Intellectual Property Protection and New Development Pattern Construction of Xinjiang Jujube

"Three new developments"is the guiding ideology of Chinese-style high-quality development in the new era.Jujube(Zizyphus jujube Mill.)is a plant of Zizyphus of Rhamnaceae,which originated in China and has been listed as one of the"five fruits"since ancient times.Xinjiang is the most important jujube producing area in China,and its yield has accounted for 50%of the national jujube yield.In the five prefectures and cities of southern Xinjiang,as well as the regimental farms of southern and eastern Xinjiang of Xinjiang Production and Construction Corps,the jujube industry is an advantageous characteristic industry in agriculture.This paper studied Xinjiang jujube industry and its agricultural intellectual property resources,analyzed six major issues to be further implemented,such as the"three new developments"thinking and the strategy of building an intellectual property power,and puts forward eight strategies such as coordinating the two markets and two resources to accelerate the construction of a new development pattern and dual circulation of jujube.

Conventional Geothermal Systems and Unconventional Geothermal Developments: An Overview

This paper provides an overview of conventional geothermal systems and unconventional geothermal developments as a common reference is needed for discussions between energy professionals. Conventional geothermal systems have the heat, permeability and fluid, requiring only drilling down to °C, normal heat flow or decaying radiogenic granite as heat sources, and used in district heating. Medium-temperature (MT) 100°C - 190°C, and high-temperature (HT) 190°C - 374°C resources are mostly at plate boundaries, with volcanic intrusive heat source, used mostly for electricity generation. Single well capacities are °C - 500°C) and a range of depths (1 m to 20 Km), but lack permeability or fluid, thus requiring stimulations for heat extraction by conduction. HVAC is 1 - 2 m deep and shallow geothermal down to 500 m in wells, both capturing °C, with °C are either advanced by geothermal developers at <7 Km depth (Enhanced Geothermal Systems (EGS), drilling below brittle-ductile transition zones and under geothermal fields), or by the Oil & Gas industry (Advanced Geothermal Systems, heat recovery from hydrocarbon wells or reservoirs, Superhot Rock Geothermal, and millimeter-wave drilling down to 20 Km). Their primary aim is electricity generation, relying on closed-loops, but EGS uses fractures for heat exchange with earthquake risks during fracking. Unconventional approaches could be everywhere, with shallow geothermal already functional. The deeper and hotter unconventional alternatives are still experimental, overcoming costs and technological challenges to become fully commercial. Meanwhile, the conventional geothermal resources remain the most proven opportunities for investments and development.

Classification and Spatial Pattern of Township Development in Liaoning Province, China

The classification of township development types is an urgent problem that requires solution to enable the township to choose an appropriate development path.Using a township development classification method,we determine the township development types and their spatial patterns in Liaoning Province,China.The results showed that the patterns of township development types based on their general advantages had significant spatial differentiations.The planting,and livestock and poultry breeding township development types based on general advantages were mainly distributed across the central plain of Liaoning Province,China,and also concentrated in Dandong City−Dalian City along Yellow Sea coast,and in the northwest of Chaoyang City.The business and tourism,industry and mining,and residence township development types based on general advantages were distributed mainly along the Shenyang–Dalian Economic Belt in the central and southern Liaoning Province.The ecology township development type based on general advantages was mainly distributed in the eastern and western Liaoning Province to maintain regional ecological security.Township development types based on non-advantages were sporadically distributed in the middle and western Liaoning Province.Based on the classification and spatial patterns,the differences between the distribution of twonship development types and the plan for the major functional areas of Liaoning Province were proposed which could provide the basis for the optimization of the major functional areas.

Fuzzy pattern recognition model of geological sweetspot for coalbed methane development

From the perspective of geological zone selection for coalbed methane(CBM) development, the evaluation parameters(covering geological conditions and production conditions) of geological sweetspot for CBM development are determined, and the evaluation index system of geological sweetspot for CBM development is established. On this basis, the fuzzy pattern recognition(FPR) model of geological sweetspot for CBM development is built. The model is applied to evaluate four units of No.3 Coal Seam in the Fanzhuang Block, southern Qinshui Basin, China. The evaluation results are consistent with the actual development effect and the existing research results, which verifies the rationality and reliability of the FPR model. The research shows that the proposed FPR model of geological sweetspot for CBM development does not involve parameter weighting which leads to uncertainties in the results of the conventional models such as analytic hierarchy process and multi-level fuzzy synthesis judgment, and features a simple computation without the construction of multi-level judgment matrix. The FPR model provides reliable results to support the efficient development of CBM.

Program Development and Implementation of Landscape Pattern Indexes for Land Use Based on RS

Interpretation results of RS images were taken as the foundation, ETM RS images of July 15, 2009 as the data source, ENVI was applied for the preprocessing, Arc GIS used to finish the interpretation, master data obtained, and VB used to complete program development. 12 representative landscape pattern indexes were selected, Excel data used to create Access database, and VB used to complete the program development. Selection of landscape pattern indexes, program development process and program usage were summarized, through comparing its results with Excel calculation results, it was found that calculation results of this program were correct, the usage was convenient, so needs of most users could be satisfied.

Developmental Mechanism and Distribution Pattern of Stomatal Clusters in Begonia peltatifolia

The function of stomata in plants is controlling gas exchange and modulating water balance. The distribution pattern of stomata in most vascular plants follows a certain regulation with at least one normal epidermal cell between two stomata. However, some plants restricted in several genera of vascular plants have stomatal clusters in which more than one stoma is adjacently arranged with no epidermal cells among them. The developmental process of stomatal clusters in plants, especially in non-mutant (wild type) vascular plants, has rarely been documented, and very few studies concerning the distribution pattern of stomatal clusters on leaf epidermis have been carried out. We reported the developmental mechanism and distribution pattern of stomatal clusters in Begonia peltatifolia Li native to China. The results indicated that the clustered arrangement of meristemoids at the juvenile stage of the leaf development contributed greatly to the pattern of stomatal clusters. Additionally, satellite meristemoids derived from subsidiary cells around the mature stomata also had an impact on the development as well as the pattern of stomatal clusters. Regarding stomatal cluster and singly occurring stoma both as a stomatal unit, we found that the stomatal unit density (i.e., number of stomatal unit per area) increased gradually from the middle part to the edge and the apex of the leaf, while stomatal unit size (i.e., number of stomata per stomatal unit) decreased. The possible reason of this pattern was discussed.

Spatio-temporal Pattern Characteristics of Relationship Between Urbanization and Economic Development at County Level in China

The relationship between China’s urbanization and economic development(RCUED) is an important concern nationwide. As important actors in regional strategy and policy, county-level regions have played an increasingly significant role in the development of China’s social economy. However, the existing research on the RCUED lacks the fine depiction of the county-level administrative units.Using 2000 and 2010 census data and the statistical analysis method, we uncovered the evolution characteristics of China’s urbanization and economic development and conducted a quantitative identification for the RCUED with improved methods using the quadrant map approach. In addition, we investigated the spatial correlation effect of the RCUED using the spatial autocorrelation analysis method. The results were as follows: 1) In general, a high degree of matching exists between China’s urbanization and economic development at the county level at the significance level of 0.01. The correlation coefficients between China’s urbanization and economic development in2000 and 2010 were 0.608 and 0.603, respectively. 2) A significant regional difference exists in the RCUED at the county level. Based on a comparative analysis of 2276 county units in China in the two years, we found that county units can be categorized as under-urbanized, basic coordination and over-urbanized in various areas. No situation was observed where urbanization seriously lagged behind the economic development level, so the levels of urbanization and economic development appear to be basically coordinated,and the coordination state may be gradually optimized over time. 3) Over time, the spatial dependency of the RCUED has weakened and the spatial heterogeneity has increased. Northeast China has always been an area characterized by over-urbanization. The number of county units classified as under-urbanized has begun to decline in eastern coastal urban agglomeration areas, while counties rich in resources have transformed from having point-shaped over-urbanization to plane-shaped under-urbanization along the northern border,and the number of over-urbanized county units has increased in the middle reaches of the Yangtze River. 4)’Lag-lag’ type and ’advance-advance’ type accounted for 68% of all counties in China, and these counties were shown to have obvious spatial differentiation characteristics.

An overview of efficient development practices at low permeability sandstone reservoirs in China

Low permeability sandstone reservoirs in China typically have more complicated geological conditions, pore structures, and flow characteristics as compared to medium-to-high-permeability sandstone reservoirs. Traditional geological and seepage theories, and engineering methods are not applicable to the development of these low permeability reservoirs, and wells drilled into them often produce oil and gas at very low rates. Recent breakthroughs in reservoir exploitation technology have greatly improved the productivity of low permeability reservoirs, making them the primary target for oil exploration and extraction in China. The development theories and practices applied to low permeability reservoirs in China are reviewed in this study— based on relevant geological and engineering practices, including drilling, fracturing, recovery, and surface engineering. A unique series of technological advances that aid the development of low permeability reservoirs in China are summarized here. This study may serve as a meaningful guide in achieving scale efficiency for the development of low permeability reservoirs.

The temporal and spatial patterns and potential evaluation of China＇s energy resources development

The issue of China＇s energy supply security is not only the key problem which af- fects China＇s rapid and sustainable development in the 21st century, but also the one which international attention focuses on. Based on the notable characteristic of spatial imbalance between energy production and consumption in China, this paper takes the evolution of China＇s primary energy resources development（excluding hydropower） from 1949 to 2007 as the study object, with the aim to sum up the evolutive characteristics and laws of China＇s energy resources development in the past nearly 60 years. Then, based on comprehensive considerations of coal＇s, oil＇s and natural gas＇s basic reserves, qualities, geological conditions production status, and ecological service function of every province, this paper adopts development potential index （DP）to evaluate the development potential of every province＇s en- ergy resources, and divide them into different ranks. Conclusions are drawn as follows： （1） Generally speaking, China＇s gross energy production was increasing in waves from 1949 to 2007. From the viewpoint of spatial patterns, China＇s energy resources development has shown a characteristic of ＂concentrating to the north and central areas, and evolving from linear-shaped to ＂T-shaped＂ pattern gradually since 1949. （2） The structure evolution of China＇s energy resources development in general has shown a trend of ＂coal proportion is dominant but decreasing, while oil and gas proportions are increasing＂ since 1949. （3） At the provincial scale, China＇s energy resources development potential could be divided into large, sub-large, general and small ranks, four in all. In the future, the spatial pattern of China＇s energy production will evolve from ＂T-shaped＂ to ＂R-shaped pattern＂. These conclusions will help to clarify the temporal and spatial characteristics and laws of China＇s energy resources development, and will be beneficial for China to design scientific and rational energy development strategies and plans, coordinate spatial imbalance of energy production and consumption, ensure national energy supply, avoid energy resources waste and disorderly development, and promote regional sustainable development under the globalization back-ground with changeful international energy market.

China’s Industrial Upgrading and Value Chain Restructuring Under the New Development Pattern

Global industrial chains(GICs)have become a hallmark of the world economy underpinning the global production cycle.Since the reform and opening up was introduced in 1978,China has taken an active role in global value chains(GVCs)and become the world’s factory floor.Under the external shocks to GICs,such as US trade frictions with China and the COVID-19 pandemic,China’s traditional comparative advantages in manufacturing which include its labor force and costs are waning.This has manifested in a wave of industrial relocations from China to other countries as well as China’s weakening international competitiveness.We took stock of the concepts and journey of GVCs and elaborated the intrinsic relationship between GVCs and the new development pattern of“dual circulations”.We also analyzed the trends of GVCs,the current status and problems of China’s industrial chains,and China’s market heft,complete industrial chains and the digital economy as new strengths for industrial chain upgrade.In our conclusion,this paper put forth some policy recommendations for China’s industrial chain upgrade in the context of dual circulations.

Developmental Temporal Patterns and Molecular Network Features in the Transcriptome of Rat Spinal Cord

The molecular network features of spinal cord development that are integral to tissue engineering remain poorly understood in placental mammals,especially in terms of their relationships with vital biological processes such as regeneration.Here,using a large-scale temporal transcriptomic analysis of rat spinal cord from the embryonic stage to adulthood,we show that fluctuating RNA expression levels reflect highly active transcriptional regulation,which may initiate spinal cord patterning.We also demonstrate that microRNAs(miRNAs)and transcriptional factors exhibit a mosaic profile based on their expression patterns,while differential alternative splicing events reveal that alternative splicing may be a driving force for the development of the node of Ranvier.Our study also supports the existence of a negative correlation between innate immunity and intrinsic growth capacity.Epigenetic modifications appear to perform their respective regulatory functions at different stages of development,while guanine nucleotidebinding protein(G protein)-coupled receptors(including olfactory receptors(ORs))may perform pleiotropic roles in axonal growth.This study provides a valuable resource for investigating spinal cord development and complements the increasing number of single-cell datasets.These findings also provide a genetic basis for the development of novel tissue engineering strategies.

Sustainable development pattern and the strategy in the Three Gorges Reservoir Areas

The development pattern, development situation, and existing problems of land exploitation in Zigui County, Three Gorges Reservoir Areas of China were presented. The sustainable development mode and its strategy in the Three Gorges Reservoir Areas was also discussed. A sustainable development framework for low mountain regions, middle mountain regions and high mountain regions was developed, and management countermeasures for structural optimization of complex ecosystems were advanced.

Integrative analysis of the inverse expression patterns in pancreas development and cancer progression

BACKGROUND As the malignant tumor,pancreatic cancer with a meager 5-years survival rate has been widely concerning.However,the molecular mechanisms that result in malignant transformation of pancreatic cells remain elusive.AIM To investigate the gene expression profiles in normal or malignant transformed pancreas development.METHODS MaSigPro and ANOVA were performed on two pancreas development datasets downloaded from the Gene Expression Omnibus database.Six pancreatic cancer datasets collected from TCGA database were used to establish differentially expressed genes related to pancreas development and pancreatic cancer.Moreover,gene clusters with highly similar interpretation patterns between pancreas development and pancreatic cancer progression were established by self-organizing map and singular value decomposition.Additionally,the hypergeometric test was performed to compare the corresponding interpretation patterns.Abnormal regions of metabolic pathway were analyzed using the Subpathway-GM method.RESULTS This study established the continuously upregulated and downregulated genes at different stages in pancreas development and progression of pancreatic cancer.Through analysis of the differentially expressed genes,we established the inverse and consistent direction development-cancer pattern associations.Based on the application of the Subpathway-GM analysis,we established 17 significant metabolic sub-pathways that were closely associated with pancreatic cancer.Of note,the most significant metabolites sub-pathway was related to glycerophospholipid metabolism.CONCLUSION The inverse and consistent direction development-cancer pattern associations were established.There was a significant correlation in the inverse patterns,but not consistent direction patterns.

Spatial and Temporal Pattern of Urban Smart Development in China and Its Driving Mechanism

Smart urban development is an inevitable choice, and is essential to overall strength improvement. It is important to explore an urban smart development path which unites smart growth with driving shrinkage perfectly in forming scientific and sustainable development concept and responding to new normal strategic opportunities. Based on statistic data of 294 prefecture-level cities and above in China from 2000 to 2015, we analyzed spatial and temporal evolution of urban smart development in China by constructing a dynamic fitting model of urban land expansion, population growth, and economic development as well as the coefficient of variation of urban smart development(CVSD). Further efforts were then made to consider differential distribution regularity of urban smart development so as to understand the driving mechanisms of heterogeneous classification of urban smart development in China from different scales and scale variation. Our results indicate that: 1) the disordered growth tendency of urban cities in China is overall well controlled in the middle, and late research and it mainly presented a doublet coexistence of shrinkage disordered cities and smart developing cities. It is particularly obvious that Northeast China and East China have regarded shrinkage disordered cities and smart developing cities as main development tendency separately. 2) Areas with basic stability and relative variation were relatively dispersed across the time period, but the proportion was far beyond areas with significant variation. It demonstrates a relative equilibrium spatial and temporal differential evolution pattern of prefecture-level cities and above in China, except for Tongling, Lanzhou and Chaoyang. 3) prefecture-level cities and above in China are mostly characterized by shrinkage disordered and smart development classification under the background of different scale and scale variation from 2000–2015; however, the spatial resonance relation is not obvious. 4) There are many interaction factors forming an important driving mechanism in developing the spatial and temporal pattern of urban smart development in China, including natural geographical factors, industrial structure adjustment, human capital radiation, regional traffic accessibility, and government decision-making intervention.

Methods to evaluate the impacts of physio- geographical pattern on spatio-temporal disparity of regional development

With the rapid economic development during the last 30 years in China, more and more disparities have emerged among different regions. It has been one of the hot topics in the fields of physical geography and economic geography, and also has been the task for Chinese government to handle. Nevertheless, to quantitatively assess the impacts of physio-geographical patterns （PGP） on the regional development disparity has been ignored for a long time. In this paper, a quantitative method was adopted to assess the marginal effects of the PGP on spatio-temporal disparity using the partial determination coefficients. The paper described the construction of the evaluation model step by step following its key scientific thinking. Total GDP, per capita GDP, primary industrial output value and secondary industrial output value were employed in this study as the indicators to reflect the impacts of PGP on the regional development disparity. Based on the evaluation methods built by researchers, this study firstly analyzed the temporal impacts of the PGP on spatio-temporal disparity of the regional development in China during the past 50 years, and then explained the spatial differences at each development stage. The results show that the spatio-temporal disparity in China is highly related to the PGP, and that the marginal contribution rate could be employed as an effective way to quantitatively assess the impact of the PGP on spatio-temporal disparity of the regional development.

Spatial Pattern and Influencing Factor of County-level Industrial Development in Liaoning Province of China

County-level industrial development and structure upgrade is one of the most important issues of revitaliz- ing old industrial base of China. After the cluster analysis on GDP per capita and GDP per area of each county in Liaoning Province, this paper finds the similarity of population size, land use intensity, and economic development of each county. Location quotient reflects the specialization intensity of industries in each county, and it also reflects the spatial differences of county-level industrial development. Economic development level is higher in the southeast than in the northwest of Liaoning, and the industry driving effect on county-level economy is apparent. The main influenc- ing factors include location, industrial foundation and economic system reform, capital input level, knowledge and technology dissemination, conditions of domestic and overseas markets, population and labor force transfer. Industri- alization is an important approach to urbanization for the counties in Liaoning Province. The proportion of agriculture is much higher in the northwest than in the southeast of Liaoning, so it will be take longer time for counties in the northwest of Liaoning to make industrialization, urbanization and modernization.

Economic reform, open-door policy and changes in spatial development patterns in China

The study profiles and explains the significant changes that have taken place in China's spatial development patterns since the inception of its economic reform and opening two decades ago. Principal component analysis is used to delineate spatial patterns. The analyses show that prior to the reform China's spatial development pattern was characterized by the dominance of the three municipalities and the Northeast, as well as by both the coast-interior and the north-south disparities. Northern provinces were generally more industrialized and economically powerful than the southern ones. After two decades of reform, regional development has become multi-centered with South China, the Yangtze Delta and the Beijing-Tianjin area being the three most important regions of the country. The coastal provinces as a whole rose to prominence on China's economic map while the Northeast has diminished its clout. The coast-interior gap not only remains but may have widened. The north-south disparity also still exists but there has been a role reversal with the south now in the lead position. Virtually all inland provinces now find themselves at or near the low end of the development spectrum. We argue that the major reason for the recent shifts in Chinese space economy is the spatially differentiated economic growth resulted from the reform and open door policy and from the new, uneven development strategy adopted by the Chinese government. The paper discusses four specific factors that have reshaped China's spatial development patterns.

Correlation Between Economic Development Level and Landscape Pattern in Beijing Peri-urban Areas

With the rapid changes of demographic and socio-economic structure, various ecological and environmental problems have emerged in peri-urban areas. Studies on the correlation between socio-economic development and eco-environmental preservation are inadequate. This paper analyzes the landscape pattern of peri-urban areas to address this issue. First, it studies the differentiation of economic development levels in Beijing peri-urban areas. Then, it explores the correlation between economic development level of each town and its landscape pattern using Pearson Correlation and grade difference indices. Furthermore, it summarizes the problems within current landscape pattern. Three conclusions are drawn from the analysis: (1) on the whole, the economic de- velopment level in Beijing peri-urban areas basically matches with landscape pattern; (2) landscape contagion degree decreases with the growth of economic development level in as much as 30% of Beijing peri-urban areas. This is an irrational phenomenon accord- ing to our judgment; (3) landscape fragmentation grades in more than half of the towns are higher than their economic development grades, suggesting that attention should be paid to excessive fragmentation of land use.

Relationship between Different Pronuclear Patterns and Potential of Embryo Development and Pregnancy

Objective To explore the relationship between the patterns of pronucleus and embryo development and pregnancy potential in the pronuclear stageMethods According to the number and distribution of nucleolar precursor bodies, the embryos at pronuclear stage were classified into 6 pronuclear patterns from 0 to 5, 16 - 18 h after in vitro fertilization (IV F) or intracytoplasmic sperm injection (ICSI). For each, pattern, the subsequent embryonic morphology and the pregnancy rate were analyzed.Results Embryos of Pattern 0 developed to significantly more embryos with good quality and higher pregnancy potential than the embryos developing from other patterns (83. 14% and 76. 11% respectively, P<0. 05). The pregnancy rate was decreased as less embryos of Pattern 0 were transferred . The pregnancy rate of the groups of only Pattern 0, with Pattern 0, and without Pattern 0 were 48. 08% , 32. 14% and 21. 28% respectively (P<0. 05).Conclusions The pronuclear patterns are of the predictive value of embryo development and pregnancy potential, which can be used as a new tool for the selection of embryos in IVF and ICSI.

Evolution of Temporal-spatial Pattern of Green Development Efficiency in Shandong Province

Temporal-spatial differentiation characteristics of green development efficiency in 17 prefecture-level cities of Shandong Province during 2005-2016 were studied by using SBM-undesirable model and spatial auto-correlation analysis.Results showed that ① green development efficiency considering unexpected output could more accurately represent the real cost of regional development,while lower green development efficiency considering unexpected output and traditional green development efficiency illustrated that Shandong Province has spent a lot of resources and environment in the long-term development process.② Green development efficiency of Shandong Province during 2005-2016 showed the change characteristics of "peak-valley-peak-valley",and standard deviation and coefficient of variation of green development efficiency showed fluctuation characteristics in the research period.③ Green development efficiency of Shandong Province had obvious spatial differentiation characteristics,and its polarization differentiation was obvious.