To enhance our talent cultivation model through“school-enterprise cooperation and industry-teaching fusion”,we aim to improve the“4321”Industry-Education Integration System.This includes actively promoting the use...To enhance our talent cultivation model through“school-enterprise cooperation and industry-teaching fusion”,we aim to improve the“4321”Industry-Education Integration System.This includes actively promoting the use of case banks and project banks in teaching to develop students’practical engineering skills through hands-on application of professional knowledge.Additionally,landscape design courses emphasize practical learning experiences to implement the fundamental goal of“cultivating morality”.Guided by enhancing students’practical skills,we ensure alignment with course objectives and professional training requirements,emphasizing the seamless integration of theory and practice.展开更多
The overall teaching design for the junior middle school English unit aims to maximize the use of teaching resources by using the unit as the central theme,integrating it throughout all sections and related activities...The overall teaching design for the junior middle school English unit aims to maximize the use of teaching resources by using the unit as the central theme,integrating it throughout all sections and related activities.This approach continually reinforces students’understanding and retention of individual lesson content while fostering their core literacy and skills.It promotes a comprehensive development of students’listening,speaking,reading,and writing skills,allowing them to engage repeatedly with the language materials until they internalize them as part of their language proficiency.展开更多
The monitoring and warning of urban rail transit is the core of operation management, and the breadth and depth of the monitoring range directly affect the quality of urban rail transit operation. For the current dome...The monitoring and warning of urban rail transit is the core of operation management, and the breadth and depth of the monitoring range directly affect the quality of urban rail transit operation. For the current domestic monitoring system, most of the critical equipments and technologies are introduced from abroad;it is diseconomy, and also causes hidden danger. Realizing the localization of monitoring and early warning system is imperative. Based on the analysis of the present situation of urban rail transit operation safety at home and abroad, the paper proposes to use integrated technology to design basic framework of monitoring and warning system of urban rail train, and puts forward the critical technologies to realize the system. Compared with the existing monitoring system, the integrated monitoring system has the characteristics of wide monitoring range, clear division of labor, centralized management, coordination and integration operation and intelligent management, and embodies the concept of people-oriented. It has scientific significance for future construction of domestic Integrated Monitoring and Early Warning System (IMEWS) of urban rail transit.展开更多
Traffic hub in modern cities has gradually evolved into a multi-functional, all-around and three-dimensional complex. Based on the integrated thinking and relevant urban design theories, this paper took Shenzhen Luohu...Traffic hub in modern cities has gradually evolved into a multi-functional, all-around and three-dimensional complex. Based on the integrated thinking and relevant urban design theories, this paper took Shenzhen Luohu Railway Station for example, evaluated the status quo of the study area from the perspectives of spatial form and public space, including traffic space, square, walking space, green space and waterfront system, and put forward corresponding suggestions.展开更多
According to the operational characteristics of the logistics networks for the third party logistics supplier (3PLS), the forward and reverse logistics networks together for 3PLS under the uncertain environment are ...According to the operational characteristics of the logistics networks for the third party logistics supplier (3PLS), the forward and reverse logistics networks together for 3PLS under the uncertain environment are designed. First, a fuzzy model is proposed by taking multiple customers, multiple commodities, capacitated facility location and integrated logistics facility layout into account. In the model, the fuzzy customer demands and transportation rates are illustrated by triangular fuzzy numbers. Secondly, the fuzzy model is converted into a crisp model by applying fuzzy chance constrained theory and possibility theory, and one hybrid genetic algorithm is designed for the crisp model. Finally, two different examples are designed to illustrate that the model and solution discussed are valid.展开更多
The connotation of urban-rural integration,its construction courses,construction modes in China and abroad are introduced in this study,the problems emerging from the urban-rural integration practices are analyzed,and...The connotation of urban-rural integration,its construction courses,construction modes in China and abroad are introduced in this study,the problems emerging from the urban-rural integration practices are analyzed,and strategies for the urban-rural integration in China are proposed.展开更多
Orthogonal frequency division multiplexing (OFDM) waveform enables radar and communication functions simultaneously, which encounters low angle resolution and poor data rate for traditional single input single output ...Orthogonal frequency division multiplexing (OFDM) waveform enables radar and communication functions simultaneously, which encounters low angle resolution and poor data rate for traditional single input single output (SISO) systems. To solve these problems, an integrated radar and communication system (IRCS) with multiple input multiple output (MIMO) OFDM waveform is proposed. The different limitations of radar and communication in designing such a system are investigated. Then, an optimization problem is devised to obtain suitable system parameters, including the number of subcarriers, subcarrier spacing, number of symbols, pulse repetition frequency (PRF) and length of cyclic prefix (CP). Finally, to satisfy the requirements of both radar and communication, the IRCS parameters are derived in three typical cases. Several numerical results are presented to illustrate the demands of radar and communication, inconsistent or consistent, for the IRCS parameters and the superiority of the proposed system.展开更多
In the case of the given design variables and constraint functions, this paper is concerned with the rapid overall parameters design of trajectory, propulsion and aerodynamics for long-range ballistic missiles based o...In the case of the given design variables and constraint functions, this paper is concerned with the rapid overall parameters design of trajectory, propulsion and aerodynamics for long-range ballistic missiles based on the index of the minimum take-off mass.In contrast to the traditional subsystem independent design, this paper adopts the research idea of the combination of the subsystem independent design and the multisystem integration design.Firstly, the trajectory, propulsion and aerodynamics of the subsystem are separately designed by the engineering design, including the design of the minimum energy trajectory, the computation of propulsion system parameters, and the calculation of aerodynamic coefficient and dynamic derivative of the missile by employing the software of missile DATCOM. Then, the uniform design method is used to simplify the constraint conditions and the design variables through the integration design, and the accurate design of the optimized variables would be accomplished by adopting the uniform particle swarm optimization(PSO) algorithm. Finally, the automation design software is written for the three-stage solid ballistic missile. The take-off mass of 29 850 kg is derived by the subsystem independent design, and 20 constraints are reduced by employing the uniform design on the basis of 29 design variables and 32 constraints, and the take-off mass is dropped by 1 850 kg by applying the combination of the uniform design and PSO. The simulation results demonstrate the effectiveness and feasibility of the proposed hybrid optimization technique.展开更多
A broadening of the strategic approach to environmental issues coupled with changes in the mechanisms of environmental governance and management has generated demands for new kinds of environmental knowledge and for n...A broadening of the strategic approach to environmental issues coupled with changes in the mechanisms of environmental governance and management has generated demands for new kinds of environmental knowledge and for new ways of using it. In particular there is now a strong demand for information about the environment to be linked to information about the impacts of human activities so that the unsustainable aspects of economic development can be anticipated and controlled. The scope of environmental assessment has enlarged to provide information that will help a wide range of stakeholders, including business and publics to make decisions, choosing between alternatives on the basis of sound environmental information set in a social and economic context. This paper provides a discussion of these developments and illustrates how integrated environmental assessment of a specific urban environmental problem, the reduction of health impacts of air borne particles, can deliver broad strategic information for participants in the solution.展开更多
As an important sensor in the navigation systems,star sensors and the gyro play important roles in spacecraft attitude determination system.Complex environmental factors are the main sources of error in attitude deter...As an important sensor in the navigation systems,star sensors and the gyro play important roles in spacecraft attitude determination system.Complex environmental factors are the main sources of error in attitude determination.The error influence of different benchmarks and the disintegration mode between the star sensor and the gyro is analyzed in theory.The integrated design of the star sensor and the gyro on the same benchmark can effectively avoid the error influence and improves the spacecraft attitude determination accuracy.Simulation results indicate that when the stars sensor optical axis vectors overlap the reference coordinate axis of the gyro in the same benchmark,the attitude determination accuracy improves.展开更多
The design of Human Occupied Vehicle (HOV) is a typical multidisciplinary problem, but heavily dependent on the experience of naval architects at present engineering design. In order to relieve the experience depend...The design of Human Occupied Vehicle (HOV) is a typical multidisciplinary problem, but heavily dependent on the experience of naval architects at present engineering design. In order to relieve the experience dependence and improve the design, a new Multidisciplinary Design Optimization (MDO) method "Bi-Level Integrated System Collaborative Optimization (BLISCO)" is applied to the conceptual design of an HOV, which consists of hull module, resistance module, energy module, structure module, weight module, and the stability module. This design problem is defined by 21 design variables and 23 constraints, and its objective is to maximize the ratio of payload to weight. The results show that the general performance of the HOV can be greatly improved by BLISCO.展开更多
Some key issues in supporting collaborative design in product data management(PDM ) system and 3D computer aided design(CAD) system integrated environment are analyzed. The general architecture of the integrated e...Some key issues in supporting collaborative design in product data management(PDM ) system and 3D computer aided design(CAD) system integrated environment are analyzed. The general architecture of the integrated environment is divided into five tiers and employs the transparently integrated mode, with the mode, function calling and information exchanging among independent PDM and CAD processes are carried out via message translation /parse approach. Product layout feature(PLF ) model definition is presented, PLF model is used to represent design intention at the preliminary design phase. The collaborative design methodology employing the PLF model in PDM/3D CAD integrated environment is analyzed. The design methodology can speed up the design process, reduce the investment and improve the product quality.展开更多
In order to evaluate and integrate travel time reliability and capacity reliability of a road network subjected to ice and snowfall conditions,the conceptions of travel time reliability and capacity reliability were d...In order to evaluate and integrate travel time reliability and capacity reliability of a road network subjected to ice and snowfall conditions,the conceptions of travel time reliability and capacity reliability were defined under special conditions.The link travel time model(ice and snowfall based-bureau public road,ISB-BPR) and the path choice decision model(elastic demand user equilibrium,EDUE) were proposed.The integrated reliability was defined and the model was set up.Monte Carlo simulation was used to calculate the model and a numerical example was provided to demonstrate the application of the model and efficiency of the solution algorithm.The results show that the intensity of ice and snowfall,the traffic demand and supply,and the requirements for level of service(LOS) have great influence on the reliability of a road network.For example,the reliability drops from 65% to 5% when the traffic demand increases by 30%.The comprehensive performance index may be used for network planning,design and maintenance.展开更多
The basic indexes of all-optical integrated photonic circuits include high-density integration,ultrafast response and ultralow energy consumption.Traditional methods mainly adopt conventional micro/nano-structures.The...The basic indexes of all-optical integrated photonic circuits include high-density integration,ultrafast response and ultralow energy consumption.Traditional methods mainly adopt conventional micro/nano-structures.The overall size of the circuit is large,usually reaches hundreds of microns.Besides,it is difficult to balance the ultrafast response and ultra-low energy consumption problem,and the crosstalk between two traditional devices is difficult to overcome.Here,we propose and experimentally demonstrate an approach based on inverse design method to realize a high-density,ultrafast and ultra-low energy consumption integrated photonic circuit with two all-optical switches controlling the input states of an all-optical XOR logic gate.The feature size of the whole circuit is only 2.5μm×7μm,and that of a single device is 2μm×2μm.The distance between two adjacent devices is as small as 1.5μm,within wavelength magnitude scale.Theoretical response time of the circuit is 150 fs,and the threshold energy is within 10 fJ/bit.We have also considered the crosstalk problem.The circuit also realizes a function of identifying two-digit logic signal results.Our work provides a new idea for the design of ultrafast,ultra-low energy consumption all-optical devices and the implementation of high-density photonic integrated circuits.展开更多
Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists,which is time-consuming,high cost and waste materials.This research aims to integrate vario...Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists,which is time-consuming,high cost and waste materials.This research aims to integrate various computational tools,including machine learning,molecular dynamic simulation and physiologically based absorption modeling(PBAM),to enhance andrographolide(AG)/cyclodextrins(CDs)formulation design.The light GBM prediction model we built before was utilized to predict AG/CDs inclusion's binding free energy.AG/γ-CD inclusion complexes showed the strongest binding affinity,which was experimentally validated by the phase solubility study.The molecular dynamic simulation was used to investigate the inclusion mechanism between AG andγ-CD,which was experimentally characterized by DSC,FTIR and NMR techniques.PBAM was applied to simulate the in vivo behavior of the formulations,which were validated by cell and animal experiments.Cell experiments revealed that the presence of D-α-Tocopherol polyethylene glycol succinate(TPGS)significantly increased the intracellular uptake of AG in MDCKMDR1 cells and the absorptive transport of AG in MDCK-MDR1 monolayers.The relative bioavailability of the AG-CD-TPGS ternary system in rats was increased to 2.6-fold and 1.59-fold compared with crude AG and commercial dropping pills,respectively.In conclusion,this is the first time to integrate various computational tools to develop a new AG-CD-TPGS ternary formulation with significant improvement of aqueous solubility,dissolution rate and bioavailability.The integrated computational tool is a novel and robust methodology to facilitate pharmaceutical formulation design.展开更多
This paper creates 3D solid model and assembly of U RJ 92-6 oil tank and analyses its strength by integrated CAD/CAE/CAM software I-D EAS. Through integrated simulation in computer, design efficiency and quality of oi...This paper creates 3D solid model and assembly of U RJ 92-6 oil tank and analyses its strength by integrated CAD/CAE/CAM software I-D EAS. Through integrated simulation in computer, design efficiency and quality of oil tank is greatly improved. Adopting integrated CAD/CAE/CAM software to carry out integrated research to equ ipment and products, we will be able to take overall analysis in aspects of 3-D solid modeling, pre-assembly and strength, etc., to realize non-paper designi ng and parallel designing. Problems can be found and settled during designing, w hich will increase designing efficiency and one-time success rate and realize o ptimum designing for products.展开更多
The integrated layout problem in manufacturing Systems is investigated. Anintegrated model for Concurrent layout design of cells and flow paths is formulated. A hybridapproach combined an enhanced branch-and-bound alg...The integrated layout problem in manufacturing Systems is investigated. Anintegrated model for Concurrent layout design of cells and flow paths is formulated. A hybridapproach combined an enhanced branch-and-bound algorithm with a simulated annealing scheme isproposed to solve this problem. The integrated layout method is applied to re-layout the gear pumpshop of a medium-size manufacturer of hydraulic pieces. Results show that the proposed layout methodcan concurrently provide good solutions of the cell layouts and the flow path layouts.展开更多
This paper examined the relationship between cultural consumption and the floating population’s integration into host cities based on data from China’s Seventh National Population Census and the 2018 China Migrants ...This paper examined the relationship between cultural consumption and the floating population’s integration into host cities based on data from China’s Seventh National Population Census and the 2018 China Migrants Dynamic Survey(CMDS).The findings indicate that improving the floating population’s consumption level and quality,especially the quality of development-oriented cultural consumption,can significantly improve the level of their integration.Moreover,development-oriented cultural consumption has a positive effect on the floating population’s integration and social participation,while entertainment-oriented cultural consumption facilitates their integration mainly by improving their sense of well-being.These findings could guide policymakers in developing targeted cultural consumption policies,implementing specific regional industry adjustments,and expanding domestic consumption demand.展开更多
There has been increasing interests in developing land use models for small urban areas for various planning applications such as air quality conformity analysis. The output of a land use model can serve as a major in...There has been increasing interests in developing land use models for small urban areas for various planning applications such as air quality conformity analysis. The output of a land use model can serve as a major input to a transportation model; conversely, transportation model output can provide a critical input to a land use model. The connection between the two models can be achieved by an accessibility measure. This paper presents an iterative approach to solving a regression-based land use model and a transportation model with combined trip distribution- assignment. A case study using data from a small urban area is presented to illustrate the application of the proposed modeling framework. Tests show that the procedures can converge, and the modeling framework can be a valuable tool for planners and decision-makers in evaluating land use policies and transportation investment strategies.展开更多
基金The Chongqing University of Engineering for 2024 Construction Project Landscape for Comprehensive Project Library:Riverfront Space Renewal Project of Diaoyuzui Peninsula,Dadukou,Chongqing(Project No.2024-JZ-XMK054-XM083)。
文摘To enhance our talent cultivation model through“school-enterprise cooperation and industry-teaching fusion”,we aim to improve the“4321”Industry-Education Integration System.This includes actively promoting the use of case banks and project banks in teaching to develop students’practical engineering skills through hands-on application of professional knowledge.Additionally,landscape design courses emphasize practical learning experiences to implement the fundamental goal of“cultivating morality”.Guided by enhancing students’practical skills,we ensure alignment with course objectives and professional training requirements,emphasizing the seamless integration of theory and practice.
文摘The overall teaching design for the junior middle school English unit aims to maximize the use of teaching resources by using the unit as the central theme,integrating it throughout all sections and related activities.This approach continually reinforces students’understanding and retention of individual lesson content while fostering their core literacy and skills.It promotes a comprehensive development of students’listening,speaking,reading,and writing skills,allowing them to engage repeatedly with the language materials until they internalize them as part of their language proficiency.
文摘The monitoring and warning of urban rail transit is the core of operation management, and the breadth and depth of the monitoring range directly affect the quality of urban rail transit operation. For the current domestic monitoring system, most of the critical equipments and technologies are introduced from abroad;it is diseconomy, and also causes hidden danger. Realizing the localization of monitoring and early warning system is imperative. Based on the analysis of the present situation of urban rail transit operation safety at home and abroad, the paper proposes to use integrated technology to design basic framework of monitoring and warning system of urban rail train, and puts forward the critical technologies to realize the system. Compared with the existing monitoring system, the integrated monitoring system has the characteristics of wide monitoring range, clear division of labor, centralized management, coordination and integration operation and intelligent management, and embodies the concept of people-oriented. It has scientific significance for future construction of domestic Integrated Monitoring and Early Warning System (IMEWS) of urban rail transit.
文摘Traffic hub in modern cities has gradually evolved into a multi-functional, all-around and three-dimensional complex. Based on the integrated thinking and relevant urban design theories, this paper took Shenzhen Luohu Railway Station for example, evaluated the status quo of the study area from the perspectives of spatial form and public space, including traffic space, square, walking space, green space and waterfront system, and put forward corresponding suggestions.
文摘According to the operational characteristics of the logistics networks for the third party logistics supplier (3PLS), the forward and reverse logistics networks together for 3PLS under the uncertain environment are designed. First, a fuzzy model is proposed by taking multiple customers, multiple commodities, capacitated facility location and integrated logistics facility layout into account. In the model, the fuzzy customer demands and transportation rates are illustrated by triangular fuzzy numbers. Secondly, the fuzzy model is converted into a crisp model by applying fuzzy chance constrained theory and possibility theory, and one hybrid genetic algorithm is designed for the crisp model. Finally, two different examples are designed to illustrate that the model and solution discussed are valid.
文摘The connotation of urban-rural integration,its construction courses,construction modes in China and abroad are introduced in this study,the problems emerging from the urban-rural integration practices are analyzed,and strategies for the urban-rural integration in China are proposed.
基金supported by the National Natural Science Foundation of China(6123101761671352)
文摘Orthogonal frequency division multiplexing (OFDM) waveform enables radar and communication functions simultaneously, which encounters low angle resolution and poor data rate for traditional single input single output (SISO) systems. To solve these problems, an integrated radar and communication system (IRCS) with multiple input multiple output (MIMO) OFDM waveform is proposed. The different limitations of radar and communication in designing such a system are investigated. Then, an optimization problem is devised to obtain suitable system parameters, including the number of subcarriers, subcarrier spacing, number of symbols, pulse repetition frequency (PRF) and length of cyclic prefix (CP). Finally, to satisfy the requirements of both radar and communication, the IRCS parameters are derived in three typical cases. Several numerical results are presented to illustrate the demands of radar and communication, inconsistent or consistent, for the IRCS parameters and the superiority of the proposed system.
文摘In the case of the given design variables and constraint functions, this paper is concerned with the rapid overall parameters design of trajectory, propulsion and aerodynamics for long-range ballistic missiles based on the index of the minimum take-off mass.In contrast to the traditional subsystem independent design, this paper adopts the research idea of the combination of the subsystem independent design and the multisystem integration design.Firstly, the trajectory, propulsion and aerodynamics of the subsystem are separately designed by the engineering design, including the design of the minimum energy trajectory, the computation of propulsion system parameters, and the calculation of aerodynamic coefficient and dynamic derivative of the missile by employing the software of missile DATCOM. Then, the uniform design method is used to simplify the constraint conditions and the design variables through the integration design, and the accurate design of the optimized variables would be accomplished by adopting the uniform particle swarm optimization(PSO) algorithm. Finally, the automation design software is written for the three-stage solid ballistic missile. The take-off mass of 29 850 kg is derived by the subsystem independent design, and 20 constraints are reduced by employing the uniform design on the basis of 29 design variables and 32 constraints, and the take-off mass is dropped by 1 850 kg by applying the combination of the uniform design and PSO. The simulation results demonstrate the effectiveness and feasibility of the proposed hybrid optimization technique.
文摘A broadening of the strategic approach to environmental issues coupled with changes in the mechanisms of environmental governance and management has generated demands for new kinds of environmental knowledge and for new ways of using it. In particular there is now a strong demand for information about the environment to be linked to information about the impacts of human activities so that the unsustainable aspects of economic development can be anticipated and controlled. The scope of environmental assessment has enlarged to provide information that will help a wide range of stakeholders, including business and publics to make decisions, choosing between alternatives on the basis of sound environmental information set in a social and economic context. This paper provides a discussion of these developments and illustrates how integrated environmental assessment of a specific urban environmental problem, the reduction of health impacts of air borne particles, can deliver broad strategic information for participants in the solution.
文摘As an important sensor in the navigation systems,star sensors and the gyro play important roles in spacecraft attitude determination system.Complex environmental factors are the main sources of error in attitude determination.The error influence of different benchmarks and the disintegration mode between the star sensor and the gyro is analyzed in theory.The integrated design of the star sensor and the gyro on the same benchmark can effectively avoid the error influence and improves the spacecraft attitude determination accuracy.Simulation results indicate that when the stars sensor optical axis vectors overlap the reference coordinate axis of the gyro in the same benchmark,the attitude determination accuracy improves.
基金financially supported by the National Natural Science Foundation of China(Grant No.51109132)the Specialized Research Fund for the Doctoral Program of Higher Education of China(Grant No.20110073120015)
文摘The design of Human Occupied Vehicle (HOV) is a typical multidisciplinary problem, but heavily dependent on the experience of naval architects at present engineering design. In order to relieve the experience dependence and improve the design, a new Multidisciplinary Design Optimization (MDO) method "Bi-Level Integrated System Collaborative Optimization (BLISCO)" is applied to the conceptual design of an HOV, which consists of hull module, resistance module, energy module, structure module, weight module, and the stability module. This design problem is defined by 21 design variables and 23 constraints, and its objective is to maximize the ratio of payload to weight. The results show that the general performance of the HOV can be greatly improved by BLISCO.
基金Supported by the National High Technology Re-search and Development Programof China(2003AA411011)
文摘Some key issues in supporting collaborative design in product data management(PDM ) system and 3D computer aided design(CAD) system integrated environment are analyzed. The general architecture of the integrated environment is divided into five tiers and employs the transparently integrated mode, with the mode, function calling and information exchanging among independent PDM and CAD processes are carried out via message translation /parse approach. Product layout feature(PLF ) model definition is presented, PLF model is used to represent design intention at the preliminary design phase. The collaborative design methodology employing the PLF model in PDM/3D CAD integrated environment is analyzed. The design methodology can speed up the design process, reduce the investment and improve the product quality.
基金Project(E200940) supported by the Natural Science Foundation of Heilongjiang Province, ChinaProject(2009GC20008020) supported by the Technology Research and Development Program of Shandong Province, China
文摘In order to evaluate and integrate travel time reliability and capacity reliability of a road network subjected to ice and snowfall conditions,the conceptions of travel time reliability and capacity reliability were defined under special conditions.The link travel time model(ice and snowfall based-bureau public road,ISB-BPR) and the path choice decision model(elastic demand user equilibrium,EDUE) were proposed.The integrated reliability was defined and the model was set up.Monte Carlo simulation was used to calculate the model and a numerical example was provided to demonstrate the application of the model and efficiency of the solution algorithm.The results show that the intensity of ice and snowfall,the traffic demand and supply,and the requirements for level of service(LOS) have great influence on the reliability of a road network.For example,the reliability drops from 65% to 5% when the traffic demand increases by 30%.The comprehensive performance index may be used for network planning,design and maintenance.
基金the National Key Research and Development Program of China under Grant No.2018YFB2200403the National Natural Science Foundation of China under Grant Nos.11734001,91950204,92150302.
文摘The basic indexes of all-optical integrated photonic circuits include high-density integration,ultrafast response and ultralow energy consumption.Traditional methods mainly adopt conventional micro/nano-structures.The overall size of the circuit is large,usually reaches hundreds of microns.Besides,it is difficult to balance the ultrafast response and ultra-low energy consumption problem,and the crosstalk between two traditional devices is difficult to overcome.Here,we propose and experimentally demonstrate an approach based on inverse design method to realize a high-density,ultrafast and ultra-low energy consumption integrated photonic circuit with two all-optical switches controlling the input states of an all-optical XOR logic gate.The feature size of the whole circuit is only 2.5μm×7μm,and that of a single device is 2μm×2μm.The distance between two adjacent devices is as small as 1.5μm,within wavelength magnitude scale.Theoretical response time of the circuit is 150 fs,and the threshold energy is within 10 fJ/bit.We have also considered the crosstalk problem.The circuit also realizes a function of identifying two-digit logic signal results.Our work provides a new idea for the design of ultrafast,ultra-low energy consumption all-optical devices and the implementation of high-density photonic integrated circuits.
基金financially supported by the FDCT Project 0029/2018/A1the University of Macao Research Grants(MYRG2019-00041-ICMS)performed in part at the High-Performance Computing Cluster(HPCC)which is supported by Information and Communication Technology Office(ICTO)of the University of Macao。
文摘Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists,which is time-consuming,high cost and waste materials.This research aims to integrate various computational tools,including machine learning,molecular dynamic simulation and physiologically based absorption modeling(PBAM),to enhance andrographolide(AG)/cyclodextrins(CDs)formulation design.The light GBM prediction model we built before was utilized to predict AG/CDs inclusion's binding free energy.AG/γ-CD inclusion complexes showed the strongest binding affinity,which was experimentally validated by the phase solubility study.The molecular dynamic simulation was used to investigate the inclusion mechanism between AG andγ-CD,which was experimentally characterized by DSC,FTIR and NMR techniques.PBAM was applied to simulate the in vivo behavior of the formulations,which were validated by cell and animal experiments.Cell experiments revealed that the presence of D-α-Tocopherol polyethylene glycol succinate(TPGS)significantly increased the intracellular uptake of AG in MDCKMDR1 cells and the absorptive transport of AG in MDCK-MDR1 monolayers.The relative bioavailability of the AG-CD-TPGS ternary system in rats was increased to 2.6-fold and 1.59-fold compared with crude AG and commercial dropping pills,respectively.In conclusion,this is the first time to integrate various computational tools to develop a new AG-CD-TPGS ternary formulation with significant improvement of aqueous solubility,dissolution rate and bioavailability.The integrated computational tool is a novel and robust methodology to facilitate pharmaceutical formulation design.
文摘This paper creates 3D solid model and assembly of U RJ 92-6 oil tank and analyses its strength by integrated CAD/CAE/CAM software I-D EAS. Through integrated simulation in computer, design efficiency and quality of oil tank is greatly improved. Adopting integrated CAD/CAE/CAM software to carry out integrated research to equ ipment and products, we will be able to take overall analysis in aspects of 3-D solid modeling, pre-assembly and strength, etc., to realize non-paper designi ng and parallel designing. Problems can be found and settled during designing, w hich will increase designing efficiency and one-time success rate and realize o ptimum designing for products.
基金This project is supported by National Natural Science Foundation of China (No.59990470)Doctoral Foundation of Ministry of Education, China(No.20010487024).
文摘The integrated layout problem in manufacturing Systems is investigated. Anintegrated model for Concurrent layout design of cells and flow paths is formulated. A hybridapproach combined an enhanced branch-and-bound algorithm with a simulated annealing scheme isproposed to solve this problem. The integrated layout method is applied to re-layout the gear pumpshop of a medium-size manufacturer of hydraulic pieces. Results show that the proposed layout methodcan concurrently provide good solutions of the cell layouts and the flow path layouts.
基金Study on Green Development in Agriculture and Rural Areas to Enable the Building of a Low-Carbon Society (LD23YB02)funded by the 2023 Chengdu Green and Low-Carbon Development Research Base Project.
文摘This paper examined the relationship between cultural consumption and the floating population’s integration into host cities based on data from China’s Seventh National Population Census and the 2018 China Migrants Dynamic Survey(CMDS).The findings indicate that improving the floating population’s consumption level and quality,especially the quality of development-oriented cultural consumption,can significantly improve the level of their integration.Moreover,development-oriented cultural consumption has a positive effect on the floating population’s integration and social participation,while entertainment-oriented cultural consumption facilitates their integration mainly by improving their sense of well-being.These findings could guide policymakers in developing targeted cultural consumption policies,implementing specific regional industry adjustments,and expanding domestic consumption demand.
文摘There has been increasing interests in developing land use models for small urban areas for various planning applications such as air quality conformity analysis. The output of a land use model can serve as a major input to a transportation model; conversely, transportation model output can provide a critical input to a land use model. The connection between the two models can be achieved by an accessibility measure. This paper presents an iterative approach to solving a regression-based land use model and a transportation model with combined trip distribution- assignment. A case study using data from a small urban area is presented to illustrate the application of the proposed modeling framework. Tests show that the procedures can converge, and the modeling framework can be a valuable tool for planners and decision-makers in evaluating land use policies and transportation investment strategies.