Background:In order to clarify the inmpat ofγirradiation on the chemical composition of traditional Chinese medicine,this paper carefully choosed Chuanxiong Rhizoma to carry on a demonstration study.Methods:Through a...Background:In order to clarify the inmpat ofγirradiation on the chemical composition of traditional Chinese medicine,this paper carefully choosed Chuanxiong Rhizoma to carry on a demonstration study.Methods:Through a meticulous assessment,a comprehensive comparison was made between the irradiated and unirradiated Chuanxiong Rhizoma samples.The property characteristics were investigated by colorimeter and electronic nose.The changes in chemical structures and contents was analyzed by fourier infrared spectroscopy,high performance liquid chromatography and fingerprinting.In a quest to uncover the presence of any new radiolysis products,cutting-edge techniques like ultra performance liquid chromatography-quadrupole-time of flight-mass spectrometry and gas chromatography-mass spectrometry were employed.Moreover,the difference of antioxidant activity were investigated.Results:The irradiation doses within 12 kGy had no significant effects on the content of the main chemical components,characteristics and in vitro antioxidant activity of Chuanxiong Rhizoma,while changes in some functional groups and degradation of some volatile oil components containing olefins need further study.Conclusion:This study indicates that^(60)Co-γirradiation is a stable method for sterilization of Chuanxiong Rhizoma.It’s also provide a reference for the establishment of irradiation standards for Chuanxiong Rhizoma and other aromatic medicinal plants.展开更多
Lonicera japonica,also known as honeysuckle,is an evergreen shrub in the family of Syzygium.By consulting Sciencedirect databases and Web of Science databases,79 related articles were found,of which 22 were related to...Lonicera japonica,also known as honeysuckle,is an evergreen shrub in the family of Syzygium.By consulting Sciencedirect databases and Web of Science databases,79 related articles were found,of which 22 were related to chemical composition and pharmacological activity.These articles show that L.japonica has a wide range of pharmacological activities,including antiviral,anti-tumor,and antioxidant effects.These activities have important applications in the pharmaceutical,food,and fragrance industries.This review focuses on the chemical composition and pharmacological effects of L.japonicae,which is of great significance to the development of new drugs and therapeutic methods.展开更多
Croton crassifolius(CC)is a kind of traditional Chinese medicine rich in terpenoids,with among which diterpene species are the most.CC had biological activities in the treatment of cancer,inflammation,ulcerative colit...Croton crassifolius(CC)is a kind of traditional Chinese medicine rich in terpenoids,with among which diterpene species are the most.CC had biological activities in the treatment of cancer,inflammation,ulcerative colitis,osteoporosis and Alzheimer’s disease.This study reviews the chemical compositions and pharmacological activities of CC to provide reference for further research.展开更多
Parkinson’s disease is a common neurodegenerative disease with movement disorders associated with the intracytoplasmic deposition of aggregate proteins such asα-synuclein in neurons.As one of the major intracellular...Parkinson’s disease is a common neurodegenerative disease with movement disorders associated with the intracytoplasmic deposition of aggregate proteins such asα-synuclein in neurons.As one of the major intracellular degradation pathways,the autophagy-lysosome pathway plays an important role in eliminating these proteins.Accumulating evidence has shown that upregulation of the autophagy-lysosome pathway may contribute to the clearance ofα-synuclein aggregates and protect against degeneration of dopaminergic neurons in Parkinson’s disease.Moreover,multiple genes associated with the pathogenesis of Parkinson’s disease are intimately linked to alterations in the autophagy-lysosome pathway.Thus,this pathway appears to be a promising therapeutic target for treatment of Parkinson’s disease.In this review,we briefly introduce the machinery of autophagy.Then,we provide a description of the effects of Parkinson’s disease–related genes on the autophagy-lysosome pathway.Finally,we highlight the potential chemical and genetic therapeutic strategies targeting the autophagy–lysosome pathway and their applications in Parkinson’s disease.展开更多
A new natural product (1) together with 26 know compounds were isolated from the Bulbs of Ornithogalum caudatum. Their structures were established on the basis of spectral analyses as n-butyl pyroglutamate (1), nonade...A new natural product (1) together with 26 know compounds were isolated from the Bulbs of Ornithogalum caudatum. Their structures were established on the basis of spectral analyses as n-butyl pyroglutamate (1), nonadecyl alcohol(2), eicosanol(3), behenic acid(4), b-sitosterol(5), stigmasterol(6), glycerol 1-monocerotate(7), pyrocatechol(8), p-ethoxybenzoic acid(9), p-coumarinic acid(10), protocatechuric acid(11), ursolic acid(12), betulinic acid(13), fumaric acid(14), succinic acid(15), uracil(16), xanthine(17), quercetin(18), kaempferol (19), isorham-netin(20), adenosine(21), daucosterol(22), stigmasterol 3-O-b-D-glucopyranoside(23), quercetin 3-O-b-D-glucopyra-noside(24), kaempferol 3-O-b-D-glucopyranoside(25), rutin(26), and kaempferol 3-O-b-rutinoside(27). All of them, except compound 5, were isolated from this plant for the first time.展开更多
Semiaquilegia adoxoides ( DC. ) Makino ( Chinese name ''Tian-Kui-Zi'' ) , theonly species of genus Semiaquilegia, belongs to the Ranunculaceae family. As a perennial herbaceousplant, both the aerial pa...Semiaquilegia adoxoides ( DC. ) Makino ( Chinese name ''Tian-Kui-Zi'' ) , theonly species of genus Semiaquilegia, belongs to the Ranunculaceae family. As a perennial herbaceousplant, both the aerial parts and the roots are used in traditional Chinese medicine for differentmedications. The roots are often used to treat inflammation, snake bite, bruises and injuries,tonsillitis, mastitis, scrofula, and cancer for their antibacterial, anti-inflammatory, andantineoplastic activities. The aerial parts are used for the treatment of mastitis, bruises, andheart diseases, such as endomyocarditis. The medicinal usage of this plant prompted us toinvestigate its chemical constituents. As a result, nine compounds 1-9 ( see Figure 1) were isolatedfrom the roots of S. adoxoides. Among them, compounds 1-7 and 9 were isolated from the genusSemiaquilegia for the first time.展开更多
To study the chemical constituents of Sappan Lignum. Chemical constituents were isolated by method of solvent extraction, repeated chromatography with silica gel, Sephadex LH-20, and ODS. The structures were elucidate...To study the chemical constituents of Sappan Lignum. Chemical constituents were isolated by method of solvent extraction, repeated chromatography with silica gel, Sephadex LH-20, and ODS. The structures were elucidated based on spectro- scopic data. Fourteen compounds were isolated and their structures were identified as brazilin (1), sappanone B (2), (E)-3-(3,4- dihydroxybenzylidene)-7-hydroxychroman-4-one (3), 3-deoxysappanone B (4), brazilide A (5), euxanthone (6), quercetin (7), rhamnetin (8), sappanchalcone (9), 3-deoxysappanchalcone (10), butein (11), 2,4,5-trihydroxybenzaldehyde (12), 3,8,9-trihydroxy- 6H-benzo[c]chromen-6-one (13) and 13-sitosterol (14). Compounds 12 and 13 were two new natural compounds, and the ^13C NMR data of compound 13 were reported for the first time. Compound 6 was the first xanthone isolated from the genus Caesalpinia.展开更多
To study the chemical constituents of Hedysarum gmelinii. Methods Theconstituents were separated and purified by different methods of chromatography, and theirstructures were elucidated by DR, MS and NMR. Results Eigh...To study the chemical constituents of Hedysarum gmelinii. Methods Theconstituents were separated and purified by different methods of chromatography, and theirstructures were elucidated by DR, MS and NMR. Results Eight compounds were isolated from Hedysarumgmelinii, including three triteipenoids, two flavonoids and two other compounds. Their structureswere identified as squasapogenol (1), soyasapogenol (2), lupeol (3), 3, 9-dihydroxy coumestan (4),3-hydroxy-9-me-thoxy pterocarpan (5), β-sitosterol (6), palmatic acid (7), and hexadecanoic acid 2,3-dihydroxypropyl ester (8). Conclusion All the compounds have been isolated from this plant forthe first time. Compounds 1 — 4 and 8 were obtained from this genus for the first time. The NMRdata of 1 are reported for the first time.展开更多
Thalictrum plants are perennial herbs in the family Ranuneulaceae, many of which are of important medicinal values. Alkaloids are major active constituents in Thalictrum plants in addition to a small amount of triterp...Thalictrum plants are perennial herbs in the family Ranuneulaceae, many of which are of important medicinal values. Alkaloids are major active constituents in Thalictrum plants in addition to a small amount of triterpene and flavonoids. The major pharmacological functions of the active constituents include: anti-tumor, anti- virus, antibiosis, antiphlogosis, hypotensive action, and etc. This paper summarizes the methods for determining the contents of chemical constituents in Thalictrum plants and new chemical constituents discovered in this genus in recent ten years.展开更多
Aim To study the chemical constituents from the stems of Xylosma controversum Clos. Methods The constituents were isolated by solvent extraction, repeated chromatography with silica gel, Sephadex LH-20, and RP-18 colu...Aim To study the chemical constituents from the stems of Xylosma controversum Clos. Methods The constituents were isolated by solvent extraction, repeated chromatography with silica gel, Sephadex LH-20, and RP-18 columns. The structures were elucidated by spectral analysis. Results Thirteen compounds were isolated and their structures were identified as (-)-syringaresinol (1), syringaresinol-4-O-β-D-glucopyranoside (2), syringaresinol-4,4′-bis-O-β-D-glucopyranoside (3), (±)-catechin (4), catechin-3-O- β-D-glucopyranoside (5), catechin-5-O-β-D-glucopyranoside (6), 1,3-bis-(4-hydroxy-3,5-dimethoxyphenyl)-1,3-propanediol (7), (R)-(+)-chaulmoogric acid (8), friedelin (9), uracile (10), benzoic acid (11), vaniUic acid (12), and 4-hydroxybenzoic acid (13). Conclusion All the compounds described above were isolated from this genus for the first time.展开更多
Aim To study the chemical constituents of the flower buds of Tussilago farfara L. in the China National GAP Base of Traditional Chinese Materia Medica and provide scientific basis for quality control. Methods The cons...Aim To study the chemical constituents of the flower buds of Tussilago farfara L. in the China National GAP Base of Traditional Chinese Materia Medica and provide scientific basis for quality control. Methods The constituents were separated and purified by different chromatographic methods, and their structures were elucidated by IR, MS and NMR techniques. Results Twenty eight compounds were isolated from the flower buds of T. farfara. Their structures were identified as n- heptacosane (1), bis(2-ethylhexyl)phthalate (2), 7β-[3'-ethylcrotonoyloxy]-1α-[2'-methylbutyryloxy]-3,14-dehydro-Z-notonipetranone (3), 7β-[3'-ethylcrotonoyloxy]-1α-[2'-methylbutyryloxy]-3,14-dehydro-E-notonipetranone (4), tussilagone (5), dibutyl phthalate (6), bauer-7-ene-3β,16α-diol (7), isobauerenol (8), stigmasterol (9), β-sitosterol (10), 2,2-dimethyl-6-acetylchromanone (11), n- hexadecanoic acid (12), 7β-hydroxysitosterol (13), 7α-hydroxysitosterol (14), 7,14-bisdesacylnotonipetrone (15), 2,3- dihydroxypropylpalmitate (16), daucosterol (17), 6-hydroxy-2,6-dimethylhept-2-en-4-one (18), ferulic acid (19), isoferulic acid (20), caffeic acid (21), α-D-glucose (22), sucrose (23), phthalic acid (24), p-hydroxybenzoic acid (25), gallic acid (26), uridine (27), and adenosine (28). Conclusion Compounds 1, 12-16, 18 and 20 were obtained from the genus Tussilago for the first time.展开更多
Aim To investigate the chemical constituents from Potentilla multifida L..Methods Chromatographic technique was employed for the isolation and purification of theconstituents, and the structures were identified by spe...Aim To investigate the chemical constituents from Potentilla multifida L..Methods Chromatographic technique was employed for the isolation and purification of theconstituents, and the structures were identified by spectral evidence. Results Four compounds wereisolated involving ade-nosine (1), apigenin-6-C-arabinopyranosyl-8-C-glucopyranoside (2),apigenin-7-O-β-D-glucuronide (3) and luteolin-7-O-β-D-glucuronide (4). Conclusion The fourcompounds were obtained from the genus Potentilla for the first time.展开更多
From the fruit of Rosa davidii Crep., eleven compounds were isolated and identified by spectral evidence, viz. 2 alpha, 3 beta, 19 beta -trihydroxyl-olean-12-en-28-oic acid (1), 2 alpha, 3 beta -dihydroxyl-urs-28 (13)...From the fruit of Rosa davidii Crep., eleven compounds were isolated and identified by spectral evidence, viz. 2 alpha, 3 beta, 19 beta -trihydroxyl-olean-12-en-28-oic acid (1), 2 alpha, 3 beta -dihydroxyl-urs-28 (13)-lactone (2), arjunic acid (3), euscaphic acid (4), 2 alpha, 3 beta -dihydroxyl-urs-12-en-28-oic acid (5), oleanolic acid (6), kaempferol (7), tiliroside (8), quercetin (9), daucosterol (10) and beta -sitosterol (11). Among them, 1 and 2 were new compounds.展开更多
[Objective] This study aimed to isolate and identify the chemical constituents of Selaginella tamariscina. [Method] The chemical compounds isolated from the whole plant of traditional Chinese herb S. tamariscina were ...[Objective] This study aimed to isolate and identify the chemical constituents of Selaginella tamariscina. [Method] The chemical compounds isolated from the whole plant of traditional Chinese herb S. tamariscina were purified through column chromatography and preparative thin-layer chromatography, and then chemical structures of the compounds were determined by NMR and mass spectrometry. Finally, the anticancer activity of the compounds 5, 6 and 7 was measured by MTT assay. [Result] Seven compounds, containing carnaubic acid (1), glucose (2), β-sitosterol (3), amentoflavone (4), selaginellin (5), selaginellin M (6) and selaginellin A (7), were isolated from methanol extracts of S. tamariscina. Among the three tested compounds, compound 7 exhibited the most effective activity to inhibit the HeLa cell growth. [Conclusion] This study will provide a basis for better development and utilization of Selaginella plant resources.展开更多
To investigate the chemical constituents of the roots ofPolygala sibirica L. The separation and purification were performed by solvent extraction and repeated chromatography with silica gel, Sephadex LH-20, ODS column...To investigate the chemical constituents of the roots ofPolygala sibirica L. The separation and purification were performed by solvent extraction and repeated chromatography with silica gel, Sephadex LH-20, ODS columns, and semiprep. HPLC. The structures were elucidated by spectral analysis. Twelve known compounds were isolated and identified as tenuifoliside A (1), tenuifoliside B (2), glomeratose A (3), 3',6-disinapoyl sucrose (4), sibiricose A5 (5), sibiricose A6 (6), sibiricose A1 (7), sibiricose A2 (8), polygalatenoside E (9), 1-O-L-arabinopyranosyl-O-(6→1)-β-D-glucopyranosyl-salicylate (10), canthoside A (11), and methyl- 3,4,5-trimethoxycinnamate (12). Compound 11 was obtained from genus Polygala for the first time, and compounds 2, 9, 10 and 12 were isolated from this plant for the first time.展开更多
Three compounds were obtained from the mycelia of an endophytic fungus Gliocladium sp. (designated as strain F) of Taxus chinensis (Pilg.) Rehd. growing in Fujian Province, China. Their structures were determined on t...Three compounds were obtained from the mycelia of an endophytic fungus Gliocladium sp. (designated as strain F) of Taxus chinensis (Pilg.) Rehd. growing in Fujian Province, China. Their structures were determined on the basis of spectral analysis. (20S,22S)-4a-homo-22-hydroxy-4-oxaergosta-7,24(28)-dien-3-one was a novel compound. 4,8,12,16-tetramethyl-1,5,9,13-tetraoxacyclohexadecane-2,6,10,14-tetraone was firstly isolated from the genus ofGliocladium and 6,9-epoxyergosta-7,22-dien-3-ol was firstly obtained from the strain F.展开更多
Aim To study the chemical constituents from Coriolus versicolor L.. Methods Chromatographic techniques were employed for separation and purification. The structures were identified on the basis of spectroscopic analys...Aim To study the chemical constituents from Coriolus versicolor L.. Methods Chromatographic techniques were employed for separation and purification. The structures were identified on the basis of spectroscopic analysis. Results Eight compounds were isolated and identified as ergosta-7, 22-dien-313 -yl palmitate (1), ergosta-7, 22-dien-313 -ol (2), betulic acid (3), 4-hydroxy benzoic acid (4), 3- methoxy-4-hydroxy benzoic acid (5), 3, 5-dimethoxyl-4-hydroxy benzoic acid (6), 2-furoic acid (7), and nicotinic acid (8). Conclusion Eight compounds were reported for the first time from Coriolus versicolor L..展开更多
Aim To investigate the chemical constituents of Salvia cavaleriei Levi. var. erythrophylla (Hemsl.) Stib. Methods Compounds were isolated by silica gel column chromatography and Sephadex LH-20 gel column chromatogra...Aim To investigate the chemical constituents of Salvia cavaleriei Levi. var. erythrophylla (Hemsl.) Stib. Methods Compounds were isolated by silica gel column chromatography and Sephadex LH-20 gel column chromatography, and the structures were identified by spectral analysis. Result Five compounds were identified as 3β, 6β, 23-trihydroxyolean-12-en-28-oic acid (1), ursolic acid (2), n-heptadecanoic acid (3), n-octadecanoic acid (4), and β-sitosterol (5). Conclusion Five compounds were isolated from the plant for the first time.展开更多
Aim To investigate the active constituents responsible for thepharmacological activities of Angelica sinensis (Oliv) Diels. Methods Chromatography was used toisolate chemical components, and spectroscopy was used to i...Aim To investigate the active constituents responsible for thepharmacological activities of Angelica sinensis (Oliv) Diels. Methods Chromatography was used toisolate chemical components, and spectroscopy was used to identify their structures. Results Sevencompounds were isolated and their structures were identified as ferulic acid (1), conife-rylferukte(2) , bis (2-ethylhexyl) phthalate (3), dibutyl phthalate (4), lignoceric acid (5), palmitic acid(6), and Z-6, 7-cis-dihydroxyligustilide (7) Conclusion Bis (2-ethylhexyl) phthalate and dibutylphthalate were obtained from Angelica sinensis for the first time.展开更多
Aim To investigate the chemical constituents of Ixeris sonchifolia Hance. Methods The chemical constituents were isolated by various column chromatographic methods and the structures were elucidated and characterized ...Aim To investigate the chemical constituents of Ixeris sonchifolia Hance. Methods The chemical constituents were isolated by various column chromatographic methods and the structures were elucidated and characterized by spectral evidences. Result Thirteen compounds were obtained and identified as 3β-acetoxy-20-taraxasten-22-one (1), bauerenyl acetate (2), 3β-acetoxy- 11-oxours-12-ene (3), oleanic acid (4), oleanane (5), 8-desoxyartelin (6), aesculetin (7), ferulic acid (8), vanillic acid (9), sonchifolinin (10), hexacosanol (11), β-sitosterol (12), and daucosterol (13). Conclusion Compounds 1, 5, and 8 were isolated from this genus for the first time; compound 7 was obtained firstly from this plant.展开更多
基金This work was financially supported by Nationalities Introduces Talented Research Startup Project of Southwest Minzu University(RQD2021055)Sichuan Science and Technology Program(R22ZYZF0005)Innovative Scientific Research Project for Postgraduates of Southwest Minzu University(ZD2022798).
文摘Background:In order to clarify the inmpat ofγirradiation on the chemical composition of traditional Chinese medicine,this paper carefully choosed Chuanxiong Rhizoma to carry on a demonstration study.Methods:Through a meticulous assessment,a comprehensive comparison was made between the irradiated and unirradiated Chuanxiong Rhizoma samples.The property characteristics were investigated by colorimeter and electronic nose.The changes in chemical structures and contents was analyzed by fourier infrared spectroscopy,high performance liquid chromatography and fingerprinting.In a quest to uncover the presence of any new radiolysis products,cutting-edge techniques like ultra performance liquid chromatography-quadrupole-time of flight-mass spectrometry and gas chromatography-mass spectrometry were employed.Moreover,the difference of antioxidant activity were investigated.Results:The irradiation doses within 12 kGy had no significant effects on the content of the main chemical components,characteristics and in vitro antioxidant activity of Chuanxiong Rhizoma,while changes in some functional groups and degradation of some volatile oil components containing olefins need further study.Conclusion:This study indicates that^(60)Co-γirradiation is a stable method for sterilization of Chuanxiong Rhizoma.It’s also provide a reference for the establishment of irradiation standards for Chuanxiong Rhizoma and other aromatic medicinal plants.
基金supported by National Nature Science Foundation of China (81973284)Scientific Research Foundation of the Education Department of Liaoning Province (LJKZ0944)Jiangsu Province Capability Improvement Project through Science,Technology and Education (ZDXYS202207).
文摘Lonicera japonica,also known as honeysuckle,is an evergreen shrub in the family of Syzygium.By consulting Sciencedirect databases and Web of Science databases,79 related articles were found,of which 22 were related to chemical composition and pharmacological activity.These articles show that L.japonica has a wide range of pharmacological activities,including antiviral,anti-tumor,and antioxidant effects.These activities have important applications in the pharmaceutical,food,and fragrance industries.This review focuses on the chemical composition and pharmacological effects of L.japonicae,which is of great significance to the development of new drugs and therapeutic methods.
基金supported by National Nature Science Foundation of China (81973284)Scientific Research Foundation of the Education Department of Liaoning Province (LJKZ0944).
文摘Croton crassifolius(CC)is a kind of traditional Chinese medicine rich in terpenoids,with among which diterpene species are the most.CC had biological activities in the treatment of cancer,inflammation,ulcerative colitis,osteoporosis and Alzheimer’s disease.This study reviews the chemical compositions and pharmacological activities of CC to provide reference for further research.
基金supported by the National Natural Science Foundation of China,No.82101340(to FJ).
文摘Parkinson’s disease is a common neurodegenerative disease with movement disorders associated with the intracytoplasmic deposition of aggregate proteins such asα-synuclein in neurons.As one of the major intracellular degradation pathways,the autophagy-lysosome pathway plays an important role in eliminating these proteins.Accumulating evidence has shown that upregulation of the autophagy-lysosome pathway may contribute to the clearance ofα-synuclein aggregates and protect against degeneration of dopaminergic neurons in Parkinson’s disease.Moreover,multiple genes associated with the pathogenesis of Parkinson’s disease are intimately linked to alterations in the autophagy-lysosome pathway.Thus,this pathway appears to be a promising therapeutic target for treatment of Parkinson’s disease.In this review,we briefly introduce the machinery of autophagy.Then,we provide a description of the effects of Parkinson’s disease–related genes on the autophagy-lysosome pathway.Finally,we highlight the potential chemical and genetic therapeutic strategies targeting the autophagy–lysosome pathway and their applications in Parkinson’s disease.
基金This work was supported by the Ministry of Science and Technology of China (96-901-05-266).
文摘A new natural product (1) together with 26 know compounds were isolated from the Bulbs of Ornithogalum caudatum. Their structures were established on the basis of spectral analyses as n-butyl pyroglutamate (1), nonadecyl alcohol(2), eicosanol(3), behenic acid(4), b-sitosterol(5), stigmasterol(6), glycerol 1-monocerotate(7), pyrocatechol(8), p-ethoxybenzoic acid(9), p-coumarinic acid(10), protocatechuric acid(11), ursolic acid(12), betulinic acid(13), fumaric acid(14), succinic acid(15), uracil(16), xanthine(17), quercetin(18), kaempferol (19), isorham-netin(20), adenosine(21), daucosterol(22), stigmasterol 3-O-b-D-glucopyranoside(23), quercetin 3-O-b-D-glucopyra-noside(24), kaempferol 3-O-b-D-glucopyranoside(25), rutin(26), and kaempferol 3-O-b-rutinoside(27). All of them, except compound 5, were isolated from this plant for the first time.
基金Ministry of Science and Technology of People'sRepublic of China (No. 2004AA2Z3730)
文摘Semiaquilegia adoxoides ( DC. ) Makino ( Chinese name ''Tian-Kui-Zi'' ) , theonly species of genus Semiaquilegia, belongs to the Ranunculaceae family. As a perennial herbaceousplant, both the aerial parts and the roots are used in traditional Chinese medicine for differentmedications. The roots are often used to treat inflammation, snake bite, bruises and injuries,tonsillitis, mastitis, scrofula, and cancer for their antibacterial, anti-inflammatory, andantineoplastic activities. The aerial parts are used for the treatment of mastitis, bruises, andheart diseases, such as endomyocarditis. The medicinal usage of this plant prompted us toinvestigate its chemical constituents. As a result, nine compounds 1-9 ( see Figure 1) were isolatedfrom the roots of S. adoxoides. Among them, compounds 1-7 and 9 were isolated from the genusSemiaquilegia for the first time.
文摘To study the chemical constituents of Sappan Lignum. Chemical constituents were isolated by method of solvent extraction, repeated chromatography with silica gel, Sephadex LH-20, and ODS. The structures were elucidated based on spectro- scopic data. Fourteen compounds were isolated and their structures were identified as brazilin (1), sappanone B (2), (E)-3-(3,4- dihydroxybenzylidene)-7-hydroxychroman-4-one (3), 3-deoxysappanone B (4), brazilide A (5), euxanthone (6), quercetin (7), rhamnetin (8), sappanchalcone (9), 3-deoxysappanchalcone (10), butein (11), 2,4,5-trihydroxybenzaldehyde (12), 3,8,9-trihydroxy- 6H-benzo[c]chromen-6-one (13) and 13-sitosterol (14). Compounds 12 and 13 were two new natural compounds, and the ^13C NMR data of compound 13 were reported for the first time. Compound 6 was the first xanthone isolated from the genus Caesalpinia.
基金National Natural Science Foundation of China (20432030)
文摘To study the chemical constituents of Hedysarum gmelinii. Methods Theconstituents were separated and purified by different methods of chromatography, and theirstructures were elucidated by DR, MS and NMR. Results Eight compounds were isolated from Hedysarumgmelinii, including three triteipenoids, two flavonoids and two other compounds. Their structureswere identified as squasapogenol (1), soyasapogenol (2), lupeol (3), 3, 9-dihydroxy coumestan (4),3-hydroxy-9-me-thoxy pterocarpan (5), β-sitosterol (6), palmatic acid (7), and hexadecanoic acid 2,3-dihydroxypropyl ester (8). Conclusion All the compounds have been isolated from this plant forthe first time. Compounds 1 — 4 and 8 were obtained from this genus for the first time. The NMRdata of 1 are reported for the first time.
基金Supported by the State Key Development Program for Basic Research of ChinaScientific and Technological Development Project of Shandong Province(2008GG2NS02022)~~
文摘Thalictrum plants are perennial herbs in the family Ranuneulaceae, many of which are of important medicinal values. Alkaloids are major active constituents in Thalictrum plants in addition to a small amount of triterpene and flavonoids. The major pharmacological functions of the active constituents include: anti-tumor, anti- virus, antibiosis, antiphlogosis, hypotensive action, and etc. This paper summarizes the methods for determining the contents of chemical constituents in Thalictrum plants and new chemical constituents discovered in this genus in recent ten years.
基金Program for Changjiang Scholar and InnovativeTeam in Peking University (Grant number: 985-2-063-112).
文摘Aim To study the chemical constituents from the stems of Xylosma controversum Clos. Methods The constituents were isolated by solvent extraction, repeated chromatography with silica gel, Sephadex LH-20, and RP-18 columns. The structures were elucidated by spectral analysis. Results Thirteen compounds were isolated and their structures were identified as (-)-syringaresinol (1), syringaresinol-4-O-β-D-glucopyranoside (2), syringaresinol-4,4′-bis-O-β-D-glucopyranoside (3), (±)-catechin (4), catechin-3-O- β-D-glucopyranoside (5), catechin-5-O-β-D-glucopyranoside (6), 1,3-bis-(4-hydroxy-3,5-dimethoxyphenyl)-1,3-propanediol (7), (R)-(+)-chaulmoogric acid (8), friedelin (9), uracile (10), benzoic acid (11), vaniUic acid (12), and 4-hydroxybenzoic acid (13). Conclusion All the compounds described above were isolated from this genus for the first time.
基金The National High-Tech"863"Project(Grant No.2004AA2Z3730-07)State Projects of the Tenth-Five-year Plan(Grant No.2001-BA701A62-11).
文摘Aim To study the chemical constituents of the flower buds of Tussilago farfara L. in the China National GAP Base of Traditional Chinese Materia Medica and provide scientific basis for quality control. Methods The constituents were separated and purified by different chromatographic methods, and their structures were elucidated by IR, MS and NMR techniques. Results Twenty eight compounds were isolated from the flower buds of T. farfara. Their structures were identified as n- heptacosane (1), bis(2-ethylhexyl)phthalate (2), 7β-[3'-ethylcrotonoyloxy]-1α-[2'-methylbutyryloxy]-3,14-dehydro-Z-notonipetranone (3), 7β-[3'-ethylcrotonoyloxy]-1α-[2'-methylbutyryloxy]-3,14-dehydro-E-notonipetranone (4), tussilagone (5), dibutyl phthalate (6), bauer-7-ene-3β,16α-diol (7), isobauerenol (8), stigmasterol (9), β-sitosterol (10), 2,2-dimethyl-6-acetylchromanone (11), n- hexadecanoic acid (12), 7β-hydroxysitosterol (13), 7α-hydroxysitosterol (14), 7,14-bisdesacylnotonipetrone (15), 2,3- dihydroxypropylpalmitate (16), daucosterol (17), 6-hydroxy-2,6-dimethylhept-2-en-4-one (18), ferulic acid (19), isoferulic acid (20), caffeic acid (21), α-D-glucose (22), sucrose (23), phthalic acid (24), p-hydroxybenzoic acid (25), gallic acid (26), uridine (27), and adenosine (28). Conclusion Compounds 1, 12-16, 18 and 20 were obtained from the genus Tussilago for the first time.
文摘Aim To investigate the chemical constituents from Potentilla multifida L..Methods Chromatographic technique was employed for the isolation and purification of theconstituents, and the structures were identified by spectral evidence. Results Four compounds wereisolated involving ade-nosine (1), apigenin-6-C-arabinopyranosyl-8-C-glucopyranoside (2),apigenin-7-O-β-D-glucuronide (3) and luteolin-7-O-β-D-glucuronide (4). Conclusion The fourcompounds were obtained from the genus Potentilla for the first time.
文摘[Objective] This study aimed to isolate and identify the chemical constituents of Selaginella tamariscina. [Method] The chemical compounds isolated from the whole plant of traditional Chinese herb S. tamariscina were purified through column chromatography and preparative thin-layer chromatography, and then chemical structures of the compounds were determined by NMR and mass spectrometry. Finally, the anticancer activity of the compounds 5, 6 and 7 was measured by MTT assay. [Result] Seven compounds, containing carnaubic acid (1), glucose (2), β-sitosterol (3), amentoflavone (4), selaginellin (5), selaginellin M (6) and selaginellin A (7), were isolated from methanol extracts of S. tamariscina. Among the three tested compounds, compound 7 exhibited the most effective activity to inhibit the HeLa cell growth. [Conclusion] This study will provide a basis for better development and utilization of Selaginella plant resources.
基金Program for Changjiang Scholar and Innovative Team in University(Grant No.985-2-063-112)Program for New Century Excellent Talents in University(Grant No.985-2-102-113).
文摘To investigate the chemical constituents of the roots ofPolygala sibirica L. The separation and purification were performed by solvent extraction and repeated chromatography with silica gel, Sephadex LH-20, ODS columns, and semiprep. HPLC. The structures were elucidated by spectral analysis. Twelve known compounds were isolated and identified as tenuifoliside A (1), tenuifoliside B (2), glomeratose A (3), 3',6-disinapoyl sucrose (4), sibiricose A5 (5), sibiricose A6 (6), sibiricose A1 (7), sibiricose A2 (8), polygalatenoside E (9), 1-O-L-arabinopyranosyl-O-(6→1)-β-D-glucopyranosyl-salicylate (10), canthoside A (11), and methyl- 3,4,5-trimethoxycinnamate (12). Compound 11 was obtained from genus Polygala for the first time, and compounds 2, 9, 10 and 12 were isolated from this plant for the first time.
文摘Three compounds were obtained from the mycelia of an endophytic fungus Gliocladium sp. (designated as strain F) of Taxus chinensis (Pilg.) Rehd. growing in Fujian Province, China. Their structures were determined on the basis of spectral analysis. (20S,22S)-4a-homo-22-hydroxy-4-oxaergosta-7,24(28)-dien-3-one was a novel compound. 4,8,12,16-tetramethyl-1,5,9,13-tetraoxacyclohexadecane-2,6,10,14-tetraone was firstly isolated from the genus ofGliocladium and 6,9-epoxyergosta-7,22-dien-3-ol was firstly obtained from the strain F.
基金Program for Changjiang Scholars and Innova-tive Team in University (985-2-063-112).
文摘Aim To study the chemical constituents from Coriolus versicolor L.. Methods Chromatographic techniques were employed for separation and purification. The structures were identified on the basis of spectroscopic analysis. Results Eight compounds were isolated and identified as ergosta-7, 22-dien-313 -yl palmitate (1), ergosta-7, 22-dien-313 -ol (2), betulic acid (3), 4-hydroxy benzoic acid (4), 3- methoxy-4-hydroxy benzoic acid (5), 3, 5-dimethoxyl-4-hydroxy benzoic acid (6), 2-furoic acid (7), and nicotinic acid (8). Conclusion Eight compounds were reported for the first time from Coriolus versicolor L..
文摘Aim To investigate the chemical constituents of Salvia cavaleriei Levi. var. erythrophylla (Hemsl.) Stib. Methods Compounds were isolated by silica gel column chromatography and Sephadex LH-20 gel column chromatography, and the structures were identified by spectral analysis. Result Five compounds were identified as 3β, 6β, 23-trihydroxyolean-12-en-28-oic acid (1), ursolic acid (2), n-heptadecanoic acid (3), n-octadecanoic acid (4), and β-sitosterol (5). Conclusion Five compounds were isolated from the plant for the first time.
文摘Aim To investigate the active constituents responsible for thepharmacological activities of Angelica sinensis (Oliv) Diels. Methods Chromatography was used toisolate chemical components, and spectroscopy was used to identify their structures. Results Sevencompounds were isolated and their structures were identified as ferulic acid (1), conife-rylferukte(2) , bis (2-ethylhexyl) phthalate (3), dibutyl phthalate (4), lignoceric acid (5), palmitic acid(6), and Z-6, 7-cis-dihydroxyligustilide (7) Conclusion Bis (2-ethylhexyl) phthalate and dibutylphthalate were obtained from Angelica sinensis for the first time.
文摘Aim To investigate the chemical constituents of Ixeris sonchifolia Hance. Methods The chemical constituents were isolated by various column chromatographic methods and the structures were elucidated and characterized by spectral evidences. Result Thirteen compounds were obtained and identified as 3β-acetoxy-20-taraxasten-22-one (1), bauerenyl acetate (2), 3β-acetoxy- 11-oxours-12-ene (3), oleanic acid (4), oleanane (5), 8-desoxyartelin (6), aesculetin (7), ferulic acid (8), vanillic acid (9), sonchifolinin (10), hexacosanol (11), β-sitosterol (12), and daucosterol (13). Conclusion Compounds 1, 5, and 8 were isolated from this genus for the first time; compound 7 was obtained firstly from this plant.