Multisensory mechanisms of gait and balance in Parkinson’s disease:an integrative review

Understanding the neural underpinning of human gait and balance is one of the most pertinent challenges for 21st-century translational neuroscience due to the profound impact that falls and mobility disturbances have on our aging population.Posture and gait control does not happen automatically,as previously believed,but rather requires continuous involvement of central nervous mechanisms.To effectively exert control over the body,the brain must integrate multiple streams of sensory information,including visual,vestibular,and somatosensory signals.The mechanisms which underpin the integration of these multisensory signals are the principal topic of the present work.Existing multisensory integration theories focus on how failure of cognitive processes thought to be involved in multisensory integration leads to falls in older adults.Insufficient emphasis,however,has been placed on specific contributions of individual sensory modalities to multisensory integration processes and cross-modal interactions that occur between the sensory modalities in relation to gait and balance.In the present work,we review the contributions of somatosensory,visual,and vestibular modalities,along with their multisensory intersections to gait and balance in older adults and patients with Parkinson’s disease.We also review evidence of vestibular contributions to multisensory temporal binding windows,previously shown to be highly pertinent to fall risk in older adults.Lastly,we relate multisensory vestibular mechanisms to potential neural substrates,both at the level of neurobiology(concerning positron emission tomography imaging)and at the level of electrophysiology(concerning electroencephalography).We hope that this integrative review,drawing influence across multiple subdisciplines of neuroscience,paves the way for novel research directions and therapeutic neuromodulatory approaches,to improve the lives of older adults and patients with neurodegenerative diseases.

Aging impairs the osteocytic regulation of collagen integrity and bone quality

Poor bone quality is a major factor in skeletal fragility in elderly individuals.The molecular mechanisms that establish and maintain bone quality,independent of bone mass,are unknown but are thought to be primarily determined by osteocytes.We hypothesize that the age-related decline in bone quality results from the suppression of osteocyte perilacunar/canalicular remodeling(PLR),which maintains bone material properties.We examined bones from young and aged mice with osteocyte-intrinsic repression of TGFβsignaling(TβRII^(ocy−/−))that suppresses PLR.The control aged bone displayed decreased TGFβsignaling and PLR,but aging did not worsen the existing PLR suppression in male TβRII^(ocy−/−)bone.This relationship impacted the behavior of collagen material at the nanoscale and tissue scale in macromechanical tests.The effects of age on bone mass,density,and mineral material behavior were independent of osteocytic TGFβ.We determined that the decline in bone quality with age arises from the loss of osteocyte function and the loss of TGFβ-dependent maintenance of collagen integrity.

“One Core,Two Sources”:The Endogenous Logic of China’s Path to Develop Human Rights from the Perspective of“Two Integrations”

Abstract:The development of China’s human rights path is driv-en by both external and internal factors,influenced by general prin-ciples of human rights worldwide while also following China’s own endogenous logic.The concept of the“Two Integrations”reflects the continuous theoretical innovation of the Chinese Communist Party based on China’s national conditions,significantly illustrating the en-dogenous logic of China’s human rights path.Among these,the“basic principles of Marxism”occupy a“core”position within the endoge-nous logic of China’s human rights path,and to some extent,embody an understanding of the inherent laws of human rights.Meanwhile,“China’s specific realities”and“fine traditional Chinese culture”serve as the“living water sources”for the ongoing advancement of China’s human rights.The“Two Integrations”represent an intrinsic requirement of historical materialism and practical materialism.The logical structure of“One Core,Two Sources”explains the endogenous nature of China’s human rights path,offering both an interpretation of the driving forces behind China’s human rights path and a defense of its rationality.

Ethics and Integrity in Building Employee＇s Perceptions

Malaysia has long been involved in the initiative of becoming a high income country by the year 2020. In this essence, fighting and eliminating any means of corruption in the public and private companies have been one of the key challenges in the long run. The globalization of businesses has somehow led to an increase in the number of unethical conduct and hazardous corruption. In the urge to enliven ethics and integrity in a company and among employees, the whole business processes and stakeholders should position code of ethics and integrity at its highest standard. However, can ethics and integrity really increase the company＇s reputation, strengthening its business operations and sustainability, and deliver trust amongst employees and employers？ The objective of this study is to analyze the perceptions of employees on issues pertaining ethics and integrity. The study has been conducted in one of the giant telecommunication companies in Malaysia where a sample of 7,056 employees were the participants involved in the survey. The study has used questionnaires to collect data. The data have then been analysed using the SPSS data analysis software. The findings explained that employees view the company as an ethical place to work where the finance department is deemed to have the highest level of integrity. While in matters of corruption risk areas, there are still practices of bribery. It is also founded that a majority of respondents about 93% agree that the company＇s initiatives are effective in building business integrity and that the level of business ethics and integrity has improved over the last two years. Running a business with ethics and integrity while selecting the fight business partners will create a corporation of ethics, integrity, and anti-corruption.

Studies on the Evolutionary Laws and Maintaining Mechanism of Renewability of the Yellow River's Water Resources

The Yellow River has a vast catchment area and historically it is the mother river of the Chinese nation. Now it serves as one of the main theatres for the on-going national campaign to develop China's western hinterland.……

New Majorized Results on Hilbert's Integral Inequality

In this paper, some new majorized results on Hilbert’s integral inequality are showed.

AN NUMERICAL ALGORI THM FOR LAPLACE′S INTEGRAL BY B-SPLINE

Algorithm for Laplace ′s integral is given when the inverse image function has high order discontinui ty. The multi-node technique of B-spline is used to describe the interruption point, cusp and non-smooth point of the inverse image function. The difference quotient and de Boor algorithm are used to derive the image function of the Lapl ace′s integral under non-uniform partition. And a set of practical formula is got when the partition is quasi-uniform. The scheme enables the image function to be approximated within any prescribed tolerance. Experiments also show that g ood result is achieved. It is much faster than that of Simpsons rule, and much s impler than that of Berge method, the traditional efficient method. It is no lon ger to find the zero points and coefficients of Gauss-Laguerre or Gauss-Legend re polynomials. The image function of Laplace′s integral can also be computed while the inverse image function is hyper-function with high order discontinuity.

教育硕士产教融合“U-G-S&E”育人模式探析

产教融合是教育与产业的深度合作,我国产教融合的政策经历了从职业教育到普通教育的发展。产教融合符合教育硕士人才培养的逻辑,“U-G-S&E”育人模式以高校为主导,政府提供政策引导和资金支持,中小学和企业协同参与教育硕士的培养。通过实践探索发现,“U-G-S&E”模式可以更好地激发学生提升职业能力的动力,助力学生职业生涯规划和就业,提升以赛赋能的效果,帮助高校校内导师、中小学和企业的校外导师加深对教育链、人才链与产业链、创新链有机衔接的理解,助力孵化本地企业参与遴选国家产教融合型企业,推动本地企业更好的融入国家现代教育体系建设。

AN INTEGRAL ESTIMATE AND THE EQUIVALENT NORMS ON F(p, q, s, k) SPACES IN THE UNIT BALL

In this article, the authors give a typical integral＇s bidirectional estimates for allcases. At the same time, several equivalent characterizations on the F（p, q, s, k） space in theunit ball of Cn are given.

Study on Characteristics of 3-D Translating-Pulsating Source Green Function of Deep-Water Havelock Form and Its Fast Integration Method

The singularities, oscillatory performances and the contributing factors to the 3-＇D translating-pulsating source Green function of deep-water Havelock form which consists of a local disturbance part and a far-field wave-like part, are analyzed systematically. Relative numerical integral methods about the two parts are presented in this paper. An improved method based on LOBATTO rule is used to eliminate singularities caused respectively by infinite discontinuity and jump discontinuous node from the local disturbance part function, which makes the improvement of calculation efficiency and accuracy possible. And variable substitution is applied to remove the singularity existing at the end of the integral interval of the far-field wave-like part function. Two auxiliary techniques such as valid interval calculation and local refinement of integral steps technique in narrow zones near false singularities are applied so as to avoid unnecessary integration of invalid interval and improve integral accordance. Numerical test results have proved the efficiency and accuracy in these integral methods that thus can be applied to calculate hydrodynamic performance of floating structures moving in waves.

Integral Inequalities of Hermite-Hadamard Type for Functions Whose 3rd Derivatives Are <i>s</i>-Convex

In the paper, the authors find some new inequalities of Hermite-Hadamard type for functions whose third derivatives are s-convex and apply these inequalities to discover inequalities for special means.

The discrete variational principle and the first integrals of Birkhoff systems＊

This paper shows that first integrals of discrete equation of motion for Birkhoff systems can be determined explicitly by investigating the invariance properties of the discrete Pfaffian. The result obtained is a discrete analogue of theorem of Noether in the calculus of variations. An example is given to illustrate the application of the results.

Functional Integrals and Excitation Energy in Three-Band Hubbard Model

The normal and anomalous Green＇s functions of antiferromagnetie state in three-band Hubbard model are studied by using functional integrals and temperature Green＇s function method. The equations of energy spectrum are derived. In addition, excitation energy of Fermi fields are calculated under long wave approximation.

A Hilbert-Type Inequality with Some Parameters and the Integral in Whole Plane

In this paper, by introducing some parameters and estimating the weight coefficient, we give a new Hilbert’s inequality with the integral in whole plane and with a non-homogeneous and the equivalent form is given as well. The best constant factor is calculated by the way of Complex Analysis.

THE HADAMARD INEQUALITY FOR CONVEX FUNCTION VIA FRACTIONAL INTEGRALS

In this paper, we establish several inequalities for some differantiable mappings that are connected with the Riemann-Liouville fractional integrals. The analysis used in the proofs is fairly elementary.

EXISTENCE AND UNIQUENESS OF SOLUTIONS FOR NONLINEAR FRACTIONAL DIFFERENTIAL EQUATIONS WITH NON-SEPARATED TYPE INTEGRAL BOUNDARY CONDITIONS

In this paper, we study a boundary value problem of nonlinear fractional dif- ferential equations of order q （1 〈 q 〈 2） with non-separated integral boundary conditions. Some new existence and uniqueness results are obtained by using some standard fixed point theorems and Leray-Schauder degree theory. Some illustrative examples are also presented. We extend previous results even in the integer case q = 2.

Boundedness of singular integrals along surfaces on Lebesgue spaces

In the paper, we establish the LP（Rn＋1）-boundedness for a class of singular integral operators associated to surfaces of revolution {（y,γ（｜y｜）, y ∈ Rn} with rough kernels. We also give several applications of this inequality.

Science Letters:The Moore’s Law for photonic integrated circuits

We formulate a “Moore’s law” for photonic integrated circuits (PICs) and their spatial integration density using two methods. One is decomposing the integrated photonics devices of diverse types into equivalent basic elements, which makes a comparison with the generic elements of electronic integrated circuits more meaningful. The other is making a complex compo- nent equivalent to a series of basic elements of the same functionality, which is used to calculate the integration density for func- tional components realized with different structures. The results serve as a benchmark of the evolution of PICs and we can con- clude that the density of integration measured in this way roughly increases by a factor of 2 per year. The prospects for a continued increase of spatial integration density are discussed.

Hermite-Hadamard Type Fractional Integral Inequalities for Preinvex Functions

In this article, we extend some estimates of the right-hand side of the Hermite-Hadamard type inequality for preinvex functions with fractional integral.The notion of logarithmically s-Godunova-Levin-preinvex function in second sense is introduced and then a new Herrnite-Hadarnard inequality is derived for the class of logarithmically s-Godunova-Levin-preinvex function.

Detection of Prorocentrum donghaiense using sandwich hybridization integrated with nuclease protection assay

Prorocentrum donghaiense is an important harmful algae bloom （HAB） causing creature in China＇s seas, and the conventional visual detection can not cope with long-term monitoring and highthroughput sampling projects. An assay for P. donghaiense with sandwich hybridization integrated with nuclease protection assay （NPA-SH） was established. Tests with mixed samples and spiked field ones confirmed its good specificity and sensitivity. The cell number of P. donghaiense correlated well with the optical density, and the regression equation is y=4× 10^- 6x＋ 0.694 9, in which x is the cell number, and y is the optical density, with r2=0.953 5. These results show that the NPA-SH method has good feasibility in the detection of P. donghaiense. Results of NPA-SH and microscopy are excellent for each sample. The NPA-SH method was a simple way in quantitative detection of P. donghaiense, and the whole process could be finished in about six hours, which provided a new approach in high-throughput sampling and long-term monitoring of P. donghaiense.