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Multi-Criteria Wildfire Risk Hazard Assessment in GIS Environment: Projection for the Future and Impact on RES Projects Installation Planning
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作者 Aggelos Pallikarakis Flora Konstantopoulou 《Journal of Geoscience and Environment Protection》 2024年第5期242-265,共24页
It is alarming for the fact that Wildfires number, severity and consequently impact have significantly increased during the last years, an aftermath of the Climate Change. One of the most affected areas worldwide is M... It is alarming for the fact that Wildfires number, severity and consequently impact have significantly increased during the last years, an aftermath of the Climate Change. One of the most affected areas worldwide is Mediterranean, due to the unique combination of its type of vegetation and demanding climatic conditions. This research is focused on the Region of Epirus in Greece, an area with significant natural vegetation and a range of geomorphological aspects. In order to estimate the Wildfire Risk Hazard, several factors have been used: geomorphological (slope, aspect, elevation, TWI, Hydrographic network), social (Settlements and landfils, roads, overhead lines and substations), environmental (land cover) and climatic (Fire Weather Index). Through a multi-criteria decision analysis (MCDA) and an analytic hierarchy process (AHP) in a GIS environment, the Wildfire Risk Hazard has been estimated not only for current conditions but also for future projections for the near future (2031-2060) and the far future (2071-2100). The selected case study includes the potential impact of the Wildfires to the installed (or targeted to be installed) RES projects in the studied region. 展开更多
关键词 RES projects Greece Epirus Analytic Hierarchy Process Multi-Criteria Decision Analysis
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Financial Calculation Problems and Countermeasure Analysis of Large-Scale Engineering Construction Projects
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作者 Qiong Hou 《Proceedings of Business and Economic Studies》 2024年第2期15-21,共7页
The financial aspects of large-scale engineering construction projects profoundly influence their success.Strengthening cost control and establishing a scientific financial evaluation system can enhance the project’s... The financial aspects of large-scale engineering construction projects profoundly influence their success.Strengthening cost control and establishing a scientific financial evaluation system can enhance the project’s economic benefits,minimize unnecessary costs,and provide decision-makers with a robust financial foundation.Additionally,implementing an effective cash flow control mechanism and conducting a comprehensive assessment of potential project risks can ensure financial stability and mitigate the risk of fund shortages.Developing a practical and feasible fundraising plan,along with stringent fund management practices,can prevent fund wastage and optimize fund utilization efficiency.These measures not only facilitate smooth project progression and improve project management efficiency but also enhance the project’s economic and social outcomes. 展开更多
关键词 Large-scale engineering construction projects Financial calculation Fund management
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Construction Safety Management of Mechanical and Electrical Installation Projects
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作者 Honglou Chi 《Journal of Architectural Research and Development》 2024年第2期50-54,共5页
Various industries today rely on the support of electromechanical equipment,expanding its scope of application and leading to an increase in electromechanical installation projects.However,due to the high level of exp... Various industries today rely on the support of electromechanical equipment,expanding its scope of application and leading to an increase in electromechanical installation projects.However,due to the high level of expertise required and the potential risks involved,it is crucial to emphasize safety management during construction.This paper delves into the significance of construction safety management for electromechanical installation projects,identifies common problems encountered during construction,and proposes solutions.This analysis aims to provide relevant personnel with essential guidance and references for managing electromechanical installation projects safely. 展开更多
关键词 Construction safety Mechanical and electrical installation Installation engineering Engineering projects Safety management
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Impact of estuarine reclamation projects on saltwater intrusion and freshwater resource 被引量:1
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作者 Hanghang LU Jianrong ZHU +3 位作者 Qing CHEN Ming LI Shunqi PAN Shenliang CHEN 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2023年第1期38-56,共19页
Estuarine projects can change local topography and influence water transport and saltwater intrusion.The Changjiang(Yangtze)River estuary is a multichannel estuary,and four major reclamation projects have been impleme... Estuarine projects can change local topography and influence water transport and saltwater intrusion.The Changjiang(Yangtze)River estuary is a multichannel estuary,and four major reclamation projects have been implemented in the Changjiang River estuary in recent years:the Xincun Shoal reclamation project(RP-XCS),the Qingcao Shoal reclamation project(RP-QCS),the Eastern Hengsha Shoal reclamation project(RP-EHS),and the Nanhui Shoal reclamation project(RP-NHS).The effects of the four reclamation projects and each project on the saltwater intrusion and water resources in the Changjiang River estuary were simulated in a 3D numerical model.Results show that for a multichannel estuary,local reclamation projects change the local topography and water diversion ratio(WDR)between channels and influence water and salt transport and freshwater utilization in the estuary.During spring tide,under the cumulative effect of the four reclamation projects,the salinity decreases by approximately 0.5in the upper reaches of the North Branch and increases by 0.5-1.0 in the middle and lower reaches of the North Branch.In the North Channel,the salinity decreases by approximately 0.5.In the North Passage,the salinity increases by 0.5-1.0.In the South Passage,the salinity increases by approximately 0.5 in the upper reaches and decreases by 0.2-0.5 on the north side of the middle and lower reaches.During neap tide,the cumulative effects of the four reclamation projects and the individual projects are similar to those during spring tide,but there are some differences.The effects of an individual reclamation project on WDR and saltwater intrusion during spring and neap tides are simulated and analyzed in detail.The cumulative effect of the four reclamation projects favors freshwater usage in the Changjiang River estuary. 展开更多
关键词 reclamation projects saltwater intrusion freshwater resources numerical model Changjiang River estuary
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HSPM:A Better Model to Effectively Preventing Open-Source Projects from Dying
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作者 Zhifang Liao Fangying Fu +3 位作者 Yiqi Zhao Sui Tan Zhiwu Yu Yan Zhang 《Computer Systems Science & Engineering》 SCIE EI 2023年第10期431-452,共22页
With the rapid development of Open-Source(OS),more and more software projects are maintained and developed in the form of OS.These Open-Source projects depend on and influence each other,gradually forming a huge OS pr... With the rapid development of Open-Source(OS),more and more software projects are maintained and developed in the form of OS.These Open-Source projects depend on and influence each other,gradually forming a huge OS project network,namely an Open-Source Software ECOsystem(OSSECO).Unfortunately,not all OS projects in the open-source ecosystem can be healthy and stable in the long term,and more projects will go from active to inactive and gradually die.In a tightly connected ecosystem,the death of one project can potentially cause the collapse of the entire ecosystem network.How can we effectively prevent such situations from happening?In this paper,we first identify the basic project characteristics that affect the survival of OS projects at both project and ecosystem levels through the proportional hazards model.Then,we utilize graph convolutional networks based on the ecosystem network to extract the ecosystem environment characteristics of OS projects.Finally,we fuse basic project characteristics and environmental project characteristics and construct a Hybrid Structured Prediction Model(HSPM)to predict the OS project survival state.The experimental results show that HSPM significantly improved compared to the traditional prediction model.Our work can substantially assist OS project managers in maintaining their projects’health.It can also provide an essential reference for developers when choosing the right open-source project for their production activities. 展开更多
关键词 project survival prediction open-source ecosystem open-source project open-source health graph neural networks
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人工智能背景下Materials Project数据库在计算材料学课程教学中的应用
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作者 胡学敏 孙孪鸿 +1 位作者 陈晓玉 叶原丰 《科教文汇》 2024年第10期90-94,共5页
该文探讨了在人工智能背景下,Materials Project数据库在计算材料学课程教学中的应用和影响。Materials Project数据库是一个集成了AI和大数据技术的开放获取的材料库,能为学生提供海量的材料晶体结构和物性数据,使教学内容更为丰富,让... 该文探讨了在人工智能背景下,Materials Project数据库在计算材料学课程教学中的应用和影响。Materials Project数据库是一个集成了AI和大数据技术的开放获取的材料库,能为学生提供海量的材料晶体结构和物性数据,使教学内容更为丰富,让学生能通过亲自操作获取和分析数据,深入理解微观结构与物性之间的关系。这一新兴的教学模式不仅提升了学生的科研能力和创新思维能力,还有助于培养具备计算材料专业知识和多学科交叉的复合型人才。总体来说,人工智能时代下,大数据的引入为计算材料学课程带来新的活力,并对未来教育改革和实践产生了积极影响。 展开更多
关键词 人工智能 Materials project数据库 计算材料学教学
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Transcriptional regulation in the development and dysfunction of neocortical projection neurons 被引量:1
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作者 Ningxin Wang Rong Wan Ke Tang 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第2期246-254,共9页
Glutamatergic projection neurons generate sophisticated excitatory circuits to integrate and transmit information among different cortical areas,and between the neocortex and other regions of the brain and spinal cord... Glutamatergic projection neurons generate sophisticated excitatory circuits to integrate and transmit information among different cortical areas,and between the neocortex and other regions of the brain and spinal cord.Appropriate development of cortical projection neurons is regulated by certain essential events such as neural fate determination,proliferation,specification,differentiation,migration,survival,axonogenesis,and synaptogenesis.These processes are precisely regulated in a tempo-spatial manner by intrinsic factors,extrinsic signals,and neural activities.The generation of correct subtypes and precise connections of projection neurons is imperative not only to support the basic cortical functions(such as sensory information integration,motor coordination,and cognition)but also to prevent the onset and progression of neurodevelopmental disorders(such as intellectual disability,autism spectrum disorders,anxiety,and depression).This review mainly focuses on the recent progress of transcriptional regulations on the development and diversity of neocortical projection neurons and the clinical relevance of the failure of transcriptional modulations. 展开更多
关键词 autism spectrum disorders COGNITION differentiation excitatory circuits intellectual disability NEOCORTEX neurodevelopmental disorders projection neuron specification transcriptional regulation
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Developing Projects with Low-code Combined with ChatGPT
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作者 Wei Xiong Bing Li +1 位作者 Zhao Wu Bo Hang 《计算机教育》 2023年第12期204-213,共10页
This paper aims to explore a simpler and more user-friendly way of generating software based on model-driven development.Previous studies have attempted to generate code from domain models,hoping to reduce coding time... This paper aims to explore a simpler and more user-friendly way of generating software based on model-driven development.Previous studies have attempted to generate code from domain models,hoping to reduce coding time by increasing modeling time.However,as code tools become more advanced,it is challenging to improve efficiency because models are abstract while implementations are concrete.This paper proposes a novel approach that integrates ChatGPT as a plug-in into the whole R&D process and combines it with our code generation tool to enhance R&D efficiency.We have developed some demos to demonstrate the effectiveness of our approach.According to our evaluation,our approach can save more than 90%of the work in implementing the code generation tool,leaving only about 10%of the work for code review,code improvement,and unit testing. 展开更多
关键词 ChatGPT Low-code Code generation Software engineering project development
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Correlations between the Global Earth Healing and Global Consciousness Projects—Brain-Mind-Matter-Interactions through Physical Noise Generators
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作者 Marcus Schmieke 《Natural Science》 2023年第5期191-198,共8页
Inspired by Roger Nelson’s Global Consciousness Project (GCP), the Global Earth Healing Project (GEHP) uses a network of several hundred physical noise generators to amplify the combined intentions of their users in ... Inspired by Roger Nelson’s Global Consciousness Project (GCP), the Global Earth Healing Project (GEHP) uses a network of several hundred physical noise generators to amplify the combined intentions of their users in order to infuse positive affirmations into the global consciousness. As mentioned in the original study design, it was intended to use the GCP as a reference for the effectiveness of its activities. The data of the GEHP consisting of 21 events from 2013 to 2020 is analyzed and statistically compared to the data of the GCP. An astonishing synchronicity was observed, which suggests an interaction between the brain states of the observers and the physical noise generators of the GCP. 展开更多
关键词 Global Consciousness project Global Consciousness Information Field Coherence PEAR Lab Quantum Entanglement Decline Effect
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Application of Anti-seepage Technology in the Construction of Hydraulic Engineering Projects
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作者 Huanlin YANG 《Meteorological and Environmental Research》 CAS 2023年第5期31-32,35,共3页
With the development of China's economy,the implementation scale and scope of hydraulic engineering projects are increasing,and the application of anti-seepage technology has an important influence on the construc... With the development of China's economy,the implementation scale and scope of hydraulic engineering projects are increasing,and the application of anti-seepage technology has an important influence on the construction quality of hydraulic engineering.In this paper,the significance and problems of the application of anti-seepage technology in the construction of hydraulic engineering projects were mainly analyzed,and specific application strategies were proposed. 展开更多
关键词 Anti-seepage technology Hydraulic engineering projects Application strategy
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Perception-Based Assessment of the Factors Causing Delays in Construction Projects
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作者 Om Prakash Giri 《Engineering(科研)》 2023年第7期431-445,共15页
Construction delay is a widespread issue in the construction industry of developing countries, and Nepal is no exception. These delays extend project durations and lead to cost overruns and disputes among stakeholders... Construction delay is a widespread issue in the construction industry of developing countries, and Nepal is no exception. These delays extend project durations and lead to cost overruns and disputes among stakeholders. To address this problem, this study aimed to identify and analyze the significant factors that contribute to construction project delays in Nepal. To gather data, a well-structured questionnaire was developed and administered to a sample of 100 participants, including contractors, consultants, and civil engineers. Various statistical tests were conducted to ensure the data’s integrity and consistency, such as reliability assessments and factor analyses. The findings of the study highlighted multiple factors contributing to delays in construction projects such as inadequate design, poor communication, and coordination among stakeholders, insufficient experience and planning by contractors, delays in material delivery and testing, labor-related problems including shortages and low qualifications, and external factors like regulatory changes and unforeseen circumstances. By identifying these major causes of construction project delays, this study presented insightful information that can contribute to the analysis and evaluation of project performance. 展开更多
关键词 Construction projects Construction Industry Delay Causes Construction De-lays project Performance
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Diagnosis of indirectly driven double shell targets with point-projection hard x-ray radiography
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作者 Chao Tian Minghai Yu +17 位作者 Lianqiang Shan Fengjuan Wu Bi Bi Qiangqiang Zhang Yuchi Wu Tiankui Zhang Feng Zhang Dongxiao Liu Weiwu Wang Zongqiang Yuan Siqian Yang Lei Yang Zhigang Deng Jian Teng Weimin Zhou Zongqing Zhao Yuqiu Gu Baohan Zhang 《Matter and Radiation at Extremes》 SCIE EI CSCD 2024年第2期50-62,共13页
We present an application of short-pulse laser-generated hard x rays for the diagnosis of indirectly driven double shell targets. Coneinserted double shell targets were imploded through an indirect drive approach on t... We present an application of short-pulse laser-generated hard x rays for the diagnosis of indirectly driven double shell targets. Coneinserted double shell targets were imploded through an indirect drive approach on the upgraded SG-II laser facility. Then, based on thepoint-projection hard x-ray radiography technique, time-resolved radiography of the double shell targets, including that of their near-peakcompression, were obtained. The backlighter source was created by the interactions of a high-intensity short pulsed laser with a metalmicrowire target. Images of the target near peak compression were obtained with an Au microwire. In addition, radiation hydrodynamicsimulations were performed, and the target evolution obtained agrees well with the experimental results. Using the radiographic images, arealdensities of the targets were evaluated. 展开更多
关键词 double projectION POINT
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Accelerated Primal-Dual Projection Neurodynamic Approach With Time Scaling for Linear and Set Constrained Convex Optimization Problems
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作者 You Zhao Xing He +1 位作者 Mingliang Zhou Tingwen Huang 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第6期1485-1498,共14页
The Nesterov accelerated dynamical approach serves as an essential tool for addressing convex optimization problems with accelerated convergence rates.Most previous studies in this field have primarily concentrated on... The Nesterov accelerated dynamical approach serves as an essential tool for addressing convex optimization problems with accelerated convergence rates.Most previous studies in this field have primarily concentrated on unconstrained smooth con-vex optimization problems.In this paper,on the basis of primal-dual dynamical approach,Nesterov accelerated dynamical approach,projection operator and directional gradient,we present two accelerated primal-dual projection neurodynamic approaches with time scaling to address convex optimization problems with smooth and nonsmooth objective functions subject to linear and set constraints,which consist of a second-order ODE(ordinary differential equation)or differential conclusion system for the primal variables and a first-order ODE for the dual vari-ables.By satisfying specific conditions for time scaling,we demonstrate that the proposed approaches have a faster conver-gence rate.This only requires assuming convexity of the objective function.We validate the effectiveness of our proposed two accel-erated primal-dual projection neurodynamic approaches through numerical experiments. 展开更多
关键词 Accelerated projection neurodynamic approach lin-ear and set constraints projection operators smooth and nonsmooth convex optimization time scaling.
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New Projects[2022.1—2023.7]
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《造纸信息》 2023年第9期101-104,共4页
On January 2^(nd),2022,the PM2 paper machine of Guanyun Limin Renewable Resource Technology Development Co.,Ltd.was successfully put into operation,with a width of 5,200 mm and a design speed of 700 m/min.The annual p... On January 2^(nd),2022,the PM2 paper machine of Guanyun Limin Renewable Resource Technology Development Co.,Ltd.was successfully put into operation,with a width of 5,200 mm and a design speed of 700 m/min.The annual production capacity of PM2 exceeds 200,000 tons,which uses waste paper to produce low-weight cardboard boxes. 展开更多
关键词 BOXES capacity projects
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Evaluating the Impact of Workshop Management on the Progress of Road Construction Projects(Case Study:Road Construction Projects of Tehran Province)
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作者 Morteza Modarresi Fatemeh Mousavi 《Journal of Management Science & Engineering Research》 2023年第1期49-59,共11页
Construction projects,including road construction,are very important.Therefore,a lot of money is spent on these projects every year.So,the lack of proper planning will increase the cost and cause irreparable damage to... Construction projects,including road construction,are very important.Therefore,a lot of money is spent on these projects every year.So,the lack of proper planning will increase the cost and cause irreparable damage to the country.The role of workshop management is one of the most important factors in increasing the cost of these types of projects.Generally,workshop management plays a very important role in improving the quality and quantity of projects and has an important place in the project implementation process.Therefore,this study evaluated the impact of workshop management on the progress of road construction projects on a case-by-case basis in road construction projects in Tehran province.According to the purpose of the research,this study was a descriptive-survey type.In addition,the tool used in this research was a questionnaire.The statistical population of this research included all experts and specialists in road construction projects,among whom 65 people were selected by snowball method.Then the collected data were analyzed using SPSS software.The results of this study showed that the management of the workshop and its role in the control and implementation of projects is a complex process,which can be implemented at high levels and effectively by combining scientific and experimental training.And a very important point in the discussion of workshop management is applying scientific management to the use of valuable experiences from others.Because management knowledge not only does not negate the use of these experiences,but also emphasizes the necessity of using them.In other words,improving the knowledge of workshop management is one of the requirements for the implementation of value engineering in construction projects,especially road construction,and it is very important. 展开更多
关键词 Construction projects Workshop management SNOWBALL Road construction
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Discussion on the Application of Pipe Jacking Construction Technology in Municipal Road Drainage Projects
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作者 Liang Liu Lizhao Zhao 《Journal of Architectural Research and Development》 2023年第6期29-35,共7页
In the construction of municipal road drainage projects,pipe jacking construction is a relatively common construction method.This construction technology can avoid a large amount of excavation work,improve drainage co... In the construction of municipal road drainage projects,pipe jacking construction is a relatively common construction method.This construction technology can avoid a large amount of excavation work,improve drainage construction efficiency,avoid large-scale damage to the road surface,and exert small traffic impact.Therefore,it is currently widely used in drainage construction,but judging from the current actual application situation,there are still many problems that require further improvement.This article mainly analyzes the advantages of and current technical problems in pipe jacking construction technology in detail,explores corresponding solutions,and lays a foundation for the optimization of municipal road drainage engineering construction. 展开更多
关键词 Municipal roads Drainage projects Pipe jacking construction Advantages
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Agricultural Investment Project Decisions Based on an Interactive Preference Disaggregation Model Considering Inconsistency
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作者 Xingli Wu Huchang Liao +1 位作者 Shuxian Sun Zhengjun Wan 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第6期3125-3146,共22页
Agricultural investment project selection is a complex multi-criteria decision-making problem,as agricultural projects are easily influenced by various risk factors,and the evaluation information provided by decisionm... Agricultural investment project selection is a complex multi-criteria decision-making problem,as agricultural projects are easily influenced by various risk factors,and the evaluation information provided by decisionmakers usually involves uncertainty and inconsistency.Existing literature primarily employed direct preference elicitation methods to address such issues,necessitating a great cognitive effort on the part of decision-makers during evaluation,specifically,determining the weights of criteria.In this study,we propose an indirect preference elicitation method,known as a preference disaggregation method,to learn decision-maker preference models fromdecision examples.To enhance evaluation ease,decision-makers merely need to compare pairs of alternatives with which they are familiar,also known as reference alternatives.Probabilistic linguistic preference relations are employed to account for the presence of incomplete and uncertain information in such pairwise comparisons.To address the inconsistency among a group of decision-makers,we develop a pair of 0-1mixed integer programming models that consider both the semantics of linguistic terms and the belief degrees of decision-makers.Finally,we conduct a case study and comparative analysis.Results reveal the effectiveness of the proposed model in solving agricultural investment project selection problems with uncertain and inconsistent decision information. 展开更多
关键词 Multiple criteria analysis preference disaggregation INCONSISTENCY probability linguistic preference relation investment project selection
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Spatial diversion and coordination of flood water for an urban flood control project in Suzhou, China
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作者 Yu Xu You-peng Xu +2 位作者 Qiang Wang Yue-feng Wang Chao Gao 《Water Science and Engineering》 EI CAS CSCD 2024年第2期108-117,共10页
Suzhou City,located in the Yangtze River Delta in China,is prone to flooding due to a complex combination of natural factors,including its monsoon climate,low elevation,and tidally influenced position,as well as inten... Suzhou City,located in the Yangtze River Delta in China,is prone to flooding due to a complex combination of natural factors,including its monsoon climate,low elevation,and tidally influenced position,as well as intensive human activities.The Large Encirclement Flood Control Project(LEFCP)was launched to cope with serious floods in the urban area.This project changed the spatiotemporal pattern of flood processes and caused spatial diversion of floods from the urban area to the outskirts of the city.Therefore,this study developed a distributed flood simulation model in order to understand this transition of flood processes.The results revealed that the LEFCP effectively protected the urban areas from floods,but the present scheduling schemes resulted in the spatial diversion of floods to the outskirts of the city.With rainstorm frequencies of 10.0%to 0.5%,the water level differences between two representative water level stations(Miduqiao(MDQ)and Fengqiao(FQ))located inside and outside the LEFCP area,ranged from 0.75 m to 0.24 m and from 1.80 m to 1.58 m,respectively.In addition,the flood safety margin at MDQ and the duration with the water level exceeding the warning water level at FQ ranged from 0.95 m to 0.43 m and from 4 h to 22 h,respectively.Rational scheduling schemes for the hydraulic facilities of the LEFCP in extreme precipitation cases were developed ac-cording to food simulations under seven scheduling scenarios.This helps to regulate the spatial flood diversion caused by the LEFCP during extreme precipitation. 展开更多
关键词 Urban flooding Urban flood control project Rainstorm fregue ncy Flood simulation model Suzhou City
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Cascading multi-segment rupture process of the 2023 Turkish earthquake doublet on a complex fault system revealed by teleseismic P wave back projection method
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作者 Bonan Cao Zengxi Ge 《Earthquake Science》 2024年第2期158-173,共16页
In this study,the vertical components of broadband teleseismic P wave data recorded by China Earthquake Network are used to image the rupture processes of the February 6th,2023 Turkish earthquake doublet via back proj... In this study,the vertical components of broadband teleseismic P wave data recorded by China Earthquake Network are used to image the rupture processes of the February 6th,2023 Turkish earthquake doublet via back projection analysis.Data in two frequency bands(0.5-2 Hz and 1-3 Hz)are used in the imaging processes.The results show that the rupture of the first event extends about 200 km to the northeast and about 150 km to the southwest,lasting~90 s in total.The southwestern rupture is triggered by the northeastern rupture,demonstrating a sequential bidirectional unilateral rupture pattern.The rupture of the second event extends approximately 80 km in both northeast and west directions,lasting~35 s in total and demonstrates a typical bilateral rupture feature.The cascading ruptures on both sides also reflect the occurrence of selective rupture behaviors on bifurcated faults.In addition,we observe super-shear ruptures on certain fault sections with relatively straight fault structures and sparse aftershocks. 展开更多
关键词 2023 Turkish earthquake doublet back projection method cascading segmented rupture process coseismic triggering super-shear ruptures
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How do lateral septum projections to the ventral CA1 influence sociability?
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作者 Dan Wang Di Zhao +12 位作者 Wentao Wang Fengai Hu Minghu Cui Jing Liu Fantao Meng Cuilan Liu Changyun Qiu Dunjiang Liu Zhicheng Xu Yameng Wang Yu Zhang Wei Li Chen Li 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第8期1789-1801,共13页
Social dysfunction is a risk factor for several neuropsychiatric illnesses.Previous studies have shown that the lateral septum(LS)-related pathway plays a critical role in mediating social behaviors.Howeve r,the role ... Social dysfunction is a risk factor for several neuropsychiatric illnesses.Previous studies have shown that the lateral septum(LS)-related pathway plays a critical role in mediating social behaviors.Howeve r,the role of the connections between the LS and its downstream brain regions in social behavio rs remains unclea r.In this study,we conducted a three-chamber test using electrophysiological and chemogenetic approaches in mice to determine how LS projections to ventral CA1(vCA1)influence sociability.Our res ults showed that gamma-aminobutyric acid(GABA)-e rgic neuro ns were activated following social experience,and that social behavio rs were enhanced by chemogenetic modulation of these neurons.Moreover,LS GABAergic neurons extended their functional neural connections via vCA1 glutamatergic pyramidal neurons,and regulating LSGABA→vCA1Gluneural projections affected social behaviors,which were impeded by suppressing LSprojecting vCA1 neuronal activity or inhibiting GABAAreceptors in vCA1.These findings support the hypothesis that LS inputs to the vCA1 can control social prefe rences and social novelty behaviors.These findings provide new insights rega rding the neural circuits that regulate sociability. 展开更多
关键词 chemogenetics GABA receptor GABAergic neurons glutamatergic neurons lateral septum neural excitability neural projection social novelty social preference ventral CA1
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