In reptiles,such as the red-eared slider turtle(Trachemys scripta elegans),gonadal sex determination is highly dependent on the environmental temperature during embryonic stages.This complex process,which leads to dif...In reptiles,such as the red-eared slider turtle(Trachemys scripta elegans),gonadal sex determination is highly dependent on the environmental temperature during embryonic stages.This complex process,which leads to differentiation into either testes or ovaries,is governed by the finely tuned expression of upstream genes,notably the testis-promoting gene Dmrt1 and the ovary-promoting gene Foxl2.Recent studies have identified epigenetic regulation as a crucial factor in testis development,with the H3K27me3 demethylase KDM6B being essential for Dmrt1 expression in T.s.elegans.However,whether KDM6B alone can induce testicular differentiation remains unclear.In this study,we found that overexpression of Kdm6b in T.s.elegans embryos induced the male development pathway,accompanied by a rapid increase in the gonadal expression of Dmrt1 at 31°C,a temperature typically resulting in female development.Notably,this sex reversal could be entirely rescued by Dmrt1 knockdown.These findings demonstrate that Kdm6b is sufficient for commitment to the male pathway,underscoring its role as a critical epigenetic regulator in the sex determination of the red-eared slider turtle.展开更多
The Dirac–Weyl equation characterized quasi-particles in the T3 lattice are studied under external magnetic field using the generalized uncertainty principle(GUP). The energy spectrum of the quasi-particles is found ...The Dirac–Weyl equation characterized quasi-particles in the T3 lattice are studied under external magnetic field using the generalized uncertainty principle(GUP). The energy spectrum of the quasi-particles is found by the Nikiforov–Uvarov method. Based on the energy spectrum obtained, the thermodynamic properties are given, and the influence of the GUP on the statistical properties of systems is discussed. The results show that the energy and thermodynamic functions of massless Dirac–Weyl fermions in the T3 lattice depend on the variation of the GUP parameter.展开更多
The strong contact finite determinacy of relative map germs is studied by means of classical singularity theory. We first give the definition of a strong relative contact equivalence （or KS,T equivalence） and then p...The strong contact finite determinacy of relative map germs is studied by means of classical singularity theory. We first give the definition of a strong relative contact equivalence （or KS,T equivalence） and then prove two theorems which can be used to distinguish the contact finite determinacy of relative map germs, that is, f is finite determined relative to KS,T if and only if there exists a positive integer k, such that M^5（n）ε（S;n）p ∩→ TKs,T（f）.展开更多
The condition of weightes non-dictatorship is extended and a comprehensive evaluae method emboding self-determinate which is combined with competitive view optimization principles is built. The basic process includes ...The condition of weightes non-dictatorship is extended and a comprehensive evaluae method emboding self-determinate which is combined with competitive view optimization principles is built. The basic process includes simulating the model of economic man＇s self-benefit bahaviors, taking the place of experts to evaluate, bringing in the model of minimizing the sum of included angles to integrate the information of multiple objects and put the objects in order finally. The method has the advangtages of less dependendence on the subjective information, plenty of information, fair process and simple caculating. Finally, an application example is given to illustrate the effectiveness of the proposed method.展开更多
Increasingly international and national policies are being directed at actions for the social determinants of health and for an integrated approach to health care provision, not only in terms of institutional cooperat...Increasingly international and national policies are being directed at actions for the social determinants of health and for an integrated approach to health care provision, not only in terms of institutional cooperation but also stakeholder involvement. A key component of both these policies is the development of good governance principles in all health care agencies and organizations. A neglected dimension in these debates has been the role of the public hospital which remains a vital and expensive dimension of service provision. In a case study of a public hospital in South Africa, this paper charts the readiness of its management principles and activities to provide quality health care linked to population health and to contribute to the non-medical determinant of health. Using Taylor’s principles of good governance, we conclude that there is a mixture of good and not so good governance activity. The paper concludes by examining the external constraints on the public hospital and by providing suggestions for future activities.展开更多
基金supported by the National Natural Science Foundation of China(32325049,U22A20529,32303000)Zhejiang Provincial Natural Science Foundation(LQ24C190009)+1 种基金Ningbo Natural Science Foundation(2022J192)Zhejiang Provincial Top Key Discipline of Biological Engineering(1741000592)。
文摘In reptiles,such as the red-eared slider turtle(Trachemys scripta elegans),gonadal sex determination is highly dependent on the environmental temperature during embryonic stages.This complex process,which leads to differentiation into either testes or ovaries,is governed by the finely tuned expression of upstream genes,notably the testis-promoting gene Dmrt1 and the ovary-promoting gene Foxl2.Recent studies have identified epigenetic regulation as a crucial factor in testis development,with the H3K27me3 demethylase KDM6B being essential for Dmrt1 expression in T.s.elegans.However,whether KDM6B alone can induce testicular differentiation remains unclear.In this study,we found that overexpression of Kdm6b in T.s.elegans embryos induced the male development pathway,accompanied by a rapid increase in the gonadal expression of Dmrt1 at 31°C,a temperature typically resulting in female development.Notably,this sex reversal could be entirely rescued by Dmrt1 knockdown.These findings demonstrate that Kdm6b is sufficient for commitment to the male pathway,underscoring its role as a critical epigenetic regulator in the sex determination of the red-eared slider turtle.
基金the National Natural Science Foundation of China(Grant No.11565009)。
文摘The Dirac–Weyl equation characterized quasi-particles in the T3 lattice are studied under external magnetic field using the generalized uncertainty principle(GUP). The energy spectrum of the quasi-particles is found by the Nikiforov–Uvarov method. Based on the energy spectrum obtained, the thermodynamic properties are given, and the influence of the GUP on the statistical properties of systems is discussed. The results show that the energy and thermodynamic functions of massless Dirac–Weyl fermions in the T3 lattice depend on the variation of the GUP parameter.
基金Science Foundation (20070105) for Young Teachers of Northeast Normal University
文摘The strong contact finite determinacy of relative map germs is studied by means of classical singularity theory. We first give the definition of a strong relative contact equivalence （or KS,T equivalence） and then prove two theorems which can be used to distinguish the contact finite determinacy of relative map germs, that is, f is finite determined relative to KS,T if and only if there exists a positive integer k, such that M^5（n）ε（S;n）p ∩→ TKs,T（f）.
基金supported by the National Natural Science Foundation of China(70801013)LNSTF for doc-tor(20081020).
文摘The condition of weightes non-dictatorship is extended and a comprehensive evaluae method emboding self-determinate which is combined with competitive view optimization principles is built. The basic process includes simulating the model of economic man＇s self-benefit bahaviors, taking the place of experts to evaluate, bringing in the model of minimizing the sum of included angles to integrate the information of multiple objects and put the objects in order finally. The method has the advangtages of less dependendence on the subjective information, plenty of information, fair process and simple caculating. Finally, an application example is given to illustrate the effectiveness of the proposed method.
文摘Increasingly international and national policies are being directed at actions for the social determinants of health and for an integrated approach to health care provision, not only in terms of institutional cooperation but also stakeholder involvement. A key component of both these policies is the development of good governance principles in all health care agencies and organizations. A neglected dimension in these debates has been the role of the public hospital which remains a vital and expensive dimension of service provision. In a case study of a public hospital in South Africa, this paper charts the readiness of its management principles and activities to provide quality health care linked to population health and to contribute to the non-medical determinant of health. Using Taylor’s principles of good governance, we conclude that there is a mixture of good and not so good governance activity. The paper concludes by examining the external constraints on the public hospital and by providing suggestions for future activities.
