Research motivation:Through the 12 weeks dance therapy intervention for children with autism,the purpose is to explore the intervention model of dance therapy for children with autism and the changes in motor ability,...Research motivation:Through the 12 weeks dance therapy intervention for children with autism,the purpose is to explore the intervention model of dance therapy for children with autism and the changes in motor ability,social ability,and communication ability of children with autism after dance therapy intervention.The results of the research are expected to expand the intervention mode of dance therapy in my country and provide practical reference for rehabilitation intervention of children with autism.Research methods:24 autistic boys aged 6 to 12 with mild to moderate symptoms were recruited and screened through the Internet as the subjects of this study.We randomly divided them into experimental group(N=12)and control group(N=12).All children with autism have an autism diagnosis certificate issued by Children’s Hospital or a tertiary hospital,excluding other mental diseases(such as epilepsy,major physical disability,mental illness,no history of drugs and other interventions,etc.).We used the paired sample t-test to compare the score difference between the dance treatment group and the control group before and after the two groups,and used the observation method to record the basic communication behavior and the number of active communication behaviors in the experimental group during the intervention process.All data analysis is used in SPSS 20.0.Research results:After 12 weeks of dance therapy intervention,there were statistically significant differences in the gross movement,balance,and coordination abilities of the children in the experimental group compared with those before the intervention(p<0.01).There was no significant difference between the children in the control group(p>0.05).After 12 weeks of dance therapy intervention,there were statistically significant differences in the scores of the social response scale for children with autism in the experimental group(p<0.05).There was no significant change in the scores of each item of the SRS scale before and after intervention in the control group and the dance treatment group(p>0.05).展开更多
Dragon is a traditional totem of the Chinese nation and is worshiped by the Chinese people all over the world,representing auspiciousness,strength and wisdom.China has a vast territory.As for the rich and diverse inta...Dragon is a traditional totem of the Chinese nation and is worshiped by the Chinese people all over the world,representing auspiciousness,strength and wisdom.China has a vast territory.As for the rich and diverse intangible cultural heritage,there are many cultural treasures directly related to"dragon",and fire dragon dance is one of them.展开更多
Dachuan Baijie Muddymen Dance is a kind of dance with local characteristics.From its dance movements and prop usage,it should be related to ancient Ba people’s war dance,as well as to recorded ancient dances such as...Dachuan Baijie Muddymen Dance is a kind of dance with local characteristics.From its dance movements and prop usage,it should be related to ancient Ba people’s war dance,as well as to recorded ancient dances such as“Da Xia”and“Da Wu”.展开更多
During the Chinese New Year of 2024,China National Opera&Dance Drama Theater was invited to Hungary,Sweden,Denmark and Norway to carry out the 2024"Happy Chinese NewYear"tour performance.China National O...During the Chinese New Year of 2024,China National Opera&Dance Drama Theater was invited to Hungary,Sweden,Denmark and Norway to carry out the 2024"Happy Chinese NewYear"tour performance.China National Opera&Dance Drama Theater sent a visiting team composed of 29 artists to touch the hearts of overseas audiences with the art of ethnic singing and dancing and the deep charm of the Chinese culture,and to spread the essence of the Chinese culture in the dialogue with the world.展开更多
The importance of breathing training in dance teaching is reflected in the two aspects of enhancing the quality of dance movements and sublimating the connotation of dance movements.For example,high-quality breathing ...The importance of breathing training in dance teaching is reflected in the two aspects of enhancing the quality of dance movements and sublimating the connotation of dance movements.For example,high-quality breathing can help performers complete the dance movements and improve the coordination of the movements;at the same time,the unique body rhythm formed by breathing can strengthen the visual effect of the performance and convey its spirit and soul to the audience.This requires folk dance teachers to carry out relevant training and teaching activities based on the categories and skills of dance breathing,such as changing students’ideological cognition,developing periodic breathing training courses,providing personalized guidance to students,and allowing students to adjust their learning and practice methods in the evaluation.展开更多
University libraries,as an integral component of university research capabilities,are tasked with serving education by providing research support to faculty and students.This study adopts an affordance research perspe...University libraries,as an integral component of university research capabilities,are tasked with serving education by providing research support to faculty and students.This study adopts an affordance research perspective originating from ecological psychology to explore the optimization path of research support services in libraries in the new media era.Based on the characteristics of university library services,this research analyzes three aspects:production affordance,mobile affordance,and social affordance,and proposes practical recommendations to guide future research service practices of university libraries.展开更多
Short,momentary,temporary,transient,precarious,and labile are adjectives that the current post-pandemic,ecological,climatic,war,political,economic,and social contingencies have accustomed us to employ almost compulsiv...Short,momentary,temporary,transient,precarious,and labile are adjectives that the current post-pandemic,ecological,climatic,war,political,economic,and social contingencies have accustomed us to employ almost compulsively and indiscriminately by now,and that,beyond everything,are synonyms inter-implicit with and in the ephemerality,which deserves reconsideration in its literalness as epìheméra(for a day),that can take place through a sort of its“double”,not quite mainstream but nonetheless suggestive and perhaps even effective,such as the artistic one of dance.Therefore,it is worth pausing to try and see which streaks/implications of the ephemerality itself the dance-ephemeral conveys and/or produces:the neuralgic concretions that the latter seems to me to involve and permeate,in a perspective of re-cognition/re-discovery/awareness,are time,space and the body,evidently inter-implicated.展开更多
Dance of the Happy Shades是加拿大作家艾丽斯·门罗的成名作,该部描写女性题材的短篇小说集历时15年完成于1968年出版,荣获加拿大最高文学奖项——总督奖。目前,我国有部分学者从图里翻译规范理论出发对Dance of the Happy Shade...Dance of the Happy Shades是加拿大作家艾丽斯·门罗的成名作,该部描写女性题材的短篇小说集历时15年完成于1968年出版,荣获加拿大最高文学奖项——总督奖。目前,我国有部分学者从图里翻译规范理论出发对Dance of the Happy Shades进行了汉译本对比研究,而从女性主义翻译理论出发的研究有待拓展。本文以李玉瑶汉译本为研究对象,从女性主义翻译理论视域出发,探讨女性译者如何在翻译中体现女性主义翻译意识,从而帮助读者进一步理解原著。展开更多
Adult male tree shrews vigorously defend against intruding male conspecifics. However, the characteristics of social behavior have not been entirely explored in these males. In this study, male wild-type tree shrews(T...Adult male tree shrews vigorously defend against intruding male conspecifics. However, the characteristics of social behavior have not been entirely explored in these males. In this study, male wild-type tree shrews(Tupaia belangeri chinensis)and C57 BL/6 J mice were first allowed to familiarize themselves with an open-field apparatus. The tree shrews exhibited a short duration of movement(moving) in the novel environment, whereas the mice exhibited a long duration of movement. In the 30 min social preference-avoidance test, target animals significantly decreased the time spent by the experimental tree shrews in the social interaction(SI)zone, whereas experimental male mice exhibited the opposite. In addition, experimental tree shrews displayed a significantly longer latency to enter the SI zone in the second 15 min session(targetpresent) than in the first 15 min session(targetabsent), which was different from that found in mice.Distinct behavioral patterns in response to a conspecific male were also observed in male tree shrews and mice in the first, second, and third 5 min periods. Thus, social behaviors in tree shrews and mice appeared to be time dependent. In summary,our study provides results of a modified social preference-avoidance test designed for the assessment of social behavior in tree shrews. Our findings demonstrate the existence of social avoidance behavior in male tree shrews and prosocial behavior in male mice toward unfamiliar conspecifics. The tree shrew may be a new animal model, which differs from mice, for the study of social avoidance and prosocial behaviors.展开更多
Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral response.Recent studies have shown that brain-derived neurotrophic factor expression in stressed mice ...Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral response.Recent studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and hippocampus.Determining how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress psychopathology.In this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of depression.We focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine circuit.We determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic system.Therefore,BDNF might be a biological indicator regulating stress-related processes in various brain regions.展开更多
A growing number of studies have demonstrated that repeated exposure to sevoflurane during development results in persistent social abnormalities and cognitive impairment.Davunetide,an active fragment of the activity-...A growing number of studies have demonstrated that repeated exposure to sevoflurane during development results in persistent social abnormalities and cognitive impairment.Davunetide,an active fragment of the activity-dependent neuroprotective protein(ADNP),has been implicated in social and cognitive protection.However,the potential of davunetide to attenuate social deficits following sevoflurane exposure and the underlying developmental mechanisms remain poorly understood.In this study,ribosome and proteome profiles were analyzed to investigate the molecular basis of sevoflurane-induced social deficits in neonatal mice.The neuropathological basis was also explored using Golgi staining,morphological analysis,western blotting,electrophysiological analysis,and behavioral analysis.Results indicated that ADNP was significantly down-regulated following developmental exposure to sevoflurane.In adulthood,anterior cingulate cortex(ACC)neurons exposed to sevoflurane exhibited a decrease in dendrite number,total dendrite length,and spine density.Furthermore,the expression levels of Homer,PSD95,synaptophysin,and vglut2 were significantly reduced in the sevoflurane group.Patch-clamp recordings indicated reductions in both the frequency and amplitude of miniature excitatory postsynaptic currents(mEPSCs).Notably,davunetide significantly ameliorated the synaptic defects,social behavior deficits,and cognitive impairments induced by sevoflurane.Mechanistic analysis revealed that loss of ADNP led to dysregulation of Ca^(2+)activity via the Wnt/β-catenin signaling,resulting in decreased expression of synaptic proteins.Suppression of Wnt signaling was restored in the davunetide-treated group.Thus,ADNP was identified as a promising therapeutic target for the prevention and treatment of neurodevelopmental toxicity caused by general anesthetics.This study provides important insights into the mechanisms underlying social and cognitive disturbances caused by sevoflurane exposure in neonatal mice and elucidates the regulatory pathways involved.展开更多
Equal access to social infrastructures is a fundamental prerequisite for sustainable development,but has long been a great challenge worldwide.Previous studies have primarily focused on the accessibility to social inf...Equal access to social infrastructures is a fundamental prerequisite for sustainable development,but has long been a great challenge worldwide.Previous studies have primarily focused on the accessibility to social infras-tructures in urban areas across various scales,with less attention to rural areas,where inequality can be more severe.Particularly,few have investigated the disparities of accessibility to social infrastructures between urban and rural areas.Here,using the Changsha-Zhuzhou-Xiangtan urban agglomeration,China,as an example,we investigated the inequality of accessibility in both urban and rural areas,and further compared the urban-rural difference.Accessibility was measured by travel time of residents to infrastructures.We selected four types of social infrastructures including supermarkets,bus stops,primary schools,and health care,which were funda-mentally important to both urban and rural residents.We found large disparities in accessibility between urban and rural areas,ranging from 20 min to 2 h.Rural residents had to spend one to two more hours to bus stops than urban residents,and 20 min more to the other three types of infrastructures.Furthermore,accessibility to multiple infrastructures showed greater urban-rural differences.Rural residents in more than half of the towns had no access to any infrastructure within 15 min,while more than 60%of the urban residents could access to all infrastructures within 15 min.Our results revealed quantitative accessibility gap between urban and rural areas and underscored the necessity of social infrastructures planning to address such disparities.展开更多
Adolescents are considered one of the most vulnerable groups affected by suicide.Rapid changes in adolescents’physical and mental states,as well as in their lives,significantly and undeniably increase the risk of sui...Adolescents are considered one of the most vulnerable groups affected by suicide.Rapid changes in adolescents’physical and mental states,as well as in their lives,significantly and undeniably increase the risk of suicide.Psychological,social,family,individual,and environmental factors are important risk factors for suicidal behavior among teenagers and may contribute to suicide risk through various direct,indirect,or combined pathways.Social-emotional learning is considered a powerful intervention measure for addressing the crisis of adolescent suicide.When deliberately cultivated,fostered,and enhanced,selfawareness,self-management,social awareness,interpersonal skills,and responsible decision-making,as the five core competencies of social-emotional learning,can be used to effectively target various risk factors for adolescent suicide and provide necessary mental and interpersonal support.Among numerous suicide intervention methods,school-based interventions based on social-emotional competence have shown great potential in preventing and addressing suicide risk factors in adolescents.The characteristics of school-based interventions based on social-emotional competence,including their appropriateness,necessity,cost-effectiveness,comprehensiveness,and effectiveness,make these interventions an important means of addressing the crisis of adolescent suicide.To further determine the potential of school-based interventions based on social-emotional competence and better address the issue of adolescent suicide,additional financial support should be provided,the combination of socialemotional learning and other suicide prevention programs within schools should be fully leveraged,and cooperation between schools and families,society,and other environments should be maximized.These efforts should be considered future research directions.展开更多
ONE of Hong Kong’s modern-looking neighborhoods in Wan Chai District is home to the Tai Hang Fire Dragon Dance,a folk art form with a history of over 100 years.Many years ago,this neighborhood was a village populated...ONE of Hong Kong’s modern-looking neighborhoods in Wan Chai District is home to the Tai Hang Fire Dragon Dance,a folk art form with a history of over 100 years.Many years ago,this neighborhood was a village populated by a subgroup of the Han Chinese people named the Hakka,who live mainly in the provinces of Guangdong,Jiangxi,and Fujian in China and speak the Hakka language.It is said that ever since a plague swept through the village,the villagers started to perform a fire dragon dance for three days around the Mid-Autumn Festival in the eighth month of the lunar calendar every year to pray for peace.This later evolved into a festive event in Hong Kong.This tradition was included in the National Intangible Cultural Heritage List in 2011.展开更多
The tango of life begins with the very first cell division.New research reveals that to dance their way through development,dividing cells must pass along not just DNA but molecular“memories”that guide their destini...The tango of life begins with the very first cell division.New research reveals that to dance their way through development,dividing cells must pass along not just DNA but molecular“memories”that guide their destinies.When this handoff gets fumbled,the dance falls apart.展开更多
Background and Objective:Social media(SoMe)has emerged as a tool in health professions education(HPE),particularly amidst the challenges posed by the coronavirus disease 2019(COVID-19)pandemic.Despite the academia’s ...Background and Objective:Social media(SoMe)has emerged as a tool in health professions education(HPE),particularly amidst the challenges posed by the coronavirus disease 2019(COVID-19)pandemic.Despite the academia’s initial skepticism SoMe has been gaining traction in supporting learning communities,and offering opportunities for innovation in HPE.Our study aims to explore the integration of SoMe in HPE.Four key components were outlined as necessary for a successful integration,and include designing learning experiences,defining educator roles,selecting appropriate platforms,and establishing educational objectives.Methods:This article stemmed from the online Teaching Skills Series module on SoMe in education from the Ophthalmology Foundation,and drew upon evidence supporting learning theories relevant to SoMe integration and models of education.Additionally,we conducted a literature review considering Englishlanguage articles on the application of SoMe in ophthalmology from PubMed over the past decade.Key Content and Findings:Early adopters of SoMe platforms in HPE have leveraged these tools to enhance learning experiences through interaction,dialogue,content sharing,and active learning strategies.By integrating SoMe into educational programs,both online and in-person,educators can overcome time and geographical constraints,fostering more diverse and inclusive learning communities.Careful consideration is,however,necessary to address potential limitations within HPE.Conclusions:This article lays groundwork for expanding SoMe integration in HPE design,emphasizing the supportive scaffold of various learning theories,and the need of furthering robust research on examining its advantages over traditional educational formats.Our literature review underscores an ongoing multifaceted,random application of SoMe platforms in ophthalmology education.We advocate for an effective incorporation of SoMe in HPE education,with the need to comply with good educational practice.展开更多
From cultural and creative products to performance,animation,and avant-garde technology,the timehonored Guangdong lion dance has always been on the new stage of China chic.AS the sounds of drums and gongs reached thei...From cultural and creative products to performance,animation,and avant-garde technology,the timehonored Guangdong lion dance has always been on the new stage of China chic.AS the sounds of drums and gongs reached their climax,a cute big-headed ornate stylized lion leading 12 others interacted happily with spectators and participants in a lion dance parade in Xiqiao Town,Foshan City,the third largest city in Guangdong Province.Some took out their phones and recorded the joyous moment,and others went up and touched the lion heads to get good fortune.This is a moment when the Nanhai Lion Dance Troupe was celebrating its first birthday.展开更多
JINGXI Taiping Drum is a traditional form of dancing that is prevalent in Mentougou District of Beijing. With its great popularity and display of profound cultural elements, it was included in the first batch of China...JINGXI Taiping Drum is a traditional form of dancing that is prevalent in Mentougou District of Beijing. With its great popularity and display of profound cultural elements, it was included in the first batch of China’s national intangible cultural heritage items in 2006.展开更多
THE elephant-foot drum dance is one of the most popular and representative traditional dances of the Dai people,one of China’s 56 ethnic groups.Performing the dance requires a high level of skills and can involve one...THE elephant-foot drum dance is one of the most popular and representative traditional dances of the Dai people,one of China’s 56 ethnic groups.Performing the dance requires a high level of skills and can involve one or two individuals,or a group of people.This form of dance was originally intended to ward off evil spirits and usher in a good year.In addition to the Dai people,it is also popular among other ethnic groups in China such as Deang,Jingpo,Achang to name a few.It was listed as a national intangible cultural heritage item in 2008.展开更多
GUOZHUANG Dance is one of the three major folk dances practiced by the Tibetan people."Guozhuang Dance"means"singing and dancing in a circle"in the Tibetan language and is mainly popular in Diqing ...GUOZHUANG Dance is one of the three major folk dances practiced by the Tibetan people."Guozhuang Dance"means"singing and dancing in a circle"in the Tibetan language and is mainly popular in Diqing Tibetan Autonomous Prefecture of Yunnan Province in southwestern China.It has a history of more than 1,000 years,as evidenced by ancient dancing images on a Tang Dynasty Tibetan-language tablet discovered in Shigujiaozi Village of Lijiang in Yunnan Province.This age-old dancing style was included in the national intangible cultural heritage list in 2006.展开更多
文摘Research motivation:Through the 12 weeks dance therapy intervention for children with autism,the purpose is to explore the intervention model of dance therapy for children with autism and the changes in motor ability,social ability,and communication ability of children with autism after dance therapy intervention.The results of the research are expected to expand the intervention mode of dance therapy in my country and provide practical reference for rehabilitation intervention of children with autism.Research methods:24 autistic boys aged 6 to 12 with mild to moderate symptoms were recruited and screened through the Internet as the subjects of this study.We randomly divided them into experimental group(N=12)and control group(N=12).All children with autism have an autism diagnosis certificate issued by Children’s Hospital or a tertiary hospital,excluding other mental diseases(such as epilepsy,major physical disability,mental illness,no history of drugs and other interventions,etc.).We used the paired sample t-test to compare the score difference between the dance treatment group and the control group before and after the two groups,and used the observation method to record the basic communication behavior and the number of active communication behaviors in the experimental group during the intervention process.All data analysis is used in SPSS 20.0.Research results:After 12 weeks of dance therapy intervention,there were statistically significant differences in the gross movement,balance,and coordination abilities of the children in the experimental group compared with those before the intervention(p<0.01).There was no significant difference between the children in the control group(p>0.05).After 12 weeks of dance therapy intervention,there were statistically significant differences in the scores of the social response scale for children with autism in the experimental group(p<0.05).There was no significant change in the scores of each item of the SRS scale before and after intervention in the control group and the dance treatment group(p>0.05).
文摘Dragon is a traditional totem of the Chinese nation and is worshiped by the Chinese people all over the world,representing auspiciousness,strength and wisdom.China has a vast territory.As for the rich and diverse intangible cultural heritage,there are many cultural treasures directly related to"dragon",and fire dragon dance is one of them.
基金Research Center for the Protection and Development of Tangible Cultural Heritage in East Sichuan in 2022 (Project No.2022YB17)2018 Sichuan University of Arts and Sciences Ba Culture Research Special Project“Ba Culture Literature Compilation and Research” (Project Number:2018BWH001Z).
文摘Dachuan Baijie Muddymen Dance is a kind of dance with local characteristics.From its dance movements and prop usage,it should be related to ancient Ba people’s war dance,as well as to recorded ancient dances such as“Da Xia”and“Da Wu”.
文摘During the Chinese New Year of 2024,China National Opera&Dance Drama Theater was invited to Hungary,Sweden,Denmark and Norway to carry out the 2024"Happy Chinese NewYear"tour performance.China National Opera&Dance Drama Theater sent a visiting team composed of 29 artists to touch the hearts of overseas audiences with the art of ethnic singing and dancing and the deep charm of the Chinese culture,and to spread the essence of the Chinese culture in the dialogue with the world.
文摘The importance of breathing training in dance teaching is reflected in the two aspects of enhancing the quality of dance movements and sublimating the connotation of dance movements.For example,high-quality breathing can help performers complete the dance movements and improve the coordination of the movements;at the same time,the unique body rhythm formed by breathing can strengthen the visual effect of the performance and convey its spirit and soul to the audience.This requires folk dance teachers to carry out relevant training and teaching activities based on the categories and skills of dance breathing,such as changing students’ideological cognition,developing periodic breathing training courses,providing personalized guidance to students,and allowing students to adjust their learning and practice methods in the evaluation.
文摘University libraries,as an integral component of university research capabilities,are tasked with serving education by providing research support to faculty and students.This study adopts an affordance research perspective originating from ecological psychology to explore the optimization path of research support services in libraries in the new media era.Based on the characteristics of university library services,this research analyzes three aspects:production affordance,mobile affordance,and social affordance,and proposes practical recommendations to guide future research service practices of university libraries.
文摘Short,momentary,temporary,transient,precarious,and labile are adjectives that the current post-pandemic,ecological,climatic,war,political,economic,and social contingencies have accustomed us to employ almost compulsively and indiscriminately by now,and that,beyond everything,are synonyms inter-implicit with and in the ephemerality,which deserves reconsideration in its literalness as epìheméra(for a day),that can take place through a sort of its“double”,not quite mainstream but nonetheless suggestive and perhaps even effective,such as the artistic one of dance.Therefore,it is worth pausing to try and see which streaks/implications of the ephemerality itself the dance-ephemeral conveys and/or produces:the neuralgic concretions that the latter seems to me to involve and permeate,in a perspective of re-cognition/re-discovery/awareness,are time,space and the body,evidently inter-implicated.
文摘Dance of the Happy Shades是加拿大作家艾丽斯·门罗的成名作,该部描写女性题材的短篇小说集历时15年完成于1968年出版,荣获加拿大最高文学奖项——总督奖。目前,我国有部分学者从图里翻译规范理论出发对Dance of the Happy Shades进行了汉译本对比研究,而从女性主义翻译理论出发的研究有待拓展。本文以李玉瑶汉译本为研究对象,从女性主义翻译理论视域出发,探讨女性译者如何在翻译中体现女性主义翻译意识,从而帮助读者进一步理解原著。
基金the National Natural Science Foundation of China(81671344,31500859)Major International(Regional)Joint Research Project of the National Natural Science Foundation of China(81920108018)+1 种基金1.3.5 Project for Disciplines of Excellence,Special Foundation for Brain Research from the Science and Technology Program of Guangdong(2018B030334001)West China Hospital of Sichuan University(ZY2016103,ZY2016203)。
文摘Adult male tree shrews vigorously defend against intruding male conspecifics. However, the characteristics of social behavior have not been entirely explored in these males. In this study, male wild-type tree shrews(Tupaia belangeri chinensis)and C57 BL/6 J mice were first allowed to familiarize themselves with an open-field apparatus. The tree shrews exhibited a short duration of movement(moving) in the novel environment, whereas the mice exhibited a long duration of movement. In the 30 min social preference-avoidance test, target animals significantly decreased the time spent by the experimental tree shrews in the social interaction(SI)zone, whereas experimental male mice exhibited the opposite. In addition, experimental tree shrews displayed a significantly longer latency to enter the SI zone in the second 15 min session(targetpresent) than in the first 15 min session(targetabsent), which was different from that found in mice.Distinct behavioral patterns in response to a conspecific male were also observed in male tree shrews and mice in the first, second, and third 5 min periods. Thus, social behaviors in tree shrews and mice appeared to be time dependent. In summary,our study provides results of a modified social preference-avoidance test designed for the assessment of social behavior in tree shrews. Our findings demonstrate the existence of social avoidance behavior in male tree shrews and prosocial behavior in male mice toward unfamiliar conspecifics. The tree shrew may be a new animal model, which differs from mice, for the study of social avoidance and prosocial behaviors.
基金supported financially by the National Natural Science Foundation of China,No.82071272(to YZ).
文摘Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral response.Recent studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and hippocampus.Determining how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress psychopathology.In this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of depression.We focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine circuit.We determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic system.Therefore,BDNF might be a biological indicator regulating stress-related processes in various brain regions.
基金supported by the National Natural Science Foundation of China(82171170,81971076,82371277 to H.Z.,82101345 to L.R.L.)。
文摘A growing number of studies have demonstrated that repeated exposure to sevoflurane during development results in persistent social abnormalities and cognitive impairment.Davunetide,an active fragment of the activity-dependent neuroprotective protein(ADNP),has been implicated in social and cognitive protection.However,the potential of davunetide to attenuate social deficits following sevoflurane exposure and the underlying developmental mechanisms remain poorly understood.In this study,ribosome and proteome profiles were analyzed to investigate the molecular basis of sevoflurane-induced social deficits in neonatal mice.The neuropathological basis was also explored using Golgi staining,morphological analysis,western blotting,electrophysiological analysis,and behavioral analysis.Results indicated that ADNP was significantly down-regulated following developmental exposure to sevoflurane.In adulthood,anterior cingulate cortex(ACC)neurons exposed to sevoflurane exhibited a decrease in dendrite number,total dendrite length,and spine density.Furthermore,the expression levels of Homer,PSD95,synaptophysin,and vglut2 were significantly reduced in the sevoflurane group.Patch-clamp recordings indicated reductions in both the frequency and amplitude of miniature excitatory postsynaptic currents(mEPSCs).Notably,davunetide significantly ameliorated the synaptic defects,social behavior deficits,and cognitive impairments induced by sevoflurane.Mechanistic analysis revealed that loss of ADNP led to dysregulation of Ca^(2+)activity via the Wnt/β-catenin signaling,resulting in decreased expression of synaptic proteins.Suppression of Wnt signaling was restored in the davunetide-treated group.Thus,ADNP was identified as a promising therapeutic target for the prevention and treatment of neurodevelopmental toxicity caused by general anesthetics.This study provides important insights into the mechanisms underlying social and cognitive disturbances caused by sevoflurane exposure in neonatal mice and elucidates the regulatory pathways involved.
基金supported by funding from the National Natural Science Foundation of China(Grant No.U21A2010)the National Science Fund for Distinguished Young Scholars(Grant No.42225104)the National Key Research and Development Program(Grant No.2022YFF130110O).
文摘Equal access to social infrastructures is a fundamental prerequisite for sustainable development,but has long been a great challenge worldwide.Previous studies have primarily focused on the accessibility to social infras-tructures in urban areas across various scales,with less attention to rural areas,where inequality can be more severe.Particularly,few have investigated the disparities of accessibility to social infrastructures between urban and rural areas.Here,using the Changsha-Zhuzhou-Xiangtan urban agglomeration,China,as an example,we investigated the inequality of accessibility in both urban and rural areas,and further compared the urban-rural difference.Accessibility was measured by travel time of residents to infrastructures.We selected four types of social infrastructures including supermarkets,bus stops,primary schools,and health care,which were funda-mentally important to both urban and rural residents.We found large disparities in accessibility between urban and rural areas,ranging from 20 min to 2 h.Rural residents had to spend one to two more hours to bus stops than urban residents,and 20 min more to the other three types of infrastructures.Furthermore,accessibility to multiple infrastructures showed greater urban-rural differences.Rural residents in more than half of the towns had no access to any infrastructure within 15 min,while more than 60%of the urban residents could access to all infrastructures within 15 min.Our results revealed quantitative accessibility gap between urban and rural areas and underscored the necessity of social infrastructures planning to address such disparities.
文摘Adolescents are considered one of the most vulnerable groups affected by suicide.Rapid changes in adolescents’physical and mental states,as well as in their lives,significantly and undeniably increase the risk of suicide.Psychological,social,family,individual,and environmental factors are important risk factors for suicidal behavior among teenagers and may contribute to suicide risk through various direct,indirect,or combined pathways.Social-emotional learning is considered a powerful intervention measure for addressing the crisis of adolescent suicide.When deliberately cultivated,fostered,and enhanced,selfawareness,self-management,social awareness,interpersonal skills,and responsible decision-making,as the five core competencies of social-emotional learning,can be used to effectively target various risk factors for adolescent suicide and provide necessary mental and interpersonal support.Among numerous suicide intervention methods,school-based interventions based on social-emotional competence have shown great potential in preventing and addressing suicide risk factors in adolescents.The characteristics of school-based interventions based on social-emotional competence,including their appropriateness,necessity,cost-effectiveness,comprehensiveness,and effectiveness,make these interventions an important means of addressing the crisis of adolescent suicide.To further determine the potential of school-based interventions based on social-emotional competence and better address the issue of adolescent suicide,additional financial support should be provided,the combination of socialemotional learning and other suicide prevention programs within schools should be fully leveraged,and cooperation between schools and families,society,and other environments should be maximized.These efforts should be considered future research directions.
文摘ONE of Hong Kong’s modern-looking neighborhoods in Wan Chai District is home to the Tai Hang Fire Dragon Dance,a folk art form with a history of over 100 years.Many years ago,this neighborhood was a village populated by a subgroup of the Han Chinese people named the Hakka,who live mainly in the provinces of Guangdong,Jiangxi,and Fujian in China and speak the Hakka language.It is said that ever since a plague swept through the village,the villagers started to perform a fire dragon dance for three days around the Mid-Autumn Festival in the eighth month of the lunar calendar every year to pray for peace.This later evolved into a festive event in Hong Kong.This tradition was included in the National Intangible Cultural Heritage List in 2011.
文摘The tango of life begins with the very first cell division.New research reveals that to dance their way through development,dividing cells must pass along not just DNA but molecular“memories”that guide their destinies.When this handoff gets fumbled,the dance falls apart.
文摘Background and Objective:Social media(SoMe)has emerged as a tool in health professions education(HPE),particularly amidst the challenges posed by the coronavirus disease 2019(COVID-19)pandemic.Despite the academia’s initial skepticism SoMe has been gaining traction in supporting learning communities,and offering opportunities for innovation in HPE.Our study aims to explore the integration of SoMe in HPE.Four key components were outlined as necessary for a successful integration,and include designing learning experiences,defining educator roles,selecting appropriate platforms,and establishing educational objectives.Methods:This article stemmed from the online Teaching Skills Series module on SoMe in education from the Ophthalmology Foundation,and drew upon evidence supporting learning theories relevant to SoMe integration and models of education.Additionally,we conducted a literature review considering Englishlanguage articles on the application of SoMe in ophthalmology from PubMed over the past decade.Key Content and Findings:Early adopters of SoMe platforms in HPE have leveraged these tools to enhance learning experiences through interaction,dialogue,content sharing,and active learning strategies.By integrating SoMe into educational programs,both online and in-person,educators can overcome time and geographical constraints,fostering more diverse and inclusive learning communities.Careful consideration is,however,necessary to address potential limitations within HPE.Conclusions:This article lays groundwork for expanding SoMe integration in HPE design,emphasizing the supportive scaffold of various learning theories,and the need of furthering robust research on examining its advantages over traditional educational formats.Our literature review underscores an ongoing multifaceted,random application of SoMe platforms in ophthalmology education.We advocate for an effective incorporation of SoMe in HPE education,with the need to comply with good educational practice.
文摘From cultural and creative products to performance,animation,and avant-garde technology,the timehonored Guangdong lion dance has always been on the new stage of China chic.AS the sounds of drums and gongs reached their climax,a cute big-headed ornate stylized lion leading 12 others interacted happily with spectators and participants in a lion dance parade in Xiqiao Town,Foshan City,the third largest city in Guangdong Province.Some took out their phones and recorded the joyous moment,and others went up and touched the lion heads to get good fortune.This is a moment when the Nanhai Lion Dance Troupe was celebrating its first birthday.
文摘JINGXI Taiping Drum is a traditional form of dancing that is prevalent in Mentougou District of Beijing. With its great popularity and display of profound cultural elements, it was included in the first batch of China’s national intangible cultural heritage items in 2006.
文摘THE elephant-foot drum dance is one of the most popular and representative traditional dances of the Dai people,one of China’s 56 ethnic groups.Performing the dance requires a high level of skills and can involve one or two individuals,or a group of people.This form of dance was originally intended to ward off evil spirits and usher in a good year.In addition to the Dai people,it is also popular among other ethnic groups in China such as Deang,Jingpo,Achang to name a few.It was listed as a national intangible cultural heritage item in 2008.
文摘GUOZHUANG Dance is one of the three major folk dances practiced by the Tibetan people."Guozhuang Dance"means"singing and dancing in a circle"in the Tibetan language and is mainly popular in Diqing Tibetan Autonomous Prefecture of Yunnan Province in southwestern China.It has a history of more than 1,000 years,as evidenced by ancient dancing images on a Tang Dynasty Tibetan-language tablet discovered in Shigujiaozi Village of Lijiang in Yunnan Province.This age-old dancing style was included in the national intangible cultural heritage list in 2006.