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1-苯基吲哚的合成
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作者 冯筱晴 唐龙 +2 位作者 王瑞瑞 王羚竹 宋国强 《化工进展》 EI CAS CSCD 北大核心 2013年第10期2486-2490,共5页
以二苯胺和乙二酰氯为起始原料经偶联、酰化、还原反应得到1-苯基吲哚,并探索了其影响因素。结果表明合成中间体N,N-二苯基-2-氯-2-氧代乙酰胺的较佳条件为:n(二苯胺):n(乙二酰氯)=1∶3,反应温度20~25℃,反应2.5 h,收率98.02%,HPLC纯度... 以二苯胺和乙二酰氯为起始原料经偶联、酰化、还原反应得到1-苯基吲哚,并探索了其影响因素。结果表明合成中间体N,N-二苯基-2-氯-2-氧代乙酰胺的较佳条件为:n(二苯胺):n(乙二酰氯)=1∶3,反应温度20~25℃,反应2.5 h,收率98.02%,HPLC纯度97.68%;产品1-苯基靛红的较优合成工艺条件为:n(N,N-二苯基-2-氯-2-氧代乙酰胺):n(无水AlCl3)=1∶3,反应温度10℃,反应时间2 h,收率86.76%,HPLC纯度98.45%;目标产物1-苯基吲哚的最佳工艺条件为:n(1-苯基靛红):n(硼氢化钠)=1∶3,n(1-苯基靛红):n(氯化锌)=1∶0.05,反应温度110℃,反应时间12 h,收率72.41%,HPLC纯度98.14%。产品及中间体结构经1H NMR、MS和显微熔点仪分析表征确认。 展开更多
关键词 二苯胺 N N-二苯基-2-氯-2-氧代乙酰胺 1-苯基靛红 1-苯基吲哚 合成
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苯妥英钠的合成 被引量:10
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作者 李公春 吴长增 +3 位作者 郭俊伟 孙婷 牛亮峰 鞠志宇 《浙江化工》 CAS 2015年第8期23-25,共3页
由苯甲醛在维生素B1作催化剂及碱性条件下进行安息香缩合得到安息香,然后在酸性条件下用三氯化铁氧化安息香制取二苯乙二酮,二苯乙二酮与尿素在碱性条件下反应得到苯妥英,再由苯妥英与氢氧化钠反应成盐得到苯妥英钠。
关键词 苯妥英钠 二苯乙二酮 安息香 苯甲醛 合成
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Antioxidant and Phenolic Content of Nuts, Oil Seeds, Milk and Milk Products Commonly Consumed in India 被引量:2
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作者 Dande Sreeramulu Manchala Raghunath 《Food and Nutrition Sciences》 2011年第5期422-427,共6页
Food provides not only essential nutrients required for life, but also bioactive compounds usefull to maintan good health and disease prevention. Abundant epidemiological evidences suggest that consumption of food ric... Food provides not only essential nutrients required for life, but also bioactive compounds usefull to maintan good health and disease prevention. Abundant epidemiological evidences suggest that consumption of food rich in antioxi-dants (non-nutritional components) can prevent degenerative diseases. A total of 26 commonly consumed nuts, oil seeds, edible oils, milk and milk products were chosen for the study. Considering the fact that antioxidant content (AOC) and phenolic contents (PC) of these foods was not established systematically in Indian context. Therefore, we have assessed and correlated the AOC and PC, an important antioxidant constituents of plant foods. AOC was assessed by DPPH (2, 2-Diphenyl-1-picryl hydrazyl) scavenging activity and FRAP (Ferric reducing antioxidant power) methods and phenolic content (PC), using Folin-Ciocalteu reagent. Among the nuts and oil seeds arecanut had the highest phenolic and antioxidant content 10841, 4220341 mg/100g respectively. In milk, edible oils and sugars the values ranged from 336 -11674 mg/100g. Jaggery had the highest PC and AOC among the foods studied . Although AOC and PC showed wide variation among the foods, AOC was correlated significantly with PC. Indeed the ‘r’ value between PC and AOC (DPPH and FRAP) was 0.99 (p < 0.01) among the nuts and oil seeds, while in milk, milk products and sugars, the “r” values ranged from 0.93 and 0.99 (p < 0.01) respectively. The overall results indicate that the phenolic compounds may be significant contributors to the AOC of the foods studied. 展开更多
关键词 ANTIOXIDANT CONTENT (AOC) 2 2-diphenyl -1-picryl hydrazyl (DPPH) Ferric Reducing ANTIOXIDANT Power (FRAP) Polyphenols PHENOLIC CONTENT (PC) 4 6-tripyridyl-s-triazine (TPTZ).
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