As the first works of Chinese grammar, "Ma Shi Wen Tong" has epoch-making significance in the history of Chinese grammar. It marks that Chinese grammar study has become an independent science. This research ...As the first works of Chinese grammar, "Ma Shi Wen Tong" has epoch-making significance in the history of Chinese grammar. It marks that Chinese grammar study has become an independent science. This research intends to generalize "Wen Tong".展开更多
Predicting the mechanical behaviors of structure and perceiving the anomalies in advance are essential to ensuring the safe operation of infrastructures in the long run.In addition to the incomplete consideration of i...Predicting the mechanical behaviors of structure and perceiving the anomalies in advance are essential to ensuring the safe operation of infrastructures in the long run.In addition to the incomplete consideration of influencing factors,the prediction time scale of existing studies is rough.Therefore,this study focuses on the development of a real-time prediction model by coupling the spatio-temporal correlation with external load through autoencoder network(ATENet)based on structural health monitoring(SHM)data.An autoencoder mechanism is performed to acquire the high-level representation of raw monitoring data at different spatial positions,and the recurrent neural network is applied to understanding the temporal correlation from the time series.Then,the obtained temporal-spatial information is coupled with dynamic loads through a fully connected layer to predict structural performance in next 12 h.As a case study,the proposed model is formulated on the SHM data collected from a representative underwater shield tunnel.The robustness study is carried out to verify the reliability and the prediction capability of the proposed model.Finally,the ATENet model is compared with some typical models,and the results indicate that it has the best performance.ATENet model is of great value to predict the realtime evolution trend of tunnel structure.展开更多
Objective:To investigate the mechanism of the effect of Daodi Tongguan Decoction on ovarian function in rats with premature ovarian failure.Methods:Forty SD female rats with regular estrous cycle were randomly divided...Objective:To investigate the mechanism of the effect of Daodi Tongguan Decoction on ovarian function in rats with premature ovarian failure.Methods:Forty SD female rats with regular estrous cycle were randomly divided into the blank group,the model group,the positive group(Bujiale 0.099 mg/kg),the Daodigitongguan decoction high-dose group(1.4 g/100 g)and the Daodigitongguan decoction medium-dose group(0.7 g/100 g).The model group,positive group,Daodi Tongguan Decoction high-dose group and Daodi Tongguan decoction medium-dose group were given Tripterygium wilfordii polyglycoside tablets suspension(50 mg/kg)by continuous gavage for 14 days to establish a rat model of premature ovarian failure.After the modeling,each group was given the corresponding intervention agent for 28 consecutive days.After the intervention,serum and ovarian tissue were collected from rats in each group.The morphological structure of rat ovarian tissue was observed after HE staining.Serum AMH level was determined by ELISA.The expressions of Bcl-2,Bax and VEGF in ovarian tissue were detected by IHC.The apoptosis of granulosa cells in ovary was observed by TUNEL.Results:Compared to the normal group,the growth follicles in the model group were reduced and the atretic follicles were increased.Serum AMH level was significantly decreased(P<0.01).The expression of Bax protein in ovarian tissue was increased(P<0.01).The protein expressions of Bcl-2 and VEGF were decreased(P<0.01,P<0.05),and the apoptosis rate of follicular granulosa cells in ovarian tissue was increased(P<0.01).Compared to the molding group,the serum AMH level in the TCM dose groups was increased to varying degrees,and the change of the AMH in high-dose group was the most significant(P<0.05).The expression of Bax protein in ovarian tissue decreased(P<0.05),while the expression of Bcl-2 and VEGF protein increased(P<0.05,P<0.05).The apoptosis rate of follicular granulosa cells in ovarian tissue was decreased in the high dose group(P<0.05).Conclusion:Daodi Tongguan Decoction can improve the histological morphology of ovary and relieve ovarian injury,and its mechanism may be related to improving the sex hormone level of POF model rats,reducing the expression level of Bax protein in ovarian tissue,increasing the expression level of Bcl-2 and VEGF protein in ovarian tissue,and reducing the apoptosis rate of follicular granulosa cells in ovarian tissue.展开更多
文摘As the first works of Chinese grammar, "Ma Shi Wen Tong" has epoch-making significance in the history of Chinese grammar. It marks that Chinese grammar study has become an independent science. This research intends to generalize "Wen Tong".
基金This work is supported by the National Natural Science Foundation of China(Grant No.51991392)Key Deployment Projects of Chinese Academy of Sciences(Grant No.ZDRW-ZS-2021-3-3)the Second Tibetan Plateau Scientific Expedition and Research Program(STEP)(Grant No.2019QZKK0904).
文摘Predicting the mechanical behaviors of structure and perceiving the anomalies in advance are essential to ensuring the safe operation of infrastructures in the long run.In addition to the incomplete consideration of influencing factors,the prediction time scale of existing studies is rough.Therefore,this study focuses on the development of a real-time prediction model by coupling the spatio-temporal correlation with external load through autoencoder network(ATENet)based on structural health monitoring(SHM)data.An autoencoder mechanism is performed to acquire the high-level representation of raw monitoring data at different spatial positions,and the recurrent neural network is applied to understanding the temporal correlation from the time series.Then,the obtained temporal-spatial information is coupled with dynamic loads through a fully connected layer to predict structural performance in next 12 h.As a case study,the proposed model is formulated on the SHM data collected from a representative underwater shield tunnel.The robustness study is carried out to verify the reliability and the prediction capability of the proposed model.Finally,the ATENet model is compared with some typical models,and the results indicate that it has the best performance.ATENet model is of great value to predict the realtime evolution trend of tunnel structure.
基金National Natural Science Foundation of China(No.81360594)Autonomous Region Traditional Chinese Medicine Inheritance and Development Special Fund Project‑Luo Zhijuan Guangxi Famous Traditional Chinese Medicine Inheritance Studio Construction Project(No.[2022]2)。
文摘Objective:To investigate the mechanism of the effect of Daodi Tongguan Decoction on ovarian function in rats with premature ovarian failure.Methods:Forty SD female rats with regular estrous cycle were randomly divided into the blank group,the model group,the positive group(Bujiale 0.099 mg/kg),the Daodigitongguan decoction high-dose group(1.4 g/100 g)and the Daodigitongguan decoction medium-dose group(0.7 g/100 g).The model group,positive group,Daodi Tongguan Decoction high-dose group and Daodi Tongguan decoction medium-dose group were given Tripterygium wilfordii polyglycoside tablets suspension(50 mg/kg)by continuous gavage for 14 days to establish a rat model of premature ovarian failure.After the modeling,each group was given the corresponding intervention agent for 28 consecutive days.After the intervention,serum and ovarian tissue were collected from rats in each group.The morphological structure of rat ovarian tissue was observed after HE staining.Serum AMH level was determined by ELISA.The expressions of Bcl-2,Bax and VEGF in ovarian tissue were detected by IHC.The apoptosis of granulosa cells in ovary was observed by TUNEL.Results:Compared to the normal group,the growth follicles in the model group were reduced and the atretic follicles were increased.Serum AMH level was significantly decreased(P<0.01).The expression of Bax protein in ovarian tissue was increased(P<0.01).The protein expressions of Bcl-2 and VEGF were decreased(P<0.01,P<0.05),and the apoptosis rate of follicular granulosa cells in ovarian tissue was increased(P<0.01).Compared to the molding group,the serum AMH level in the TCM dose groups was increased to varying degrees,and the change of the AMH in high-dose group was the most significant(P<0.05).The expression of Bax protein in ovarian tissue decreased(P<0.05),while the expression of Bcl-2 and VEGF protein increased(P<0.05,P<0.05).The apoptosis rate of follicular granulosa cells in ovarian tissue was decreased in the high dose group(P<0.05).Conclusion:Daodi Tongguan Decoction can improve the histological morphology of ovary and relieve ovarian injury,and its mechanism may be related to improving the sex hormone level of POF model rats,reducing the expression level of Bax protein in ovarian tissue,increasing the expression level of Bcl-2 and VEGF protein in ovarian tissue,and reducing the apoptosis rate of follicular granulosa cells in ovarian tissue.
