Interpersonal distances, coping strategies and psychopathology in patients with depression and schizophrenia

AIM: To explore(1) intergroup differences in comfortable interpersonal distances(CIDs) and the use of coping strategies;(2) the association of these parameters with individual symptomatology; and(3) the interplay between CIDs and coping styles in patients with depression and schizophrenia. METHODS: The parameters of interest were assessed by means of standardized questionnaires: CID and Coping Inventory for Stressful Situations. Psychopathology was evaluated with the Beck Depression Inventory and Positive and Negative Syndromes Scale. ANOVA, Pearson's correlations and multiple regression analyses were used to examine relationships among the variables.RESULTS: Compared with controls, depressed patients were more distanced from family members, significant others and self-images, whereas patients with schizophrenia were less distanced from neutral and threatrelated stimuli. Distancing from self-images was mostly associated with depression severity in depressed patients, whereas distancing from hostile and threat-related stimuli with the severity of psychotic and affective symptoms in patients with schizophrenia. Both patient groups used more emotion-oriented than task-oriented and avoidance-oriented coping strategies. Self-distancing among patients with schizophrenia was positively associated with the use of the social diversion coping, implying social support seeking. CONCLUSION: Patients with depression and schizophrenia use different maladaptive emotion- regulation strategies to cope with their symptoms and related distress. Training in stress management might provide these patients with skills for more effective emotion regulation.

Study on Distance Learning Support Services Strategy Based on Effective Interaction

Achieving effective interaction can the students get good learning results,and enhance the quality of distance learning.The paper firstly analyzes the research on distance learning support services and the problems of distance learning interaction in order to clarify the significance of implementing effective interaction.Then it puts forward the learning support services strategies based on effective interaction,which means to promote distance learning interaction and enhance the students'self-learning ability.

Study on the Strategies of Distance Learning Support Services Based on Effective Interaction

The paper firstly analyzes the problems of distance learning interaction in order to clarify the significance of implementing effective interaction.Then it puts forward the learning support services strategies based on effective interaction,which means to design strategies from the perspective of effective interaction to improve the effect of distance learning.

Survey of coverage,strategy and cost of hepatitis B vaccination in rural and urban areas of China

AIM In order to understand the coverage, immunization strategy and cost of hepatitis B (HB) vaccination of China in recent years. METHODS A two stage household random sampling method was used in the survey. RESULTS The survey carried out at 112 Disease Surveillance Points (DSPs) of 25 provinces, autonomous regions and municipalities of China in 1996, showed that the coverage rates of HB vaccination among neonates were 96 9% in the urban DSPs and 50 8% in the rural DSPs in 1993-1994, while in students aged 7-9 years, they were 85 8% and 31 5% in 1994, respectively. Up to 1994, 97 5% of the urban DSPs and 73 9% of the rural DSPs on a neonate vaccination against HB program were included in EPI. About 93% of the urban DSPs and 44% of the rural DSPs did HBsAg and HBeAg screening for all or part of pregnant women. The neonates received the regimen of high dose HB vaccine in combination with hepatitis B immune globin (HBIG) if their mothers were HBsAg and/or HBeAg positive in pregnancy, otherwise they received the low dose vaccine (10μg×3). Part of DSPs had a lower neonate coverage due to unreasonable allocation of the vaccines (used for adults not at risk) or higher cost or insufficient supply of the vaccines. It is necessary to evaluate the quality of serological lab test to HBVMs in the maternal prescreening. CONCLUSION Remarkable achievements have been made according to the national planning and policy of HB immunization in China.

Optimal Vaccination Strategies in an SIR Epidemic Model with Time Scales

Childhood related diseases such as measles are characterised by short periodic outbreaks lasting about 2 weeks. This means therefore that the timescale at which such diseases operate is much shorter than the time scale of the human population dynamics. We analyse a compartmental model of the SIR type with periodic coefficients and different time scales for 1) disease dynamics and 2) human population dynamics. Interest is to determine the optimal vaccination strategy for such diseases. In a model with time scales, Singular Perturbation theory is used to determine stability condition for the disease free state. The stability condition is here referred to as instantaneous stability condition, and implies vaccination is done only when an instantaneous threshold condition is met. We make a comparison of disease control using the instantaneous condition to two other scenarios: one where vaccination is done constantly over time (constant vaccination strategy) and another where vaccination is done when a periodic threshold condition is satisfied (orbital stability from Floquet theory). Results show that when time scales of the disease and human population match, we see a difference in the performance of the vaccination strategies and above all, both the two threshold strategies outperform a constant vaccination strategy.

Distribution of Miss Distance for Pursuit-Evasion Problem

Miss distance is a critical parameter of assessing the performance for highly maneuvering targets interception(HMTI). In a realistic terminal guidance system, the control of pursuer depends on the estimate of unknown state, thus the miss distance becomes a random variable with a prior unknown distribution. Currently, such a distribution is mainly evaluated by the method of Monte Carlo simulation. In this paper, by integrating the estimation error model of zero-effort miss distance(ZEM) obtained by our previous work, an analytic method for solving the distribution of miss distance is proposed, in which the system is presumed to use a bang-bang control strategy. By comparing with the results of Monte Carlo simulations under four different types of disturbances(maneuvers), the correctness of the proposed method is validated. Results of this paper provide a powerful tool for the design, analysis and performance evaluation of guidance system.

Modeling and Analysis of COVID-19 Optimizated Vaccination Strategies with Age Structure

The rational and effective implementation of epidemic prevention and control measures is crucial to controlling the spread of COVID-19, and vaccination is a key part to be considered in the development of epidemic prevention and control strategies. In order to give full play to the greater role of vaccination strategies in epidemic prevention and control, more accurate and efficient vaccination strategies should be explored. Based on the classical SEIR dynamic model, this paper established a COVID-19 dynamic model of population age structure in the form of population grouping and combined with the transmission characteristics of the COVID-19 epidemic. An optimization model with the goal of minimizing daily infection was established to analyze the optimization studies on infection-related specificity of vaccination for different age groups under the condition of limited daily vaccine supply at the early stage of the epidemic, and to obtain the priority of vaccination strategies for Chinese age groups. And the effect of the heterogeneity of infection rate and hospitalization rate on the priority of vaccine allocation.

Overcoming Challenges in COVID-19 Vaccination among Ethnic Minority Groups in Bangladesh: A Qualitative Exploration

This study aimed to explore the barriers affecting COVID-19 vaccine uptake among ethnic minorities and to propose strategies to strengthen government initiatives for inclusive vaccination. Grounded in social constructivism, this qualitative study was conducted in the greater Sylhet Division, where many ethnic communities live. Using purposive sampling, semi-structured interviews were conducted with 49 participants, including ethnic men and women, community leaders, and healthcare providers. Two focus group discussions (FGDs) were also conducted to ensure data validation, and the results were analyzed using thematic analysis, which revealed several factors, such as free vaccinations, media, close community-knit healthcare centers, informal communication that positively influenced vaccine uptake, such as awareness campaigns, informal communication, media involvement, and free vaccine availability. However, socio-economic and technological barriers pose significant challenges, including misconceptions about vaccines, limited access to technology, long distances to vaccination centers, inconvenient service hours, and reliance on traditional medicine. To promote inclusive vaccination, the study recommends establishing localized vaccine camps, improving technological infrastructure such as the Internet and network access, enhancing communication strategies, providing special services for women, the elderly and disabled individuals, and ensuring a reliable vaccine supply. Future researchers could apply longitudinal studies, including a lager study area and broader range of participants to address the missing perspectives in the current study.

Toward innovative veterinary nanoparticle vaccines

Nanoparticles are significant for veterinary vaccine development because they are safer and more effective than conventional formulations.One promising area of research involves self-assembled protein nanoparticles(SAPNs),which have shown potential for enhancing antigen-presenting cell uptake,B-cell activation,and lymph node trafficking.Numerous nanovaccines have been utilized in veterinary medicine,including natural self-assembled protein nanoparticles,rationally designed self-assembled protein nanoparticles,animal virus-derived nanoparticles,bacteriophagederived nanoparticles,and plant-derived nanoparticles,which will be discussed in this review.SAPN vaccines can produce robust cellular and humoral immune responses and have been shown to protect against various animal infectious diseases.This article attempts to summarize these diverse nanovaccine types and their recent research progress in the field of veterinary medicine.Furthermore,this paper highlights their disadvantages and methods for improving their immunogenicity.

Vaccination for solid organ transplanted patients:Recommendations,efficacy,and safety

Solid organ transplant recipients face unique challenges in managing their im-munosuppressed status,making vaccination a critical consideration.This review aimed to comprehensively analyze current recommendations,evaluate the effi-cacy of vaccinations in this population,and assess safety concerns.We explored the latest evidence on vaccine types,timing,and potential benefits for transplant patients,highlighting the importance of individualized approaches for routinely used vaccines as well as coronavirus disease 2019 vaccines.By synthesizing avai-lable data,this review underscored the pressing need to optimize vaccination strategies,ensuring that transplant recipients can obtain the full protection against many pathogens while minimizing risks associated with their post-transplant immunosuppression.

Research on optimal immunization strategies for hepatitis B in different endemic areas in China

INTRODUCTION At present hepatitis B vaccine immunization is an unique effective measure for controlling hepatitis B.It is important o determine optimal immunization

Treatment strategies for nodal and gastrointestinal follicular lymphoma:Current status and future development

In recent years,therapies for follicular lymphoma (FL) have steadily improved.A series of phase Ⅲ trials comparing the effect of rituximab with chemotherapy vs chemotherapy alone in treating FL have indicated significant improvements in progression-free survival (PFS) and overall survival.Recent studies have found that prolonged response durations and PFS were obtained with maintenance therapy using rituximab or interferon after completion of first line therapy.For patients with relapsed or refractory FL,phase Ⅱ studies have assessed the effectiveness of combination therapies using a Toll-like receptor-9 agonist (1018ISS),oblimersen sodium (a Bcl-2 antisense oligonucleotide),bendamustine,and rituximab,as well as veltuzumab,a new humanized anti-CD20 antibody,and epratuzumab.In addition,the effectiveness of yttrium-90 ibritumomab tiuxetan and iodine-131 tositumomab as radioimmunotherapies has been reported.Furthermore,three phase Ⅲ studies on an idiotype vaccine are near completion.Unfortunately,these vaccines,which appeared highly effective in phase Ⅰ and Ⅱ trials,do not appear to result in prolonged PFS.This report will summarize the current knowledge on therapies for treatment of FL,and will conclude with a brief discussion of feasiblefuture options for effective treatments.Lastly,we added descriptions of the management of gastrointestinal FL,which is considered to be controversial because it is rare.

Research on terminal maneuver strategy of anti-ship missiles

To design the terminal maneuver strategy of an anti-ship missile,first,the analytical solution of miss distance when an anti-ship missile has planar weaving maneuver and three-dimension spiral maneuver is presented,in which not only the amplitude and frequency are considered but also the initial phase is taken into account.Next,based on the analytical solution of miss distance,the effects on the miss distance of the amplitude,frequency,initial phase of the anti-ship missile＇s maneuver acceleration and the order of flight control system of the air-ship missile are analyzed.Finally,the optimum weaving maneuver and spiral maneuver which make the miss distance be the largest under some conditions are designed,which is of important meaning for increasing the survival probability of the anti-ship missile.

全球疫苗研发现状和展望

频繁暴发的新发突发传染病已成为影响人类公共卫生及健康的重要危险因素,目前接种疫苗依然是应对传染病最关键的手段。新型冠状病毒感染(COVID-19)疫情以来,无论是创新型疫苗基础技术还是疫苗研发策略均取得了革命性进展,以m RNA技术为代表的第三代疫苗技术逐渐成为一种新兴的疫苗研发方式。本文对近年来的不同疫苗技术特点进行全面梳理,综述了基于不同技术平台的重点疫苗产品的最新研究进展,并展望了未来疫苗研发策略,为疫苗研发工作提供经验和借鉴。

COVID-19 in patients with gastrointestinal stromal tumors: Recommendations for management and vaccination

The coronavirus disease 2019(COVID-19)pandemic profoundly affected the management and treatment of patients with malignancies.Based on the progress reported in the literature,we reviewed the recommendations for treatment and vaccination in patients with gastrointestinal stromal tumor(GIST)during COVID-19.We focus on whether there is a risk and what could be the possible effects of vaccinating patients with GIST/cancer.Since the situation is quickly changing,and the health services have been severely disrupted,the diagnosis,treatment and recommendations for vaccination of these patients against COVID-19 are still not updated.The approval of vaccines in the pandemic gave hope that we would soon be able to return to a more normal life.However,the oncology community needs to adapt and provide the most effective treatment and care models for patients with rare cancer,such as GIST.Collecting data on the impact of vaccination in patients with GIST/cancer also will be beneficial in expanding knowledge about the future planning of treatment strategies and optimizing care in the event of a subsequent pandemic.

当前成人在线教学的问题审视与优化策略及其远程教育学阐释

当前成人在线教学的教师没有明确转换教师角色与任务,常常只是将传统课堂搬迁到网络上,在线主体的心理距离因时空分离不断扩大,教师对在线教学的认知、行为与情感投入不够,强烈影响了学员的学习投入感、师生疏离感与教学成效。从远程教育学看,成人远程教育的关键是设计优秀在线课程并提供学习支持服务以实现三种交互,所以,成教的直播课、录播课、仿真技能课的有效实施都需利用对应的社交平台与工具平台设计课前课中课后的支持服务,依据布鲁姆教学目标的分类区别化设计成人在线教学策略,根据内容特征与学员情感需要设计多种混合式教学,利用平台记录的学习大数据及其画像,从交互距离与远程学员自治两个维度让师生获得动态、整全的及时诊断与警示。

治疗性HPV疫苗研究开发策略专家共识

人乳头瘤病毒(HPV)是双链DNA病毒,高危HPV感染易引发宫颈癌及癌前病变风险。近年来,已有超过400多种不同亚型的HPV被鉴定出,大多数HPV感染是无症状的,可以自行消退。免疫系统正常的女性,从感染高危HPV开始,通常需要15~20年才能发展为宫颈癌;但是对于免疫系统较弱的女性,如未经治疗的HIV感染女性(WLHIV),宫颈癌可能发展得更快(可能5~10年)。2006年,预防性HPV疫苗研发上市,但对已感染HPV或癌前病变患者无治疗效果。治疗性HPV疫苗的开发可为目前预防和治疗宫颈癌的方法提供重要的补充。与预防性HPV疫苗不同,治疗性疫苗旨在诱导特异性细胞免疫而非体液免疫(中和抗体),用于清除或治疗现有的HPV感染及其引起相关的癌前病变和侵袭性宫颈癌。因此,制定合理的治疗性HPV疫苗开发策略,不仅可以让治疗性HPV疫苗产品开发企业少走弯路,提高转化效率,而且可以使HPV感染及相关病变甚至癌变患者及早受益。本课题组织领域内专家学者,参考有关文件,结合HPV临床特点和发展背景,特别编撰了《治疗性HPV疫苗研究开发策略专家共识》,明确了适应范围、相关术语等,重点阐述了治疗性HPV疫苗临床开发方向、研究人群及特性和接种规划,旨在加快和推进治疗性HPV疫苗的研发,为社会研究开发治疗性HPV疫苗产品以及国家制定治疗性HPV疫苗相关政策提供借鉴和参考。

多策略改进的蜣螂搜索算法优化3DDV-Hop节点定位

为了提升传统3DDV-Hop算法的定位精度和稳定性,提出了MIDBO-3DDV-Hop算法。该算法利用多策略改进蜣螂搜索算法(multi strategy improvement dung beetle optimizer, MIDBO)来提高3DDV-Hop算法的定位精度。该算法通过通信半径分级方法细化跳数,使用加权平均跳距来修正节点之间的跳距误差。MIDBO算法引入立方混沌初始化和反向折射机制来初始化算法种群,采用变螺旋策略增强全局搜索能力。算法还融入Levy飞行策略和自适应权重因子,以避免陷入局部最优,并平衡算法的收敛性和搜索多样性。通过MIDBO算法对3DDV-Hop算法中未知节点位置进行优化。仿真结果显示,与传统的3DDV-Hop、IPSO-3DDV-Hop和IGA-3DDV-Hop算法相比,MIDBO-3DDV-Hop算法在定位精度、稳定性和收敛速度方面均达到最优水平。

城市职购出行距离的影响因素与优化对策研究——以武汉市为例

职购行为是城市居民重要的消费活动,对其特征及成因的理解有助于完善城市就业中心与商业中心的协调布局,丰富城市生活空间的理论认识。以武汉市为例,运用LBS位置服务数据、抽样调查数据、GIS空间分析与结构方程模型方法,测度职购出行距离,揭示其影响因素。结果表明:武汉城市居民职购活动以中短程出行为主,职购距离的圈层异质性明显,城市边缘及外围地区职购便利性更差。就业地商业可达性、社会经济属性、就业通勤成本、网络购物习惯等是影响职购出行距离的重要因素。应优先对10余处职购不便问题突出的就业集聚区开展优化,既要推动基于多因素协同的综合优化,也要区别不同就业集聚区职购困难的诱致主因,实施分类型、差异化的改进措施。

基于距离感知的金属缺陷样本标签分配算法

针对金属表面缺陷检测模型在训练过程中正负样本分配时不考虑金属表面缺陷的宽高比、对目标分布的定位能力差等问题,提出了距离感知的动态标签分配(DDA)算法。DDA不改变原有检测模型的结构也不增加计算开支,根据真实框的几何特性提出新的距离损失计算范式,以优化宽高比悬殊的回归问题,将迭代过程中的回归偏移量解码为预测框坐标,最后计算预测框、锚框和真实框三者之间综合交并比信息,动态地选择正负样本以提高训练精度。在武汉某钢厂冷轧带钢表面缺陷检测中进行了验证,并引入公开的热轧带钢表面缺陷数据集进行了泛化试验,检测效果均有显著改善,对金属表面质量规范有实际应用价值。