We report here a solid-phase synthesis of 1, 4-disubstituted 1, 2, 3-triazole using polystyrene-supported selenium resin. The resin used here not only works as a simple linker, but also assists the crucial α-alkylati...We report here a solid-phase synthesis of 1, 4-disubstituted 1, 2, 3-triazole using polystyrene-supported selenium resin. The resin used here not only works as a simple linker, but also assists the crucial α-alkylation reaction and selenoxide syn-elimimation, which ensures the purity of the products.展开更多
The 1,3-dipolar cycloaddition reactions of nitrilimine with thiazolo[3,2-a]pyrimidine derivatives was investigated. Bis-cycloadducts were obtained through a domino 1,3-dipolar cycloaddition/ring-opening/ring-opening/ ...The 1,3-dipolar cycloaddition reactions of nitrilimine with thiazolo[3,2-a]pyrimidine derivatives was investigated. Bis-cycloadducts were obtained through a domino 1,3-dipolar cycloaddition/ring-opening/ring-opening/ 1,3-dipolar cycloaddition processes. The structures of the products were characterized thoroughly by NMR, IR, MS, elemental analysis together with X-ray crystallographic analysis.展开更多
A convenient and efficient procedure for the synthesis ofN, N-bicyclic pyrazolidinone derivatives has been developed via the reaction of azomethine imines with terminal alkynes under the ball milling condition without...A convenient and efficient procedure for the synthesis ofN, N-bicyclic pyrazolidinone derivatives has been developed via the reaction of azomethine imines with terminal alkynes under the ball milling condition without sol- vent, which was promoted by calcium fluoride with a catalyst of copper（I） salt. The cyclization reactions exhibited moderate to high yields.展开更多
A practical and efficient liquid-phase synthesis of 1,2,3-triazoles using poly（ethylene glycol） as support in aqueous solution was described. The title compounds, 1,2,3-triazoles 5 were obtained by a one-pot three-c...A practical and efficient liquid-phase synthesis of 1,2,3-triazoles using poly（ethylene glycol） as support in aqueous solution was described. The title compounds, 1,2,3-triazoles 5 were obtained by a one-pot three-component 1,3-dipolar cycloaddition reaction in middle yields. In addition, a series of unexpected products 7 of Sonogashira reaction were also formed under the same condition.展开更多
基金the National Natural Science Foundation of China(No.20332060)the Natural Science Foundation of Zhejiang Province(No.Y405407).
文摘We report here a solid-phase synthesis of 1, 4-disubstituted 1, 2, 3-triazole using polystyrene-supported selenium resin. The resin used here not only works as a simple linker, but also assists the crucial α-alkylation reaction and selenoxide syn-elimimation, which ensures the purity of the products.
基金Project supported by the National Natural Science Foundation of China （Nos. 20971041, 20803020, 20772027）, Chinese Ministry of Education （No. 210146） and Scientific Research Fund of Hunan Provincial Education Department （Nos. 09B032, 09C385, 09K081）.
文摘The 1,3-dipolar cycloaddition reactions of nitrilimine with thiazolo[3,2-a]pyrimidine derivatives was investigated. Bis-cycloadducts were obtained through a domino 1,3-dipolar cycloaddition/ring-opening/ring-opening/ 1,3-dipolar cycloaddition processes. The structures of the products were characterized thoroughly by NMR, IR, MS, elemental analysis together with X-ray crystallographic analysis.
基金Supported by the National Natural Science Foundation of China（Nos.21261008, 21471069）, the Special Integration Fund of Industry and Research of Hainan Province, China（No.CXY20130010）, the Natural Science Foundation of Hainan Province, China（No.213014） and the International Science and Technology Cooperation Projects of Hainan Province, China（No. KJI-IZ2014-05）.
文摘A convenient and efficient procedure for the synthesis ofN, N-bicyclic pyrazolidinone derivatives has been developed via the reaction of azomethine imines with terminal alkynes under the ball milling condition without sol- vent, which was promoted by calcium fluoride with a catalyst of copper（I） salt. The cyclization reactions exhibited moderate to high yields.
文摘A practical and efficient liquid-phase synthesis of 1,2,3-triazoles using poly（ethylene glycol） as support in aqueous solution was described. The title compounds, 1,2,3-triazoles 5 were obtained by a one-pot three-component 1,3-dipolar cycloaddition reaction in middle yields. In addition, a series of unexpected products 7 of Sonogashira reaction were also formed under the same condition.
