Ternary complex [Cu(L-Ile)(TATP)(H2O)](ClO4)] was synthesized and characterized by molar conductivity, rotational analysis, spectroscopic (IR and UV-Vis) and X-ray diffraction methods, where L-Ile=L-Isoleucine, and TA...Ternary complex [Cu(L-Ile)(TATP)(H2O)](ClO4)] was synthesized and characterized by molar conductivity, rotational analysis, spectroscopic (IR and UV-Vis) and X-ray diffraction methods, where L-Ile=L-Isoleucine, and TATP=1,4,8,9-tetraazatriphenylene. The complex crystallizes in triclinic space group P1 with two molecules in a unit cell of dimensions a=8.240 3(9) nm, b=11.914 9(13) nm, c=13.436 0(15) nm, α=109.136(2)°, β=101.101(2)°, γ=106.302(2)°. V=1.209 2(5) nm3, Z=2, Dc=1.589 Mg·m-3, μ=1.132 mm-1,R1=0.036 9, wR2=0.098 0. The crystal contains two independent was synthesized and characterized by molar conductivity, rotational analysis, spectroscopic (IR and UV-Vis) and X-ray diffraction methods, where L-Ile=L-Isoleucine, and TATP=1,4,8,9-tetraazatriphenylene. The complex crystallizes in triclinic space group P1 with two molecules in a unit cell of dimensions a=8.240 3(9) nm, b=11.914 9(13) nm, c=13.436 0(15) nm, α=109.136(2)°, β=101.101(2)°, γ=106.302(2)°. V=1.209 2(5) nm3, Z=2, Dc=1.589 Mg·m-3, μ=1.132 mm-1,R1=0.036 9, wR2=0.098 0. The crystal contains two independent [Cu(L-Ile)(TATP)(H2O)]+ complexes for Cu1 and Cu2, respectively, having essentially the same distorted square-pyramidal structure, where each Cu ion is coordinated with two nitrogen atoms of TATP and the amino nitrogen atom and one carboxylate oxygen atom of L-Ile in the equatorial positions and one water oxygen atom at an axial position. Furthermore, the primary studies on the interaction between the complex and calf thymus DNA were also performed by electronic absorption spectroscopy and viscosity methods. CCDC: 244231.展开更多
A dinuclear copper（Ⅱ） complex[Cu2（TATP）2（L-Leu）2（CIO4）2]2·2H2Owas synthesized and characterized, where, TATP=1,4,8,9-tetraazatriphenylene, and L-Leu=L-leucinate. The complex was crystallized in the tricl...A dinuclear copper（Ⅱ） complex[Cu2（TATP）2（L-Leu）2（CIO4）2]2·2H2Owas synthesized and characterized, where, TATP=1,4,8,9-tetraazatriphenylene, and L-Leu=L-leucinate. The complex was crystallized in the triclinic space group P1, with two independent molecules in a unit cell. Two Cu（Ⅱ） ions in each complex [Cu2（TATP）2（L-Leu）2（CIO4）2] molecule were found to be in different coordination geometries, i.e., Cu2 or Cu4 of a distorted square-pyramidal geometry coordinated with two nitrogens of TATP, the amino nitrogen and one carboxylate oxygen of L-Leu and one oxygen of perchlorate, and Cul or Cu3 with an octahedral geometry coordinated with the above stated similar coordinated atoms, and another carboxylate oxygen of L-Leu coordinating to Cu2 or Cu4. The complex can interact with CT-DNA by an intercalative mode and cleave pBR322 DNA in the presence of ascorbate.展开更多
Two novel complexes [Cu（TATP）（L-Leu）（H2O）]NO3·H2O and [Cu（TATP）L-Met)（H2O）]NO3·0.5H2O（TATP=1,4,8,9-tetraazatriphenylene,L-Leu=L-Leucinate,L-Met=L-Methioninate）were synthesized and characterized b...Two novel complexes [Cu（TATP）（L-Leu）（H2O）]NO3·H2O and [Cu（TATP）L-Met)（H2O）]NO3·0.5H2O（TATP=1,4,8,9-tetraazatriphenylene,L-Leu=L-Leucinate,L-Met=L-Methioninate）were synthesized and characterized by elemental analysis,molar conductivity,infrared absorption spectrum,electronic absorption spectrum and DTA-TGA.The results showed that both of the complexes had a distorted square-pyramidal geometry with two nitrogen atoms of TATP and one amino nitrogen and one carboxylate oxygen atoms of L-Leu/L-Met at the equatorial positions,and one water oxygen at the axial position.The SOD-Like activity of the complexes was determined by NBT-illumination method.The result indicated that the complexes possessed excellent SOD-like activity and showed 50% inhibition ration in the concentration of 0.355 μmol·L-1 and 0.185 μmol·L-1,respectively.The greater SOD-like activity of the complex[Cu（TATP）（L-Leu）（H2O）]NO3·H2O may be attributed to the smaller spatial hindrance of the side-chain group of L-Met.展开更多
文摘Ternary complex [Cu(L-Ile)(TATP)(H2O)](ClO4)] was synthesized and characterized by molar conductivity, rotational analysis, spectroscopic (IR and UV-Vis) and X-ray diffraction methods, where L-Ile=L-Isoleucine, and TATP=1,4,8,9-tetraazatriphenylene. The complex crystallizes in triclinic space group P1 with two molecules in a unit cell of dimensions a=8.240 3(9) nm, b=11.914 9(13) nm, c=13.436 0(15) nm, α=109.136(2)°, β=101.101(2)°, γ=106.302(2)°. V=1.209 2(5) nm3, Z=2, Dc=1.589 Mg·m-3, μ=1.132 mm-1,R1=0.036 9, wR2=0.098 0. The crystal contains two independent was synthesized and characterized by molar conductivity, rotational analysis, spectroscopic (IR and UV-Vis) and X-ray diffraction methods, where L-Ile=L-Isoleucine, and TATP=1,4,8,9-tetraazatriphenylene. The complex crystallizes in triclinic space group P1 with two molecules in a unit cell of dimensions a=8.240 3(9) nm, b=11.914 9(13) nm, c=13.436 0(15) nm, α=109.136(2)°, β=101.101(2)°, γ=106.302(2)°. V=1.209 2(5) nm3, Z=2, Dc=1.589 Mg·m-3, μ=1.132 mm-1,R1=0.036 9, wR2=0.098 0. The crystal contains two independent [Cu(L-Ile)(TATP)(H2O)]+ complexes for Cu1 and Cu2, respectively, having essentially the same distorted square-pyramidal structure, where each Cu ion is coordinated with two nitrogen atoms of TATP and the amino nitrogen atom and one carboxylate oxygen atom of L-Ile in the equatorial positions and one water oxygen atom at an axial position. Furthermore, the primary studies on the interaction between the complex and calf thymus DNA were also performed by electronic absorption spectroscopy and viscosity methods. CCDC: 244231.
基金the Natural Science Foundation of Guangdong Province,China(No. 04105986)
文摘A dinuclear copper（Ⅱ） complex[Cu2（TATP）2（L-Leu）2（CIO4）2]2·2H2Owas synthesized and characterized, where, TATP=1,4,8,9-tetraazatriphenylene, and L-Leu=L-leucinate. The complex was crystallized in the triclinic space group P1, with two independent molecules in a unit cell. Two Cu（Ⅱ） ions in each complex [Cu2（TATP）2（L-Leu）2（CIO4）2] molecule were found to be in different coordination geometries, i.e., Cu2 or Cu4 of a distorted square-pyramidal geometry coordinated with two nitrogens of TATP, the amino nitrogen and one carboxylate oxygen of L-Leu and one oxygen of perchlorate, and Cul or Cu3 with an octahedral geometry coordinated with the above stated similar coordinated atoms, and another carboxylate oxygen of L-Leu coordinating to Cu2 or Cu4. The complex can interact with CT-DNA by an intercalative mode and cleave pBR322 DNA in the presence of ascorbate.
文摘Two novel complexes [Cu（TATP）（L-Leu）（H2O）]NO3·H2O and [Cu（TATP）L-Met)（H2O）]NO3·0.5H2O（TATP=1,4,8,9-tetraazatriphenylene,L-Leu=L-Leucinate,L-Met=L-Methioninate）were synthesized and characterized by elemental analysis,molar conductivity,infrared absorption spectrum,electronic absorption spectrum and DTA-TGA.The results showed that both of the complexes had a distorted square-pyramidal geometry with two nitrogen atoms of TATP and one amino nitrogen and one carboxylate oxygen atoms of L-Leu/L-Met at the equatorial positions,and one water oxygen at the axial position.The SOD-Like activity of the complexes was determined by NBT-illumination method.The result indicated that the complexes possessed excellent SOD-like activity and showed 50% inhibition ration in the concentration of 0.355 μmol·L-1 and 0.185 μmol·L-1,respectively.The greater SOD-like activity of the complex[Cu（TATP）（L-Leu）（H2O）]NO3·H2O may be attributed to the smaller spatial hindrance of the side-chain group of L-Met.
