The Triple Helix of innovation as a double game involving domestic and foreign actors

Purpose:The collaboration relationships between innovation actors at a geographic level may be considered as grouping two separate layers,the domestic and the foreign.At the level of each layer,the relationships and the actors involved constitute a Triple Helix game.The paper distinguished three levels of analysis:the global grouping together all actors,the domestic grouping together domestic actors,and the foreign related to only actors from partner countries.Design/methodology/approach:Bibliographic records data from the Web of Science for South Korea and West Africa breakdown per innovation actors and distinguishing domestic and international collaboration are analyzed with game theory.The core,the Shapley value,and the nucleolus are computed at the three levels to measure the synergy between actors.Findings:The synergy operates more in South Korea than in West Africa;the government is more present in West Africa than in South Korea;domestic actors create more synergy in South Korea,but foreign more in West Africa;South Korea can consume all the foreign synergy,which is not the case of West Africa.Research limitations:Research data are limited to publication records;techniques and methods used may be extended to other research outputs.Practical implications:West African governments should increase their investment in science,technology,and innovation to benefit more from the synergy their innovation actors contributed at the foreign level.However,the results of the current study may not be sufficient to prove that greater investment will yield benefits from foreign synergies.Originality/value:This paper uses game theory to assess innovation systems by computing the contribution of foreign actors to knowledge production at an area level.It proposes an indicator to this end.

Enhancing Relational Triple Extraction in Specific Domains:Semantic Enhancement and Synergy of Large Language Models and Small Pre-Trained Language Models

In the process of constructing domain-specific knowledge graphs,the task of relational triple extraction plays a critical role in transforming unstructured text into structured information.Existing relational triple extraction models facemultiple challenges when processing domain-specific data,including insufficient utilization of semantic interaction information between entities and relations,difficulties in handling challenging samples,and the scarcity of domain-specific datasets.To address these issues,our study introduces three innovative components:Relation semantic enhancement,data augmentation,and a voting strategy,all designed to significantly improve the model’s performance in tackling domain-specific relational triple extraction tasks.We first propose an innovative attention interaction module.This method significantly enhances the semantic interaction capabilities between entities and relations by integrating semantic information fromrelation labels.Second,we propose a voting strategy that effectively combines the strengths of large languagemodels(LLMs)and fine-tuned small pre-trained language models(SLMs)to reevaluate challenging samples,thereby improving the model’s adaptability in specific domains.Additionally,we explore the use of LLMs for data augmentation,aiming to generate domain-specific datasets to alleviate the scarcity of domain data.Experiments conducted on three domain-specific datasets demonstrate that our model outperforms existing comparative models in several aspects,with F1 scores exceeding the State of the Art models by 2%,1.6%,and 0.6%,respectively,validating the effectiveness and generalizability of our approach.

Inhibition of growth and metastasis of triple-negative breast cancer targeted by Traditional Chinese Medicine Tubeimu in orthotopic mice models

Objective： Triple-negative breast cancer（TNBC） is highly invasive and metastatic, which is in urgent need of transformative therapeutics. Tubeimu（TBM）, the rhizome of Bolbostemma paniculatum（Maxim.） Franquet, is one of the Chinese medicinal herbs used for breast diseases since the ancient times. The present study evaluated the efficacy, especially the anti-metastatic effects of the dichloromethane extract of Tubeimu（ETBM） on TNBC orthotopic mouse models and cell lines.Methods： We applied real-time imaging on florescent orthotopic TNBC mice model and tested cell migration and invasion abilities with MDA-MB-231 cell line. Digital gene expression sequencing was performed and Kyoto Encyclopedia of Genes and Genomes（KEGG） analysis applied to explore the pathways influenced by ETBM.Moreover, quantitative real-time polymerase chain reactions（q RT-PCR） and Western blot were delivered to confirm the gene expression changes.Results： ETBM exhibited noticeable control on tumor metastasis and growth of TNBC tumors with no obvious toxicity. In compliance with this, it also showed inhibition of cell migration and invasion in vitro. Its impact on the changed biological behavior in TNBC may be a result of decreased expression of integrin β1（ITGβ1）, integrin β8（ITGβ8） and Rho GTPase activating protein 5（ARHGAP5）, which disabled the focal adhesion pathway and caused change in cell morphology.Conclusions： This study reveals that ETBM has anti-metastatic effects on MDA-MB-231-GFP tumor and may lead to a new therapeutic agent for the integrative treatment of highly invasive TNBC.

Modeling of a triple reduced surface field silicon-on-insulator lateral double-diffused metal–oxide–semiconductor field-effect transistor with low on-state resistance

An analytical model for a novel triple reduced surface field（RESURF） silicon-on-insulator（SOI） lateral doublediffused metal–oxide–semiconductor（LDMOS） field effect transistor with n-type top（N-top） layer, which can obtain a low on-state resistance, is proposed in this paper. The analytical model for surface potential and electric field distributions of the novel triple RESURF SOI LDMOS is presented by solving the two-dimensional（2D） Poisson＇s equation, which can also be applied to single, double and conventional triple RESURF SOI structures. The breakdown voltage（BV） is formulized to quantify the breakdown characteristic. Besides, the optimal integrated charge of N-top layer（Q_（ntop）） is derived, which can give guidance for doping the N-top layer. All the analytical results are well verified by numerical simulation results,showing the validity of the presented model. Hence, the proposed model can be a good tool for the device designers to provide accurate first-order design schemes and physical insights into the high voltage triple RESURF SOI device with N-top layer.

绿色认知、组织支持对粮农绿色生产技术采纳影响--基于Triple-Hurdle模型的分析

基于粮食主产区山东省319户粮农的微观数据,将粮农的绿色生产技术采纳划分为绿色生产技术采纳意愿、采纳行为、采纳程度3个方面,运用Triple-Hurdle模型进行分析研究。结果表明:绿色认知、组织支持对粮农绿色生产技术的采纳意愿、采纳行为和采纳程度具有显著正向影响;组织支持能正向调节绿色认知对粮农绿色生产采纳的影响,但在不同阶段调节效应有差异;绿色认知对粮农的绿色生产技术采纳具有组群差异,绿色认知对于大规模粮农和年轻粮农的绿色生产技术采纳影响更大。

Universal triple I fuzzy reasoning algorithm of function model based on quotient space

Aiming at the deficiencies of analysis capacity from different levels and fuzzy treating method in product function modeling of conceptual design, the theory of quotient space and universal triple I fuzzy reasoning method are introduced, and then the function modeling algorithm based on the universal triple I fuzzy reasoning method is proposed. Firstly, the product function granular model based on the quotient space theory is built, with its function granular representation and computing rules defined at the same time. Secondly, in order to quickly achieve function granular model from function requirement, the function modeling method based on universal triple I fuzzy reasoning is put forward. Within the fuzzy reasoning of universal triple I method, the small-distance-activating method is proposed as the kernel of fuzzy reasoning; how to change function requirements to fuzzy ones, fuzzy computing methods, and strategy of fuzzy reasoning are respectively investigated as well; the function modeling algorithm based on the universal triple I fuzzy reasoning method is achieved. Lastly, the validity of the function granular model and function modeling algorithm is validated. Through our method, the reasonable function granular model can be quickly achieved from function requirements, and the fuzzy character of conceptual design can be well handled, which greatly improves conceptual design.

Experimental gene therapy for brain tumors using antisense or triple helix approaches

The insulin-like growth factor l (IGF-1) iscommonly expressed in most of tumor cells and plays arole in the growth and development of animal andhuman tumors. Tumor cells transfected with a vectorencoding antisense IGF-l cDNA transcriptionalcassette driven by the mouse

Combination Therapy of Capecitabine with Cyclophosphamide as a Second-Line Treatment after Failure of Paclitaxel plus Bevacizumab Treatment in a Human Triple Negative Breast Cancer Xenograft Model

We examined the antitumor efficacy of the capecitabine (CAPE) plus cyclophosphamide (CPA) combination as a 2nd-line therapy after paclitaxel (PTX) plus bevacizumab (BEV) treatment in a xenograft model of human triple negative breast cancer (TNBC) cell line, MX-1. After tumor growth was confirmed, PTX (20 mg/kg;i.v.) + BEV (5 mg/kg;i.p.) treatment was started (Day 1). Each agent was administered once a week for 5 weeks and tumor regression was observed for at least the first 3 weeks. For 2nd-line treatment, we selected mice in which the tumor volume had increased from day 29 to day 36 and was within 130 - 250 mm3 on day 36. After randomization of mice selected on day 36, CPA (10 mg/kg;p.o.) and CAPE (539 mg/kg;p.o.) were administered daily for 14 days (days 36 - 49), followed by cessation of the drugs for 1 week. The tumor growth on day 57 was significantly suppressed in the CPA, CAPE and CAPE + CPA groups as compared with the control group (p < 0.05). Furthermore, the antitumor activity on day 57 of CAPE + CPA was significantly stronger than that of CPA or CAPE alone (p < 0.05). The thymidine phosphorylase (TP) level in tumor tissue was evaluated by immunohistochemistry on day 50, and was significantly higher in the CPA group than those in the control group (p < 0.05). Upregulation of TP in tumor tissues by CPA treatment would increase the 5-FU level in tumor tissues treated with CAPE. This would explain the possible mechanism that made CAPE + CPA superior to CAPE alone in the 2nd-line treatment. Our preclinical results suggest that the CAPE + CPA combination therapy may be effective as 2nd-line therapy after disease progression in PTX + BEV 1st-line treatment for TNBC patients.

Game Analysis and Countermeasures on Increasing Prices of Agricultural Products under Triple Supply Chain

From the perspective of supply chain of agricultural products,by establishing Stackelberg game model based on triple supply chain,this paper researches the price formation and profit distribution mechanism of agricultural products under circumstance of non-cooperation and cooperation.The results show the main factors responsible for the hiking of prices of agricultural products as follows:the cost of agricultural products climbs incessantly;the circulation cost hovers at high level;the factor inputs of agricultural products are short;inflation pressure is incessantly mounting;the profit distribution of supply chain is irrational.Finally,corresponding countermeasures are put forward.

图形化本体模型到N-TRIPLES文本转化方法研究

分析了图形化本体编辑器VOEDITROR中的OWL构造子分类方法,提出了将图形化本体模型转化为N-TRIPLES格式文本的算法,解决了可视化本体建模工具与Oracle11g之间的整合问题。目前这套算法已经应用于以VOEDTIOR、VOQUERY和Ora-cle11g为核心的基于语义Web技术的网上资源整合平台中。

eXtended Triple Diffie-Hellman协议的安全性分析

针对X3DH(eXtended Triple Diffie-Hellman)协议安全性的问题,使用形式化分析工具OFMC(On-the-Fly Model-Checker)和协议建模语言AnB对协议进行验证。首先,在Types部分对协议涉及到的通信实体进行了建模;然后,在Knowlegde部分规定了各通信实体的先验知识;其次,在Actions部分对协议的协商流程进行了建模;最后,在Goals部分对协议的机密性、完整性、双向鉴别性等安全目标进行了建模。实验结果表明,X3DH协议作为Signal协议的核心,实现了密钥协商协议所要求的机密性、完整性、双向鉴别性等安全目标,并且形式化分析工具既可以减少工作量,又可以发现人工不易发现的协议漏洞,从而更加全面、高效地验证协议的安全性。

3-D multi-parameter type traveltime tomography in a spherical coordinate frame: comparison of double and triple class simultaneous inversions

It is now common practice to perform simultaneous traveltime inversion for the velocity field and the reflector geometry in reflection/refraction tomography, or the velocity field and the hypocenter locations in regional earthquake tomography, but seldom are all three classes of model parameters updated simultaneously. This is mainly due to the trade-off between the different types of model parameters and the lack of different seismic phases to constrain the model parameters. Using a spherical-coordinate ray tracing algorithm for first and later（primary reflected） arrival tracing algorithm in combination with a popular linearized inversion solver, it is possible to simultaneously recover the three classes of model parameters in regional or global tomographic studies. In this paper we incorporate the multistage irregular shortest-path ray tracing algorithm（in a spherical coordinate system） with a subspace inversion solver to formulate a simultaneous inversion algorithm for triple model parameters updating using direct and later arrival time information.Comparison tests for two sets of data（noise free and added noise） indicate that the new triple-class parameter inversion algorithm is capable of obtaining nearly the same results as the double-class parameter inversion scheme. Furthermore,the proposed multi-parameter type inversion method is not sensitive to a modest level of picking error in the traveltime data, and also performs well with a relatively large uncertainty in earthquake hypocentral locations. This shows it to be a feasible and promising approach in regional or global tomographic applications.

On the Analysis Method of the Triple Test Cross Design

The analysis method of the triple test cross design has been discussed carefully from the two factor experiment design and the genetic models of additive dominant effect and of epistasis effect.Two points different from the previous reports have been concluded: (1)both the degrees of freedom of the orthogonal terms C2 and C3 are m, (2)the denominator in the F test to C2 and C3 is the error mean of square between plots.

Three-Dimensional Mantle Flow and Temperature Structure Beneath the Shatsky Rise Ridge-Ridge-Ridge Triple Junction

The Shatsky Rise ridge-ridge-ridge triple junction is an ancient triple junction in the Western Pacific Ocean whose initial geodynamic process is poorly understood and can only be inferred based on indirect geological and geophysical constraints.In this paper,we present three-dimensional numerical models that simulate the Shatsky Rise triple junction and calculate its coupled mantle flow and temperature structure.The mantle flow velocity field shows several distinctive features:1)stronger mantle upwelling closer to the ridge axis and triple junction;2)greater upwelling velocity at the faster-spreading ridges;and 3)the most significant increase in upwelling velocity for the slowest-spreading ridge toward the triple junction.The calculated mantle temperature field also reveals distinctive characteristics:1)sharp increases in the mantle temperature with depth and increases toward the spreading ridges and triple junction;2)the faster-spreading ridges are associated with higher temperatures at depth and identical distances from the triple junction;and 3)the slowest-spreading ridge shows the greatest increase in the along-ridge-axis temperature toward the triple junction.Compared to many present-day triple junctions with slower spreading rates,the along-ridge-axis velocity and thermal fields of the Shatsky Rise are more altered due to the presence of the triple junction.

The Looped Light of the Triple-Slit Real Experiment as a Confirmation for the Extra Dimensions of Quantum Spacetime and the Reality of Dark Energy

Looped light in a recent sophisticated real three-slit experiment is interpreted as a strong justification of the old theoretical Peano-Hilbert spacetime model of Ord and El Naschie. This in turn entails the existence of extra fractal dimensions and consequently of real dark energy density in full agreement with previous analysis as well as accurate measurements and observations of COBE, WMAP, and the type 1a supernova.

The Quantum Triple-Slit Experiment and Dark Energy

The experimental discovery of looped light in a three-slit experiment is interpreted as a strong justification of the Peano-Hilbert spacetime model. This in turn entails the existence of a dark energy density in full agreement with previous analysis as well as accurate measurements and observations.

基于多源数据和改进链路预测的新能源汽车技术机会研究

[研究目的]在绿色低碳发展的背景下,旨在识别新能源汽车领域的技术机会,为未来新能源汽车的技术研发与商业化方向提供借鉴参考,助力新能源汽车的发展。[研究方法]搜集反映新能源汽车领域基础研究、应用研究和商业化的多源数据,采用三螺旋模型,将基于改进链路预测方法得到的预测结果“节点链”进行融合对比分析,得到最终细化的新能源汽车技术机会。[研究结论]验证了基于多源数据融合思想和改进链路预测的方法识别新能源汽车技术机会的可行性。研究结果表明:新能源汽车未来技术机会主要集中在动态无线充电技术、磁悬浮技术与自动驾驶技术的结合;通过碳化硅材料等改进的驱动技术;通过光催化等改进的电池技术;制氢与车载储氢等。

美日科学城创办的实践及对中国科创中心建设的启示——基于三重螺旋和创新生态系统视角的分析

党的二十大报告中提及:“加快建设世界重要人才中心和创新高地,促进人才区域合理布局和协调发展,着力形成人才国际竞争的比较优势”“以海纳百川的宽阔胸襟借鉴吸收人类一切优秀文明成果,推动建设更加美好的世界。”那么,如何加快建设适应中国式现代化发展进程的人才中心与创新高地?这其中,该有着怎样可能的建设途径?能否更有效借鉴吸收像美日等发达国家在相应人才中心和创新高地建设方面的已有成果经验?鉴于这些考虑,本文先回顾了三重螺旋理论的来源、文献梳理及实践应用,接着回顾了创新生态系统理论的组成要义、作用机理,从而建立了结合三重螺旋理论的创新生态系统模型图。基于此,进而以硅谷、筑波为例,从创新核心层和创新支撑层深入探究这一独特、高效且持续引领创新发展的国外著名科学城建构过程和机理,进一步分析中国科技创新中心建设实践中所存在的一些问题、困境或障碍,并给出了一些相应的引领性建议和可能性借鉴。

协同创新理论下交互式智能包装三螺旋耦合机制的实证研究

目的运用三螺旋理论分析交互式智能包装设计中科学、艺术与技术内核的协同创新,扩大耦合界面,提升三螺旋内部进化动力,为智能包装设计的可持续创新设计提供新的思路和方向。方法结合模糊层次分析法(F-AHP),构建交互式智能包装三螺旋耦合机制研究模型,论证“科-艺-技”三方在保持各自形成生态循环、情感循环与反馈循环后,通过“指导-藻饰-支撑”三螺旋相互促进,实现交互式智能包装设计的创新模式。结论通过三螺旋耦合机制对交互式智能包装三元驱动力的探析,将“万物物联”“多元共生”“性能跨越”三轴协同的跨界融合,有机整合了科学、艺术与技术三方优势在互补、融合驱动与交叉创新后形成的场力,对交互式智能包装设计的创新具有指导作用,并在此基础上提出对应的设计原则与设计策略,为智能包装智慧设计研究效用的最大化提供理论依据和实践指导。

教育数字化可持续发展的UGBS机制——从何处来?向何处去?

文章从历史哲学和政治哲学的高度出发,认为教育信息化是教育领域的“工业革命”,目标是实现作为“信息型”实践的教育从劳动密集型向技术密集型的制度转型,UGBS机制的产生在这一进程中有其逻辑必然性且揭示了这一转型独特的动力学机制。对此,文章提出了UGBS概念化这一理论命题,即明确四大行动主体及其交互关系。基于“大学—产业—政府”三螺旋结构这一概念框架,结合中国教育信息化发展历史对UGBS机制的产生与发展进行了回顾与阐释,实现了历史与逻辑的统一。文章从系统论和生态学视角出发,尝试对教育数字化进程中“UGBS机制究竟向何处去”这一问题进行了回答,提出教育变革的历史轨迹正从“布朗运动”向“莱维飞行”切换,UGBS机制未来需要应对教育创新之“莱维飞行”中潜藏的风险,教育数字化让教育生态系统进化始终处于混沌边缘,UGBS机制中蕴涵着教育数字化可持续发展的密码,在破解UGBS基因组密码的同时要谨防其发生负面的基因突变。