Despite the progress has been reached with Human herpesvirus 8 (HHV-8) research, there are gaps in the knowledge of viral induced oncogenesis. The aim of the present study was to identify possible associations between...Despite the progress has been reached with Human herpesvirus 8 (HHV-8) research, there are gaps in the knowledge of viral induced oncogenesis. The aim of the present study was to identify possible associations between HHV-8 subtypes, HHV-8 loads and clinical manifestations of HIV infected patients diagnosed with different malignancies associated with HHV-8 infection. Forty six HIV-1 infected individuals diagnosed with different HHV-8 associated diseases were studied [37 epidemic Kaposi’s sarcoma (KS), 3 pleural effusion lymphoma (PEL);5 peripheral lymphadenopathies (PL);1 Hodgkin’s lymphoma (HL);1 non Hodgkin’s lymphoma (NHL)]. HHV-8 loads were determined by quantitative real time PCR (qRT-PCR) whilst HHV-8 subtypes were determined by open-reading frame (ORF)-K1 gen genotyping. HHV-8 subtypes B, A, C, A5 and E were exhibited by 31.8%, 23.4%, 19.1%, 17% and 8.5% of the studied patients, respectively. The median HHV-8 viral load did not differ between subtypes (p > 0.05) but HHV-8 viral loads were significantly higher in PEL than in epidemic KS lesion or lymph nodes (p = 0.04). Subtype B was detected in 60% of patients with B cell lymphoma (NHL, PEL and HL) whereas subtype E was only detected in patients with epidemic KS diagnosis. Our data suggest that HHV-8 DNA quantification instead of subtype identification could be used as a surrogate marker for monitoring its infection, not only in epidemic KS patients but also in HIV infected individuals with lymphoproliferative disorders.展开更多
All human beings are born from divine mercy drawing man out of unfathomable reality’s chaotic depth into the divine realm’s peaceable light.The modern sense of justice,of fair government,depends on the teachings of ...All human beings are born from divine mercy drawing man out of unfathomable reality’s chaotic depth into the divine realm’s peaceable light.The modern sense of justice,of fair government,depends on the teachings of Jesus to which all citizens must subscribe.This is not a mere ecclesiastic doctrine but an empirically proven fact.The imperfections of a finite albeit adaptable,very large computing system,which our brain appears to be,require us to be open to the infinite beyond,its recondite wisdom,for divinity to grant us a moral life&to come to our help.Jesus puts the individual human being center stage for the first time in history.The story of abounding divine mercy:Every day we humans struggle with the difficult moral law but Jesus taught us what matters most is our soul,St.Paul’s inner man,a biological function of our left brain.Relying upon the faith of the apostles,the Council of Chalcedon(AD 451)in its Confession affirmed that Jesus was an actual person in his substance,possessing two natures,human&divine.This widely has been interpreted to apply to all mankind,the soul of each human being,the inner man,is potentially divine.Forming a practical metaphysics for devout christians&skeptics:Metaphysics is needed for the purpose of undergirding faith.Origins of humanity in the deep structures of reality:Science appears to be opposite to our human spiritual existence&requires us to search for ourselves in the realm of the logos,that can serve as our guide,being one of the names of the Christ.Jesus was deeply influenced by the gifts of the Magi,brought to him from an Armenian revival during his age,source of charismatic theology,basic concepts&historical architecture.Survival by faith in the everyday human communal world:We must have a secure grasp of the Faith,its basics,memorized or divine help won’t come.Be a lifelong winner based upon your own inner man:The essential help from divinity,in our need,is granting us a moral life.Become a lifelong winner based upon your own inner man or woman.What it takes is a willing heart,a sudden inspiration.Version 1.Piety:To be aware of our marginal competence,nobody is born as a genetic loser.Version 2.Humility:To be ready for divine help,able to receive it,we need to take a step back.Version 3.Metanoia,the Ninety Degree Turn:Repentance,betterment is the beginning of faith for all of us.Miracles can&do happen,the down-&-out guide to happiness:Constant prayer is the effective remedy for a soul that has gone lost in the temptations of the human tribal world.展开更多
文摘Despite the progress has been reached with Human herpesvirus 8 (HHV-8) research, there are gaps in the knowledge of viral induced oncogenesis. The aim of the present study was to identify possible associations between HHV-8 subtypes, HHV-8 loads and clinical manifestations of HIV infected patients diagnosed with different malignancies associated with HHV-8 infection. Forty six HIV-1 infected individuals diagnosed with different HHV-8 associated diseases were studied [37 epidemic Kaposi’s sarcoma (KS), 3 pleural effusion lymphoma (PEL);5 peripheral lymphadenopathies (PL);1 Hodgkin’s lymphoma (HL);1 non Hodgkin’s lymphoma (NHL)]. HHV-8 loads were determined by quantitative real time PCR (qRT-PCR) whilst HHV-8 subtypes were determined by open-reading frame (ORF)-K1 gen genotyping. HHV-8 subtypes B, A, C, A5 and E were exhibited by 31.8%, 23.4%, 19.1%, 17% and 8.5% of the studied patients, respectively. The median HHV-8 viral load did not differ between subtypes (p > 0.05) but HHV-8 viral loads were significantly higher in PEL than in epidemic KS lesion or lymph nodes (p = 0.04). Subtype B was detected in 60% of patients with B cell lymphoma (NHL, PEL and HL) whereas subtype E was only detected in patients with epidemic KS diagnosis. Our data suggest that HHV-8 DNA quantification instead of subtype identification could be used as a surrogate marker for monitoring its infection, not only in epidemic KS patients but also in HIV infected individuals with lymphoproliferative disorders.
文摘All human beings are born from divine mercy drawing man out of unfathomable reality’s chaotic depth into the divine realm’s peaceable light.The modern sense of justice,of fair government,depends on the teachings of Jesus to which all citizens must subscribe.This is not a mere ecclesiastic doctrine but an empirically proven fact.The imperfections of a finite albeit adaptable,very large computing system,which our brain appears to be,require us to be open to the infinite beyond,its recondite wisdom,for divinity to grant us a moral life&to come to our help.Jesus puts the individual human being center stage for the first time in history.The story of abounding divine mercy:Every day we humans struggle with the difficult moral law but Jesus taught us what matters most is our soul,St.Paul’s inner man,a biological function of our left brain.Relying upon the faith of the apostles,the Council of Chalcedon(AD 451)in its Confession affirmed that Jesus was an actual person in his substance,possessing two natures,human&divine.This widely has been interpreted to apply to all mankind,the soul of each human being,the inner man,is potentially divine.Forming a practical metaphysics for devout christians&skeptics:Metaphysics is needed for the purpose of undergirding faith.Origins of humanity in the deep structures of reality:Science appears to be opposite to our human spiritual existence&requires us to search for ourselves in the realm of the logos,that can serve as our guide,being one of the names of the Christ.Jesus was deeply influenced by the gifts of the Magi,brought to him from an Armenian revival during his age,source of charismatic theology,basic concepts&historical architecture.Survival by faith in the everyday human communal world:We must have a secure grasp of the Faith,its basics,memorized or divine help won’t come.Be a lifelong winner based upon your own inner man:The essential help from divinity,in our need,is granting us a moral life.Become a lifelong winner based upon your own inner man or woman.What it takes is a willing heart,a sudden inspiration.Version 1.Piety:To be aware of our marginal competence,nobody is born as a genetic loser.Version 2.Humility:To be ready for divine help,able to receive it,we need to take a step back.Version 3.Metanoia,the Ninety Degree Turn:Repentance,betterment is the beginning of faith for all of us.Miracles can&do happen,the down-&-out guide to happiness:Constant prayer is the effective remedy for a soul that has gone lost in the temptations of the human tribal world.
