The Claimed Revolution to Understand Consciousness:Information Plays the Driving/Essential Role for the Structuration and Behavior of the Living Organisms

A prestigious conference claimed recently a revolution in neuroscience to understand consciousness.In this paper it is shown that this revolution already came,revealing the determinant role of information for human and living structures,both for their structuration and behavior,explaining consciousness at human as the result of the activity of the Informational System of Human and Living Structures.For this,it is emphasized and discussed the informational structure of the eukaryotic cell,the basic/representative composing unit of the multicellular body of human,animals,and plants,showing that the composition and functions of the informational system are basically similar with that of human.To reveal the driving role of informational mechanisms in human and subhuman organisms,it is introduced the concept of matter-related information,showing that information can be hidden/“embodied”or released/“disembodied”in or from the elemental micro/macro components of the body,during the multiple chain/cascade interactions including transduction processes.It is shown that such interactions are initiated from two main categories of informational sources:implicit(genetic)and explicit(external/internal)sources,the first category leading to structuration of the body and the second the reactive behavior.Consciousness in human and subhuman organisms,expressed by two corresponding informational relations,is the result of the release of information by the mind,acting as an informational operator/device,the development degree of mind and consciousness depending on the complexity degree and adaptation.An analogy of this Informational Model of Human and Living Structures(IMHLS)with the ancient model of chakras is highlighted,showing that these models support each other,applied with beneficial effects in Reiki technique and music-based cognitive multi-task therapy for neuro-rehabilitation.

Maternal and fetal death associated with acute pancreatitis during pregnancy:A case report

BACKGROUND Acute pancreatitis in pregnancy is a rare but serious condition that can lead to high maternal mortality and fetal loss.Instances of pregnancy complicated by severe acute pancreatitis,particularly with subsequent respiratory and cardiac arrest,are rarely reported.CASE SUMMARY We present the case of a 35-year-old woman,at 36+5 weeks of gestation,who presented with paroxysmal epigastric pain accompanied by low back pain,nausea,and vomiting.According to the clinical symptoms,B-ultrasound imaging and biochemical indicators,the patient was diagnosed with acute pancreatitis and initially managed conservatively.However,3 hours after admission,the patient experienced respiratory and cardiac arrest,and the fetus died.In this case,the adverse outcomes occurred due to the lack of aggressive fluid resuscitation and an active surgical intervention.CONCLUSION Implementing aggressive fluid resuscitation to sustain tissue perfusion,alongside the proactive evaluation of pharmacological agents that suppress gastric acid secretion and inhibit pancreatic enzyme activity,may be beneficial in mitigating the risk of a severely adverse prognosis.Effective management of acute pancreatitis during pregnancy requires careful timing of surgical intervention,a thorough evaluation of the risks and benefits regarding the continuation or termination of pregnancy,and a focus on safeguarding both maternal and fetal health.

Consciousness and Near-Death Experiences: Access to a Known World

Near-death or death-like experiences are a natural, albeit uncommon, phenomenon due to the temporary and reversible decoupling or dissociation of the Psychosoma from its material counterpart, the physical body. Indeed, these “psychophysical events” are fundamental in clinical conditions that lead to unconsciousness in individuals declared clinically dead or who have come very close to physical death. In addition, Consciousness is fundamental in the occurrence of these experiences. In fact, Consciousness, a higher order field, is the entity that vibrationally dissociates from the physical body and is also the protagonist of the entire chain of events of near-death experiences, as well as out-of-body experiences. Undoubtedly, matter is a creation of the Universal Intelligent Principle and the primary cause of all things. Thus, Consciousness is the basis of all existence, of primordial reality. Vehicle of manifestation of Consciousness, the Psychosoma is a morphogenetic, vaporous, translucent, luminous body which is also made up of all organs, including the immaterial brain [mind] and the other electromagnetic systems of the human body. The Psychosoma is, therefore, the connection bridge between Consciousness, a complex subtle field, non-electromagnetic, responsible for all phenomena of near-death experiences in connection with the dense field of gross matter, the physical body. For example, the Consciousness is the one who sees, feels pain and welcomes its family members on the verge of death during the near-death experience in any vibrational dimension, even being perceived by the Psychosoma. Here it is important to remember that dimension is not a place. It’s a vibration. It’s a frequency. The main objective of this article is to approach innovative and comprehensive concepts about the role of Consciousness in near-death experiences as well as to try to overcome limiting paradigms that prevents the progress of science. In addition, concepts based on quantum holography and information theory were raised here. Following this reasoning, I start with the formulation of a hypothesis about the role of Consciousness in near-death and out-of-body experiences. Thus, we propose a new and unique approach to Consciousness in order to investigate the role of Mind and its relationship with life and death. In this way, we intend to introduce new concepts for discussion and not give the last word to the currently unanswered questions of Consciousness regarding its interaction with the environment;with death and life and finally with respect to its origin. Finally, a selective bibliographic research was carried out in English language databases with the purpose of making the study design compatible, which presents specific concepts of a subject that had been little studied until then.

The Development of Frederic Henry's Death Consciousness and the Related Reasons in A Farewell to Arms

Frederic Henry,the hero in Ernest Hemingway's novel A Farewell to Arms,demonstrates the author's dominant motif of a man who is forced to recognize the inevitability of death and the futility of trying to escape from it.This essay divides the development of Frederic Henry's death consciousness into three stages and analyzes his psychological features of each stage.

Programmed cell death 1 inhibitor sintilimab plus S-1 and gemcitabine for liver metastatic pancreatic ductal adenocarcinoma

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly aggressive cancer with poor prognosis.When it metastasizes to the liver,treatment options become particularly limited and challenging.Current treatment options for liver metastatic PDAC are limited,and chemotherapy alone often proves insufficient.Immunotherapy,particularly programmed cell death 1(PD-1)inhibitors like sintilimab,shows potential efficacy for various cancers but has limited reports on PDAC.This study compares the efficacy and safety of sintilimab plus S-1 and gemcitabine vs S-1 and gemcitabine alone in liver metastatic PDAC.AIM To explore the feasibility and effectiveness of combined PD-1 inhibitor sintilimab and S-1 and gemcitabine(combination group)vs S-1 and gemcitabine used alone(chemotherapy group)for treating liver metastatic pancreatic adenocarcinoma.METHODS Eligible patients were those with only liver metastatic PDAC,an Eastern Cooperative Oncology Group performance status of 0-1,adequate organ and marrow functions,and no prior anticancer therapy.Participants in the combination group received intravenous sintilimab 200 mg every 3 weeks,oral S-140 mg/m²twice daily on days 1-14 of a 21-day cycle,and intravenous gemcitabine 1000 mg/m²on days 1 and 8 of the same cycle for up to eight cycles or until disease progression,death,or unacceptable toxicity.Participants in the chemotherapy group received oral S-140 mg/m²twice daily on days 1-14 of a 21-day cycle and intravenous gemcitabine 1000 mg/m²on days 1 and 8 of the same cycle for up to eight cycles.Between June 2020 and December 2021,66 participants were enrolled,with 32 receiving the combination treatment and 34 receiving chemotherapy alone.RESULTS The group receiving the combined therapy exhibited a markedly prolonged median overall survival(18.8 months compared to 10.3 months,P<0.05)and progression-free survival(9.6 months vs 5.4 months,P<0.05).compared to the chemotherapy group.The incidence of severe adverse events did not differ significantly between the two groups(P>0.05).CONCLUSION The combination of PD-1 inhibitor sintilimab with S-1 and gemcitabine demonstrated effectiveness and safety for treating liver metastatic PDAC,meriting further investigation.

The Axiology of Consciousness in Mocombeian Consciousness Field Theory

This work explores the axiology of consciousness in Mocombe’s consciousness field in the material world.The paper critically assesses Mocombe’s consciousness field theory(CFT)within the larger body of contemporary ontological debates regarding the nature,origin,and constitution of consciousness in the universe.The work goes on to highlight the manifestation of Mocombe’s consciousness field in the material resource framework that is the earth,and the nature and origins of ethics and values.

Interleukin-17A facilitates tumor progression via upregulating programmed death ligand-1 expression in hepatocellular carcinoma

BACKGROUND Hepatocellular carcinoma(HCC)is an inflammation-associated tumor with a dismal prognosis.Immunotherapy has become an important treatment strategy for HCC,as immunity is closely related to inflammation in the tumor microenvir-onment.Inflammation regulates the expression of programmed death ligand-1(PD-L1)in the immunosuppressive tumor microenvironment and affects im-munotherapy efficacy.Interleukin-17A(IL-17A)is involved in the remodeling of the tumor microenvironment and plays a protumor or antitumor role in different tumors.We hypothesized that IL-17A participates in tumor progression by affe-cting the level of immune checkpoint molecules in HCC.The upregulation of PD-L1 expression in HCC cells by IL-17A was assessed by reverse transcription PCR,western blotting,and flow cytometry.Mechanistic studies were conducted with gene knockout models and pathway inhibitors.The function of IL-17A in immune evasion was explored through coculture of T cells and HCC cells.The effects of IL-17A on the malignant biological behaviors of HCC cells were evaluated in vitro,and the antitumor effects of an IL-17A inhibitor and its synergistic effects with a PD-L1 inhibitor were studied in vivo.RESULTS IL-17A upregulated PD-L1 expression in HCC cells in a dose-dependent manner,whereas IL-17A receptor knockout or treatment with a small mothers against decapentaplegic 2 inhibitor diminished the PD-L1 expression induced by IL-17A.IL-17A enhanced the survival of HCC cells in the coculture system.IL-17A increased the viability,G2/M ratio,and migration of HCC cells and decreased the apoptotic index.Cyclin D1,VEGF,MMP9,and Bcl-1 expression increased after IL-17A treatment,whereas BAX expression decreased.The combination of IL-17A and PD-L1 inhibitors showed synergistic antitumor efficacy and increased cluster of differentiation 8+T lymphocyte infiltration in an HCC mouse model.CONCLUSION IL-17A upregulates PD-L1 expression via the IL-17A receptor/phosphorylation-small mothers against decapenta-plegic 2 signaling pathway in HCC cells.Blocking IL-17A enhances the therapeutic efficacy of PD-L1 antibodies in HCC in vivo.

Analysis of Commuting Modal Shift in Consideration of Social Interaction of Consciousness for Environment

It is the matter for achievement of the low carbon transport system that the excessive use of private vehicles can be controlled appropriately.Not only improvement of service level of modes except private vehicle,but also consciousness for environmental problem of individual trip maker is important for eco-commuting promotion.On the other hand,consciousness for environment would be changed by influence of other person.Accordingly,it is aimed in the study that the structure of decision-making process for modal shift to the eco-commuting mode in the local city is described considering environmental consciousness and social interaction.For the purpose,the consciousness for the environment problem and the travel behavior of the commuter at the suburban area in the local city are investigated by the questionnaire survey.The covariance structure about the eco-consciousness is analyzed with the database of the questionnaire survey by structural equation modeling.As the result,it can be confirmed with the structural equation model that the individual environmental consciousness is strongly related with the intention of self-sacrifice and is influenced with the local interaction of the individual connections.On the other hand,the intention of modal shift for the commuting mode is analyzed with the database of the questionnaire survey.It can be found out that the environmental consciousness is not statistically significant for commuting mode choice with the present poor level of service of public transport.However,the intention of self-sacrifice for the prevention of the global warming is statistically confirmed as the factor of modal shift with the operation of eco-commuting bus service with the RP/SP integrated estimation method.As the result,the multi-agent simulation system with social interaction model for eco consciousness is developed to measure the effect of the eco-commuting promotion.For the purpose,the carbon dioxide emission is estimated based on traffic demand and road network condition in the traffic environment model.On the other hand,the relation between agents is defined based on the small world network.The proposed multi-agent simulation is applied to measure the effect of the eco-commuting promotion such as improvement of level of service on the public transport or education of eco-consciousness.The effect of the promotion plan can be observed with the proposed multi-agent system.Finally,it can be concluded that the proposed multi-agent simulation with social interaction for eco-consciousness is useful for planning of eco-commuting promotion.

Analysis The Manifestation of The Stream of Consciousness Technique in The Novel Death of A Salesman

Death of A Salesman is the representative works,of the famous American playwright Arthur Miller(Arthur Miller,1915-2005).It is one of the most influential drama scripts in the history of American.This paper analyzes the performance of stream of consciousness,based on the stream of consciousness by way of analysis,layer by layer to reveal the theme of performance and realism in the novel Death of A Salesman,and deepen the meaning the author wants to express in the aspect of the art effect.

Glaucomatous retinal ganglion cells:death and protection

Glaucoma is a group of diseases characterized by progressive optic nerve degeneration,with the characteristic pathological change being death of retinal ganglion cells(RGCs),which ultimately causes visual field loss and irreversible blindness.Elevated intraocular pressure(IOP)remains the most important risk factor for glaucoma,but the exact mechanism responsible for the death of RGCs is currently unknown.Neurotrophic factor deficiency,impaired mitochondrial structure and function,disrupted axonal transport,disturbed Ca2+homeostasis,and activation of apoptotic and autophagic pathways play important roles in RGC death in glaucoma.This review was conducted using Web of Science,PubMed,Project,and other databases to summarize the relevant mechanisms of death of RGCs in glaucoma,in addition to outlining protective treatments to improve the degradation of RGCs.

Programmed cell death receptor 1 inhibitor Pembrolizumab in the treatment of advanced gastric cancer

This editorial discusses Christodoulidis et al's article,which appeared in the most recent edition.The clinical trials have demonstrated the programmed cell death receptor 1(PD-1)inhibitor Pembrolizumab involved combination therapy can improve the efficacy of advanced gastric cancer(AGC).Pembrolizumab combined with chemotherapy can enhance its sensitivity,and further eliminate tumor cells that develop resistance to chemotherapy.The combination of Pembrolizumab and Trastuzumab targeting human epidermal growth factor receptor 2 showed improved prognosis.The overall toxic effects of Pembrolizumab are significantly lower than traditional chemotherapy,and the safety is controllable.PD-1 inhibitor Pembrolizumab sheds a light on the treatment of AGC and brings new hope to the clinical practice.

Consciousness—raising教学法对高职高专非英语专业教学研究

随着社会经济的高速发展，人们对于教育投入更多的目光，尤其是在高职高专非英语专业的教学过程当中，借助于Consciousness—raising教学法的使用，往往能够获得比较良好的效果，文章对于这一课题的研究，对于相关课题的研究有着一定的借鉴意义。

The Psychological Base of Stream of Consciousness:Explained through Ulysses

This article aims to study the psychological base of the stream of consciousness through an analysis of William James' principles and Freud's theories.

Vladimir Nabokov's Political Consciousness

This study consists of three parts. PartⅠ, entitled ' Nabokov’ s Women,' concentrates on the analysis of Nabokov’ s major women identities of different types. My purpose is to demonstrate that in his creation of the women characters, Nabokov’ s political consciousness—mainly his vindication of individual freedom—is unmistakably, although indirectly, exemplified. Due to the different types of women discussed in this study, and also due to the different aspect of his political consciousness that is emphasized in different women identities, this part is subdivided into three chapters. Chapter One, entitled 'Women in the Triangle: Martha and Margot,' focuses on the two women characters in Nabokov’ s early novels. King, Queen, Knave and Laughter in the Dark, aiming to provide an in-depth analysis of the two, and to show that Nabokov has be stowed his special purpose on the creation of Martha and Margot, that is, his condemnation on those who reduce the free and active individual into objects, and such condemnation echoing with Nabokov’ s later direct vindication of individual freedom. Chapter Two, entitled 'The Eternal Feminine:Lolita and Ada,' analyzes the two title characters in Lolita and Ada, or Ardor:A Family Chronicle, illustrating that Lolita is the victim in that her free consciousness is purposefully neglected by the other, man in that case;while Ada enjoys her life totally because she can conduct her free consciousness in her own life. Chapter Three, entitled ' Other Types and Women in His Mind’ s Eye,' deals with Elisabeth, another woman character in Laughter in the Dark, who is a good traditional wife, and Liza, ex-wife of Pnin in Pnin, who is what Nabokov terms as poshlost. In addition, this chapter also provides an examination of Nabokov’ s attitude toward women. Through this analysis, Nabokov’ s Russian Complex is to a degree illustrated.

A Woman Who Refused to Be Tamed——An Analysis on Female Consciousness of Jane Eyre

Jane Eyre,rebellious woman in the Victorian Age,holds her remarkable status in the English literature as the one who dare to fight against the patriarchal society.Unlike her contemporaries,Jane Eyre believes that men and women are born to be equal and women should never be tamed by the male-centered world or feminist ego.Under the tremendous pressure,she still guards her own dignity and determines to achieve self-actualization instead of being an accessory of men.It’s her female consciousness that lead her to be an unusual figure that enjoys both the financial self-reliance and social equality.Self-respect,selfreliance and self-actualization comprise Jane’s female consciousness that is instructive to women and worths a further exploration.

Reflective Consciousness of Teaching and Learning on English Curriculum in Higher Vocational Colleges

In English classroom of higher vocational colleges,there exist two essential factors:teachers'reflective consciousness and students'reflective consciousness.The former is teachers'awareness of learning activities and effect,and it contains the teacher's reflections on the classroom practice,the presentation of learning tasks,the participation of students and the interaction between teachers and students in the classroom.The latter refers to students'awareness of self-improvement and the growing process.It focuses on the self-realization of students and their professional ability,method ability and social ability.The two factors are interactive to each other;in the interaction,the former is dominated,and the latter is strongly influenced;through the interaction,a harmonious classroom is constructed so as to achieve the effective teaching.

Time and Consciousness in T.S Eliot's The Love Song of J.Alfred Prufrock

The relationship between time and consciousness is what T.S.Eliot concerns much in his early modernist poem The love song of J.Alfred Prufrock.This paper is an analysis of the way Eliot employs the stream of consciousness technique to create a typical Western modern man who suffers greatly from meaningless life and spiritual crisis.

The Growth of Scarlett's Consciousness of Feminism in Gone with the Wind

Most feminist analyses of Scarlett in Gone with the Wind are concerned with how feminism is reflected in Scarlett's personality,while this research pays attention to how her feminist consciousness grow through three stages.

Cultivation of Innovation Consciousness in English Graduation Thesis

This paper starts with the analysis of the lack of students'innovation consciousness in the topic selection,and aims to improve the teachers cultivation of students innovation consciousness in the process of students topic selection.Five guidelines:guide students to bring forth new ideas in“minor topic selection”,combine with the practical situation of the major,seek for innovation in the intersection of multiple disciplines,seek for innovation in previous research problems and seek for innovation in problem discussion.

Neuroimaging characterization of recovery of impaired consciousness in patients with disorders of consciousness

Elucidation of critical brain areas or structures that are responsible for recovery of impaired consciousness in patients with disorders of consciousness is important because it can provide information that is useful when developing therapeutic strategies for neurorehabilitation or neurointervention in patients with disorders of consciousness.In this review,studies that have demonstrated brain changes during recovery of impaired consciousness were reviewed.These studies used positron emission tomography,electroencephalography/transcranial magnetic stimulation,diffusion tensor tractography,and diffusion tensor tractography/electroencephalography.The majority of these studies reported on the importance of supratentorial areas or structures in the recovery of impaired consciousness.The important brain areas or structures that were identified were the prefrontal cortex,basal forebrain,anterior cingulate cortex,and parietal cortex.These results have a clinically important implication that these brain areas or structures can be target areas for neurorehabilitation or neurointervention in patients with disorders of consciousness.However,most of studies were case reports;therefore,further original studies involving larger numbers of patients with disorders of consciousness are warranted.In addition,more detailed information on the brain areas or structures that are relevant to the recovery of impaired consciousness is needed.