期刊文献+
共找到108,147篇文章
< 1 2 250 >
每页显示 20 50 100
Effect of psychological nursing interventions on effectiveness and quality of life in schizophrenia patients receiving modified electroconvulsive therapy
1
作者 Jing Lu 《World Journal of Clinical Cases》 SCIE 2024年第16期2751-2757,共7页
BACKGROUND Schizophrenia is a common and severe mental disorder characterized by severe thought disturbances,hallucinations,delusions,and emotional instability.For some patients,conventional treatment methods may not ... BACKGROUND Schizophrenia is a common and severe mental disorder characterized by severe thought disturbances,hallucinations,delusions,and emotional instability.For some patients,conventional treatment methods may not effectively alleviate symptoms,necessitating the use of alternative therapeutic approaches.Modified electroconvulsive therapy(MECT)is an effective treatment modality for schizophrenia,inducing anti-depressive and antipsychotic effects through the stimulation of brain electrical activity.AIM To explore the impact of psychological nursing intervention(PNI)before and after MECT on the efficacy and quality of life of patients with schizophrenia.METHODS Eighty patients with schizophrenia who received MECT treatment from 2021 to 2023 were randomly divided into two groups:The intervention group(n=40)and the control group(n=40).The intervention group received PNI before and after MECT,while the control group received routine nursing care.The efficacy of MECT was evaluated by the Positive and Negative Syndrome Scale(PANSS)and the Clinical Global Impression Scale(CGI)before and after the treatment.The quality of life was assessed by the Short Form 36 Health Survey(SF-36)after the treatment.RESUITS The intervention group had significantly lower scores of PANSS and CGI than the control group after the treatment(P<0.05).The intervention group also had significantly higher scores of SF-36 than the control group in all domains except physical functioning(P<0.05).CONCLUSION PNI before and after MECT can improve the efficacy and quality of life of patients with schizophrenia.It is suggested that nurses should provide individualized and comprehensive psychological care for patients undergoing MECT to enhance their recovery and well-being. 展开更多
关键词 psychological nursing interventions Modified electroconvulsive therapy schizophrenia EFFICACY Quality of life Positive and negative syndrome scale
下载PDF
Clinical risk factors for preterm birth and evaluating maternal psychology in the postpartum period
2
作者 Jia-Jun Chen Xue-Jin Chen +2 位作者 Qiu-Min She Jie-Xi Li Qiu-Hong Luo 《World Journal of Psychiatry》 SCIE 2024年第5期661-669,共9页
BACKGROUND Although the specific pathogenesis of preterm birth(PTB)has not been thoroughly clarified,it is known to be related to various factors,such as pregnancy complications,maternal socioeconomic factors,lifestyl... BACKGROUND Although the specific pathogenesis of preterm birth(PTB)has not been thoroughly clarified,it is known to be related to various factors,such as pregnancy complications,maternal socioeconomic factors,lifestyle habits,reproductive history,environmental and psychological factors,prenatal care,and nutritional status.PTB has serious implications for newborns and families and is associated with high mortality and complications.Therefore,the prediction of PTB risk can facilitate early intervention and reduce its resultant adverse consequences.AIM To analyze the risk factors for PTB to establish a PTB risk prediction model and to assess postpartum anxiety and depression in mothers.METHODS A retrospective analysis of 648 consecutive parturients who delivered at Shenzhen Bao’an District Songgang People’s Hospital between January 2019 and January 2022 was performed.According to the diagnostic criteria for premature infants,the parturients were divided into a PTB group(n=60)and a full-term(FT)group(n=588).Puerperae were assessed by the Self-rating Anxiety Scale(SAS)and Self rating Depression Scale(SDS),based on which the mothers with anxiety and depression symptoms were screened for further analysis.The factors affecting PTB were analyzed by univariate analysis,and the related risk factors were identified by logistic regression.RESULTS According to univariate analysis,the PTB group was older than the FT group,with a smaller weight change and greater proportions of women who underwent artificial insemination and had gestational diabetes mellitus(P<0.05).In addition,greater proportions of women with reproductive tract infections and greater white blood cell(WBC)counts(P<0.05),shorter cervical lengths in the second trimester and lower neutrophil percentages(P<0.001)were detected in the PTB group than in the FT group.The PTB group exhibited higher postpartum SAS and SDS scores than did the FT group(P<0.0001),with a higher number of mothers experiencing anxiety and depression(P<0.001).Multivariate logistic regression analysis revealed that a greater maternal weight change,the presence of gestational diabetes mellitus,a shorter cervical length in the second trimester,a greater WBC count,and the presence of maternal anxiety and depression were risk factors for PTB(P<0.01).Moreover,the risk score of the FT group was lower than that of the PTB group,and the area under the curve of the risk score for predicting PTB was greater than 0.9.CONCLUSION This study highlights the complex interplay between postpartum anxiety and PTB,where maternal anxiety may be a potential risk factor for PTB,with PTB potentially increasing the incidence of postpartum anxiety in mothers.In addition,a greater maternal weight change,the presence of gestational diabetes mellitus,a shorter cervical length,a greater WBC count,and postpartum anxiety and depression were identified as risk factors for PTB. 展开更多
关键词 Preterm birth Risk factors Postpartum psychological state Risk model Prediction
下载PDF
Research on Information Architecture Design of Short-Form Video Social Platforms Based on Cognitive Psychology
3
作者 Zhengyang Liu Albert Young Choi 《Psychology Research》 2024年第1期1-13,共13页
This study investigates how cognitive psychology principles can be integrated into the information architecture design of short-form video platforms,like TikTok,to enhance user experience,engagement,and sharing.Using ... This study investigates how cognitive psychology principles can be integrated into the information architecture design of short-form video platforms,like TikTok,to enhance user experience,engagement,and sharing.Using a questionnaire,it explores TikTok users’habits and preferences,highlighting how social media fatigue(SMF)impacts their interaction with the platform.The paper offers strategies to optimize TikTok’s design.It suggests refining the organizational system using principles like chunking,schema theory,and working memory capacity.Additionally,it proposes incorporating shopping features within TikTok’s interface to personalize product suggestions and enable monetization for influencers and content creators.Furthermore,the study underlines the need to consider gender differences and user preferences in improving TikTok’s sharing features,recommending streamlined and customizable sharing options,collaborative sharing,and a system to acknowledge sharing milestones.Aiming to strengthen social connections and increase sharing likelihood,this research provides insights into enhancing information architecture for short-form video platforms,contributing to their growth and success. 展开更多
关键词 information architecture design short-form video social cognitive psychology user experience
下载PDF
Study on the Influence of Food Packaging on the Psychology of Different Groups of Consumers
4
作者 CHEN Dai-yao 《Journal of Literature and Art Studies》 2024年第4期306-309,共4页
With the vigorous development of consumer culture in today’s society,various types of food packaging also appear in front of consumers in different forms.There are very big differences in food packaging in terms of s... With the vigorous development of consumer culture in today’s society,various types of food packaging also appear in front of consumers in different forms.There are very big differences in food packaging in terms of shape,color,style and other aspects of information transmission,which have the most direct impact on the audience’s food consumption needs.Driven by the consumption-oriented society,food packaging has shown very obvious comprehensive characteristics,is significantly interdisciplinary,and has close connections with other disciplines.This article will analyze and sort out the impact of food packaging on consumer psychology from different perspectives. 展开更多
关键词 packaging design food design consumer psychology
下载PDF
Exploration of Child-friendly Urban Park Design Strategies Based on Child Behavioral Psychology
5
作者 WANG Youxuan ZENG Junfeng 《Journal of Landscape Research》 2024年第1期7-11,共5页
By studying the behavioral psychology and needs of children,this paper analyzes the essence of child-friendly parks from the perspective of children,and discusses the design principles and key points of child-friendly... By studying the behavioral psychology and needs of children,this paper analyzes the essence of child-friendly parks from the perspective of children,and discusses the design principles and key points of child-friendly parks,so as to provide a practical basis for the construction of child-friendly cities. 展开更多
关键词 Landscape architecture Child-friendly cities Child behavioral psychology Urban public space Park planning and design
下载PDF
Application of Color Psychology in Korean Brand Identity Design-Etude House
6
作者 Jingyao Luo Choi Albort Young 《Cultural and Religious Studies》 2024年第1期24-31,共8页
The purpose of this analysis is to delve into the application of color psychology in the logo design of Korean cosmetic brands,using Etude House as an example for an exhaustive analysis.By examining the history of the... The purpose of this analysis is to delve into the application of color psychology in the logo design of Korean cosmetic brands,using Etude House as an example for an exhaustive analysis.By examining the history of the Etude House brand,the evolution of the logo design,and the changes in color choices,we analyze the traditional concepts of color symbolism in Korean culture and the culture of color in contemporary society in order to reveal the important role of color in cosmetic brand image.Through an in-depth analysis of the use of color in Etude House’s brand identity,we further analyze the impact of color on consumer emotions and purchasing behavior,as well as the potential impact of brand identity changes on market performance.Finally,the conclusions of the analysis summarize the practical application of color psychology in Etude House’s brand logo design,suggest recommendations for other Korean cosmetic brands to draw upon in their logo design,and discuss future directions. 展开更多
关键词 color psychology brand identity design Etude House Korean cosmetics consumer emotions market performance
下载PDF
Exploration of the Curriculum Reform Path in the Period of High-Quality Development of University Educational Psychology
7
作者 Chunyang Gao Le Li Xuetong Zhao 《Journal of Contemporary Educational Research》 2024年第7期75-81,共7页
The theoretical and applied characteristics of educational psychology courses in colleges and universities are prominent,and actively promoting curriculum reform is more conducive to promoting the implementation of ta... The theoretical and applied characteristics of educational psychology courses in colleges and universities are prominent,and actively promoting curriculum reform is more conducive to promoting the implementation of talent training goals,which is in line with the practical needs of social development for high-quality talents.However,curriculum reform is a systematic project,which involves the innovation of curriculum content systems,teaching methods,teaching evaluations,and so on.This paper mainly expounds on the curriculum reform path in the period of high-quality development of educational psychology in colleges and universities,hoping to play a reference role in improving the level of education management. 展开更多
关键词 Educational psychology High-quality development COURSES Reform path
下载PDF
A Discussion on Chinese Family Education from the Perspective of Positive Psychology
8
作者 Tian Sun Yiyan Zhang 《Journal of Contemporary Educational Research》 2024年第6期83-88,共6页
In modern society,positive psychology has gained increasing attention as an important branch of psychology.This paper explores some issues and educational strategies in modern family education from the perspective of ... In modern society,positive psychology has gained increasing attention as an important branch of psychology.This paper explores some issues and educational strategies in modern family education from the perspective of positive psychology.Firstly,the paper introduces the origin and basic concepts of positive psychology.Secondly,the current situation and problems of Chinese family education are analyzed.Lastly,a series of strategies applicable to family education based on the principles of positive psychology are proposed.These strategies include establishing a positive family education environment,cultivating children’s positive psychological qualities,adopting positive educational approaches and methods,paying attention to children’s individual differences and diverse development,fostering children’s positive emotional experiences and expression abilities,as well as enhancing children’s social adaptability.By implementing these strategies,family education can better promote children’s holistic development,improve their mental health and well-being,and lay a solid foundation for their future. 展开更多
关键词 Positive psychology Family education Educational strategies
下载PDF
A Review of Research on Second Language Acquisition from a Positive Psychology Perspective
9
作者 Yanhui Wu 《Journal of Contemporary Educational Research》 2024年第6期189-193,共5页
This paper reviews the research on second language acquisition from the perspective of positive psychology.First,it introduces the background and purpose of the study and discusses the significance of the application ... This paper reviews the research on second language acquisition from the perspective of positive psychology.First,it introduces the background and purpose of the study and discusses the significance of the application of positive psychology in the field of language acquisition.Then,the basic theories of positive psychology,including the core concepts and principles of positive psychology,are summarized.Subsequently,the theory of second language acquisition is defined and outlined,including the definition,characteristics,and related developmental theories of second language acquisition.On this basis,the study of second language acquisition from the perspective of positive psychology is discussed in detail.By combing and synthesizing the literature,this paper summarizes the current situation and trend of second language acquisition research under the perspective of positive psychology and puts forward some future research directions and suggestions. 展开更多
关键词 Positive psychology Second language acquisition Language learning motivation Positive emotion Positive mindset
下载PDF
Research on the Generation Path of Heuristic Teaching Language Based on Positive Psychology Theory 被引量:1
10
作者 Haiqiang Tu 《International Journal of Mental Health Promotion》 2023年第4期485-504,共20页
As the essence of traditional Chinese educational thought,heuristic teaching has gradually enriched and devel-oped its ideas through the continuous efforts of educational researchers of the past dynasties.In front-lin... As the essence of traditional Chinese educational thought,heuristic teaching has gradually enriched and devel-oped its ideas through the continuous efforts of educational researchers of the past dynasties.In front-line teach-ing,heuristic teaching,as a teaching principle that can help teachers and students to interact and learn,undoubtedly plays an important role in students’acquisition of knowledge and scientific thinking activities.But teachers’understanding of heuristic teaching is not the same.In actual teaching,there are obvious gaps in language ability among different teachers.This research aims to enrich the heuristic teaching theory based on the perspective of psychology,and provide a certain theoretical basis for teacher training.Through the research and analysis of the generation path of the heuristic teaching language,this paper helps more teachers realize the advantages of the heuristic teaching language,improve their own heuristic teaching language level,and provide reference for the scientific teaching evaluation standard.We apply the heuristic instruction language approach proposed in this study and apply it to real classrooms.In the application,it can be clearly found that the students’thinking and participation have been strengthened,and the teaching effect has been significantly improved com-pared with the past,which indicates that the heuristic teaching language generation path in this study has certain practical application value. 展开更多
关键词 Heuristic language of instruction positive psychology biology class application path
下载PDF
The burden of depression,anxiety and schizophrenia among the older population in ageing and aged countries:an analysis of the Global Burden of Disease Study 2019 被引量:1
11
作者 Ying Cheng Yu Fang +3 位作者 Jinxin Zheng shiyang Guan Meiti Wang Wu Hong 《General Psychiatry》 CSCD 2024年第1期83-93,共11页
Background Depression,anxiety and schizophrenia among older persons have become global public health challenges.However,the burden of these disorders in ageing and aged countries has not been analysed.Aims To investig... Background Depression,anxiety and schizophrenia among older persons have become global public health challenges.However,the burden of these disorders in ageing and aged countries has not been analysed.Aims To investigate the burden of depression,anxiety and schizophrenia among older adults in ageing and aged countries.Methods Using data from the Global Burden of Disease Study 2019,we calculated the estimated annual percentage change(EAPC)in the age-standardised incidence rates(ASiR)and age-standardised disability-adjusted life years(DALYs)rates(ASDR)for depression,anxiety and schizophrenia of older people in ageing countries(China,India,Indonesia)and aged countries(Japan,Italy,Portugal)between 1990 and 2019.Trends in incidence and DALYs were analysed by gender and age.Results In 2019,the highest incidence of depression,anxiety and schizophrenia in the older population in aged countries was in Japan(927271.3(752552.3-1125796.5),51498.2(37625.7-70487.3)and 126.0(61.0-223.2),respectively),while the highest incidence in ageing countries was in China(5797556.9(4599403.4-7133006.5),330256.1(246448.9-445987.4)and 1067.7(556.2-1775.9),respectively).DALYs for these disorders were similar,with the highest in Japan and China.From 1990 to 2019,the ASIR for depressive disorders decreased in aged countries but increased in ageing countries;the ASIR for anxiety disorders and schizophrenia declined in both ageing and aged countries.The ASDR for depressive disorders was consistent with the ASIR but not for anxiety disorders and schizophrenia.The ASIR for depressive disorders was higher in older women,while the opposite was observed in anxiety disorders and schizophrenia.Notably,the conditions of burden of depressive disorders,anxiety disorders and schizophrenia in the 65-70-year-old age group were the most burdensome.Conclusions The incidence and DALYs of these three mental disorders increased while exhibiting differences between ageing and aged countries.Raising awareness about formulating health policies for preventing and treating mental disorders in the older population is necessary to reduce the future burden posed by the ageing challenge. 展开更多
关键词 schizophrenia BURDEN ageing
下载PDF
Comparison of Self-Strength, Seeking Help and Happiness between Pakistani and Chinese Adolescents: A Positive Psychology Inquiry
12
作者 Umaira Tabbasam Amjad Islam Amjad +1 位作者 Tariq Ahmed Xing Qiang 《International Journal of Mental Health Promotion》 2023年第3期389-402,共14页
Adolescents’emotions and preferences are influenced by their childhood experiences.In today’s world,there is a pervasive eagerness for happiness.Happiness has been linked to feelings of self-strength,seeking help,and... Adolescents’emotions and preferences are influenced by their childhood experiences.In today’s world,there is a pervasive eagerness for happiness.Happiness has been linked to feelings of self-strength,seeking help,and psy-chological health.The current quantitative research was designed with a positive psychological perspective to compare Pakistani and Chines adolescents’self-strength,seeking help,and happiness.The research design of the study was causal-comparative.The study population consisted of 400 Pakistani and 409 Chinese adolescents studying in the elementary grades of both countries.The sample was selected by using a simple random sampling technique.It consisted of 413 boys(51%)and 396 girls(49%),319(39)of them were from the age group of 13–14 years,386(48%)of them were from the age group of 15–16 years,and 104(12.9%)were from the age group of 17–18 years.Three different scales were developed to collect study data.Independent sample t-test and simple linear regression were used to test study hypotheses.The analysis revealed that Pakistani adolescents have signifi-cantly higher self-strength,seeking help and happiness than their counterparts.It was also found that adolescents’self-strength and seeking help significant affect their happiness.Based on thefindings,it was suggested to inves-tigate the factors contributing to the improved self-strength,seeking help,and happiness of Pakistani adolescents.It was also recommended to investigate the mediating effect of adolescents’self-strength on the relationship between their happiness and seeking help. 展开更多
关键词 Comparative study HAPPINESS seeking help positive psychology self-strength
下载PDF
The Big Five Model in Relation to Job Performance:A New Look at Organizational Psychology
13
作者 Bafetis Alexandros Michael Galanakis 《Psychology Research》 2023年第1期1-8,共8页
The Big Five Theory is often regarded as psychology’s most influential personality theoretical approach.The goal of this study is to examine the role of the Big Five Theory in the workplace,especially which personali... The Big Five Theory is often regarded as psychology’s most influential personality theoretical approach.The goal of this study is to examine the role of the Big Five Theory in the workplace,especially which personality qualities are more likely to predict work success.Which traits should companies emphasize throughout the hiring and selection processes?How can businesses use the Big Five personality model to locate employees that are more productive,efficient,and devoted to the organization’s goals?A detailed assessment of existing recent research addresses the aforementioned issues.Following a review of many current articles on the subject,it was established that using this model had a positive influence on individual and group performance,working relationships,manager work performance,and workplace innovation. 展开更多
关键词 organizational psychology PERSONALITY Big Five Model job performance
下载PDF
Transformation Design of Old Parks Based on Behavior Psychology: A Case Study of Hefei Xiaoyaojin Park
14
作者 GE Juan CAO Menghan +3 位作者 CHEN Jiaxin HU Yueyue LI Quanjun LI Yinan 《Journal of Landscape Research》 2023年第5期35-40,共6页
City park undertakes the function of urban core green island. Hefei Xiaoyaojin Park providesa leisure and entertainment place for Hefei citizens. Although it has been continuously transformed andupgraded, there are st... City park undertakes the function of urban core green island. Hefei Xiaoyaojin Park providesa leisure and entertainment place for Hefei citizens. Although it has been continuously transformed andupgraded, there are still many places to be improved. Through behavior observation and questionnaire,the usage and satisfaction evaluation of tourists in Xiaoyaojin Park were obtained, and the transformationdesign of Xiaoyaojin Park was analyzed from the perspective of behavior psychology by analyzing thebehavior of tourists in different zones of Xiaoyaojin. Based on the premise of exploring the behaviorof tourists in different spaces, a city park environment that meets the needs of tourists can be created bypromoting the cultural context of the Three Kingdoms, improving the plant landscape and infrastructureof the site, optimizing the spatial function, and exploring the park design and transformation strategy that ismore in line with the needs of people, in order to provide new ideas for the future landscape transformationof Xiaoyaojin park, and offer reference suggestions for the future transformation design of old city parks. 展开更多
关键词 Behavior psychology Old park City park Environmental optimization
下载PDF
Designing interactive glazing through an engineering psychology approach:Six augmented reality scenarios that envision future car human-machine interface
15
作者 Wei LIU Yancong ZHU +5 位作者 Ruonan HUANG Takumi OHASHI Jan AUERNHAMMER Xiaonan ZHANG Ce SHI Lu WANG 《Virtual Reality & Intelligent Hardware》 2023年第2期157-170,共14页
Background With an increasing number of vehicles becoming autonomous,intelligent,and connected,paying attention to the future usage of car human-machine interface with these vehicles should become more relevant.Severa... Background With an increasing number of vehicles becoming autonomous,intelligent,and connected,paying attention to the future usage of car human-machine interface with these vehicles should become more relevant.Several studies have addressed car HMI but were less attentive to designing and implementing interactive glazing for every day(autonomous)driving contexts.Methods Reflecting on the literature,we describe an engineering psychology practice and the design of six novel future user scenarios,which envision the application of a specific set of augmented reality(AR)support user interactions.Additionally,we conduct evaluations on specific scenarios and experiential prototypes,which reveal that these AR scenarios aid the target user groups in experiencing a new type of interaction.The overall evaluation is positive with valuable assessment results and suggestions.Conclusions This study can interest applied psychology educators who aspire to teach how AR can be operationalized in a human-centered design process to students with minimal pre-existing expertise or minimal scientific knowledge in engineering psychology. 展开更多
关键词 Augmented reality Interactive glazing Engineering psychology Car human-machine interface Human-computer interaction Human-centered design User experience Generation Z
下载PDF
Research Progress on the Association between Schizophrenia and Toxoplasma gondii Infection
16
作者 Yiting Zhu Xiaohui Yang +3 位作者 Miaoru Chen Yu Hu Yunfeng Chang Xiang Wu 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2024年第6期647-660,共14页
Toxoplasma gondii(T.gondii or Tg),is an obligatory intracellular parasite with humans as its intermediate hosts.In recent years,significant correlations between T.gondii infection and schizophrenia have been reported,... Toxoplasma gondii(T.gondii or Tg),is an obligatory intracellular parasite with humans as its intermediate hosts.In recent years,significant correlations between T.gondii infection and schizophrenia have been reported,including the possible mediating mechanisms.Currently,mechanisms and hypotheses focus on central neurotransmitters,immunity,neuroinflammation,and epigenetics;however,the exact underlying mechanisms remain unclear.In this article,we review the studies related to T.gondii infection and schizophrenia,particularly the latest research progress.Research on dopamine(DA)and other neurotransmitters,the blood-brain barrier,inflammatory factors,disease heterogeneity,and other confounders is also discussed.In addition,we also summarized the results of some new epidemiological investigations. 展开更多
关键词 Toxoplasma gondii schizophrenia NEUROTRANSMITTERS NEUROINFLAMMATION IMMUNITY EPIGENETICS
下载PDF
Navigating personal recovery:multinomial logistic regression analysis of schizophrenia outcomes in community-dwelling individuals
17
作者 Jutharat Thongsalab Jintana Yunibhand Penpaktr Uthis 《General Psychiatry》 CSCD 2024年第2期254-264,共11页
Background Schizophrenia is a chronic mental disorder affecting individuals globally,emphasising the significance of personal recovery in mental healthcare.Understanding the recovery stages and the associated factors ... Background Schizophrenia is a chronic mental disorder affecting individuals globally,emphasising the significance of personal recovery in mental healthcare.Understanding the recovery stages and the associated factors can provide essential insights for targeted interventions.Aims This study aimed to discern the stages of personal recovery in Thai patients with schizophrenia and elucidate the associated factors with each stage.Methods A multistage sampling technique was employed,selecting 231 patients with schizophrenia from mental health outpatient departments of general and psychiatric hospitals.Data collected from March to May 2023 included screening for psychotic symptoms using the Brief Psychiatric Rating Scale and six self-report questionnaires—Stage of Recovery Scale,Beck Cognitive Insight Scale,Brief Resilience Scale,Family Support,Therapeutic Relationship-Patients Version and Social Support Questionnaire—along with personal data sheets.Pearson correlation and multinomial logistic regression were performed.Results The predominant personal recovery stage among participants was stage 3,‘living with disabilities’,comprising 42.4%of the participants.Key factors contributing to personal recovery,explaining approximately 38.4%of the variance,included resilience,family support,therapeutic alliance,hospitalisations since onset and recovery-oriented nursing service utilisation.Logit equations for stages 3 and 4 are as follows:stage 3(living with disability):logit=−4.44+0.74×resilience+0.07×therapeutic alliance+0.02×recovery-oriented nursing service utilisation;stage 4(living beyond disability):logit=−11.57-0.05×hospitalisation since onset+1.96×resilience+0.11×family support+0.06×therapeutic alliance.Conclusion The findings emphasise the significance of mental health nursing interventions.In conjunction with recovery-oriented nursing services,strengthening resilience,therapeutic alliances and family support may accelerate personal recovery and reduce hospitalisations among individuals with schizophrenia. 展开更多
关键词 schizophrenia selecting globally
下载PDF
Prediction of treatment response to antipsychotic drugs for precision medicine approach to schizophrenia:randomized trials and multiomics analysis
18
作者 Liang-Kun Guo Yi Su +24 位作者 Yu-Ya-Nan Zhang Hao Yu Zhe Lu Wen-Qiang Li Yong-Feng Yang Xiao Xiao Hao Yan Tian-Lan Lu Jun Li Yun-Dan Liao Zhe-Wei Kang Li-Fang Wang Yue Li Ming Li Bing Liu Hai-Liang Huang Lu-Xian Lv Yin Yao Yun-Long Tan Gerome Breen Ian Everall Hong-Xing Wang Zhuo Huang Dai Zhang Wei-Hua Yue 《Military Medical Research》 SCIE CAS CSCD 2024年第1期19-33,共15页
Background:Choosing the appropriate antipsychotic drug(APD)treatment for patients with schizophrenia(SCZ)can be challenging,as the treatment response to APD is highly variable and difficult to predict due to the lack ... Background:Choosing the appropriate antipsychotic drug(APD)treatment for patients with schizophrenia(SCZ)can be challenging,as the treatment response to APD is highly variable and difficult to predict due to the lack of effective biomarkers.Previous studies have indicated the association between treatment response and genetic and epigenetic factors,but no effective biomarkers have been identified.Hence,further research is imperative to enhance precision medicine in SCZ treatment.Methods:Participants with SCZ were recruited from two randomized trials.The discovery cohort was recruited from the CAPOC trial(n=2307)involved 6 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,Quetiapine,Aripiprazole,Ziprasidone,and Haloperidol/Perphenazine(subsequently equally assigned to one or the other)groups.The external validation cohort was recruited from the CAPEC trial(n=1379),which involved 8 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,and Aripiprazole groups.Additionally,healthy controls(n=275)from the local community were utilized as a genetic/epigenetic reference.The genetic and epigenetic(DNA methylation)risks of SCZ were assessed using the polygenic risk score(PRS)and polymethylation score,respectively.The study also examined the genetic-epigenetic interactions with treatment response through differential methylation analysis,methylation quantitative trait loci,colocalization,and promoteranchored chromatin interaction.Machine learning was used to develop a prediction model for treatment response,which was evaluated for accuracy and clinical benefit using the area under curve(AUC)for classification,R^(2) for regression,and decision curve analysis.Results:Six risk genes for SCZ(LINC01795,DDHD2,SBNO1,KCNG2,SEMA7A,and RUFY1)involved in cortical morphology were identified as having a genetic-epigenetic interaction associated with treatment response.The developed and externally validated prediction model,which incorporated clinical information,PRS,genetic risk score(GRS),and proxy methylation level(proxyDNAm),demonstrated positive benefits for a wide range of patients receiving different APDs,regardless of sex[discovery cohort:AUC=0.874(95%CI 0.867-0.881),R^(2)=0.478;external validation cohort:AUC=0.851(95%CI 0.841-0.861),R^(2)=0.507].Conclusions:This study presents a promising precision medicine approach to evaluate treatment response,which has the potential to aid clinicians in making informed decisions about APD treatment for patients with SCZ.Trial registration Chinese Clinical Trial Registry(https://www.chictr.org.cn/),18 Aug 2009 retrospectively registered:CAPOC-ChiCTR-RNC-09000521(https://www.chictr.org.cn/showproj.aspx?proj=9014),CAPEC-ChiCTRRNC-09000522(https://www.chictr.org.cn/showproj.aspx?proj=9013). 展开更多
关键词 schizophrenia Antipsychotic drug Treatment response Prediction model GENETICS EPIGENETICS
下载PDF
New role of platelets in schizophrenia:predicting drug response
19
作者 Yamin Zhang Yanghao Zheng +12 位作者 Peiyan Ni Sugai Liang Xiaojing Li Hua Yu Wei Wei Xueyu Qi Xueli Yu Rui Xue Liansheng Zhao Wei Deng Qiang Wang Wanjun Guo Tao Li 《General Psychiatry》 CSCD 2024年第2期197-206,共10页
Background Elevated platelet count(PLTc)is associated with first-episode schizophrenia and adverse outcomes in individuals with precursory psychosis.However,the impact of antipsychotic medications on PLTc and its asso... Background Elevated platelet count(PLTc)is associated with first-episode schizophrenia and adverse outcomes in individuals with precursory psychosis.However,the impact of antipsychotic medications on PLTc and its association with symptom improvement remain unclear.Aims We aimed to investigate changes in PLTc levels following antipsychotic treatment and assess whether PLTc can predict antipsychotic responses and metabolic changes after accounting for other related variables.Methods A total of 2985 patients with schizophrenia were randomised into seven groups.Each group received one of seven antipsychotic treatments and was assessed at 2,4 and 6 weeks.Clinical symptoms were evaluated using the positive and negative syndrome scale(PANSS).Additionally,we measured blood cell counts and metabolic parameters,such as blood lipids.Repeated measures analysis of variance was used to examine the effect of antipsychotics on PLTc changes,while structural equation modelling was used to assess the predictive value of PLTc on PANSS changes.Results PLTc significantly increased in patients treated with aripiprazole(F=6.00,p=0.003),ziprasidone(F=7.10,p<0.001)and haloperidol(F=3.59,p=0.029).It exhibited a positive association with white blood cell count and metabolic indicators.Higher baseline PLTc was observed in non-responders,particularly in those defined by the PANSS-negative subscale.In the structural equation model,PLTc,white blood cell count and a latent metabolic variable predicted the rate of change in the PANSS-negative subscale scores.Moreover,higher baseline PLTc was observed in individuals with less metabolic change,although this association was no longer significant after accounting for baseline metabolic values.Conclusions Platelet parameters,specifically PLTc,are influenced by antipsychotic treatment and could potentially elevate the risk of venous thromboembolism in patients with schizophrenia.Elevated PLTc levels and associated factors may impede symptom improvement by promoting inflammation.Given PLTc’s easy measurement and clinical relevance,it warrants increased attention from psychiatrists.Trial registration number ChiCTR-TRC-10000934. 展开更多
关键词 schizophrenia assessed TREATMENT
下载PDF
Effects of psychological intervention on negative emotions and psychological resilience in breast cancer patients after radical mastectomy
20
作者 Jing Wang Dong-Xue Kang +1 位作者 Ai-Jun Zhang Bing-Rui Li 《World Journal of Psychiatry》 SCIE 2024年第1期8-14,共7页
Breast cancer(BC)is the most common malignant tumor in women,and the treatment process not only results in physical pain but also significant psychological distress in patients.Psychological intervention(PI)has been r... Breast cancer(BC)is the most common malignant tumor in women,and the treatment process not only results in physical pain but also significant psychological distress in patients.Psychological intervention(PI)has been recognized as an important approach in treating postoperative psychological disorders in BC patients.It has been proven that PI has a significant therapeutic effect on postoperative psychological disorders,improving patients'negative emotions,enhancing their psychological resilience,and effectively enhancing their quality of life and treatment compliance. 展开更多
关键词 Breast cancer psychological intervention Negative emotions psychological resilience Radical surgery
下载PDF
上一页 1 2 250 下一页 到第
使用帮助 返回顶部