PDRG1 is a small oncogenic protein of 133 residues. In normal human tissues, the p53 and DNA damageregulated gene 1(PDRG1) gene exhibits maximal expression in the testis and minimal levels in the liver. Increased expr...PDRG1 is a small oncogenic protein of 133 residues. In normal human tissues, the p53 and DNA damageregulated gene 1(PDRG1) gene exhibits maximal expression in the testis and minimal levels in the liver. Increased expression has been detected in several tumor cells and in response to genotoxic stress. High-throughput studies identified the PDRG1 protein in a variety of macromolecular complexes involved in processes that are altered in cancer cells. For example, this oncogene has been found as part of the RNA polymerase Ⅱ complex, the splicing machinery and nutrient sensing machinery, although its role in these complexes remains unclear. More recently, the PDRG1 protein was found as an interaction target for the catalytic subunits of methionine adenosyltransferases. These enzymes synthesize S-adenosylmethionine, the methyl donor for, among others, epigenetic methylations that occur on the DNA and histones. In fact, downregulation of S-adenosylmethionine synthesis is the first functional effect directly ascribed to PDRG1. The existence of global DNA hypomethylation, together with increased PDRG1 expression, in many tumor cells highlights the importance of this interaction as one of the putative underlying causes for cell transformation. Here, we will review the accumulated knowledge on this oncogene, emphasizing the numerous aspects that remain to be explored.展开更多
The influences of P and rare earth （RE） complex modifier on the microstructure and mechanical properties of hypereutectic Al-21%Si alloy were studied. The ingots were made by metal mold casting and the proportion of...The influences of P and rare earth （RE） complex modifier on the microstructure and mechanical properties of hypereutectic Al-21%Si alloy were studied. The ingots were made by metal mold casting and the proportion of Ce＋P ingredient was different. The result showed that the size of grains could be refined obviously by the Ce＋P modifier and the effect of phosphorus was more intensive The primary silicon crystal was refined, while the needle-like eutectic silicon was turned fibrous or short. The alloy mechanical prop- erties had the best performance when 0.08% P and 0.6% Ce were added. The modification of primary silicon grains mainly depended on the heterogeneous nucleation mechanism, and the metamorphic mechanism of eutectic silicon was explained by adsorbing-twirming theory. The strengthening mechanism of experimental alloy was also discussed. The σb, 20 ℃ increases from 236.2 to 287.6 MPa and σb, 300 ℃ increases from 142.5 to 210 MPa.展开更多
基金support by the Ministerio Educación y CienciaMinisterio de Economía y Competitividad of Spain(until June 2013)
文摘PDRG1 is a small oncogenic protein of 133 residues. In normal human tissues, the p53 and DNA damageregulated gene 1(PDRG1) gene exhibits maximal expression in the testis and minimal levels in the liver. Increased expression has been detected in several tumor cells and in response to genotoxic stress. High-throughput studies identified the PDRG1 protein in a variety of macromolecular complexes involved in processes that are altered in cancer cells. For example, this oncogene has been found as part of the RNA polymerase Ⅱ complex, the splicing machinery and nutrient sensing machinery, although its role in these complexes remains unclear. More recently, the PDRG1 protein was found as an interaction target for the catalytic subunits of methionine adenosyltransferases. These enzymes synthesize S-adenosylmethionine, the methyl donor for, among others, epigenetic methylations that occur on the DNA and histones. In fact, downregulation of S-adenosylmethionine synthesis is the first functional effect directly ascribed to PDRG1. The existence of global DNA hypomethylation, together with increased PDRG1 expression, in many tumor cells highlights the importance of this interaction as one of the putative underlying causes for cell transformation. Here, we will review the accumulated knowledge on this oncogene, emphasizing the numerous aspects that remain to be explored.
基金supported by Advancing Front Science of Henan Province(092300410049)
文摘The influences of P and rare earth （RE） complex modifier on the microstructure and mechanical properties of hypereutectic Al-21%Si alloy were studied. The ingots were made by metal mold casting and the proportion of Ce＋P ingredient was different. The result showed that the size of grains could be refined obviously by the Ce＋P modifier and the effect of phosphorus was more intensive The primary silicon crystal was refined, while the needle-like eutectic silicon was turned fibrous or short. The alloy mechanical prop- erties had the best performance when 0.08% P and 0.6% Ce were added. The modification of primary silicon grains mainly depended on the heterogeneous nucleation mechanism, and the metamorphic mechanism of eutectic silicon was explained by adsorbing-twirming theory. The strengthening mechanism of experimental alloy was also discussed. The σb, 20 ℃ increases from 236.2 to 287.6 MPa and σb, 300 ℃ increases from 142.5 to 210 MPa.
