and provide scientific basis for TCM decoction to cure more insomnia patients.Methods:42 mices,half male and half female,were randomly divided into 7 groups,6 in each group,Blank group,Model group,Positive group,Sanwei Anmian Decoction group(abbreviated as Sanwei group),Suanzaoren group,Maidong group,Yuanzhi group.Intraperitoneal injection(ip)of PCPA 350 mg·kg^-1 in other groups except Blank group to establish a mice model of insomnia.On the next day after the successful modeling,10ml·kg^-1 corresponding decoction was given to Sanwei group,Suanzaoren group,Yuanzhi group and Maidong group respectively,0.8mg·kg^-1 estazolam for Positive group,Blank group and the Model group with the same amount of normal saline,three times a day for two days.The body weight and the number of autonomous activities of mice were observed.The sleep rate,sleep latency and sleep time were recorded after the last administration,and the contents of serum 5-hydroxytryptamine(5-HT)and dopamine(DA)were detected.Results:The changes of hair yellowing,alarm,food loss and weight loss in mice showed that the model was successful.After the last administration,compared with the Model group and the Blank group,the weight of mice in Sanwei Anmian Decoction and each disassembled prescription group increased,the autonomous activity decreased,the number of mice fell asleep increased,the concentration of 5-HT in serum increased and the concentration of DA decreased,P<0.01,which was statistically significant.Conclusions:Sanwei Anmian Decoction can effectively improve the symptoms of PCPA insomnia mice model.For single drug,Suanzaoren Decoction has the most obvious effect on the treatment of insomnia.
文摘目的:观察曲直汤加味联合塞来昔布治疗肝肾亏虚型膝骨关节炎的临床效果。方法:将60例膝骨关节炎患者按随机数字表法分为对照组和观察组,每组各30例,分别给予塞来昔布和曲直汤加味联合塞来昔布治疗,疗程均为4周。观察西安大略和麦克马斯特大学骨关节炎指数值(Western Ontario and Mc Master University osteoarthritis index,WOMAC)、膝关节功能量表(Lysholm)和视觉模拟疼痛量表(visual analogue scale,VAS)治疗前后的数值变化及临床疗效。结果:治疗后,两组患者WOMAC指数、VAS评分显著下降,Lysholm评分明显提高,且观察组显著优于对照组(P<0.05);观察组总有效率为96.67%,明显高于对照组的73.33%(P<0.05)。结论:与单用塞来昔布相比,曲直汤加味联合塞来昔布可进一步减轻患者的临床症状,提高膝关节的功能,显著改善患者的生活质量。
