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Dengue Fever Epidemiological Status and Relationship with Meteorological Variables in Guangzhou, Southern China, 2007-2012 被引量:12
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作者 LI Tie Gang YANG Zhi Cong +2 位作者 LUO Lei DI Biao WANG Ming 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2013年第12期994-997,共4页
Ecological methodology plus negative binomial regression were used to identify dengue fever (DF) epidemiological status and its relationship with meteorological variables. From 2007 to 2012, annual incidence rate of... Ecological methodology plus negative binomial regression were used to identify dengue fever (DF) epidemiological status and its relationship with meteorological variables. From 2007 to 2012, annual incidence rate of DF in Guangzhou was 0.33, 0.11, 0.15, 0.64, 0.45, and 1.34 (per 100 000) respectively, showing an increasing trend. Each 1℃ rise of temperature corresponded to an increase of 10.23% (95% CI 7.68% to 12.83%) in the monthly number of DF cases, whereas l hPa rise of atmospheric pressure corresponded to a decrease in the number of cases by 5.14% (95% CI: 7.10%-3.14%). Likewise, each one meter per second rise in wind velocity led to an increase by 43.80% or 107.53%, and one percent rise of relative humidity led to an increase by 2.04% or 2.19%. 展开更多
关键词 Dengue Fever Epidemiological Status and relationship with Meteorological variables in Guangzhou Southern China WIND
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基于errors-in-variables的预测模型及其应用 被引量:5
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作者 程龙生 《数理统计与管理》 CSSCI 北大核心 2005年第2期55-59,共5页
预测是统计学实际应用的一个主要方面,多元线性回归预测是一种很好的方法,广泛地应用在各种实际领域,但其局限性及不足也是明显的。本文以一种新的观点认识数据,即认为变量的观测里均含有误差,同时认为不应删除经慎重选择进来的解释变... 预测是统计学实际应用的一个主要方面,多元线性回归预测是一种很好的方法,广泛地应用在各种实际领域,但其局限性及不足也是明显的。本文以一种新的观点认识数据,即认为变量的观测里均含有误差,同时认为不应删除经慎重选择进来的解释变量。为此,本文提出了一种新的多元预测方法———多元线性EIV预测。本文还考虑了新预测模型的一个实例应用,并从相对偏差上与多元回归预测进行了比较,从而揭示了多元线性EIV预测的先进性及较好的预测精度。 展开更多
关键词 预测 回归分析 Errors-in-variables(EIV) 结构关系模型
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一类线性errors-in-variables模型的参数强相合估计及其a.s.收敛速度 被引量:1
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作者 程龙生 姚景尹 《高校应用数学学报(A辑)》 CSCD 北大核心 1996年第3期313-320,共8页
本文讨论了如下一类线性errors-in-variables模型——多元线性结构关系模型β′xk+α=0,ξk=xk+εk.{k=1,2,…,n.其中,{xk:k=1,2,…,n}为一组i.i.d.的m维随机向量,{... 本文讨论了如下一类线性errors-in-variables模型——多元线性结构关系模型β′xk+α=0,ξk=xk+εk.{k=1,2,…,n.其中,{xk:k=1,2,…,n}为一组i.i.d.的m维随机向量,{εk:k=1,2,…,n}是i.i.d.的随机误差,E(ε1)=0,Var(ε1)=σ2Im.且{xk:k=1,2,…,n}与{εk:k=1,2,…,n}相互独立.在一些条件下,我们证明了估计量β,α,σ2的强相合性、唯一性,并给出了估计量的收敛速度为o(n-1-1q),这里q∈[1,2). 展开更多
关键词 收敛速度 线性模型 强相合估计 多元分析
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Comparative Study of Variable Selection Using Genetic Algorithm with Various Types of Chromosomes
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作者 陈国华 陆瑶 夏之宁 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2010年第9期1431-1437,共7页
In this study,different methods of variable selection using the multilinear step-wise regression(MLR) and support vector regression(SVR) have been compared when the performance of genetic algorithms(GAs) using v... In this study,different methods of variable selection using the multilinear step-wise regression(MLR) and support vector regression(SVR) have been compared when the performance of genetic algorithms(GAs) using various types of chromosomes is used.The first method is a GA with binary chromosome(GA-BC) and the other is a GA with a fixed-length character chromosome(GA-FCC).The overall prediction accuracy for the training set by means of 7-fold cross-validation was tested.All the regression models were evaluated by the test set.The poor prediction for the test set illustrates that the forward stepwise regression(FSR) model is easier to overfit for the training set.The results using SVR methods showed that the over-fitting could be overcome.Further,the over-fitting would be easier for the GA-BC-SVR method because too many variables fleetly induced into the model.The final optimal model was obtained with good predictive ability(R2 = 0.885,S = 0.469,Rcv2 = 0.700,Scv = 0.757,Rex2 = 0.692,Sex = 0.675) using GA-FCC-SVR method.Our investigation indicates the variable selection method using GA-FCC is the most appropriate for MLR and SVR methods. 展开更多
关键词 support vector regression genetic algorithm variable selection quantitative structure activity relationship multiple linear regression
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端粒长度与10种常见肌肉骨骼疾病的关系孟德尔随机化分析
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作者 罗伟东 蒲彬 +3 位作者 古鹏 黄枫 郑晓辉 陈福洪 《中国组织工程研究》 CAS 北大核心 2025年第3期654-660,共7页
背景:多项观察性研究表明,端粒长度与肌肉骨骼疾病之间存在潜在的关联,然而它们之间的潜在机制仍不清楚。目的:利用两样本孟德尔随机化分析来探索端粒长度与肌肉骨骼疾病之间的遗传因果关系。方法:从英国生物银行中获得端粒长度的全基... 背景:多项观察性研究表明,端粒长度与肌肉骨骼疾病之间存在潜在的关联,然而它们之间的潜在机制仍不清楚。目的:利用两样本孟德尔随机化分析来探索端粒长度与肌肉骨骼疾病之间的遗传因果关系。方法:从英国生物银行中获得端粒长度的全基因组关联研究汇总数据。从FinnGen财团中获得了关于10种常见肌肉骨骼疾病(骨坏死、骨髓炎、骨质疏松、类风湿关节炎、腰痛、椎管狭窄、痛风、肩周炎、强直性脊柱炎和下肢深静脉血栓)的全基因组关联研究汇总数据。使用逆方差加权、孟德尔随机化-Egger和加权中位数方法评估端粒长度与10种肌肉骨骼疾病的因果关系,逆方差加权作为主要的孟德尔随机化分析方法,并进行敏感性分析探讨结果稳健性。结果与结论:①逆方差加权法结果表明,遗传预测的端粒长度与类风湿关节炎(OR=0.78,95%CI:0.64-0.95,P=0.015)和骨坏死(OR=0.56,95%CI:0.36-0.90,P=0.016)风险之间存在负向因果关系,但未发现端粒长度与其他8种肌肉骨骼疾病之间存在因果关系(P均>0.05)。②敏感性分析结果表明因果关系稳健,孟德尔随机化-Egger截距分析未检测到潜在的水平多效性(P均>0.05)。③此项孟德尔随机化研究支持端粒长度对类风湿关节炎和骨坏死的保护作用的结论,然而,未来将需要更多的基础和临床研究来验证。 展开更多
关键词 端粒长度 肌肉骨骼疾病 孟德尔随机化 全基因组关联研究 单核苷酸多态性 因果关系 工具变量
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Assessment of Genetic Variability and Inter-specific Relationships among Four Species of Groupers (Genus Epinephelus) from South China Sea Using Microsatellite Markers 被引量:2
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作者 尹绍武 黄海 +1 位作者 骆剑 胡亚丽 《Agricultural Science & Technology》 CAS 2012年第2期428-433,共6页
[Objective] The study aimed to evaluate the genetic variability and interspecific relationships among four species of groupers from South China Sea, including E. fario, E. merra, E. malabaricus and E. coioides. [Metho... [Objective] The study aimed to evaluate the genetic variability and interspecific relationships among four species of groupers from South China Sea, including E. fario, E. merra, E. malabaricus and E. coioides. [Method] Twenty one mircosatellite loci of groupers were selected from GenBank and eight high polymorphic loci were used to further genetic analysis. [Result] The mean number of alleles per locus (A), effective number of alleles (Ne), mean polymorphism information content (PIC), observed heterozygosity (Ho) and expected heterozygosity (He) were 4.38±1.60, 3.69±0.86, 0.69±0.08, 0.67±0.08, 0.72±0.06 in E. malabaricus; 3.88±1.13, 3.55±1.04, 0.66±0.10, 0.68±0.21, 0.70±0.08 in E.coioides; 6.00±1.07, 4.68±0.65, 0.78±0.03, 0.73±0.25, 0.79±0.03 in E. fario; 5.50±1.07, 4.58±0.80, 0.76±0.05, 0.75±0.18, 0.78±0.04 in E. merra, respectively. [Conclusion] We compared the values above, the order of the genetic variability among these grouper species was E. fario E. merra E. malabaricus E. coioides. We found that the level of genetic variability of these groupers species was relatively higher than that of other marine fish, so their genetic status was good. In addition, the analyisis of genetic relationship showed that E. malabaricus and E. coioides was the closest and it was the farthest between E. merra and E. coioides. 展开更多
关键词 GROUPER EPINEPHELUS Genetic variability Species relationships Microsatellite marker
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Contrasting the Indian and western North Pacific summer monsoons in terms of their intensity of interannual variability and biennial relationship with ENSO 被引量:3
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作者 CHEN Baiyang WANG Lei WU Minmin 《Atmospheric and Oceanic Science Letters》 CSCD 2020年第5期462-469,共8页
The intensity of interannual variability(IIV)of the monsoon and monsoon–ENSO biennial relationship(MEBR)were examined and compared for both the Indian summer monsoon(ISM)and western North Pacific summer monsoon(WNPSM... The intensity of interannual variability(IIV)of the monsoon and monsoon–ENSO biennial relationship(MEBR)were examined and compared for both the Indian summer monsoon(ISM)and western North Pacific summer monsoon(WNPSM)during 1958–2018.Covariability of the IIV and MEBR were identified for the two monsoons.When the MEBR was strong(weak),the IIV of the monsoon was observed to be large(small).This rule applied to both the ISM and WNPSM.Out-ofphase relationships were found between the ISM and the WNPSM.When the IIV and MEBR of the ISM were strong(weak),those of the WNPSM tended to be weak(strong).During the period with a stronger(weaker)ENSO–Atlantic coupling after(before)the mid-1980 s,the IIV and MEBR of the WNPSM(ISM)were observed to be stronger.The increasing influences from the tropical Atlantic sea surface temperature(SST)may trigger the observed seesaw pattern of the ISM and WNPSM in terms of the IIV and MEBR multidecadal variability.The results imply that tropical Atlantic SST may need to be given more attention and consideration when predicting future monsoon variability of the ISM and WNPSM. 展开更多
关键词 Indian summer monsoon western North Pacific summer monsoon ENSO intensity of interannual variability monsoon–ENSO biennial relationship
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Perspectives on the non-stationarity of the relationship between Indian and East Asian summer rainfall variations 被引量:1
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作者 WU Ren-Guang HU Kai-Ming LIN Zhong-Da 《Atmospheric and Oceanic Science Letters》 CSCD 2018年第2期104-111,共8页
The relationship between Indian and East Asian summer rainfall variations is non-stationary in observations as well as in historical simulations of climate models.Is this non-stationarity due to changes in effects of ... The relationship between Indian and East Asian summer rainfall variations is non-stationary in observations as well as in historical simulations of climate models.Is this non-stationarity due to changes in effects of external forcing or internal atmospheric processes? Whilst ENSO is an important oceanic forcing of Indian and East Asian summer rainfall variations,its impacts cannot explain the observed long-term changes in the Indian-East Asian summer rainfall relationship.Monte Carlo test indicates that the role of random processes cannot be totally excluded in the observed longterm changes of the relationship.Analysis of climate model outputs shows that the Indian-North China summer rainfall relationship displays obvious temporal variations in both individual and ensemble mean model simulations and large differences among model simulations.This suggests an important role played by atmospheric internal variability in changes of the Indian-East Asian summer rainfall relationship.This point of view is supported by results from a 100-years AGCM simulation with climatological SST specified in the global ocean.The correlation between Indian and North China or southern Japan summer rainfall variations displays large fluctuations in the AGCM simulation 展开更多
关键词 Indian and East Asian summer rainfall nonstationary relationship ENSOinternal atmospheric variability
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Consistency in <i>Z</i>-<i>R</i>Relationship Variability Regardless Precipitating Systems, Climatic Zones Observed from Two Types of Disdrometer 被引量:1
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作者 Bakary Bamba Abé Delfin Ochou +1 位作者 Eric-Pascal Zahiri Modeste Kacou 《Atmospheric and Climate Sciences》 2014年第5期941-955,共15页
Data from rain Drop Size Distributions gathered on five sites in Africa as well as those of the pilot site in Kourou (French Guyana, South America), located in different climatic zones, and collected by two types of d... Data from rain Drop Size Distributions gathered on five sites in Africa as well as those of the pilot site in Kourou (French Guyana, South America), located in different climatic zones, and collected by two types of disdrometer (the impact JW RD-69 disdrometer and the Optical Spectro-Pluviometer, OSP) are used to study the consistency of the reflectivity factor-rain rate at the ground (Z-R) relationship variability. The results clearly confirm that the relationship Z-R knows a large spatial variability, from a type of precipitation to another and within the same precipitation regardless the type of disdrometer used for DSD measurements. Base on the similarity of the relations reflectivity factor-rain rate and ratio median volume diameter over the total number of drops-rain rate, the variability of the Z-R coefficients (A, b) through the simultaneously implication of the size and number of drops which characterize the DSD was exhibited. It was shown that the relationships A-α and b-β designed to understand the involvement of parameters D0 and NT of DSD in the variability of the relationship Z-R are similar regardless the types of disdrometer used. However, the relations A-α in the Sahelian region appear to deviate from those of Guinean, equatorial and Soudanian zones. The plausible reasons were discussed. 展开更多
关键词 Drop Size Distributions CONSISTENCY in Z-R relationship VARIABILITY Squall Lines Thunderstorm Stratiform Rain JW RD-69 DISDROMETER Optical Spectro-Pluviometer OSP
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Analysis of the relationship between blood pressure variability and subtle cognitive decline in older adults
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作者 Hui-Feng Guo Yi Wu +1 位作者 Jie Li Feng-Feng Pan 《World Journal of Psychiatry》 SCIE 2023年第11期872-883,共12页
BACKGROUND Blood pressure variability(BPV)has been shown to be related to mild cognitive impairment and Alzheimer's disease in a number of studies.However,the relationship between BPV and subtle cognitive decline(... BACKGROUND Blood pressure variability(BPV)has been shown to be related to mild cognitive impairment and Alzheimer's disease in a number of studies.However,the relationship between BPV and subtle cognitive decline(SCD)has received minimal attention in this field of research to date and has rarely been reported.AIM To examine whether SCD is independently associated with changes in BPV in older adults.METHODS Participants were selected based on having participated in cognitive function evaluation and ambulatory blood pressure measurement at the Shanghai Sixth People's Hospital Affiliated with Shanghai Jiao Tong University School of Medicine between June 2020 and August 2022.The participants included 182 individuals with SCD as the experimental group and 237 with normal cognitive function as the control group.The basic data,laboratory examinations,scale tests,and ambulatory blood pressure test results of the two groups were analyzed retrospectively,and the relationship between SCD and BPV was subsequently evaluated.RESULTS Significant differences were observed between the two groups of participants(P<0.05)in terms of age,education level,prevalence rate of diabetes,fasting blood glucose level,24-h systolic blood pressure standard deviation and coefficient of variation,24-h diastolic blood pressure standard deviation and coefficient of variation.The scale monitoring results showed significant differences in the scores for memory,attention,and visual space between the experimental and control groups.Logistic regression analysis indicated that age,education level,blood sugar level,and BPV were factors influencing cognitive decline.Linear regression analysis showed that there was an independent correlation between blood pressure variation and SCD,even after adjusting for related factors.Each of the above differences was still significant.CONCLUSION This study suggests that increased BPV is associated with SCD. 展开更多
关键词 Blood pressure VARIABILITY ELDERLY Subtle cognitive decline relationship
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“三生万物”规律生——趣谈“三”妙之处
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作者 郑华 王新刚 朱励霖 《大学物理》 2024年第8期28-29,41,共3页
本文通过列举语言、数学、物理中与数字“三”有关的特殊性,推理出三变量关系是很多公式和模型的基础,是我们认识世界和理解世界规律的起点.在思维能力训练和复杂问题的生成与人类认知规律方面三变量关系有着神奇的作用.
关键词 “三”妙之处 三变量关系 思维训练
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基于改进K-means聚类和皮尔逊相关系数户变关系异常诊断 被引量:4
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作者 周纲 黄瑞 +3 位作者 刘度度 张芝敏 胡军华 高云鹏 《电测与仪表》 北大核心 2024年第3期76-82,152,共8页
用电信息采集系统易出现台区户变关系错误问题,传统诊断技术主要针对少用户台区出现异常用户情况,但对于多达数百用户台区,存在多相邻台区异常用户特征提取难题。文中首先通过主成分分析对GIS系统获取台区总表和用户电表电压数据实现降... 用电信息采集系统易出现台区户变关系错误问题,传统诊断技术主要针对少用户台区出现异常用户情况,但对于多达数百用户台区,存在多相邻台区异常用户特征提取难题。文中首先通过主成分分析对GIS系统获取台区总表和用户电表电压数据实现降维,建立改进K-means聚类提取电压数据特征,提出改进皮尔逊相关系数算法分析待检测用户,据此建立基于改进K-means聚类和改进皮尔逊相关系数的户变关系异常诊断方法,实现多异常用户所属正确台区诊断。实际算例分析结果表明,文中提出算法在识别同一台区一个及多个异常用户、不同台区多个异常用户情况下均能有效实现异常用户的准确检测与分析,相比传统检测方法,实现简单且准确性更高。 展开更多
关键词 户变关系 GIS系统 主成分分析 改进K-means聚类
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矿工安全态度与煤矿险兆事件影响关系研究 被引量:1
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作者 田水承 王清焱 +1 位作者 林维 毛俊睿 《安全与环境学报》 CAS CSCD 北大核心 2024年第6期2321-2328,共8页
为进一步提升煤矿事故防控水平,探明矿工安全态度和人口学变量对煤矿险兆事件的影响关系。在文献调研安全态度、人口学变量和险兆事件各子维度的基础上,以矿工安全态度量表(Safety Attitudes Questionnaire, SAQ)、煤矿险兆事件量表(Nea... 为进一步提升煤矿事故防控水平,探明矿工安全态度和人口学变量对煤矿险兆事件的影响关系。在文献调研安全态度、人口学变量和险兆事件各子维度的基础上,以矿工安全态度量表(Safety Attitudes Questionnaire, SAQ)、煤矿险兆事件量表(Near-Miss Questionnaire, NMQ)作为研究工具,综合运用单因素方差分析、皮尔逊相关性分析及分层回归的方法,开展矿工安全态度和人口学变量对煤矿险兆事件的影响关系研究。结果表明:年龄对险兆事件认知、识别的影响较弱,矿工经历险兆事件数量对险兆事件认知有弱影响关系;安全态度对险兆事件及险兆事件认知、识别存在显著正向影响,管理层安全承诺、班组安全氛围和工作压力正向影响险兆事件的部分子维度。 展开更多
关键词 安全社会工程 安全态度 险兆事件 人口学变量 影响关系
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生物机制类实验设计题的变量关系模型构建
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作者 蔡燕燕 俞如旺 《生物学教学》 北大核心 2024年第6期79-81,共3页
通过构建中间因变量和中间自变量两种实验变量关系模型,演绎和归纳生物机制类实验设计题的解题思路并应用于教学中,提升学生分析解决问题的能力。
关键词 生物机制 实验设计题 变量关系 解题模型
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公共管理“注意力分配”研究应该注意什么——兼及国内外相关研究的比较分析
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作者 苏寻 马卫红 《上海行政学院学报》 CSSCI 北大核心 2024年第5期85-98,共14页
注意力分配是近年国内公共管理研究的热点之一,且相关研究呈现明显的研究偏好。从比较视角检视此种倾向可以丰富和扩展该领域的研究多样性。通过比较分析发现,国内外相关研究在思维方式、关注焦点、方法运用、变量操作等方面存在差异。... 注意力分配是近年国内公共管理研究的热点之一,且相关研究呈现明显的研究偏好。从比较视角检视此种倾向可以丰富和扩展该领域的研究多样性。通过比较分析发现,国内外相关研究在思维方式、关注焦点、方法运用、变量操作等方面存在差异。总体而言,国外注意力分配相关文献呈现出多样性特征,主要把注意力分配作为结果变量来看;国内研究则集中于政府官员的注意力分配,分析注意力分配对其行动的影响,但对注意力分配变量性质的认知却不统一。对于该领域今后的研究,建议着重注意以下议题:注意力的适应性功能、行为主体的“幻想”对注意力分配的牵引作用、行为学习与模仿效应对注意力分配解释力的消解,以及注意力损耗等现象。 展开更多
关键词 注意力分配 思维方式 研究方法 变量关系 公共管理
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融合图注意力的复杂时序知识图谱推理问答模型
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作者 蒋汶娟 过弋 付娇娇 《计算机应用》 CSCD 北大核心 2024年第10期3047-3057,共11页
在时序知识图谱问答(TKGQA)任务中,针对模型难以捕获并利用问句中隐含的时间信息增强模型的复杂问题推理能力的问题,提出一种融合图注意力的时序知识图谱推理问答(GACTR)模型。所提模型采用四元组形式的时序知识库(KB)进行预训练,同时... 在时序知识图谱问答(TKGQA)任务中,针对模型难以捕获并利用问句中隐含的时间信息增强模型的复杂问题推理能力的问题,提出一种融合图注意力的时序知识图谱推理问答(GACTR)模型。所提模型采用四元组形式的时序知识库(KB)进行预训练,同时引入图注意力网络(GAT)以有效捕获问句中隐式时间信息;通过与RoBERTa(Robustly optimized Bidirectional Encoder Representations from Transformers pretraining approach)模型训练的关系表示进行集成,进一步增强问句的时序关系表示;将该表示与预训练的时序知识图谱(TKG)嵌入相结合,以获得最高评分的实体或时间戳作为答案预测结果。在最大的基准数据集CRONQUESTIONS上的实验结果显示,GACTR模型在时序推理模式下能更好地捕获隐含时间信息,有效提升模型的复杂推理能力。与基线模型CRONKGQA(Knowledge Graph Question Answering on CRONQUESTIONS)相比,GACTR模型在处理复杂问题类型和时间答案类型上的Hits@1结果分别提升了34.6、13.2个百分点;与TempoQR(Temporal Question Reasoning)模型相比,分别提升了8.3、2.8个百分点。 展开更多
关键词 时序知识图谱 复杂问答 图注意力网络 时序推理 时序关系表示
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基于对比训练图嵌入的知识图谱多跳问答
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作者 陈秋元 李梁 《计算机工程与设计》 北大核心 2024年第11期3434-3440,共7页
在不完全知识图谱上进行问答的研究中,现有方法通过知识图谱嵌入与问题嵌入的联合训练对问题进行推理时,多跳问题上的性能比单跳问题上的性能有显著下降。为缓解以上问题,提出一种使用对比训练的知识图谱嵌入提高模型节点预测能力,结合... 在不完全知识图谱上进行问答的研究中,现有方法通过知识图谱嵌入与问题嵌入的联合训练对问题进行推理时,多跳问题上的性能比单跳问题上的性能有显著下降。为缓解以上问题,提出一种使用对比训练的知识图谱嵌入提高模型节点预测能力,结合关系链筛选答案的方法。使用对比训练图嵌入和问题嵌入联合训练,得出候选答案并筛选出正确答案。在Meta-QA数据集上验证该方法的有效性,在不完全知识图谱上对比基准模型Embed-KGQA有6.4%的3-hop准确率提升。 展开更多
关键词 多跳问答 不完全知识图谱 对比训练 知识图谱嵌入 关系链 链路预测 语言模型
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基于两样本孟德尔随机化探究甲状腺功能减退症与膝骨关节炎的因果关系
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作者 徐小东 王配婕 +3 位作者 谢文鹏 李琦 傅永升 王卫国 《风湿病与关节炎》 2024年第2期6-11,共6页
目的:通过两样本孟德尔随机化方法研究甲状腺功能减退症与膝骨关节炎发病风险的因果关系。方法:获取甲状腺功能减退症和膝骨关节炎的全基因组关联研究(GWAS)数据并进行汇总,两者的数据均来自欧洲人群;将单核苷酸多态性(SNP)作为工具变量... 目的:通过两样本孟德尔随机化方法研究甲状腺功能减退症与膝骨关节炎发病风险的因果关系。方法:获取甲状腺功能减退症和膝骨关节炎的全基因组关联研究(GWAS)数据并进行汇总,两者的数据均来自欧洲人群;将单核苷酸多态性(SNP)作为工具变量(IVs)并选择敏感的SNPs进行分析,通过逆方差加权法(IVW)、加权中位数法(WME)、MR-Egger回归法进行两样本孟德尔随机化分析,将OR值作为标准评估甲状腺功能减退症与膝骨关节炎发病风险的因果关系,通过异质性和多效性检验对得到的结果进行验证。结果:共纳入27个SNPs位点作为IVs,IVW法的OR=4.737,95%CI=[1.038,20.524],P=0.038,表明甲状腺功能减退症和膝骨关节炎之间有因果关系。MR-Egger回归方程截距项为0.001 5(P=0.775),表明该结果不受基因多效性的影响。结论:甲状腺功能减退症与膝骨关节炎存在因果关系,且膝骨关节炎的发病风险随着甲状腺功能减退症发病风险增加而增加。 展开更多
关键词 膝骨关节炎 甲状腺功能减退症 孟德尔随机化研究 全基因组关联分析 工具变量 单核苷酸多态性 因果关系
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2023年广东高考生物学卷第21题科学思维测评分析
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作者 黎金兰 《生物学教学》 北大核心 2024年第6期74-76,共3页
科学思维是测评生物学学科核心素养的重要内容。2023年广东生物学卷第21题,围绕红树林修复特色情境,根据事物的因果关系,设问层层递进,逻辑严谨清晰,测评了科学思维的判断、解释、预测、设计四个水平。
关键词 科学思维 因果关系 生物学高考试题
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题组反思式教学在实变函数教学中的应用探究
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作者 王文 杨世国 《大学数学》 2024年第1期36-41,共6页
题组反思式教学研究在中小学教学研究中经常出现,但对大学数学教学的研究很少.结合当前教育部针对师范专业师范认证的指标,以实变函数课程教学为例,探究了高校数学课堂教学中使用题组反思式教学的策略与方法,通过设计题组并引导学生反... 题组反思式教学研究在中小学教学研究中经常出现,但对大学数学教学的研究很少.结合当前教育部针对师范专业师范认证的指标,以实变函数课程教学为例,探究了高校数学课堂教学中使用题组反思式教学的策略与方法,通过设计题组并引导学生反思的教学模式构建,丰富题组反思式教学模式在大学数学课程教学中的应用研究. 展开更多
关键词 实变函数 题组反思式教学 教学思考
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