Study of tree shrew biology and models: A booming and prosperous field for biomedical research

The tree shrew(Tupaia belangeri)has long been proposed as a suitable alternative to non-human primates(NHPs)in biomedical and laboratory research due to its close evolutionary relationship with primates.In recent years,significant advances have facilitated tree shrew studies,including the determination of the tree shrew genome,genetic manipulation using spermatogonial stem cells,viral vector-mediated gene delivery,and mapping of the tree shrew brain atlas.However,the limited availability of tree shrews globally remains a substantial challenge in the field.Additionally,determining the key questions best answered using tree shrews constitutes another difficulty.Tree shrew models have historically been used to study hepatitis B virus(HBV)and hepatitis C virus(HCV)infection,myopia,and psychosocial stress-induced depression,with more recent studies focusing on developing animal models for infectious and neurodegenerative diseases.Despite these efforts,the impact of tree shrew models has not yet matched that of rodent or NHP models in biomedical research.This review summarizes the prominent advancements in tree shrew research and reflects on the key biological questions addressed using this model.We emphasize that intensive dedication and robust international collaboration are essential for achieving breakthroughs in tree shrew studies.The use of tree shrews as a unique resource is expected to gain considerable attention with the application of advanced techniques and the development of viable animal models,meeting the increasing demands of life science and biomedical research.

Enhancing PDF Malware Detection through Logistic Model Trees

Malware is an ever-present and dynamic threat to networks and computer systems in cybersecurity,and because of its complexity and evasiveness,it is challenging to identify using traditional signature-based detection approaches.The study article discusses the growing danger to cybersecurity that malware hidden in PDF files poses,highlighting the shortcomings of conventional detection techniques and the difficulties presented by adversarial methodologies.The article presents a new method that improves PDF virus detection by using document analysis and a Logistic Model Tree.Using a dataset from the Canadian Institute for Cybersecurity,a comparative analysis is carried out with well-known machine learning models,such as Credal Decision Tree,Naïve Bayes,Average One Dependency Estimator,Locally Weighted Learning,and Stochastic Gradient Descent.Beyond traditional structural and JavaScript-centric PDF analysis,the research makes a substantial contribution to the area by boosting precision and resilience in malware detection.The use of Logistic Model Tree,a thorough feature selection approach,and increased focus on PDF file attributes all contribute to the efficiency of PDF virus detection.The paper emphasizes Logistic Model Tree’s critical role in tackling increasing cybersecurity threats and proposes a viable answer to practical issues in the sector.The results reveal that the Logistic Model Tree is superior,with improved accuracy of 97.46%when compared to benchmark models,demonstrating its usefulness in addressing the ever-changing threat landscape.

Computation Tree Logic Model Checking of Multi-Agent Systems Based on Fuzzy Epistemic Interpreted Systems

Model checking is an automated formal verification method to verify whether epistemic multi-agent systems adhere to property specifications.Although there is an extensive literature on qualitative properties such as safety and liveness,there is still a lack of quantitative and uncertain property verifications for these systems.In uncertain environments,agents must make judicious decisions based on subjective epistemic.To verify epistemic and measurable properties in multi-agent systems,this paper extends fuzzy computation tree logic by introducing epistemic modalities and proposing a new Fuzzy Computation Tree Logic of Knowledge(FCTLK).We represent fuzzy multi-agent systems as distributed knowledge bases with fuzzy epistemic interpreted systems.In addition,we provide a transformation algorithm from fuzzy epistemic interpreted systems to fuzzy Kripke structures,as well as transformation rules from FCTLK formulas to Fuzzy Computation Tree Logic(FCTL)formulas.Accordingly,we transform the FCTLK model checking problem into the FCTL model checking.This enables the verification of FCTLK formulas by using the fuzzy model checking algorithm of FCTL without additional computational overheads.Finally,we present correctness proofs and complexity analyses of the proposed algorithms.Additionally,we further illustrate the practical application of our approach through an example of a train control system.

An approach to estimate tree height using PolInSAR data constructed by the Sentinel-1 dual-pol SAR data and RVoG model

We estimate tree heights using polarimetric interferometric synthetic aperture radar(PolInSAR)data constructed by the dual-polarization(dual-pol)SAR data and random volume over the ground(RVoG)model.Considering the Sentinel-1 SAR dual-pol(SVV,vertically transmitted and vertically received and SVH,vertically transmitted and horizontally received)configuration,one notes that S_(HH),the horizontally transmitted and horizontally received scattering element,is unavailable.The S_(HH)data were constructed using the SVH data,and polarimetric SAR(PolSAR)data were obtained.The proposed approach was first verified in simulation with satisfactory results.It was next applied to construct PolInSAR data by a pair of dual-pol Sentinel-1A data at Duke Forest,North Carolina,USA.According to local observations and forest descriptions,the range of estimated tree heights was overall reasonable.Comparing the heights with the ICESat-2 tree heights at 23 sampling locations,relative errors of 5 points were within±30%.Errors of 8 points ranged from 30%to 40%,but errors of the remaining 10 points were>40%.The results should be encouraged as error reduction is possible.For instance,the construction of PolSAR data should not be limited to using SVH,and a combination of SVH and SVV should be explored.Also,an ensemble of tree heights derived from multiple PolInSAR data can be considered since tree heights do not vary much with time frame in months or one season.

Predicting distant metastasis in nasopharyngeal carcinoma using gradient boosting tree model based on detailed magnetic resonance imaging reports

BACKGROUND Development of distant metastasis(DM)is a major concern during treatment of nasopharyngeal carcinoma(NPC).However,studies have demonstrated im-proved distant control and survival in patients with advanced NPC with the addition of chemotherapy to concomitant chemoradiotherapy.Therefore,precise prediction of metastasis in patients with NPC is crucial.AIM To develop a predictive model for metastasis in NPC using detailed magnetic resonance imaging(MRI)reports.METHODS This retrospective study included 792 patients with non-distant metastatic NPC.A total of 469 imaging variables were obtained from detailed MRI reports.Data were stratified and randomly split into training(50%)and testing sets.Gradient boosting tree(GBT)models were built and used to select variables for predicting DM.A full model comprising all variables and a reduced model with the top-five variables were built.Model performance was assessed by area under the curve(AUC).RESULTS Among the 792 patients,94 developed DM during follow-up.The number of metastatic cervical nodes(30.9%),tumor invasion in the posterior half of the nasal cavity(9.7%),two sides of the pharyngeal recess(6.2%),tubal torus(3.3%),and single side of the parapharyngeal space(2.7%)were the top-five contributors for predicting DM,based on their relative importance in GBT models.The testing AUC of the full model was 0.75(95%confidence interval[CI]:0.69-0.82).The testing AUC of the reduced model was 0.75(95%CI:0.68-0.82).For the whole dataset,the full(AUC=0.76,95%CI:0.72-0.82)and reduced models(AUC=0.76,95%CI:0.71-0.81)outperformed the tumor node-staging system(AUC=0.67,95%CI:0.61-0.73).CONCLUSION The GBT model outperformed the tumor node-staging system in predicting metastasis in NPC.The number of metastatic cervical nodes was identified as the principal contributing variable.

Attribute-driven Fuzzy Fault Tree Model for Adaptive Lubricant Failure Diagnosis

Lubricant diagnosis serves as a crucial accordance for condition-based maintenance(CBM)involving oil changing and wear examination of critical parts in equipment.However,the accuracy of traditional end-to-end diagnosis models is often limited by the inconsistency and random fluctuations in multiple monitoring indicators.To address this,an attribute-driven adaptive diagnosis method is developed,involving three attributes:physicochemical,contamination,and wear.Correspondingly,a fuzzy fault tree(termed FFT)-based model is constructed containing the logic correlations from monitoring indicators to attributes and to lubricant failures.In particular,inference rules are integrated to mitigate conflicts arising from the reverse degradation of multiple indicators.With this model,the lubricant conditions can be accurately assessed through rule-based reasoning.Furthermore,to enhance its intelligence,the model is dynamically optimized with lubricant analysis knowledge and monitoring data.For verification,the developed model is tested with lubricant samples from both the fatigue experiment and actual aero-engines.Fatigue experiments reveal that the proposed model can improve the lubricant diagnosis accuracy from 73.4%to 92.6%compared with the existing methods.While for the engine lubricant test,a high accuracy of 90%was achieved.

适于GlobalAllomeTree国际数据平台的标准化中国主要树种树高-胸径方程研建

GlobalAllomeTree作为共享异速方程的国际网络平台,逐渐受到全球高度关注。当前,为促进该项国际合作,针对当前该平台缺乏中国主要树种生长异速方程的现状,系统性更新标准化中国主要树种树高-胸径方程。由于树冠和下部灌木及草丛遮挡,树高相对于胸径测量具有一定的难度,因此需要使用数学工具进行计算。选取了36个树种为材料构建树高-胸径关系方程,以全国主要树种的二元材积模型、各地区一元材积表为基础材料,以取样径阶为1 cm间隔所生成1692组树高-胸径数据作为建立方程样本,1238组外业调查数据为验证样本。建模结果表明:36个主要树种的1692组树高-胸径数据建立的全国通用性树高-胸径方程拟合相关系数(R2)为0.801,方程拟合结果较好,说明可以通过测定胸径,带入树高(H,m)-胸径(D,cm)方程(H=aDb)预估树高;对36个主要树种的树高-胸径方程进行拟合,决定系数R2值均大于0.916,平均误差(ME)、平均绝对误差(MAE)和均方根误差(RMSE)相对较小,方程整体精度较高,可广泛推广;将外业采集的1238组树高-胸径数据,根据36个主要树种树高-胸径方程拟合公式及参数估计值a、b进行方程精度验证,方程预测的平均相对误差为16.86%,在误差允许范围内,并且模型形式规范,可为GlobalAllomeTree平台用户提供科学参考。

采用STAMP-24Model的多组织事故分析

安全生产事故往往由多组织交互、多因素耦合造成,事故原因涉及多个组织。为预防和遏制多组织生产安全事故的发生,基于系统理论事故建模与过程模型(Systems-Theory Accident Modeling and Process,STAMP)、24Model,构建一种用于多组织事故分析的方法,并以青岛石油爆炸事故为例进行事故原因分析。结果显示:STAMP-24Model可以分组织,分层次且有效、全面、详细地分析涉及多个组织的事故原因,探究多组织之间的交互关系;对事故进行动态演化分析,可得到各组织不安全动作耦合关系与形成的事故失效链及管控失效路径,进而为预防多组织事故提供思路和参考。

基于改进24Model-ISM-SNA建筑工人不安全行为关联路径研究

建筑施工现场环境复杂,为有效控制不安全行为发生,基于行为安全“2-4”模型对360份具有代表性的建筑安全事故调查报告进行分析,提取出22个不安全行为的主要影响因素。利用灰色关联分析方法(GRA)改进的集成ISM-SNA模型,将不安全行为风险因素划分为表层、过渡层与深层,然后对风险因素进行可视化分析、中心度分析及凝聚子群分析,揭示了各致因因素间的关联关系和传导路径。结果表明,建筑工人不安全行为影响因素可划分成7级3阶的多级递阶结构,安全意识、现场监管、外部环境是建筑工人不安全行为的关键影响因素,同时现场监管和隐患排查到位能有效降低不安全行为的发生。

基于24Model-D-ISM的地铁站火灾疏散影响因素研究

为预防地铁站火灾事故,深入了解地铁站火灾人员疏散影响因素间的内在联系与层次结构,基于第6版“2-4”模型(24Model)分析63起地铁站火灾疏散事故,充分考虑各个因素之间的交互作用,提取19个影响地铁站人员疏散的关键因素,建立地铁站火灾人员疏散影响因素指标体系;采用算子客观赋权法(C-OWA)改进决策试验与评价实验法(DEMATEL),确定地铁站火灾人员疏散的重要影响因素;在此基础上,采用解释结构模型(ISM)分析各个因素间的层次结构及相互作用路径,构建地铁站火灾人员疏散影响因素的多级递阶结构模型。研究结果表明:疏散引导、恐慌从众行为、人员拥挤为地铁站火灾人员疏散的关键影响因素;地铁站火灾人员疏散受表层因素、中间层因素、深层因素共同作用的影响,其中,疏散教育与培训、设施维护与检查、疏散预案等因素是根源影响因素,重视根源影响因素的改善有利于从本质上预防和控制事故的发生。

Improved Prediction of Slope Stability under Static and Dynamic Conditions Using Tree-BasedModels

Slope stability prediction plays a significant role in landslide disaster prevention and mitigation.This paper’s reduced error pruning(REP)tree and random tree(RT)models are developed for slope stability evaluation and meeting the high precision and rapidity requirements in slope engineering.The data set of this study includes five parameters,namely slope height,slope angle,cohesion,internal friction angle,and peak ground acceleration.The available data is split into two categories:training(75%)and test(25%)sets.The output of the RT and REP tree models is evaluated using performance measures including accuracy(Acc),Matthews correlation coefficient(Mcc),precision(Prec),recall(Rec),and F-score.The applications of the aforementionedmethods for predicting slope stability are compared to one another and recently established soft computing models in the literature.The analysis of the Acc together with Mcc,and F-score for the slope stability in the test set demonstrates that the RT achieved a better prediction performance with(Acc=97.1429%,Mcc=0.935,F-score for stable class=0.979 and for unstable case F-score=0.935)succeeded by the REP tree model with(Acc=95.4286%,Mcc=0.896,F-score stable class=0.967 and for unstable class F-score=0.923)for the slope stability dataset The analysis of performance measures for the slope stability dataset reveals that the RT model attains comparatively better and reliable results and thus should be encouraged in further research.

24Model与LCM原因因素定义对比研究

为探究损失致因模型(LCM)原因因素定义与事故致因“2-4”模型(24Model)存在的异同和优缺点,梳理2个模型各层面原因和结果的定义,对比定义内容及其对事故原因分析等安全实务的指导作用,并以一起瓦斯爆炸事故为例加以实证分析,获得二者分析结果之间的差异。研究结果表明:LCM是首个将管理因素纳入事故致因分析的一维事件序列模型,可明确各层面原因因素的定义和因素间的逻辑关系,但部分定义存在交叉重复的问题,并没有揭示安全工作指导思想等深层次事故致因因素;24Model作为系统性事故致因模型,对各类因素的定义均以组织为主体,描述事件、事故、安全的概念内涵,划分个体安全动作、安全能力和组织安全管理体系的类别并给出含义解析,探究组织安全文化层面的问题并以32个元素体现;2个模型的事故原因分析方法均建立在对各层级原因因素定义的基础上,并适用于模型理论体系本身。

Are allometric model parameters of aboveground biomass for trees phylogenetically constrained?

Knowledge of which biological and functional traits have,or lack,phylogenetic signal in a particular group of organisms is important to understanding the formation and functioning of biological communities.Allometric biomass models reflecting tree growth characteristics are commonly used to predict forest biomass.However,few studies have examined whether model parameters are constrained by phylogeny.Here,we use a comprehensive database(including 276 tree species) compiled from 894 allometric biomass models published in 302 articles to examine whether parameters a and b of the model W=aD~b(where W stands for aboveground biomass,D is diameter at breast height) exhibit phylogenetic signal for all tree species as a whole and for different groups of tree species.For either model parameter,we relate difference in model parameter between different tree species to phylogenetic distance and to environmental distance between pairwise sites.Our study shows that neither model parameter exhibits phylogenetic signals(Pagel's λ and Blomberg's K both approach zero).This is the case regardless of whether all tree species in our data set were analyzed as a whole or tree species in different taxonomic groups(gymnosperm and angiosperm),leaf duration groups(evergreen and deciduous),or ecological groups(tropical,temperate and boreal) were analyzed separately.Our study also shows that difference in each parameter of the allometric biomass model is not significantly related to phylogenetic and environmental distances between tree species in different sites.

Novel Soft ComputingModel for Predicting Blast-Induced Ground Vibration in Open-Pit Mines Based on the Bagging and Sibling of Extra Trees Models

This study considered and predicted blast-induced ground vibration(PPV)in open-pit mines using bagging and sibling techniques under the rigorous combination of machine learning algorithms.Accordingly,four machine learning algorithms,including support vector regression(SVR),extra trees(ExTree),K-nearest neighbors(KNN),and decision tree regression(DTR),were used as the base models for the purposes of combination and PPV initial prediction.The bagging regressor(BA)was then applied to combine these base models with the efforts of variance reduction,overfitting elimination,and generating more robust predictive models,abbreviated as BA-ExTree,BAKNN,BA-SVR,and BA-DTR.It is emphasized that the ExTree model has not been considered for predicting blastinduced ground vibration before,and the bagging of ExTree is an innovation aiming to improve the accuracy of the inherently ExTree model,as well.In addition,two empirical models(i.e.,USBM and Ambraseys)were also treated and compared with the bagging models to gain a comprehensive assessment.With this aim,we collected 300 blasting events with different parameters at the Sin Quyen copper mine(Vietnam),and the produced PPV values were also measured.They were then compiled as the dataset to develop the PPV predictive models.The results revealed that the bagging models provided better performance than the empirical models,except for the BA-DTR model.Of those,the BA-ExTree is the best model with the highest accuracy(i.e.,88.8%).Whereas,the empirical models only provided the accuracy from 73.6%–76%.The details of comparisons and assessments were also presented in this study.

Risk Assessment of Deep-Water Horizontal X-Tree Installation

Due to the high potential risk and many influencing factors of subsea horizontal X-tree installation,to guarantee the successful completion of sea trials of domestic subsea horizontal X-trees,this paper established a modular risk evaluation model based on a fuzzy fault tree.First,through the analysis of the main process oftree down and combining the Offshore&Onshore Reliability Data(OREDA)failure statistics and the operation procedure and the data provided by the job,the fault tree model of risk analysis of the tree down installation was established.Then,by introducing the natural language of expert comprehensive evaluation and combining fuzzy principles,quantitative analysis was carried out,and the fuzzy number was used to calculate the failure probability of a basic event and the occurrence probability of a top event.Finally,through a sensitivity analysis of basic events,the basic events of top events significantly affected were determined,and risk control and prevention measures for the corresponding high-risk factors were proposed for subsea horizontal X-tree down installation.

基于FP-tree的新能源汽车产业国际竞争力影响因素关联挖掘算法

为充分挖掘新能源汽车产业国际竞争力影响因素、探究价值增长点,提出了基于FP-tree的影响因素关联挖掘算法。通过构建国际竞争力各指标影响因素的关联规则,分析任意事务数据集中的关联数据,利用最小支持度参数minsup按照从上到下的方式搜索,确定最长的频繁项目集,采用FP-tree关联频繁项目集,设定分支关联性挖掘标准,实现了新能源汽车产业国际竞争力影响因素的挖掘。测试结果表明,设计算法的最小支持度和数据关联挖掘时间较短,置信度分析具有较高的稳定性。

基于i-Tree模型的行道树生态系统服务价值

行道树作为街道绿化系统的骨架,支撑着城市生态系统服务功能的正常运转。以武汉市临江大道中段为例,基于i-Tree构建行道树生态系统服务的综合评议模型,通过以货币值作为统一衡量标准分析演算研究地27种常见行道树及街道整体生态系统服务价值,旨在为行道树树种选择优化,以及街道景观与生态环境的提升提供参考。结果表明:1)在街道的植景搭配中,整体生态系统服务价值排序为:美学价值>能源节省价值>雨水截留价值>空气净化价值>生态固碳价值。2)研究地全部行道树年生态系统服务价值约131.8万元,平均1 km行道树年生态系统服务价值可达28.65万元,单株行道树年平均生态系统服务价值可达307.23元。3)行道树具有可观的生态系统服务价值,同时也存在明显种间差异,其中能源节省、美学价值和雨水截留价值在演算树种中价值量较高,空气净化和生态固碳价值量较低。因此,在街道行道树配置过程中,应将能源节省、美学价值和雨水截留价值作为首要参考因素,再结合街道属性综合考虑树种选择与应用,以构建功能全面的城市行道树生态系统服务结构,提高行道树整体的生态系统服务价值。

Projecting Wintertime Newly Formed Arctic Sea Ice through Weighting CMIP6 Model Performance and Independence

Precipitous Arctic sea-ice decline and the corresponding increase in Arctic open-water areas in summer months give more space for sea-ice growth in the subsequent cold seasons. Compared to the decline of the entire Arctic multiyear sea ice,changes in newly formed sea ice indicate more thermodynamic and dynamic information on Arctic atmosphere–ocean–ice interaction and northern mid–high latitude atmospheric teleconnections. Here, we use a large multimodel ensemble from phase 6 of the Coupled Model Intercomparison Project(CMIP6) to investigate future changes in wintertime newly formed Arctic sea ice. The commonly used model-democracy approach that gives equal weight to each model essentially assumes that all models are independent and equally plausible, which contradicts with the fact that there are large interdependencies in the ensemble and discrepancies in models' performances in reproducing observations. Therefore, instead of using the arithmetic mean of well-performing models or all available models for projections like in previous studies, we employ a newly developed model weighting scheme that weights all models in the ensemble with consideration of their performance and independence to provide more reliable projections. Model democracy leads to evident bias and large intermodel spread in CMIP6 projections of newly formed Arctic sea ice. However, we show that both the bias and the intermodel spread can be effectively reduced by the weighting scheme. Projections from the weighted models indicate that wintertime newly formed Arctic sea ice is likely to increase dramatically until the middle of this century regardless of the emissions scenario.Thereafter, it may decrease(or remain stable) if the Arctic warming crosses a threshold(or is extensively constrained).

Anisotropic time-dependent behaviors of shale under direct shearing and associated empirical creep models

Understanding the anisotropic creep behaviors of shale under direct shearing is a challenging issue.In this context,we conducted shear-creep and steady-creep tests on shale with five bedding orientations (i.e.0°,30°,45°,60°,and 90°),under multiple levels of direct shearing for the first time.The results show that the anisotropic creep of shale exhibits a significant stress-dependent behavior.Under a low shear stress,the creep compliance of shale increases linearly with the logarithm of time at all bedding orientations,and the increase depends on the bedding orientation and creep time.Under high shear stress conditions,the creep compliance of shale is minimal when the bedding orientation is 0°,and the steady-creep rate of shale increases significantly with increasing bedding orientations of 30°,45°,60°,and 90°.The stress-strain values corresponding to the inception of the accelerated creep stage show an increasing and then decreasing trend with the bedding orientation.A semilogarithmic model that could reflect the stress dependence of the steady-creep rate while considering the hardening and damage process is proposed.The model minimizes the deviation of the calculated steady-state creep rate from the observed value and reveals the behavior of the bedding orientation's influence on the steady-creep rate.The applicability of the five classical empirical creep models is quantitatively evaluated.It shows that the logarithmic model can well explain the experimental creep strain and creep rate,and it can accurately predict long-term shear creep deformation.Based on an improved logarithmic model,the variations in creep parameters with shear stress and bedding orientations are discussed.With abovementioned findings,a mathematical method for constructing an anisotropic shear creep model of shale is proposed,which can characterize the nonlinear dependence of the anisotropic shear creep behavior of shale on the bedding orientation.

Rising utilization of stable isotopes in tree rings for climate change and forest ecology

Analyses of stable isotopes(C,O,H)in tree rings are increasingly important cross-disciplinary programs.The rapid development in this field documented in an increasing number of publications requires a comprehensive review.This study includes a bibliometric analysis-based review to better understand research trends in tree ring stable isotope research.Overall,1475 publications were selected from the Web of Science Core Collection for 1974-2023.The findings are that:(1)numbers of annual publications and citations increased since 1974.From 1974 to 1980,there were around two relevant publications per year.However,from 2020 to 2022,this rose sharply to 109 publications per year.Likewise,average article citations were less than four per year before 1990,but were around four per article per year after 2000;(2)the major subjects using tree ring stable isotopes include forestry,geosciences,and environmental sciences,contributing to 42.5%of the total during 1974-2023;(3)the top three most productive institutions are the Chinese Academy of Sciences(423),the Swiss Federal Institute for Forest,Snow and Landscape Research(227),and the University of Arizona(204).These achievements result from strong collaborations;(4)review papers,for example,(Dawson et al.,Annu Rev Ecol Syst 33:507-559,2002)and(McCarroll and Loader,Quat Sci Rev 23:771-801,2004),are among the most cited,with more than 1000 citations;(5)tree ring stable isotope studies mainly focus on climatology and ecology,with atmospheric CO_(2) one of the most popular topics.Since 2010,precipitation and drought have received increasing attention.Based on this analysis,the research stages,key findings,debated issues,limitations and direc-tions for future research are summarized.This study serves as an important attempt to understand the progress on the use of stable isotopes in tree rings,providing scientific guid-ance for young researchers in this field.