Construction of the underlying circRNA-miRNA-mRNA regulatory network and a new diagnostic model in ulcerative colitis by bioinformatics analysis

BACKGROUND Circular RNAs(circRNAs)are involved in the pathogenesis of many diseases through competing endogenous RNA(ceRNA)regulatory mechanisms.AIM To investigate a circRNA-related ceRNA regulatory network and a new predictive model by circRNA to understand the diagnostic mechanism of circRNAs in ulcerative colitis(UC).METHODS We obtained gene expression profiles of circRNAs,miRNAs,and mRNAs in UC from the Gene Expression Omnibus dataset.The circRNA-miRNA-mRNA network was constructed based on circRNA-miRNA and miRNA-mRNA interactions.Functional enrichment analysis was performed to identify the biological mechanisms involved in circRNAs.We identified the most relevant differential circRNAs for diagnosing UC and constructed a new predictive nomogram,whose efficacy was tested with the C-index,receiver operating characteristic curve(ROC),and decision curve analysis(DCA).RESULTS A circRNA-miRNA-mRNA regulatory network was obtained,containing 12 circRNAs,three miRNAs,and 38 mRNAs.Two optimal prognostic-related differentially expressed circRNAs,hsa_circ_0085323 and hsa_circ_0036906,were included to construct a predictive nomogram.The model showed good discrimination,with a C-index of 1(>0.9,high accuracy).ROC and DCA suggested that the nomogram had a beneficial diagnostic ability.CONCLUSION This novel predictive nomogram incorporating hsa_circ_0085323 and hsa_circ_0036906 can be conveniently used to predict the risk of UC.The circRNa-miRNA-mRNA network in UC could be more clinically significant.

Research on Online-Offline Hybrid Teaching Mode of College English in the Context of New Liberal Arts

English is an important course in colleges,and students’proficiency in the language can significantly affect their learning in multiple disciplines.At present,offline classroom teaching is still the primary mode of college English teaching,and online teaching has not been widely used.Under the background of new liberal arts,the teaching tasks and objectives of college English have changed,and it is imperative to carry out online-offline hybrid teaching mode.This paper analyzes the feasibility of the online-offline hybrid teaching mode of college English,summarizes its problems,and explores its implementation strategies in the context of the new liberal arts,to provide references for teachers.

Rationale and Pathway for New Industrialization in the Context of Chinese Modernization

The concepts of modernization and industrialization have different connotations that are specific to their historical backgrounds,and their theoretical innovation and development may benefit from China’s experiences.Industrialization is the cornerstone of modernization,and holds the key to its success.China’s experiences in blazing a new trail of industrialization are challenging the traditional Western theory of industrialization and deepening the connotations of Chinese modernization.New industrialization is a key entry point for steering China’s modernization drive and theoretical innovations.This paper offers an overview of the theory of Chinese modernization and its evolving trend along China’s socialist industrialization path,as well as the rationale and pathway for new industrialization in the context of Chinese modernization.As our findings suggest,the new industrialization concept has taken hold in every key aspect of Chinese modernization.When combined with the theory of Chinese modernization,the theoretical implications of new industrialization play a crucial role in propelling Chinese modernization forward along a new journey in the new era.

Electromechanical Transient Modeling Analysis of Large-Scale New Energy Grid Connection

The synchronous virtual machine uses inverter power to imitate the performance of the conventional synchronous machine.It also has the same inertia,damping,frequency,voltage regulation,and other external performance as the generator.It is the key technology to realize new energy grid connections’stable and reliable operation.This project studies a dynamic simulation model of an extensive new energy power system based on the virtual synchronous motor.A new energy storage method is proposed.The mathematical energy storage model is established by combining the fixed rotor model of a synchronous virtual machine with the charge-discharge power,state of charge,operation efficiency,dead zone,and inverter constraint.The rapid conversion of energy storage devices absorbs the excess instantaneous kinetic energy caused by interference.The branch transient of the critical cut set in the system can be confined to a limited area.Thus,the virtual synchronizer’s kinetic and potential energy can be efficiently converted into an instantaneous state.The simulation of power system analysis software package(PSASP)verifies the correctness of the theory and algorithm in this paper.This paper provides a theoretical basis for improving the transient stability of new energy-connected power grids.

Professional Cognitive Education Model for Agricultural Water Conservancy Engineering under the Background of New Agricultural Science

The construction of new agricultural science requires the use of modern scientific and technological means to transform and enhance current agricultural related majors.The agricultural water conservancy engineering major,with its inherent disciplinary advantages,plays an indispensable and important role in the construction of new agricultural science.In recent years,the lack of professional cognitive education has gradually become a significant problem in the training of talents in agricultural water conservancy engineering.Therefore,this paper deeply analyzes the problems and reasons faced by professional cognitive education,and proposes specific educational strategies for several key aspects such as enrollment promotion,freshman enrollment education,construction of teacher team,combination of scientific research and teaching,and strengthening professional cognition through competition activities.It aims to provide reference for improving the quality of professional cognitive education and exploring effective ways.

Man in Nature: A New Critical Reading of Wallace Steven’s “The Snow Man” in the Context of Modernism

The study of Wallace Stevens has a long and varied history. His life, poetry and philosophy have been interpreted in the demensions of romanticism, modernism, postmodernism and ecologism, with focuses on specific aspects such as linguistic structure, the feminine, painting, music and faith. In recent years, studies of Stevens have expanded to include the Chinese elements and the relationship between imagination and reality in his poetry. This thesis intends to examine how irony, ambiguity, tension and paradox cooperate in “The Snow Man” to refresh the reader on man-nature relationship, to understand how Wallace Stevens reflects and reconciles the existential angst of “nothingness” popular in the early 20th century by this poem, and develops a positive or even optimistic attitude.

Organic Combination of Smart Agriculture and Farming-reading Education : Research on Talent Training Model in the New Agricultural Science

By analyzing the complementarity between smart agriculture and farming-reading education,and the advantages of organic combination of the two:addressing the challenges of agricultural modernization and cultivating new talents;enhancing students interest in learning and improving their sense of responsibility and mission;promoting the inheritance of traditional agricultural culture and modern agricultural technology innovation,the organic combination mode of smart agriculture and farming-reading education in the cultivation of new agricultural talents is explored.The analysis shows that it has the following applications in the cultivation of new agricultural talents:in terms of the integration of educational concepts,it combines the modern concept of smart agriculture with the traditional value of farming-reading education;in terms of constructing a curriculum system and adding courses related to smart agriculture,it retains basic courses in farming-reading education,and promotes interdisciplinary integration;in terms of practical teaching platforms,it establishes smart agriculture training bases and farming-reading education bases,and adopts a combination of virtual and real teaching methods;in terms of guiding innovation and entrepreneurship,it encourages students to participate in innovation and entrepreneurship projects,and strengthens industry-university-research cooperation;in terms of teacher team construction,it improves the quality of the teacher team and integrates educational resources both inside and outside the school.Moreover,its evaluation system and incentive mechanism are proposed:constructing a multi-dimensional evaluation system,combining quantitative and qualitative,process and result evaluation,and introducing the third-party evaluation;establishing scholarships and grants,providing support for innovation and entrepreneurship,conducting honor recognition and publicity,and offering career development support.

Study on the Construction and Evaluation System of Clinical Midwifery Teaching Faculty under the New Nursing Model

Objective:To explore the impact of the construction of a clinical midwifery teaching faculty and the development of an evaluation system under the new nursing model on the current teaching quality.Methods:From July 2022 to March 2023,10 clinical teaching teachers and 20 midwifery interns from Beijing Anzhen Hospital affiliated with Capital Medical University were selected as the subjects of this study.The clinical teaching teachers and midwifery interns were divided into an observation group and a control group,with each group including 5 clinical teaching teachers and 10 midwifery interns.The observation group received daily management and evaluation under the new nursing model,while the control group received management and evaluation under the traditional nursing model.The teaching quality evaluation of clinical midwifery teaching teachers by midwifery interns,the exit exam scores of midwifery interns,and the scores of clinical teaching teachers’internship lectures and teaching rounds were compared between the two groups.Results:In the observation group,the scores for teaching attitude,teaching skills,and teaching management in the teaching quality evaluation of clinical midwifery teaching teachers were higher than those in the control group.The professional theory scores(91.28±3.64)and overall nursing comprehensive scores(92.56±4.38)of midwifery interns in the observation group were higher than those of midwifery interns in the control group(81.58±2.27 and 80.29±3.33,respectively).The scores for internship lectures(89.32±4.15)and teaching rounds(90.64±5.52)in the observation group were also significantly higher than those in the control group(80.46±3.28 and 81.24±4.38,respectively),and the differences were statistically significant(P<0.05).Conclusion:The management of the clinical midwifery teaching faculty under the new nursing model effectively improved the quality of clinical teaching.It significantly enhanced the teaching effectiveness of clinical teaching teachers and the proficiency of midwifery interns in clinical operations,making it worthy of promotion and use.

Selection of New Energy Development Models in Rural Jilin Province under Different Situations

Jilin Province’s vast rural areas are endowed with abundant new energy resources,which provide a fundamental condition for the development of new energy in rural Jilin.This paper will explore the various possibilities of new energy development in rural Jilin under the background of grid infrastructure construction,the deepening of electricity market reform,the modernization of agriculture and rural areas,and the transformation of energy.It will draw conclusions on the reasonable development models of new energy in rural Jilin under different scenarios,providing a reference for the development of new energy in rural Jilin and rural revitalization.

Research on the Dual-Creation Talent Training Model of New Energy Automobile Based on Virtual Simulation

At present,as China vigorously develops new energy automobiles,the social demand for related talents has increased significantly,so the relevant institutions need to optimize and adjust the talent training mode to help the development of new energy automobiles.This paper summarizes the existing problems of China’s new energy automobile talent training mode,and analyzes the significance of the virtual simulation-based dual-creation talent training mode of new energy automobile and its specific implementation strategies,in order to provide references for the relevant personnel.

Exploration and Practice of Innovative and Entrepreneurial Talent Training Model in Medical Colleges under the Background of“New Medicine”

Innovation and entrepreneurship education has become one of the important directions of higher education reform,but innovation and entrepreneurship education in medical colleges generally lags behind other discipline universities or comprehensive universities.Actively exploring the training mode of innovation and entrepreneurship talents is of great significance for cultivating innovative medical talents needed by the country and society.At present,innovation and entrepreneurship education in higher medical colleges is facing many challenges,the most important of which include the lack of concept in innovation and entrepreneurship education,medical students’weak awareness of innovation and entrepreneurship,and poor construction of innovation and entrepreneurship teaching staff.To address these challenges,we will introduce incentive measures for innovation and entrepreneurship education at the college level,and improve the guarantee and incentive mechanisms for innovation and entrepreneurship education;create an“Innovation and Entrepreneurship Education Platform”for teachers and students to exchange ideas on innovation and entrepreneurship;start building a high-quality team of innovation and entrepreneurship teachers,promote the continuous improvement of the quality of innovation and entrepreneurship education,and ensure the quality of medical talent training.

The Reform and Practice of Multicultural Cultivation Mode of Art Talents in Colleges and Universities Under the Strategy of “Three Highs and Four New”

As an important link in the development of modern quality education,art education is one of the methods to guide students to have a diversified vision.Under the background of multiculturalism,we need to explore the connotation and value of art education with the concept of“three highs and four new,”so that students can realize interdisciplinary and cross-cultural cognition through an immersive experience and practical operation in a wide range of multicultural situations,and to develop the knowledge of art education with the concept of“three highs and four new.”Based on the multicultural background,this paper focuses on the integration of multiculturalism into the reform practice of“student-centered”in colleges and universities,so as to cultivate art talents adapted to the multicultural background,in order to achieve the great mission of“three highs and four new”and better lead the innovative development of art education in colleges and universities.

Economic Analysis and Research of New Energy Vehicle Promotion Model

New energy vehicles represent the inevitable trend of future development.Compared to traditional fuel vehicles,they are more energy-saving and environmentally friendly,effectively reducing air pollution and mitigating excessive exploitation of oil resources,a stance strongly supported by governments.However,new energy vehicles possess certain drawbacks in terms of price and usability compared to traditional counterparts.Therefore,external support is imperative for their development.This paper delineates four main sections:the background of new energy vehicle promotion and application,a comparative analysis of domestic and foreign promotion models,specific promotion suggestions,and future development prospects.By leveraging insights from economic analysis,the optimal promotion model for new energy vehicles is elucidated.

Research on Key Points of Design of Standard Plants in Modern Industrial Parks Under the Background of Promoting the Development of New Quality Productive Forces

With the progress of science and technology and the acceleration of industrialization,the modern industrial park is an important carrier of industrial development.The importance of its standard plant design has become increasingly prominent.With the development of new quality productive forces as the background,this research deeply discusses the key points of standard plant design in modern industrial parks.This paper uses literature review and case analysis to systematically analyze the important role of standard plant design in developing new quality productive forces in modern industrial parks and puts forward suggestions for optimizing design.It is found that the rationality,intelligence,and environmental protection of plant design are the key factors affecting the development of new quality productive forces.The paper summarizes the core points of modern industrial park standard plant design to provide a reference for the future development of related industries.

Research on Landscape Ecology Mode of New Resources-based Cities—A Case Study of Yulin City of Shaanxi Province in China

Based on the overall understanding of new cities developing based on resources,by taking Yulin City of Shaanxi Province for example and combining with relevant statistical data,main problems existing in resources development have been pointed out,covering simple resources industrial structure and serious wastes in resources development;insufficient intensive processing of products and low level of resources integrated utilization;and deteriorative regional eco-environment.On this basis,a new mode of landscape ecology of resource-based cities have been proposed,emphasizing constructing new green energy industrial development mode from the perspective of microscopic view;ecological industrial park of circular economy from the perspective of mesoscopic view;and the overall ecological recovery mode of the mining area from the perspective of macroscopic view.It hopes to give a vital inspiration to the sustainable development of new resources-based cities.

NEW TYPE OF LINEAR ULTRASONIC MOTOR WITH TWO DEGREES OF FREEDOM USING LONGITUDINAL AND BENDING MODE

A new type of linear ultrasonic motor with two degrees of freedom (DOF) motion is presented. The concept of the new typical motor is based on the combination of a longitudinal and two bending modes. The construction and the operational principle of motor are described, and the elliptical motion of the driving point of the actuator is proved. Meanwhile, a prototype linear motor is designed by using the finite element method (FEM) and is constructed for experiments. The vibration modes are tested with the laser doppler vibrometer (PSV-300F), and the experimental results prove that the design requirements on the mode shape of the actuator and nature frequency are satisfied. The test run of the motor indicates that the operational principle of the motor and the design results are correct, and the output properties are also tested.

Research on Innovation of Rural Tourism Development Mode under New Situation

Through analysis on problems emerging during rural tourism development,the paper pointed out that the predicament of rural tourism development lied in aging,homogenization and initialization of tourist products.Then,it further analyzed reasons causing such predicament,and emphasized three aspects which were similarity and relative stability of tourist resources,dispersiveness and non-professionalization of development subjects,restriction and substitutability of industrial factors.On this basis,it discussed innovative strategies to solve these problems,and pointed out that innovation was the key to promote transformation and upgrading of rural tourism.The major tasks of rural tourism innovation were promoting villagers' innovative ability construction,building innovative agriculture and characteristic villages,exploring operation model of rural tourism cooperation,relying on leading enterprises and agricultural park,pushing land transfer and tourist land reform,and introducing large enterprises to development new programs.

An Optimal Model for Carbon Sinks of CDM Project to Build a New Countryside Based on Cyclic Economy under Uncertainty

Based on the status and characteristics of Clean Development Mechanism （CDM） renewable energy project and the mode of cyclic economy, aimed at achieving the maximum capacity of carbon sinks in the system, Lvjin Jiayuan—New Countryside Distripark CDM project in Wuchuan County was taken as an example for developing an interval linear programming （ILP） model to optimize the crops planting scheme and cows breeding scheme by using interval optimal method. The case showed that the optimized crops planting scheme and cows breeding scheme obtained from the optimal model was reasonable with relatively preferable overall performance. In the context of meeting economic benefits and fertilizer, electricity demand, [231 287.8, 273 312.7] t of CO2 could be absorbed and fixed, which had increased by [12.94, 33.46]% compared with the feasibility scheme of case project and provided technical support for making the decision in CDM project.

Investigation of Mode and Modulation Responses in Semiconductor PS-DFB Lasers:Use of a Vector-Newton Method

A numerical model for steady state analysis and analytical expressions for the AM and FM modulation responses of DFB lasers are presented.The small signal modulation responses of 3 phase shift(PS) DFB is investigated for the first time.A new method(Vector Newton method) to obtain multiple longitudinal mode of DFB lasers is used.It is demonstrated that this method is suitable for obtaining multiple solution of high nonlinear equations.Longitudinal photon density distribution and multiple longitudinal mode of 3PS DFB and simple DFB lasers are analyzed.The results show that modulation response characteristics of 3PS DFB laser is as good as that of DFB,and PS can weaken the longitudinal spatial hole burning (LHSB) effect and is in favor of single longitudinal mode operating of lasers.

Integration of Traditional Culture and Modern Landscape——A Case Study of Pioneering Park in Hefei New Political and Cultural District

The New Political and Cultural District of Hefei City is a typical case of the newly and quickly constructed areas with a high starting point in China in recent years, in which traditional culture and the spirit of age integrate harmoniously. Pioneering Park is a theme park with the pioneering spirit as the subject, which successfully absorbs the artistic method of traditional natural garden layout and combines the modern landscape design concept with plant landscaping as the dominant part, utilizes the recreational environment integrating with national style and modern concept to represent the pioneering spirit of the age.