Stem cell transplantation for treating Parkinson's disease Literature analysis based on the Web of Science

OBJECTIVE： To identify global research trends of stem cell transplantation for treating Parkinson＇s disease using a bibliometric analysis of the Web of Science. DATA RETRIEVAL： We performed a bibliometric analysis of data retrievals for stem cell transplantation for treating Parkinson＇s disease from 2002 to 2011 using the Web of Science. SELECTION CRITERIA： Inclusion criteria： （a） peer-reviewed articles on stem cell transplantation for treating Parkinson＇s disease which were published and indexed in the Web of Science; （b） type of articles： original research articles, reviews, meeting abstracts, proceedings papers, book chapters, editorial material and news items; （c） year of publication： 2002-2011. Exclusion criteria： （a） articles that required manual searching or telephone access; （b） we excluded documents that were not published in the public domain; （c） we excluded a number of corrected papers from the total number of articles. MAIN OUTCOME MEASURES： （1） Type of literature; （2） annual publication output; （3） distribution according to journals; （4） distribution according to subject areas; （5） distribution according to country; （6） distribution according to institution; （7） comparison of countries that published the most papers on stem cell transplantation from different cell sources for treating Parkinson＇s disease; （8） comparison of institutions that published the most papers on stem cell transplantation from different cell sources for treating Parkinson＇s disease in the Web of Science from 2002 to 2011; （9） comparison of studies on stem cell transplantation from different cell sources for treating Parkinson＇s disease RESULTS： In total, 1 062 studies on stem cell transplantation for treating Parkinson＇s disease appeared in the Web of Science from 2002 to 2011, almost one third of which were from American authors and institutes. The number of studies on stem cell transplantation for treating Parkinson＇s disease had gradually increased over the past 10 years. Papers on stem cell transplantation for treating Parkinson＇s disease appeared in journals such as Stem Cells and Experimental Neurology. Although the United States published more articles addressing neural stem cell and embryonic stem cell transplantation for treating Parkinson＇s disease, China ranked first for articles published on bone marrow mesenchymal stem cell transplantation for treating Parkinson＇s disease. CONCLUSION： From our analysis of the literature and research trends, we found that stem cell transplantation for treating Parkinson＇s disease may offer further benefits in regenerative medicine.

The top cited articles on glioma stem cells in Web of Science

BACKGROUND： Glioma is the most common intracranial tumor and has a poor patient prognosis. The presence of brain tumor stem cells was gradually being understood and recognized, which might be beneficial for the treatment of glioma. OBJECTIVE： To use bibliometric indexes to track study focuses on glioma stem cell, and to investigate the relationships among geographic origin, impact factors, and highly cited articles indexed in Web of Science. METHODS： A list of citation classics for glioma stem cells was generated by searching the database of Web of Science-Expanded using the terms ＂glioma stem cell＂ or ＂glioma, stem cell＇＂ or ＂brain tumor stem cell＂. The top 63 cited research articles which were cited more than 100 times were retrieved by reading the abstract or full text if needed. Each eligible article was reviewed for basic information on subject categories, country of origin, journals, authors, and source of journals. Inclusive criteria： （1） articles in the field of glioma stem cells which was cited more than 100 times; （2） fundamental research on humans or animals, clinical trials and case reports; （3） research article; （4） year of publication： 1899-2012; and （5） citation database： Science Citation Index-Expanded. Exclusive criteria： （1） articles needing to be manually searched or accessed only by telephone; （2） unpublished articles; and （3） reviews, conference proceedings, as well as corrected papers. RESULTS： Of 2 040 articles published, the 63 top-cited articles were published between 1992 and 2010. The number of citations ranged from 100 to 1 754, with a mean of 280 citations per article. These citation classics came from nineteen countries, of which 46 articles came from the United States. Duke University and University of California, San Francisco led the list of classics with seven papers each. The 63 top-cited articles were published in 28 journals, predominantly Cancer Research and Cancer Cell, followed by Cell Stem Cell and Nature. CONCLUSION： Our bibliometric analysis provides a historical perspective on the progress of glioma stem cell research. Articles originating from outstanding institutions of the United States and published in high-impact journals are most likely to be cited.

Study on Internet-based Expert Prevention System against Diseases, Pests and Weeds of Tumorous Stem Mustard

With the acknowledgement of species, symptoms and control measures for diseases, pests and weeds in tumorous stem mustard, the expert prevention system has been studied and developed based on internct, and the system mainly includes knowledge database, inference engine, browser web and so on. The knowledge database has been established by Micrsoft Access 2003 software; the procedure of inference engine has been compiled by JavaScript; the pages of browser web have been made by Dreamweaver MX software. The expert system is fuR-featured and user-friendly, which can provide control knowledge against the diseases, pests and weeds of tumorous stem mustard for the majority of farmers, scientific technological person and grass-roots level managers quickly and conveniently,

Application of magnetic resonance imaging for monitoring stem cell transplantation for the treatment of cerebral ischemia

OBJECTIVE： To identify global research trends in the application of MRI for monitoring stem cell transplantation using a bibliometric analysis of Web of Science. DATA RETRIEVAL： We performed a bibliometric analysis of studies relating to the application of MRI for detecting stem cell transplantation for the treatment of cerebral ischemia using papers in Web of Science published from 2002 to 2011. SELECTION CRITERIA： The inclusion criteria were： （a） peer-reviewed articles on the application of MRI for detecting transplanted stem cells published and indexed in Web of Science; （b） year of publication between 2002 and 2011. Exclusion criteria were： （a） articles that required manual searching or telephone access; （b） some corrected papers. MAIN OUTCOME MEASURES： （1） Annual publication output; （2） distribution according to journals; （3） distribution according to institution; （4） distribution according to country; （5） top cited authors over the last 10 years. RESULTS： A total of 1 498 studies related to the application of MRI for monitoring stem cell transplantation appeared in Web of Science from 2002 to 2011, almost half of which were derived from American authors and institutes. The number of studies on the application of MRI for detecting stem cell transplantation has gradually increased over the past 10 years. Most papers on this topic appeared in Magnetic Resonance in Medicine. CONCLUSION： This analysis suggests that few experimental studies have been investigated the use of MRI for tracking SPIO-labeled human umbilical cord blood-derived mesenchymal stem cells during the treatment of cerebral ischemia.

Stem cell transplantation for treating spinal cord injury A literature comparison between studies of stem cells obtained from various sources

OBJECTIVE： To identify global research trends of stem cell transplantation for treating spinal cord injury using a bibliometric analysis of the Web of Science. DATA RETRIEVAL： We performed a bibliometric analysis of data retrievals for stem cell transplantation for treating spinal cord injury from 2002 to 2011 using the Web of Science. SELECTION CRITERIA： Inclusion criteria： （a） peer-reviewed articles on stem cell transplantation for treating spinal cord injury that were published and indexed in the Web of Science; （b） type of articles： original research articles, reviews, meeting abstracts, proceedings papers, book chapters, editorial material, and news items; and （c） year of publication： 2002-2011. Exclusion criteria： （a） articles that required manual searching or telephone access; （b） documents that were not published in the public domain; and （c） a number of corrected papers from the total number of articles. MAIN OUTCOME MEASURES： （1） Annual publication output; （2） distribution according to country; （3） distribution according to institution; （4） distribution according to journals; （5） distribution according to funding agencies; and （6） top cited articles over the last 10 years. RESULTS： Bone marrow mesenchymal stem cells and embryonic stem cells have been widely used for treating spinal cord injury. In total, 191 studies of bone marrow mesenchymal stem cell transplantation and 236 studies of embryonic stem cell transplantation for treating spinal cord injury appeared in the Web of Science from 2002 to 2011, and almost half of which were derived from American or Japanese authors and institutes. The number of studies of stem cell transplantation for treating spinal cord injury has gradually increased over the past 10 years. Most papers on stem cell transplantation for treating spinal cord injury appeared in journals with a particular focus on stem cell research, such as Stem Cells and Cell Transplantation. Although umbilical cord blood stem cells and adipose-derived stem cells have been studied for treating spinal cord injury, the number of published papers was much smaller, with only 21 and 17 records, respectively, in the Web of Science. CONCLUSION： Based on our analysis of the literature and research trends, we found that stem cells transplantation obtained from various sources have been studied for treating spinal cord injury; however, it is difficult for researchers to reach a consensus on this theme.

Research progress in muscle-derived stem cells Literature retrieval results based on international database

OBJECTIVE： To identify global research trends of muscle-derived stem cells （MDSCs） using a bibliometric analysis of the Web of Science, Research Portfolio Online Reporting Tools of the National Institutes of Health （NIH）, and the Clinical Trials registry database （ClinicalTrials.gov）. DATA RETRIEVAL： We performed a bibliometric analysis of data retrievals for MDSCs from 2002 to 2011 using the Web of Science, NIH, and ClinicalTrials.gov. SELECTION CRITERIA： Inclusion criteria： （1） Web of Science： （a） peer-reviewed articles on MDSCs that were published and indexed in the Web of Science. （b） Type of articles： original research articles, reviews, meeting abstracts, proceedings papers, book chapters, editorial material and news items. （c） Year of publication： 2002-2011. （d） Citation databases： Science Citation Index-Expanded （SCI-E）, 1899-present; Conference Proceedings Citation Index-Science （CPCI-S）, 1991-present; Book Citation Index-Science （BKCI-S）, 2005-present. （2） NIH： （a） Projects on MDSCs supported by the NIH. （b） Fiscal year： 1988-present. （3） ClinicalTrials.gov： All clinical trials relating to MDSCs were searched in this database. Exclusion criteria： （1） Web of Science： （a） Articles that required manual searching or telephone access. （b） We excluded documents that were not published in the public domain. （c） We excluded a number of corrected papers from the total number of articles. （d） We excluded articles from the following databases： Social Sciences Citation Index （SSCI）, 1898-present; Arts ＆ Humanities Citation Index （A＆HCI）, 1975-present; Conference Proceedings Citation Index - Social Science ＆ Humanities （CPCI-SSH）, 1991-present; Book Citation Index - Social Sciences ＆ Humanities （BKCI-SSH）, 2005-present; Current Chemical Reactions （CCR-EXPANDED）, 1985-present; Index Chemicus （IC）, 1993-present. （2） NIH： （a） We excluded publications related to MDSCs that were supported by the NIH. （b） We limited the keyword search to studies that included MDSCs within the title or abstract. （3） ClinicalTrials.gov： （a） We excluded clinical trials that were not in the ClinicalTrials.gov database. （b） We excluded clinical trials that dealt with stem cells other than MDSCs in the ClinicalTrials.gov database. MAIN OUTCOME MEASURES： （1） Type of literature; （2） annual publication output; （3） distribution according to journals; （4） distribution according to country; （5） distribution according to institution; （6） top cited authors over the last 10 years; （7） projects financially supported by the NIH; and （8） clinical trials registered. RESULTS： （1） In all, 802 studies on MDSCs appeared in the Web of Science from 2002 to 2011, almost half of which derived from American authors and institutes. The number of studies on MDSCs has gradually increased over the past 10 years. Most papers on MDSCs appeared in journals with a particular focus on cell biology research, such as Experimental Cell Research, Journal of Cell Science, and PLoS One. （2） Eight MDSC research projects have received over US$6 billion in funding from the NIH. The current project led by Dr. Johnny Huard of the University of Pittsburgh-＂Muscle-Based Tissue Engineering to Improve Bone Healing＂-is supported by the NIH. Dr. Huard has been the most productive and top-cited author in the field of gene therapy and adult stem cell research in the Web of Science over last 10 years. （3） On ClinicalTrials.gov, ＂Muscle Derived Cell Therapy for Bladder Exstrophy Epispadias Induced Incontinence＂ Phase 1 is registered and sponsored by Johns Hopkins University and has been led by Dr. John P. Gearhart since November 2009. CONCLUSION： From our analysis of the literature and research trends, we found that MDSCs may offer further benefits in regenerative medicine.

考虑梗腋影响的波形钢腹板组合箱梁剪力滞效应研究

考虑梗腋在波形钢腹板组合箱梁剪力滞效应的影响,通过剪力流公式定义了考虑梗腋影响的修正系数,运用变分法得到对应的微分方程,然后求出简支波形钢腹板组合箱梁在集中荷载作用下的剪力滞系数计算公式,采用数值模拟进行对比验证。最后通过调整梗腋尺寸参数,研究梗腋形状变化对剪力滞效应的影响。结果表明,考虑梗腋影响后的理论计算结果与有限元结果吻合较好;波形钢腹板组合箱梁的剪力滞效应现象随着梗腋影响系数的增大而减小;考虑梗腋影响的波形钢腹板组合箱梁剪力滞系数较未考虑情况大幅度降低,在集中荷载下剪力滞效应系数减小约10%;当梗腋宽度与上翼板宽度的比值大于0.5时,对剪力滞效应的影响变化较小,梗腋高度为其宽度的0.16~0.19倍时对剪力滞效应影响最大。

基于云存储的政府网络信息资源保存型元数据研究

云存储是一种新兴的数字信息存储概念,鉴于其在分布式存储、协同存储、动态分配存储空间、平滑迁移和备份方面的优势,适合用于政府网络信息资源的长期保存。但当前还没有用于记录和支持利用云存储进行政府网络信息资源长期保存的元数据的研究。鉴于此,拟从保存元数据框架、长期保存实践、云存储参与方及角色定位、云存储系统体系结构四个方面来分析和制定针对政府Web资源的保存型元数据框架,并提供该框架下的核心元素集。

基于Deform的石油钻杆接头精密塑性成形工艺研究

基于有限元软件Deform,根据冲孔连皮位置和坯料形状的变化,对石油钻杆接头精密塑性成形过程进行了数值模拟,对锻件的温度场、应力及应变场、载荷情况进行了对比分析。结果能为解决锻件充不足,提高锻件组织性能,进一步改变成形工艺提供依据。

基于德勒兹“根茎”理论的生态城市形态审美研究

本文借鉴德勒兹异质共生的"根茎"理论,通过对城市系统隐性秩序和深层结构的研究,提出城市形态结构模式与主体日常生存状态的整生图式——"根茎"审美图式,并根据其细分的线形"茎干"态、分形"簇群"态、拓扑"网络"态三种审美图式,分析其在空间适宜性、形态整合性、环境场域性等方面具有的高度生态性。

Internet下的茎瘤芥病虫草害防治专家系统研究

以茎瘤芥病虫草害的种类、症状、防治措施为知识,研究开发Internet下的茎瘤芥病虫草害防治专家系统,主要包括知识库、推理机、浏览器页面等。利用Micrsoft Access 2003软件建立知识库,使用JavaScript脚本语言编写推理机程序,利用Dreamweaver MX软件建立浏览器页面。该专家系统功能齐全、界面友好,能快速方便地为广大农民、科技人员、基层管理人员等提供茎瘤芥病虫草害防治知识。

十次小组(Team 10)成员坎迪里斯-约西齐-伍兹事务所规划作品探析

本文通过对十次小组(Team 10)主要成员乔治·坎迪里斯(George Candilis)、亚历克西斯·约西齐(Alexis Josic)、沙德拉赫·伍兹(Shadrach Woods)等三位来自不同国家的建筑师所组成的设计团队于20世纪50、60年代在欧洲共同完成的城市设计作品进行介绍,对其提出的"空中街道"、"茎干"、"网状"等城市规划思想深入剖析,以其代表作法国图卢兹一莱·米雷尔新城为例,阐述该事务所的主要规划思想以及对当今规划实践的借鉴之处。

基于CiteSpace可视化知识图谱分析的牙源性干细胞研究评述

目的:探讨牙源性干细胞研究的现状。方法:在Web of Science核心数据库,以"SU=dental stem cell"为检索式,共检索出3221条记录。在Cite Space中,分别选择"Country"、"Institution"、"Author"来分析发文的国家、机构分布及作者发文情况,选择"Keyword"、"Cited Reference"进行关键词共现和引文共现分析。结果:自1999年以来,牙源性干细胞研究论文数量持续上升;发文量最多的国家是美国,发文量最多的机构是中国的第四军医大学,发文量最多的作者是美国南加州大学的Shi ST。近5年出现次数较多(≥10次)的突变关键词有immature permanent teeth、exfoliated deciduous teeth、human periodontal ligament、osteogenic differentiation、mineral trioxide aggregate等。结论:牙源性干细胞研究是近一段时间口腔基础研究的热门,研究集中在牙髓干细胞、牙周膜干细胞、脱落乳牙干细胞等实现牙髓再生、牙再生、骨再生及其他组织细胞的再生。利用Cite Space软件可以简捷地理顺学科领域脉络。

基于CiteSpace的肿瘤干细胞研究态势的文献计量学分析

目的通过对肿瘤干细胞(CSCs)研究文献进行计量学分析,探索CSCs领域的研究热点和研究趋势。方法基于Web of Science核心数据库,通过CiteSpace对发表文章年度分布、作者、机构、国家、期刊、被引情况和关键词等进行分析,并对关键词的词频、中心性和聚类情况进行探讨。结果(1)筛选后共纳入8131篇文献,中国是发文量最多的国家,中山大学是发文量最多的机构。(2)CSCs在乳腺癌、胰腺癌中的研究;CSCs分选和鉴定分子标志物ALDH和基因PTEN、Sox2、C-myc、EZH2的研究;EMT诱导产生CSCs并促进肿瘤转移的机制研究;CSCs防御化学药物、放射、靶向药物攻击导致耐受的细胞和分子机制的研究;Wnt/β-catenin信号通路和肿瘤微环境调节CSCs分化的机制研究;靶向抑制CSCs治疗恶性肿瘤的药物研究是CSCs领域研究的热点。(3)CSCs干性研究-CSCs生物学机制研究-CSCs应用于肿瘤的治疗是CSCs的研究趋势。结论EMT诱生CSCs促进肿瘤转移、CSCs抵抗化学药物的攻击、间充质干细胞对CSCs调节、CSCs的代谢、靶向CSCs抑制剂的研究是CSCs领域现在和未来研究的重点和方向。

间充质干细胞治疗脊髓损伤的可视化分析

目的分析近5年间充质干细胞(MSCs)治疗脊髓损伤的研究现状和热点。方法检索2014年至2018年Web of Science中SCI-E收录的相关文献,采用CiteSpace软件分析作者、国家/机构的合作关系,对关键词进行共现分析、聚类分析、动态前沿演化及burst分析,对期刊、文献的共被引情况进行分析,绘制可视化图谱并分析结果。结果与结论共纳入作者236位,其中49位作者发文量≥3篇,高产作者主要以Zeng Y S和Chen L为代表。共纳入国家/机构162个,其中85个国家/机构发文量≥3篇;共纳入期刊75个,Exp Neurol是收录文章最多的期刊;共纳入关键词107个,热点关键词为脊髓损伤、MSCs、移植、骨髓、修复、功能恢复,可形成6个聚类群。预测发展趋势为提取培养祖细胞,并诱导其定向分化;MSCs治疗脊髓损伤的免疫调节、抗炎、神经再生作用机制研究,以及组织工程技术,生物材料在该领域的研究。

基于CiteSpace和VOSviewer的肝癌干细胞研究的文献计量学分析

目的通过肝癌干细胞(LCSCs)进行文献计量学分析,探索近10年LCSCs领域的研究热点和研究趋势。方法基于Web of Science核心数据库,通过CiteSpace和VOSviewer对2011—2020年发表文章的年度分布、国家、机构、作者、期刊、被引情况和关键词等进行可视化分析,并对关键词的词频、中心性和聚类情况进行探讨。结果2011—2020年LCSCs相关文献发表量为1000篇,LCSCs相关文献发文量总体呈增长趋势;发文量前5位的国家分别是中国、美国、日本、韩国和意大利;发文量前5位的研究机构分别是第二军医大学、中山大学、复旦大学、香港大学和上海交通大学;发文量前5位的作者分别是Stephanie Ma、Taro Yamashita、Jia Fan、Hongyang Wang和Shuichi Kaneko;发文量前5位的期刊分别是Oncotarget、Hepatology、Cancer letters、PLoS One和Scientific Reports;被引文献中,Taro等2009年发表的“EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features”被引频次最高;LCSCs鉴定的干性标志物的研究,调控LCSCs的转录因子、长链非编码RNA、微小RNAs、癌基因和信号通路的研究等是LCSCs领域研究的热点;LCSCs干性研究-靶向LCSCs治疗研究-LCSCs生物学机制研究是LCSCs的研究趋势,靶向LCSCs的抑制剂研究是LCSCs的重点研究方向。结论调控LCSCs的基因和信号通路的研究是LCSCs领域的研究热点,靶向LCSCs的药物研究是LCSCs领域的重点研究方向。

五十年的精彩,设计依然年轻——2011年米兰国际家具展侧记及城市设计服务体系之浅议

本文结合笔者在意大利求学的生活体会,以建筑设计和工业设计的双重视角,从主展馆(Rho Fiera)、卫星沙龙展览(Salone Satellite)及最具盛名的户外沙龙展(Salone Fuori)三个方面,详细介绍了展会的信息,分析了2011年米兰家具展所体现出来的世界知名家具品牌产品的新资讯、新趋势,从而总结出最新的设计理念。文章重点着墨于米兰国际家具展中最具特色而国内鲜有介绍的户外沙龙展,探讨旧厂房集中区域的功能转变思路,深入探寻"临时展览"的概念在米兰的应用,分析米兰作为世界时尚设计之都的品牌战略。