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How do advancements in technology affect the development and use of textile binders?
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《China Textile》 2024年第4期24-25,共2页
The textile industry is constantly evolving,and advancements in technology are playing a pivotal role in shaping the development and use of textile binders.According to Reports and Insights,the global textile binder m... The textile industry is constantly evolving,and advancements in technology are playing a pivotal role in shaping the development and use of textile binders.According to Reports and Insights,the global textile binder market is expected to reach a value of USD 5.33 billion by 2032,exhibiting a healthy CAGR of 4.4%.This growth is fueled by a confluence of factors,with technological innovation at the forefront.Let's delve into how these advancements are impacting the landscape of textile binders。 展开更多
关键词 advancement LANDSCAPE technology
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China committed to global advancement of new technology in navigation
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《China Report ASEAN》 2024年第11期6-9,共4页
The recent 2024 World Conference of the International Federation of Navigation in Beijing focused on the expansion of navigation applications.Hosted by the China Navigation Society,the event aimed to explore the integ... The recent 2024 World Conference of the International Federation of Navigation in Beijing focused on the expansion of navigation applications.Hosted by the China Navigation Society,the event aimed to explore the integration of navigation,communication,and remote sensing technologies.The head of the International Cooperation Department of the Ministry of Transport emphasized China’s commitment to promoting innovation in navigation.China has become the nation with the largest shipping infrastructure,the highest volume of goods transported by sea,and one of the largest fleets globally. 展开更多
关键词 globally advancement COMMITTED
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Advanced Technologies for Volatile Organic Compound (VOC) Emission Treatment: An Overview
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作者 Yizhe Li 《Journal of Electronic Research and Application》 2024年第2期1-6,共6页
This paper presents a comprehensive overview of various advanced technologies employed in the treatment of volatile organic compounds(VOCs),which are crucial pollutants in industrial emissions.The study explores diffe... This paper presents a comprehensive overview of various advanced technologies employed in the treatment of volatile organic compounds(VOCs),which are crucial pollutants in industrial emissions.The study explores different methods,including direct combustion,thermal combustion,catalytic combustion,low-temperature plasma purification,photocatalytic purification,membrane separation,and adsorption methods.Each technology is critically analyzed for its operational principles,efficiency,and applicability under different conditions.Special attention is given to adsorption concentration and catalytic combustion parallel method,highlighting its efficiency in treating low-concentration,high-volume VOC emissions.The paper also delves into the advantages and limitations of each method,providing insights into their effectiveness in various industrial scenarios.The study aims to offer a detailed guide for selecting appropriate VOC treatment technologies,contributing to enhanced environmental protection and sustainable industrial practices. 展开更多
关键词 Volatile organic compounds(VOCs) Emission treatment technologies Catalytic combustion Adsorption methods Environmental protection
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Advances of Genetic Testing Technology in Etiology Diagnosis of Recurrent Spontaneous Abortion
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作者 Qing Xiao Ziwei Li Jinzhi Lu 《Yangtze Medicine》 2023年第2期76-86,共11页
Recurrent spontaneous abortion (RSA) is a complex and heterogeneous disorder with multiple etiologies. Genetic factors are thought to play an important role in the etiology of RSA. With recent advances in genetic test... Recurrent spontaneous abortion (RSA) is a complex and heterogeneous disorder with multiple etiologies. Genetic factors are thought to play an important role in the etiology of RSA. With recent advances in genetic testing technologies, there has been an increasing interest in using these tools to diagnose the etiology of RSA. This review discusses the different types of genetic testing methods, such as karyotyping, chromosomal microarray analysis, next-generation sequencing, and their applications in the diagnosis of the etiology RSA. The use of genetic testing in the diagnosis of RSA has the potential to improve the accuracy of diagnosis and the understanding of the underlying mechanisms of the disorder, which could lead to better management and treatment of affected individuals. 展开更多
关键词 Recurrent Spontaneous Abortion ETIOLOGY Genetic Testing technology
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Advance of the Research on Testing of Animal Viruses by LAMP Technology in Abroad 被引量:3
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作者 朱海霞 张强 +3 位作者 吴国华 颜新敏 李健 赵志荀 《Agricultural Science & Technology》 CAS 2011年第7期1029-1030,1066,共3页
Loop-mediated isothermal amplification(LAMP) is an amplification method developed by Notomi et al and has been applied successfully for the detection of many viruses.This paper introduced the current status of LAMP ... Loop-mediated isothermal amplification(LAMP) is an amplification method developed by Notomi et al and has been applied successfully for the detection of many viruses.This paper introduced the current status of LAMP and recent developments,and the method applying in the diagnosis of animal viruses in abroad. 展开更多
关键词 LAMP technology Animal viruses advance of the Research
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基于PLCSIM Advanced和Simulink的自动化生产线仿真实训平台设计
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作者 安翠娟 张凯 +3 位作者 王国霞 张敏 丁大伟 武善雷 《实验科学与技术》 2024年第1期37-43,51,共8页
为解决自动化生产线实训线下课程实验硬件套数不足、实验时长和场地受限等问题,提升教学质量,设计了一种基于PLCSIM Advanced和Simulink的自动化生产线仿真实训平台。该仿真平台以实训设备为依托,使用Simulink搭建被控对象仿真模型,在PL... 为解决自动化生产线实训线下课程实验硬件套数不足、实验时长和场地受限等问题,提升教学质量,设计了一种基于PLCSIM Advanced和Simulink的自动化生产线仿真实训平台。该仿真平台以实训设备为依托,使用Simulink搭建被控对象仿真模型,在PLCSIM Advanced仿真控制器中编写控制算法,通过应用程序接口(application programming interface,API)通信实现对象模型与控制器间数据的实时交换和仿真。以纸张张力控制设备为例,介绍了仿真实训平台搭建和实施过程。实践教学表明,该仿真平台提高了自动化生产线实训课程的教学成效,激发了学生实践学习的兴趣,提升了学生发现、解决复杂工程问题的能力,让学生深刻体会到团队合作和有效沟通的重要性。 展开更多
关键词 自动化生产线实训 仿真平台 张力控制系统 人机交互界面 PLCSIM advanced SIMULINK
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Research Advance on Absorption Law of Cadmium by Rice and Safety Control Technology of Cadmium in Rice Grain 被引量:6
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作者 陈群芳 叶瑶瑶 +3 位作者 徐青 范克关 王飞娟 朱诚 《Agricultural Science & Technology》 CAS 2014年第10期1801-1804,共4页
Heavy metal pol ution, especial y cadmium pol ution, has threatened the safety production of rice. The research advance on law of absorption, distribution and accumulation of cadmium in rice and on recent safety contr... Heavy metal pol ution, especial y cadmium pol ution, has threatened the safety production of rice. The research advance on law of absorption, distribution and accumulation of cadmium in rice and on recent safety control technology of cadmium in rice grain was summarized in this paper. We hoped to lay a foundation for the safety production of rice. 展开更多
关键词 RICE CADMIUM Low accumulation Safety control technology
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Present situation and prospect of immunotherapy for unresectable locally advanced esophageal cancer during peri-radiotherapy 被引量:1
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作者 Feng-Mei Wang Peng Mo +2 位作者 Xue Yan Xin-Yue Lin Zhi-Chao Fu 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第1期1-7,共7页
Four major studies(Checkmate577,Keynote-590,Checkmate649 and Attraction-4)of locally advanced esophageal cancer published in 2020 have established the importance of immunotherapy,represented by anti-programmed death p... Four major studies(Checkmate577,Keynote-590,Checkmate649 and Attraction-4)of locally advanced esophageal cancer published in 2020 have established the importance of immunotherapy,represented by anti-programmed death protein(PD)-1 in postoperative adjuvant treatment and advanced first-line treatment of locally advanced or advanced esophageal cancer and esophagogastric junction cancer,from the aspects of proof of concept,long-term survival,overall survival rate and progression-free survival.For unresectable or inoperable nonmetastatic esophageal cancer,concurrent radiotherapy and chemotherapy is the standard treatment recommended by various guidelines.Because its curative effect is still not ideal,it is necessary to explore radical radiotherapy and chemotherapy in the future,and it is considered to be promising to combine them with immunotherapeutic drugs such as anti-PD-1.This paper mainly discusses how to combine radical concurrent radiotherapy and chemotherapy with immunotherapy for unresectable local advanced esophageal cancer. 展开更多
关键词 Esophageal carcinoma Locally advanced RADIOTHERAPY IMMUNOTHERAPY
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A performance-based hybrid deep learning model for predicting TBM advance rate using Attention-ResNet-LSTM 被引量:1
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作者 Sihao Yu Zixin Zhang +2 位作者 Shuaifeng Wang Xin Huang Qinghua Lei 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第1期65-80,共16页
The technology of tunnel boring machine(TBM)has been widely applied for underground construction worldwide;however,how to ensure the TBM tunneling process safe and efficient remains a major concern.Advance rate is a k... The technology of tunnel boring machine(TBM)has been widely applied for underground construction worldwide;however,how to ensure the TBM tunneling process safe and efficient remains a major concern.Advance rate is a key parameter of TBM operation and reflects the TBM-ground interaction,for which a reliable prediction helps optimize the TBM performance.Here,we develop a hybrid neural network model,called Attention-ResNet-LSTM,for accurate prediction of the TBM advance rate.A database including geological properties and TBM operational parameters from the Yangtze River Natural Gas Pipeline Project is used to train and test this deep learning model.The evolutionary polynomial regression method is adopted to aid the selection of input parameters.The results of numerical exper-iments show that our Attention-ResNet-LSTM model outperforms other commonly-used intelligent models with a lower root mean square error and a lower mean absolute percentage error.Further,parametric analyses are conducted to explore the effects of the sequence length of historical data and the model architecture on the prediction accuracy.A correlation analysis between the input and output parameters is also implemented to provide guidance for adjusting relevant TBM operational parameters.The performance of our hybrid intelligent model is demonstrated in a case study of TBM tunneling through a complex ground with variable strata.Finally,data collected from the Baimang River Tunnel Project in Shenzhen of China are used to further test the generalization of our model.The results indicate that,compared to the conventional ResNet-LSTM model,our model has a better predictive capability for scenarios with unknown datasets due to its self-adaptive characteristic. 展开更多
关键词 Tunnel boring machine(TBM) advance rate Deep learning Attention-ResNet-LSTM Evolutionary polynomial regression
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Clinical diagnostic advances in intestinal anastomotic techniques:Hand suturing,stapling,and compression devices 被引量:1
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作者 Ah Young Lee Joo Young Cho 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第5期1231-1234,共4页
The development of intestinal anastomosis techniques,including hand suturing,stapling,and compression anastomoses,has been a significant advancement in surgical practice.These methods aim to prevent leakage and minimi... The development of intestinal anastomosis techniques,including hand suturing,stapling,and compression anastomoses,has been a significant advancement in surgical practice.These methods aim to prevent leakage and minimize tissue fibrosis,which can lead to stricture formation.The healing process involves various phases:hemostasis and inflammation,proliferation,and remodeling.Mechanical staplers and sutures can cause inflammation and fibrosis due to the release of profibrotic chemokines.Compression anastomosis devices,including those made of nickel-titanium alloy,offer a minimally invasive option for various surgical challenges and have shown safety and efficacy.However,despite advancements,anastomotic techniques are evaluated based on leakage risk,with complications being a primary concern.Newer devices like Magnamosis use magnetic rings for compression anastomosis,demonstrating greater strength and patency compared to stapling.Magnetic technology is also being explored for other medical treatments.While there are promising results,particularly in animal models,the realworld application in humans is limited,and further research is needed to assess their safety and practicality. 展开更多
关键词 ANASTOMOSES Diagnostic advances Anastomotic techniques Technique Intestine
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Recent Progress in Reinforcement Learning and Adaptive Dynamic Programming for Advanced Control Applications 被引量:4
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作者 Ding Wang Ning Gao +2 位作者 Derong Liu Jinna Li Frank L.Lewis 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第1期18-36,共19页
Reinforcement learning(RL) has roots in dynamic programming and it is called adaptive/approximate dynamic programming(ADP) within the control community. This paper reviews recent developments in ADP along with RL and ... Reinforcement learning(RL) has roots in dynamic programming and it is called adaptive/approximate dynamic programming(ADP) within the control community. This paper reviews recent developments in ADP along with RL and its applications to various advanced control fields. First, the background of the development of ADP is described, emphasizing the significance of regulation and tracking control problems. Some effective offline and online algorithms for ADP/adaptive critic control are displayed, where the main results towards discrete-time systems and continuous-time systems are surveyed, respectively.Then, the research progress on adaptive critic control based on the event-triggered framework and under uncertain environment is discussed, respectively, where event-based design, robust stabilization, and game design are reviewed. Moreover, the extensions of ADP for addressing control problems under complex environment attract enormous attention. The ADP architecture is revisited under the perspective of data-driven and RL frameworks,showing how they promote ADP formulation significantly.Finally, several typical control applications with respect to RL and ADP are summarized, particularly in the fields of wastewater treatment processes and power systems, followed by some general prospects for future research. Overall, the comprehensive survey on ADP and RL for advanced control applications has d emonstrated its remarkable potential within the artificial intelligence era. In addition, it also plays a vital role in promoting environmental protection and industrial intelligence. 展开更多
关键词 Adaptive dynamic programming(ADP) advanced control complex environment data-driven control event-triggered design intelligent control neural networks nonlinear systems optimal control reinforcement learning(RL)
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A frequency servo SoC with output power stabilization loop technology for miniaturized atomic clocks 被引量:1
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作者 Hongyang Zhang Xinlin Geng +3 位作者 Zonglin Ye Kailei Wang Qian Xie Zheng Wang 《Journal of Semiconductors》 EI CAS CSCD 2024年第6期13-22,共10页
A frequency servo system-on-chip(FS-SoC)featuring output power stabilization technology is introduced in this study for high-precision and miniaturized cesium(Cs)atomic clocks.The proposed power stabilization loop(PSL... A frequency servo system-on-chip(FS-SoC)featuring output power stabilization technology is introduced in this study for high-precision and miniaturized cesium(Cs)atomic clocks.The proposed power stabilization loop(PSL)technique,incorporating an off-chip power detector(PD),ensures that the output power of the FS-SoC remains stable,mitigating the impact of power fluctuations on the atomic clock's stability.Additionally,a one-pulse-per-second(1PPS)is employed to syn-chronize the clock with GPS.Fabricated using 65 nm CMOS technology,the measured phase noise of the FS-SoC stands at-69.5 dBc/Hz@100 Hz offset and-83.9 dBc/Hz@1 kHz offset,accompanied by a power dissipation of 19.7 mW.The Cs atomic clock employing the proposed FS-SoC and PSL obtains an Allan deviation of 1.7×10^(-11) with 1-s averaging time. 展开更多
关键词 CMOS technology atomic clock phase-locked loop output power stabilization 1PPS
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Development and technology status of energy storage in depleted gas reservoirs 被引量:1
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作者 Jifang Wan Yangqing Sun +4 位作者 Yuxian He Wendong Ji Jingcui Li Liangliang Jiang Maria Jose Jurado 《International Journal of Coal Science & Technology》 EI CAS CSCD 2024年第2期198-221,共24页
Utilizing energy storage in depleted oil and gas reservoirs can improve productivity while reducing power costs and is one of the best ways to achieve synergistic development of"Carbon Peak–Carbon Neutral"a... Utilizing energy storage in depleted oil and gas reservoirs can improve productivity while reducing power costs and is one of the best ways to achieve synergistic development of"Carbon Peak–Carbon Neutral"and"Underground Resource Utiliza-tion".Starting from the development of Compressed Air Energy Storage(CAES)technology,the site selection of CAES in depleted gas and oil reservoirs,the evolution mechanism of reservoir dynamic sealing,and the high-flow CAES and injection technology are summarized.It focuses on analyzing the characteristics,key equipment,reservoir construction,application scenarios and cost analysis of CAES projects,and sorting out the technical key points and existing difficulties.The devel-opment trend of CAES technology is proposed,and the future development path is scrutinized to provide reference for the research of CAES projects in depleted oil and gas reservoirs. 展开更多
关键词 Depleted gas reservoirs technology and development Siting analysis Safety evaluation Compressed air energy storage
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Design and analysis of an advanced thermal management system for the solar close observations and proximity experiments spacecraft 被引量:1
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作者 Liu Liu Kangli Bao +4 位作者 Jianchao Feng Xiaofei Zhu Haoyu Wang Xiaofeng Zhang Jun Lin 《Astronomical Techniques and Instruments》 CSCD 2024年第1期52-61,共10页
In this paper,the mission and the thermal environment of the Solar Close Observations and Proximity Experiments(SCOPE)spacecraft are analyzed,and an advanced thermal management system(ATMS)is designed for it.The relat... In this paper,the mission and the thermal environment of the Solar Close Observations and Proximity Experiments(SCOPE)spacecraft are analyzed,and an advanced thermal management system(ATMS)is designed for it.The relationship and functions of the integrated database,the intelligent thermal control system and the efficient liquid cooling system in the ATMS are elaborated upon.For the complex thermal field regulation system and extreme space thermal environment,a modular simulation and thermal field planning method are proposed,and the feasibility of the planning algorithm is verified by numerical simulation.A solar array liquid cooling system is developed,and the system simulation results indicate that the temperatures of the solar arrays meet the requirements as the spacecraft flies by perihelion and aphelion.The advanced thermal management study supports the development of the SCOPE program and provides a reference for the thermal management in other deep-space exploration programs. 展开更多
关键词 Solar Close Observations and Proximity Experiments Adaptive thermal control method Thermal field planning method Pumped liquid cooling system advanced thermal management system
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Review of advanced road materials, structures, equipment, and detection technologies 被引量:2
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作者 JRE Editorial Office Maria Chiara Cavalli +37 位作者 De Chen Qian Chen Yu Chen Augusto Cannone Falchetto Mingjing Fang Hairong Gu Zhenqiang Han Zijian He Jing Hu Yue Huang Wei Jiang Xuan Li Chaochao Liu Pengfei Liu Quantao Liu Guoyang Lu Yuan Ma Lily Poulikakos Jinsong Qian Aimin Sha Liyan Shan Zheng Tong B.Shane Underwood Chao Wang Chaohui Wang Di Wang Haopeng Wang Xuebin Wang Chengwei Xing Xinxin Xu Min Ye Huanan Yu Huayang Yu Zhe Zeng You Zhan Fan Zhang Henglong Zhang Wenfeng Zhu 《Journal of Road Engineering》 2023年第4期370-468,共99页
As a vital and integral component of transportation infrastructure,pavement has a direct and tangible impact on socio-economic sustainability.In recent years,an influx of groundbreaking and state-of-the-art materials,... As a vital and integral component of transportation infrastructure,pavement has a direct and tangible impact on socio-economic sustainability.In recent years,an influx of groundbreaking and state-of-the-art materials,structures,equipment,and detection technologies related to road engineering have continually and progressively emerged,reshaping the landscape of pavement systems.There is a pressing and growing need for a timely summarization of the current research status and a clear identification of future research directions in these advanced and evolving technologies.Therefore,Journal of Road Engineering has undertaken the significant initiative of introducing a comprehensive review paper with the overarching theme of“advanced road materials,structures,equipment,and detection technologies”.This extensive and insightful review meticulously gathers and synthesizes research findings from 39 distinguished scholars,all of whom are affiliated with 19 renowned universities or research institutions specializing in the diverse and multidimensional field of highway engineering.It covers the current state and anticipates future development directions in the four major and interconnected domains of road engineering:advanced road materials,advanced road structures and performance evaluation,advanced road construction equipment and technology,and advanced road detection and assessment technologies. 展开更多
关键词 Road engineering advanced road material advanced road structure advanced road equipment advanced road detection technology
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Conversion therapy for unresectable hepatocellular carcinoma:Advances and challenges
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作者 Yan-Fei He 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第10期4289-4297,共9页
Recently,the World Journal of Gastrointestinal Oncology published an article entitled“Pathologically successful conversion hepatectomy for advanced giant hepatocellular carcinoma after multidisciplinary therapy:A cas... Recently,the World Journal of Gastrointestinal Oncology published an article entitled“Pathologically successful conversion hepatectomy for advanced giant hepatocellular carcinoma after multidisciplinary therapy:A case report and review of the literature”,in which the authors shared their successful experience with complete surgical resection after multidisciplinary conversion therapy.The study by Chu et al demonstrates the great challenges that the advanced hepatocellular carcinoma(HCC)poses to surgical oncology,reveals the complexity of conversion therapy for unresectable HCC,emphasizes the important role of a multidisciplinary management model in conversion therapy,and enriches our understanding of the dynamics of personalized treatment for different patients.At present,conversion therapy is a hot research topic in the treatment of unresectable HCC,which has brought new hope to many patients with moderately advanced HCC.However,there are still many urgent problems to be solved in conversion therapy.Here,we would like to further discuss the advances and challenges of conversion therapy for unresectable HCC with the authors and the general readers. 展开更多
关键词 Unresectable hepatocellular carcinoma Conversion therapy CHALLENGES advanceS advanced hepatocellular carcinoma Targeted therapy IMMUNOTHERAPY
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Analysis of Low Fertility Rates in Advanced Economies
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作者 LI Chenkai 《Management Studies》 2024年第4期252-254,共3页
In economics,opportunity cost means the maximum value of choosing one behavior over others in the situation where resources are limited(Parkin,2016).In the process of making reproductive decision,opportunity cost reve... In economics,opportunity cost means the maximum value of choosing one behavior over others in the situation where resources are limited(Parkin,2016).In the process of making reproductive decision,opportunity cost reveals the trade-off between time,resources,and economic benefits that individuals face when choosing to have children or not.During this process,the technological changes make the paths of career development diverse and rapidly changing,remarkably increasing the opportunity cost of childbirth and parenting.This leads to individuals more inclined to postpone or reduce childbirth when balancing their careers and families,thereby resulting in low fertility rates in developed economies. 展开更多
关键词 low fertility advanced economies technological changes
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Development status and prospect of underground thermal energy storage technology 被引量:1
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作者 Ying-nan Zhang Yan-guang Liu +3 位作者 Kai Bian Guo-qiang Zhou Xin Wang Mei-hua Wei 《Journal of Groundwater Science and Engineering》 2024年第1期92-108,共17页
Underground Thermal Energy Storage(UTES)store unstable and non-continuous energy underground,releasing stable heat energy on demand.This effectively improve energy utilization and optimize energy allocation.As UTES te... Underground Thermal Energy Storage(UTES)store unstable and non-continuous energy underground,releasing stable heat energy on demand.This effectively improve energy utilization and optimize energy allocation.As UTES technology advances,accommodating greater depth,higher temperature and multi-energy complementarity,new research challenges emerge.This paper comprehensively provides a systematic summary of the current research status of UTES.It categorized different types of UTES systems,analyzes the applicability of key technologies of UTES,and evaluate their economic and environmental benefits.Moreover,this paper identifies existing issues with UTES,such as injection blockage,wellbore scaling and corrosion,seepage and heat transfer in cracks,etc.It suggests deepening the research on blockage formation mechanism and plugging prevention technology,improving the study of anticorrosive materials and water treatment technology,and enhancing the investigation of reservoir fracture network characterization technology and seepage heat transfer.These recommendations serve as valuable references for promoting the high-quality development of UTES. 展开更多
关键词 Aquifer thermal energy storage Borehole thermal energy storage Cavern thermal energy storage Thermal energy storage technology Benefit evaluation
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6G New Multiple Access Technology
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作者 Yifei Yuan Yongpeng Wu +3 位作者 Lei Wang Zhifeng Yuan Wei Bai Yuanwei Liu 《China Communications》 SCIE CSCD 2024年第1期I0002-I0005,共4页
As a basic technology at physical layer of mobile communications,non-orthogonal multiple access has been attracting wide attention across the academia and the industry.During the standardization of the fifth-generatio... As a basic technology at physical layer of mobile communications,non-orthogonal multiple access has been attracting wide attention across the academia and the industry.During the standardization of the fifth-generation(5G)of mobile communications,3GPP conducted preliminary study on non-orthogonal multiple access without reaching the consensus to standardize the technology. 展开更多
关键词 technology ACCESS attracting
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Diagnosis and treatment of refractory infectious diseases using nanopore sequencing technology:Three case reports
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作者 Qing-Mei Deng Jian Zhang +5 位作者 Yi-Yong Zhang Min Jia Du-Shan Ding Yu-Qin Fang Hong-Zhi Wang Hong-Cang Gu 《World Journal of Clinical Cases》 SCIE 2024年第22期5208-5216,共9页
BACKGROUND Infectious diseases are still one of the greatest threats to human health,and the etiology of 20%of cases of clinical fever is unknown;therefore,rapid identification of pathogens is highly important.Traditi... BACKGROUND Infectious diseases are still one of the greatest threats to human health,and the etiology of 20%of cases of clinical fever is unknown;therefore,rapid identification of pathogens is highly important.Traditional culture methods are only able to detect a limited number of pathogens and are time-consuming;serologic detection has window periods,false-positive and false-negative problems;and nucleic acid molecular detection methods can detect several known pathogens only once.Three-generation nanopore sequencing technology provides new options for identifying pathogens.CASE SUMMARY Case 1:The patient was admitted to the hospital with abdominal pain for three days and cessation of defecation for five days,accompanied by cough and sputum.Nanopore sequencing of the drainage fluid revealed the presence of orallike bacteria,leading to a clinical diagnosis of bronchopleural fistula.Cefoperazone sodium sulbactam treatment was effective.Case 2:The patient was admitted to the hospital with fever and headache,and CT revealed lung inflammation.Antibiotic treatment for Streptococcus pneumoniae,identified through nanopore sequencing of cerebrospinal fluid,was effective.Case 3:The patient was admitted to our hospital with intermittent fever and an enlarged neck mass that had persisted for more than six months.Despite antibacterial treatment,her symptoms worsened.The nanopore sequencing results indicate that voriconazole treatment is effective for Aspergillus brookii.The patient was diagnosed with mixed cell type classical Hodgkin's lymphoma with infection.CONCLUSION Three-generation nanopore sequencing technology allows for rapid and accurate detection of pathogens in human infectious diseases. 展开更多
关键词 Nanopore sequencing technology Third-generation sequencing technology INFECTION PATHOGEN Case report
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