Recent advances in quantifying the inactive lithium and failure mechanism of Li anodes in rechargeable lithium metal batteries

Lithium metal is considered as the ultimate anode material for the next generation of high-energy density batteries.However,non-uniform lithium dendrite growth,serious electrolyte consumption,and significant volume changes during lithium deposition/stripping processes lead to sustained accumulation of inactive lithium and poor cycling reversibility.Quantifying the formation and evolution of inactive lithium under different conditions and fully evaluating the complex failure modes are the key issues in this challenging field.This article comprehensively reviews recent research progress on the quantification of formation and evolution of inactive lithium detected by different quantitative techniques in rechargeable lithium metal batteries.The key research challenges such as failure mechanism,modification strategies and operando characterization of lithium metal anodes are systematically summarized and prospected.This review provides a new angle of view to understand failure mechanism of lithium metal anodes and inspiration and guidance for the future development of rechargeable lithium metal batteries.

Serum Immunoglobulin Concentrations in Juvenile Idiopathic Arthritis Cases during Active and Inactive Disease States

Background: Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children. Both the humoral and cell mediated immunities are involved in the pathogenesis of JIA. It is reported that overall immunoglobulin levels in JIA patients are significantly higher than their control during the active state of disease. Methodology: This prospective observational study was conducted over a period of 18 months All the newly diagnosed oligo-articular and poly-articular JIA patients having active disease were included by purposive sampling. Data were collected by a semi-structured predesigned questionnaire. Result: Most of the study subjects (57.6%) belonged to age group > 3 - 9 years. Oligo JIA was diagnosed in 66.7% and poly JIA in 33.3% of JIA children. The difference in mean (±SD) ESR (33.52 ± 21.29 and 15.09 ± 7.71 mm in 1st hour) at active and inactive states was highly significant. Mean (±SD) difference of IgG, IgM and IgA in active and inactive states of disease were highly significant. Conclusion: Higher and abnormal levels of immunoglobulin (IgG, IgM, and IgA) were present among JIA patients in active disease state which became normal during inactive disease state after treatment.

MEC辅助的Inactive状态用户动态位置管理方案

移动边缘计算(mobile edge computing,MEC)作为5G网络架构演进的关键技术,能够满足系统对于吞吐量、时延及智能化要求。同时,5G引入用户(user equipment,UE)无线资源控制(radio resource control,RRC) Inactive状态作为用户的主要状态。在分析MEC的特点、网络架构、装置结构的基础上,基于Inactive状态特点,对当前Inactive状态的寻呼和位置跟踪方案进行分析和对比,提出一种基于MEC的UE数据包缓存和动态位置管理方案,该方案由部署在靠近无线接入网(radio access network,RAN)基站侧的MEC缓存Inactive UE数据包,并更新UE的RAN通知区域(RAN notification area,RNA)。和传统的方案相比,该方案能有效解决锚点g NB(5G-NodeB)的容量问题,并且实现UE有效的位置管理。

Regional and Synoptic-scale Features Associated with Inactive Periods of the Summer Monsoon over South China

This paper presents an observational study of the physical processes responsible for the inactive period (break) of the summer monsoon over South China (SC). The break of the monsoon is defined by using the rainfall data over Hong Kong Meteorological parameters provided by the European Centre for Medium-Range Weather Forecasts (ECMWF) for the period 1985-1990 are examined. Daily values of each parameter for the six years are then composited each day for the period of 5 days before to 1 day after the break. It is found that several days before the break, changes opposite to those occurred during the onset and active periods begin to take place. This suggests that a feedback mechanism is present which tends to restore the atmosphere to a more stable state. This mechanism may be initiated by the formation of convective clouds during the onset and active periods. These clouds then reduce the solar radiation to the ground, leading to a gradual drop in the temperature. This drop, together with the cooling of the atmosphere due to the large amounts of rainfall, causes the pressure over the SC region to become higher, which in turn induces a westward extension of the subtropical ridge. The decrease in temperature over SC may also shift the location of the heat source to the west, which leads to a concomitant westward shift of the convergence of the southerlies and results in less moisture-laden air reaching the SC region. The atmosphere then becomes unfavourable for heavy convection and therefore a break starts.

Hepatitis B surface antigen clearance in inactive hepatitis B surface antigen carriers treated with peginterferon alfa-2a

AIM: To examine the association between interferon(IFN) therapy and loss of hepatitis B surface antigen(HBs Ag) in inactive HBs Ag carriers. METHODS: This was a retrospective cohort study in inactive HBs Ag carriers, who were treatment-naive, with a serum HBs Ag level < 100 IU/m L and an undetectable hepatitis B virus(HBV) DNA level(< 100 IU/m L). All the 20 treated patients received subcutaneous PEG-IFN alfa-2a 180 μg/wk for 72 wk and were then followed for 24 wk. There were 40 untreated controls matched with 96 wk of observation. Serum HBs Ag, HBV DNA, and alanine aminotransferases were monitored every 3 mo in the treatment group and every 3-6 mo in the control group. RESULTS: Thirteen(65.0%) of 20 treated patients achieved HBs Ag loss, 12 of whom achieved HBs Ag seroconversion. Mean HBs Ag level in treated patients decreased to 6.69 ± 13.04 IU/m L after 24 wk of treatment from a baseline level of 26.22 ± 33.00 IU/m L. Serum HBV DNA level remained undetectable(< 100 IU/m L) in all treated patients during the study. HBs Ag level of the control group decreased from 25.72 ± 25.58 IU/m L at baseline to 17.11 ± 21.62 IU/m L at week 96(P = 0.108). In the control group, no patient experienced HBs Ag loss/seroconversion, and two(5.0%) developed HBV reactivation.CONCLUSION: IFN treatment results in HBs Ag loss and seroconversion in a considerable proportion of inactive HBs Ag carriers with low HBs Ag concentrations.

The effect of electrochemically inactive Ti substituted for Ru in Li_(2)Ru_(1-x)Ti_xO_(3) on structure and electrochemical performance

The approach of substituting electrochemically active with inactive elements has widely been used to improve the electrochemical performance of Li-rich intercalation cathode materials. This especially is true for Li-rich compounds where almost all of the Li+ions are reversibly(de)intercalated during electrochemical cycling. The beneficial mechanism behind this substitution with electrochemically inactive elements is still not clear yet. Li_(2)RuO_(3) is chosen as basis for a model solid solution system to investigate the effect of electrochemically inactive elements owing to its high specific capacity of more than 300 m Ah g^(-1) and the significant contribution of anion redox mechanism. Herein, Li_(2)Ru_(1-x)Ti_xO_(3) solid solution series are synthesized and the effect of substituting with electrochemical inactive Ti for Ru on structure and electrochemical performance have been comprehensively investigated. The electrochemical performance is significantly improved, especially for Li_(2)Ru_(0.8)Ti_(0.2)O_(3), and the capacity retention after 50 cycles increases from 81% to 90%, as compared to the end member Li_(2)RuO_(3). Results of electrochemical impedance spectroscopy show that Ti substitution reduces the charge transfer impedance, which favors the Li+diffusion across the electrolyte–electrode interface and improves the electronic conductivity. For the first time,nuclear magnetic resonance was utilized to confirm that a small part of Ti ions exchange their position with Li ions in the Li layer. This research provides a better understanding of electrochemical inactive element substitution and strong insights for the functional design of the next generation of Li-rich cathode materials.

Early Warning System of Risk in Dairy Cows with Inactive Ovaries

The incidence of Inactive ovaries of dairy cows in China is relatively high. There is no complete early warning system for the occurrence of ovarian quiescence in clinical cows. This test provides early warning indicators for clinical prediction of ovary cessation in dairy cows. This experiment selected blood samples of dairy cows from 60 to 90 days postpartum in the inactive ovaries group and control group. Differential proteins were selected on the basis of proteomics, three energy indexes: AST, Glu, NEFA. Four reproductive hormones: E2, P4, FSH, LH, and four differentially expressed proteins: IGFBP-2, AHSG, APO-A4, and RBP-4. Key enzyme activities: ALDOB, LDHB, ITIH3, GPX3, SPAM1, PKM2. The ELISA test kit was used to detect the content and activity of the above markers in the test bovine serum. Through correlation analysis, binary logistic regression modeling and ROC analysis, a single indicator early warning technique for APOA4 and ITIH3 was established. The early warning values were APOA4 > 28.825 μg/L and ITIH3 > 195.07 ng/L. A multi-index early warning system based on potential biomarkers of APOA4 + ITIH3 and APOA4 + ITIH3 + E2 was established. The former had an early warning value of: APOA4 > 19.55 μg/I;ITIH3 > 191.14 ng/L;the latter has an early warning value: APOA4 > 47.56 μg/L, ITIH4 > 187.80 ng/L, E2 < 69.63 ng/L.

清空WindowsXP的Inactive icons旧列表

工具:UltraEdit (或其它十六进制编辑器,推荐使用WinHEX,它可以直接搜索UNICODE) 说明:该列表保存在各个用户本身的 NTUSER.DAT 文件中。目前尚无现成的方法/工具来清理,只好自己编辑NTUSER.DAT文件。由于用户登陆后,该文件处于受保护的状态,故需要借助另一个帐号来修改。

THE HYDROXYLATON OF INACTIVE HYDROCARBONS WITH ACTIVE CARBON SUPPORTED METALLOPORPHYRINS

A supported Mn-porphyrin catalyst was prepared by adsorption of Mn-porphyrin on active carbon, and found to be efficient for the hydroxylation of hexane with hydrogen peroxide.

间歇与持续训练对体力活动不足成人生活质量影响的Meta分析

目的:高强度间歇训练(high-intensity interval training,HIIT)和中等强度持续训练(moderate-intensity continuous training,MICT)对临床慢性病患者生活质量均有改善作用,但其对于体力活动不足成人的应用效果与调节因素尚不明确。文章旨在探究HIIT与MICT对体力活动不足成人生活质量的应用效果与调节因素。方法:在Web of Science核心合集、Medline(EBSCO Host)、PubMed和Cochrane Library数据库中进行文献检索,检索时限为各数据库建库至2023年9月。纳入文献类型为随机对照试验,研究对象为体力活动不足成人。采用RevMan 5.4软件和GRADE证据评价框架对纳入文献进行质量评价。使用R Studio(版本4.2.0)进行随机效应模型的主效应合并。亚组分析、回归分析和敏感性分析用于探讨研究异质性来源和调节因素。结果:①纳入32项中等至高质量的随机对照试验,共2083名体力活动不足成人对象(HIIT组474例;MICT组708例;对照组901例)。②相比于无训练对照组,HIIT(Hedges’g=0.61;95%CI:0.40-0.83;I2=45%)与MICT(Hedges’g=0.66;95%CI:0.25-1.08;I2=89%)均能显著提升生活质量。当直接比较HIIT与MICT时,二者之间的影响未观察到显著差异(Hedges’g=-0.01;95%CI:-0.23-0.21;I2=0%)。③亚组分析结果显示,HIIT和MICT在提高身体层面的生活质量更为有效(HIIT:Hedges’g=0.82 vs.0.75;MICT:Hedges’g=0.74 vs.0.55),而骑行在提高整体生活质量方面有更好的趋势(HIIT:Hedges’g=0.74 vs.0.36;MICT:Hedges’g=1.08 vs.0.52)。④回归分析未识别出任何显著的调节因素(所有因素P>0.05)。⑤上述Meta分析均未发现发表偏倚(Egger检验P>0.05)。结论:①中高级别的证据表明,HIIT与MICT均能改善体力活动不足成人的生活质量,且二者之间的干预效果类似。因此,在选择这两种方案时,需综合考虑安排灵活性、时间经济性以及应用可行性等因素制订个性化运动方案。②文章推荐在应用HIIT时,3次/周,使用低量方案(例如,每次5组,每组1 min),以80%-95%最大心率进行骑行可达理论最佳改善效果。③尽管MICT可提高生活质量,但尚无充分证据显示增加运动时长会带来额外益处。因此,建议在实施MICT时,每周进行3次以上,每次训练时长控制在25-60 min,并以50%-75%最大心率进行骑行,以达到理论上预期的最佳改善效果。

Metabolic rates and biochemical compositions of Apostichopus japonicus (Selenka) tissue during periods of inactivity

Estivation, hibernation, and starvation are indispensable inactive states of sea cucumbers Apostichopusjaponicus in nature and in culture ponds. Generally, temperature is the principal factor that induces estivation or hibernation in the sea cucumber. The present study provided insight into the physiological adaptations ofA. japonicus during the three types of inactivity （hibernation, estivation, and starvation） by measuring the oxygen consumption rates （Vo2） and biochemical compositions under laboratory conditions of low （3℃）, normal （17℃） and high （24℃） temperature. The results show that the characteristics of A. japonicus in dormancy （hibernation and estivation） states were quite different from higher animals, such as fishes, amphibians, reptiles, and mammals, but more closely resembled a semi-dormant state. It was observed that the shift in the A. japonicus physiological state from normal to dormancy was a chronic rather than acute process, indicated by the gradual depression of metabolic rate. While metabolic rates declined 44.9% for the estivation group and 71.7% for the hibernation group, relative to initial rates, during the 36 d culture period, metabolic rates were not maintained at constant levels during these states. The metabolic depression processes for sea cucumbers in hibernation and estivation appeared to be a passive and an active metabolic suppression, respectively. In contrast, the metabolic rates （128.904-11.70 μg/g h） of estivating sea cucumbers were notably higher （107.85±6.31 μg/gh） than in starving sea cucumbers at 17℃, which indicated that the dormancy mechanism here, as a physiological inhibition, was not as efficient as in higher animals. Finally, the principle metabolic substrate or energy source of sea cucumbers in hibernation was lipid, whereas in estivation they mainly consumed protein in the early times and both protein and lipid thereafter.

Possible Factors Involved in Oral Inactivity of Meropenem, a Carbapenem Antibiotic

Meropenem, a carbapenem antibiotic, is inactive after oral administration and administered exclusively by injection. In this study, in order to address the factors involved in the oral inactivity of meropenem, in vitro permeation characteristics across rat ileal segments was investigated using diffusion cells. Moreover, stability of meropenem was evaluated in the Japanese Pharmacopoeia (JP) 1st and 2nd fluid for disintegration test. Cefotaxime, ceftibuten, and faropenem were used for comparison. The permeation of meropenem across rat ileal segments was approximately 5-fold greater in secretory direction than in absorptive direction. The secretory-oriented transport of meropenem markedly diminished by replacement of D-glucose in the experimental medium with unmetabolizing 3-O-methyl-D-glucose, suggesting that the secretory transport of meropenem was an energy-dependent process. Cefotaxime exhibited extensively secretory-oriented permeation. On the other hand, much weaker directionalities were observed in ceftibuten and faropenem. While meropenem as well as other three β-lactam antibiotics was stable in JP 2nd fluid (pH 6.8), it declined rapidly in JP 1st fluid (pH 1.2). These results suggest that, in addition to the hydrophilic property of meropenem, its instability at gastric pH and secretory transport in the small intestine are possible factors involved in the inactivity of meropenem after oral administration.

Predictive value of blood concentration of biologics on endoscopic inactivity in inflammatory bowel disease:A systematic review

BACKGROUND Although blood concentration of biologics is an important composition of disease management in inflammatory bowel disease(IBD)patients,complexity and uncertainty of biological management encourage many disputes in predicting the outcome of IBD patients through blood concentration of biologics.AIM To verify the predictive value of blood concentration of biologics on endoscopic inactivity in IBD patients under different situations.METHODS We searched PubMed/MEDLINE,Embase,and Web of Science up to May 2020 and identified IBD patients as the research cohort as well as the correlations between blood concentration of biologics and endoscopic inactivity in IBD patients as the research direction.RESULTS A total of 23 articles with 30 clinical studies and 1939 IBD patients were included.The predictive cut-off value of blood concentration of infliximab on mucosal healing should be 2.7-10.6μg/mL in IBD.Blood concentration of infliximab reaching 5.0-12.7μg/mL or more increased the probability of fistula healing/closure in perianal fistulizing Crohn's disease.Blood concentration of adalimumab reaching 7.2-16.2μg/mL or more could predict mucosal healing in IBD.The predictive cut-off value of blood concentration of adalimumab on fistula healing/closure should be 5.9-9.8μg/mL in perianal fistulizing Crohn's disease.Blood concentration of vedolizumab surpassing 25.0μg/mL indicated mucosal healing in ulcerative colitis patients under maintenance therapy and the predictive cut-off value of blood concentration on mucosal healing or endoscopic remission under induction therapy in IBD could be 8.0-28.9μg/mL.CONCLUSION Blood concentration of biologics should not be utilized to predict endoscopic inactivity of IBD independently due to discrepancies in clinical studies,whereas conducting therapeutic drug monitoring intensively contributes to precise therapy.

The financial burden of physical inactivity

According to the World Health Organization,"physical inactivity has been identified as the fourth leading risk factor for global mortality causing an estimated 3.2 million (annual)deaths globally.”1 In the Research Highlight of the first issue of this journal,I reviewed the evidence which supports the notion that physical inactivity can cost lives,in terms of longevity and quality of life,especially in the last few years of our lives.2 Here,I would like to review the literature that reveals the financial burden due to physical inactivity.

Addressing the public health concerns of physical inactivity, low levels of fitness, and unhealthy weight among Chinese school-aged children

In China, sports and physical activity （PA） have tradition- ally been an integral part of school curricula to promote fitness and enhance healthy growth among children and ado- lescents. Three decades of economic reforms, however, have brought major changes in social, economic.

Relationship between Physical Inactivity and Long-term Outcome in Patients Aged ≥80 Years with Acute Coronary Syndrome

Physical inactivity is very common in octogenarians.However,association between physical inactivity and mortality in octogenarians with acute coronary syndrome(ACS)remains unclear.In this study,we aimed to investigate association between physical inactivity and allcause mortality in octogenarian patients with ACS.In this study,we included a total of 353 hospitalized patients,aged≥80 years,with ACS during the period of 5-year follow-up.The association between physical inactivity and all-cause mortality was analyzed by multivariable Cox aggression.Of the enrolled patients,132(37.4%)were defined as physically inactive,and 221(62.6%)as physically active.Patients with physical inactivity tended to have lower survival rate(21.2%vs.56.5%,P〈0.001)and higher mortality rate(78.8%vs.43.5%,P〈0.001),and had a worse long-term outcome than those with physical activity(chi-square=27.52,and log rank P〈0.001).The physical inactivity was still an independent predictor for long-term allcause mortality independent of confounders including age,prior heart failure,stroke,ejection fraction,beta-blocker,clopidogrel and percutaneous coronary intervention(HR:2.35,95%CI:1.26–4.37,P=0.007).Our study demonstrates that physical inactivity is independently related to increased all-cause mortality in octogenarians with ACS.

COVID-19 risk comorbidities:Time to reappraise our physical inactivity habits(again!)

Infection and mortality rates of coronavirus disease 2019(COVID-19)are astonishing.As of September 7,2020,more than 27 million people around the world have already been infected,with more than 890 thousand deaths.Hypertension,diabetes,and obesity are among the most reported comorbidities associated with mortality by this disease.All these comorbidities are also strongly associated with physical inactivity and sedentary behavior.On the other hand,it is known that aerobic and resistive exercises are excellent tools to prevent and manage these comorbidities.Hence,physically active people may have a better prognosis if infected by COVID-19.Also,science tried to warn about mortality and morbidity associated to physical inactivity more than 80 years ago.However,physical inactivity habits are getting more prevalent around the world.Reasons for that include social,technology,and economic development that led to large industrialization and urbanization.Along with these changes,both professional and domestic activities became less active.Consequently,health care costs related to hypokinesis are estimated to increase exponentially in various regions of the planet.Now,while facing COVID-19 pandemic,it is time to reinforce the physiological,social,and economic relevance of regular physical exercise.Therefore,urgent reappraisal of our physical inactivity habits should be done,again!

失活X染色体基因逃逸与系统性红斑狼疮的性别二态性

X染色体失活可平衡女性中两条X染色体的基因剂量。越来越多的证据表明,失活X染色体上存在许多能够逃逸失活的基因。逃逸的机制涉及到DNA、RNA、组蛋白的表观修饰以及众多的调控蛋白和染色质的空间结构。失活X染色体基因逃逸的研究为人类疾病(特别是自身免疫性疾病)性别二态性的研究开辟了新的途径。目前已证实包括TLR7、CD40L、IRAK-1、CXCR3、CXorf21等失活X染色体基因逃逸是系统性红斑狼疮(systemic lupus erythematosus,SLE)女性好发的重要原因。本文主要综述了失活X染色体上基因逃逸以及与SLE性别二态性形成的分子机制。阐明SLE性别二态性形成的分子机制,不仅对疾病的诊断、治疗具有重要意义,而且对深入揭示人类免疫系统的发育及调控机理也有重要的理论意义。

高糖环境下XIST对人视网膜血管内皮细胞凋亡的影响

目的:探讨高糖环境下长链非编码RNA X-非活性特异转录本(XIST)对人视网膜血管内皮细胞凋亡的影响及可能机制。方法:以人视网膜血管内皮细胞为研究对象,设对照组和高糖组,分析高糖对人视网膜血管内皮细胞XIST表达的影响;设对照组、高糖组、高糖+XIST组、高糖+阴性对照组,分析过表达XIST对高糖诱导人视网膜血管内皮细胞增殖和凋亡的影响;设对照组、高糖组、高糖+XIST组、高糖+XIST+pcDNA3.1-Wnt1组、高糖+XIST+pcDNA3.1-CON组,分析XIST通过Wnt1/β-catenin通路对高糖诱导人视网膜血管内皮细胞增殖和凋亡的影响。结果:(1)高糖组XIST相对表达量较对照组低(P<0.05)。(2)与对照组比,高糖组细胞增殖活力低,而凋亡率、Wnt1和β-catenin水平高(P<0.05);与高糖+阴性对照组比,高糖+XIST组增殖活力高,而凋亡率、Wnt1和β-catenin水平低(P<0.05)。(3)与对照组比,高糖组细胞增殖活力低,而凋亡率高(P<0.05);与高糖组比,高糖+XIST组增殖活力高,而凋亡率低(P<0.05);与高糖+XIST+pcDNA3.1-CON组比,高糖+XIST+pcDNA3.1-Wnt1组增殖活力低,而凋亡率高(P<0.05)。结论:XIST通过负调控Wnt1/β-catenin通路抑制高糖诱导的人视网膜血管内皮细胞凋亡。

血清miR-98-5p、LncRNA XIST在急性呼吸窘迫综合征患儿中与疾病严重程度、预后的关系

目的:检测急性呼吸窘迫综合征(ARDS)患儿血清中微小RNA(miR)-98-5p、长链非编码RNA(LncRNA)X染色体失活特异性转录因子(XIST)表达情况,并探究二者与疾病严重程度、预后的关系。方法:收集86例ARDS患儿为研究对象(研究组),同期健康体检儿童90名设为对照(对照组),参考柏林(2012年)ARDS病情严重程度诊断标准中动脉血氧分压/吸入氧浓度将ARDS患儿分为轻度组、中度组、重度组;另根据ARDS患儿28 d生存状况分为存活组和死亡组。实时荧光定量PCR(RT-PCR)法检测血清miR-98-5p、LncRNA XIST水平,绘制受试者工作特性(ROC)曲线分析血清中miR-98-5p、LncRNA XIST水平对ARDS患儿预后不良的预测价值;Kaplan-Meier生存曲线分析血清miR-98-5p、LncRNA XIST水平与ARDS患儿预后的关系;Pearson分析ARDS患儿血清中miR-98-5p与LncRNA XIST的相关性。结果:与对照组相比,研究组血清中miR-98-5p水平降低(P<0.01),LncRNA XIST水平升高(P<0.01)。与轻度组相比,中度组、重度组血清中miR-98-5p水平降低(P<0.05),LncRNA XIST水平升高(P<0.05);与中度组相比,重度组血清中miR-98-5p水平降低(P<0.05),LncRNA XIST水平升高(P<0.05)。与存活组相比,死亡组血清中miR-98-5p水平降低(P<0.01),LncRNA XIST水平升高(P<0.01)。ROC曲线显示,血清中miR-98-5p、LncRNA XIST水平预测ARDS患儿预后不良的ROC曲线下面积分别为0.771、0.764,截断值分别为0.54、1.97,其敏感性分别为76.1%、86.9%,特异性分别为73.7%、52.6%;血清中miR-98-5p联合LncRNA XIST预测ARDS患儿预后不良的ROC曲线下面积为0.888,其敏感性为77.6%、特异性为94.7%。miR-98-5p高表达者存活率35.14%高于低表达者12.24%(P<0.05),LncRNA XIST高表达存活率12.73%低于低表达者38.71%(P<0.01)。Pearson分析发现ARDS患儿血清中miR-98-5p与LncRNA XIST呈负相关关系(r=-0.411,P<0.05)。Starbase3.0预测发现LncRNA XIST与miR-98-5p存在结合位点。结论:ARDS患儿血清中miR-98-5p水平降低、LncRNA XIST水平升高,二者均与疾病严重程度、预后关系密切,且二者呈显著负相关,有望用于评估ARDS疾病严重程度、预后。