An efficient and green method for the synthesis of 1, 4-dihydropyridine derivatives mediated in an ionic liquid, [bmim][BF4], through a four-component condensation process of aldehydes, 1, 3-dione, Meldrum＇s acid and...An efficient and green method for the synthesis of 1, 4-dihydropyridine derivatives mediated in an ionic liquid, [bmim][BF4], through a four-component condensation process of aldehydes, 1, 3-dione, Meldrum＇s acid and ammonium acetate is disclosed in this paper.展开更多
A series of ferrocenyl 1,4 dihydropyridines were synthesized with high yields by a one pot cyclocondensation of formylferrocene,β ketoester and urea(or methyl 3 aminocrotonate) on the surface of SiO 2 under microwave...A series of ferrocenyl 1,4 dihydropyridines were synthesized with high yields by a one pot cyclocondensation of formylferrocene,β ketoester and urea(or methyl 3 aminocrotonate) on the surface of SiO 2 under microwave irradiation without solvent.All products were characterized by EA,IR, and 1 HNMR.展开更多
A visible-light-enabled,photocatalyst-free hydroacylation reaction of azodicarboxylic acid derivatives was described.This radical conjugate addition(RCA)protocol relied on the dual role of 4-acyl-1,4-dihydropyridine(a...A visible-light-enabled,photocatalyst-free hydroacylation reaction of azodicarboxylic acid derivatives was described.This radical conjugate addition(RCA)protocol relied on the dual role of 4-acyl-1,4-dihydropyridine(acyl-DHP)reagents that besides being as radical reservoirs,they also enabled the conversion of radical adducts to anion intermediates via reduction.Under“catalyst-oxidant-additive free”conditions,a wide range of structurally different acyl hydrazide products were readily obtained in 56%—99%yields.The utility of this transformation was further demonstrated by the scale-up synthesis and downstream derivatization.展开更多
A facile and efficient synthesis of new 1,4-dihydropyridine derivatives was reported via Hantzsch three-com- ponent condensation reaction of aldehydes or formylphenylboronic acids, ethyl acetoacetate, and ammonium ace...A facile and efficient synthesis of new 1,4-dihydropyridine derivatives was reported via Hantzsch three-com- ponent condensation reaction of aldehydes or formylphenylboronic acids, ethyl acetoacetate, and ammonium acetate in the presence of a catalytic amount of triethylamine under solvent-free conditions. The method described here of- fers several advantages including high yields, short reaction times, and simple work-up procedure.展开更多
Eight new macrocyclic complexes were synthesized by template reaction of 1,4-bis（3-aminopropoxy）butane with metal nitrate and 1,3-bis（2-formylphenyl）propane or 1,4-bis（2-formylphenyl）butane and their structures ...Eight new macrocyclic complexes were synthesized by template reaction of 1,4-bis（3-aminopropoxy）butane with metal nitrate and 1,3-bis（2-formylphenyl）propane or 1,4-bis（2-formylphenyl）butane and their structures were proposed on the basis of elemental analysis, FTIR, UV-vis, molar conductivity measurements, ^1H NMR and mass spectra. The metals to ligand molar ratios of the complexes were found to be 1： 1. The complexes are 1：2 electrolytes for Pb（II）, Zn（II） and Cd（II） complexes and 1：3 electrolytes for La（III） as shown by their molar conductivities （Am） in DMSO at 10^-3 mol L^-1. Due to the existence of free ions in these complexes, such complexes are electrically conductive. The configurations of La（III） and Pb（II） were proposed to probably octahedral and Zn（II） and Cd（II） complexes were proposed to probably tetrahedral.展开更多
Starting from 1H-pyrrole, unreported 3, 4-dihydropyrrolo[2, 1-c][l, 4]oxazin-1-one 4, 7-(4-chlorobenzoyl)-3, 4-dihydropyrrolo[2, 1-c][1, 4]oxazin-1-one 5 and 7-benzoyl-3, 4-dihydro-pyrrolo [2, 1-c][1, 4]oxazin-1-one 9...Starting from 1H-pyrrole, unreported 3, 4-dihydropyrrolo[2, 1-c][l, 4]oxazin-1-one 4, 7-(4-chlorobenzoyl)-3, 4-dihydropyrrolo[2, 1-c][1, 4]oxazin-1-one 5 and 7-benzoyl-3, 4-dihydro-pyrrolo [2, 1-c][1, 4]oxazin-1-one 9 were designed and synthesized. They may have antipyretic and analgesic activities.展开更多
A simple method for the oxidative aromatization of Hantzsch 1,4-dihydropyridines to the corresponding pyridines is achieved by using hydrogen peroxide as green oxidant and acetic acid as catalyst in aqueous solution.
The reagent combination of Hantzsch 1,4-dihydropyridine and Pd/C was found to be an efficient reducing system for the selective reduction of aromatic azides.
An improved procedure for the preparation of China, BAD(P)H model. (S_s)- 1 -benzyl-3- (p-tolylsulfinyl)-1.4-dihydropyridine with satisfactary chemical yield and excellent enantiopurity is reported.
A new series of quinoxalinophenazine derivatives were synthesized in good yields by the reaction of 2,3-dibromonaphthalene-1,4-dione with different aryl-1,2-diamines in DMF as solvent at 120-130℃ or under reflux cond...A new series of quinoxalinophenazine derivatives were synthesized in good yields by the reaction of 2,3-dibromonaphthalene-1,4-dione with different aryl-1,2-diamines in DMF as solvent at 120-130℃ or under reflux conditions. 3,12-dimethylbenzo[a]quinoxalino[2,3-c] phenazine with bidentate character reacts with mercury（II） bromide to give suitable crystals. All products were confirmed by IR, ^1H and ^13C NMR, and the metal complex by single-crystal X-ray method. The crystal（C24H16Br2HgN4, Mr = 720.82） belongs to the triclinic system, space group P1 with a = 10.186（6）, b = 10.421（6）, c = 11.470（7） A, α = 98.670（7）, β = 95.069（7）, γ = 109.831（7）°, V = 1119.4（12） A3, Z = 2, Dc = 2.139 Mg/m^3, μ = 10.46 mm^-1, F（000） = 676, R = 0.043 and wR = 0.115 for 3982 observed reflections with I 〉 2σ（I）.展开更多
The paper reports the synthetic procedure and character of Copper(II) binuclearcoordination compound of 1,4-bis-(1'-phenyl-3'-methyl-5'-pyrazolone Thenon-isothermal kinetics of thermal decomposition of the...The paper reports the synthetic procedure and character of Copper(II) binuclearcoordination compound of 1,4-bis-(1'-phenyl-3'-methyl-5'-pyrazolone Thenon-isothermal kinetics of thermal decomposition of the complex has been stUdied from the TG-DTGcurves by means of the Achar et al. and Coats-Redfern methods,the most probab1e kinetic equation canbe expressed as dofdtrAe -E / RT * l /(2Q).The corresponding kinetic compensation effect expressions arefound to be lnuA=0. 1794E+0. 1689.The non-isothermal thermal decomposition process of the complex isone-dimensional diffusion.But electrochemical studies of the complex(Cu2L'2)from cyclic voltamrnetriccurves by means of powder microelectrodes technique'',shows one two-electron irreversible process.展开更多
A series of 1,4-dihydropyridine derivatives were synthesized by the reaction of aromatic aldehydes,ethyl acetoacetate and ammonium bicarbonate under hydrothermal condition.Compared to the known report,this method has ...A series of 1,4-dihydropyridine derivatives were synthesized by the reaction of aromatic aldehydes,ethyl acetoacetate and ammonium bicarbonate under hydrothermal condition.Compared to the known report,this method has the advantages of excellent yields,convenience,less pollution and friendly environment.Compound b was deterimined by X-ray single-crystal diffraction.The crystal is of monoclinic,space group C2/c with a = 19.7348(12),b=7.4285(4),c = 27.2561(16),β=106.9950(10)°,V=0.38212(4)nm3,Z=8,Dc =1.236 Mg/m3,μ=0.085 mm-1,F(000)=1520,S=1.053,R=0.0574,wR=0.1732.展开更多
文摘An efficient and green method for the synthesis of 1, 4-dihydropyridine derivatives mediated in an ionic liquid, [bmim][BF4], through a four-component condensation process of aldehydes, 1, 3-dione, Meldrum＇s acid and ammonium acetate is disclosed in this paper.
文摘A series of ferrocenyl 1,4 dihydropyridines were synthesized with high yields by a one pot cyclocondensation of formylferrocene,β ketoester and urea(or methyl 3 aminocrotonate) on the surface of SiO 2 under microwave irradiation without solvent.All products were characterized by EA,IR, and 1 HNMR.
基金support from the National Natural Science Foundation of China(21702013 and 22271010)the Fundamental Research Funds for the Central Universities(XK1802-6)at the BUCT.
文摘A visible-light-enabled,photocatalyst-free hydroacylation reaction of azodicarboxylic acid derivatives was described.This radical conjugate addition(RCA)protocol relied on the dual role of 4-acyl-1,4-dihydropyridine(acyl-DHP)reagents that besides being as radical reservoirs,they also enabled the conversion of radical adducts to anion intermediates via reduction.Under“catalyst-oxidant-additive free”conditions,a wide range of structurally different acyl hydrazide products were readily obtained in 56%—99%yields.The utility of this transformation was further demonstrated by the scale-up synthesis and downstream derivatization.
文摘A facile and efficient synthesis of new 1,4-dihydropyridine derivatives was reported via Hantzsch three-com- ponent condensation reaction of aldehydes or formylphenylboronic acids, ethyl acetoacetate, and ammonium acetate in the presence of a catalytic amount of triethylamine under solvent-free conditions. The method described here of- fers several advantages including high yields, short reaction times, and simple work-up procedure.
文摘Eight new macrocyclic complexes were synthesized by template reaction of 1,4-bis（3-aminopropoxy）butane with metal nitrate and 1,3-bis（2-formylphenyl）propane or 1,4-bis（2-formylphenyl）butane and their structures were proposed on the basis of elemental analysis, FTIR, UV-vis, molar conductivity measurements, ^1H NMR and mass spectra. The metals to ligand molar ratios of the complexes were found to be 1： 1. The complexes are 1：2 electrolytes for Pb（II）, Zn（II） and Cd（II） complexes and 1：3 electrolytes for La（III） as shown by their molar conductivities （Am） in DMSO at 10^-3 mol L^-1. Due to the existence of free ions in these complexes, such complexes are electrically conductive. The configurations of La（III） and Pb（II） were proposed to probably octahedral and Zn（II） and Cd（II） complexes were proposed to probably tetrahedral.
文摘Starting from 1H-pyrrole, unreported 3, 4-dihydropyrrolo[2, 1-c][l, 4]oxazin-1-one 4, 7-(4-chlorobenzoyl)-3, 4-dihydropyrrolo[2, 1-c][1, 4]oxazin-1-one 5 and 7-benzoyl-3, 4-dihydro-pyrrolo [2, 1-c][1, 4]oxazin-1-one 9 were designed and synthesized. They may have antipyretic and analgesic activities.
文摘A simple method for the oxidative aromatization of Hantzsch 1,4-dihydropyridines to the corresponding pyridines is achieved by using hydrogen peroxide as green oxidant and acetic acid as catalyst in aqueous solution.
基金the National Natural Science Foundation of China(No.20772053)Natural Science Foundation of Gansu Province(No.3ZS061-A25-004)for financial support.
文摘The reagent combination of Hantzsch 1,4-dihydropyridine and Pd/C was found to be an efficient reducing system for the selective reduction of aromatic azides.
基金the National Natural Science Foundation of China ! 29672031 Fang Min FU of Chengdu institute of or
文摘An improved procedure for the preparation of China, BAD(P)H model. (S_s)- 1 -benzyl-3- (p-tolylsulfinyl)-1.4-dihydropyridine with satisfactary chemical yield and excellent enantiopurity is reported.
基金贵州省科技基础研究计划项目(ZK[2021]049)资助贵州省普通高等学校青年科技人才成长项目(KY[2022]145)资助+4 种基金贵州大学引进人才科研项目(贵大人基合字[2020]6号)资助贵州大学培育项目(贵大培育[2019]48号)资助国家自然科学基金项目(22007022)资助贵州省自然科学基金项目(ZZK[2021]034)资助贵州省教育厅青年科技人才成长项目(Qjh KY Zi[2021]041)资助。
文摘A new series of quinoxalinophenazine derivatives were synthesized in good yields by the reaction of 2,3-dibromonaphthalene-1,4-dione with different aryl-1,2-diamines in DMF as solvent at 120-130℃ or under reflux conditions. 3,12-dimethylbenzo[a]quinoxalino[2,3-c] phenazine with bidentate character reacts with mercury（II） bromide to give suitable crystals. All products were confirmed by IR, ^1H and ^13C NMR, and the metal complex by single-crystal X-ray method. The crystal（C24H16Br2HgN4, Mr = 720.82） belongs to the triclinic system, space group P1 with a = 10.186（6）, b = 10.421（6）, c = 11.470（7） A, α = 98.670（7）, β = 95.069（7）, γ = 109.831（7）°, V = 1119.4（12） A3, Z = 2, Dc = 2.139 Mg/m^3, μ = 10.46 mm^-1, F（000） = 676, R = 0.043 and wR = 0.115 for 3982 observed reflections with I 〉 2σ（I）.
文摘The paper reports the synthetic procedure and character of Copper(II) binuclearcoordination compound of 1,4-bis-(1'-phenyl-3'-methyl-5'-pyrazolone Thenon-isothermal kinetics of thermal decomposition of the complex has been stUdied from the TG-DTGcurves by means of the Achar et al. and Coats-Redfern methods,the most probab1e kinetic equation canbe expressed as dofdtrAe -E / RT * l /(2Q).The corresponding kinetic compensation effect expressions arefound to be lnuA=0. 1794E+0. 1689.The non-isothermal thermal decomposition process of the complex isone-dimensional diffusion.But electrochemical studies of the complex(Cu2L'2)from cyclic voltamrnetriccurves by means of powder microelectrodes technique'',shows one two-electron irreversible process.
文摘A series of 1,4-dihydropyridine derivatives were synthesized by the reaction of aromatic aldehydes,ethyl acetoacetate and ammonium bicarbonate under hydrothermal condition.Compared to the known report,this method has the advantages of excellent yields,convenience,less pollution and friendly environment.Compound b was deterimined by X-ray single-crystal diffraction.The crystal is of monoclinic,space group C2/c with a = 19.7348(12),b=7.4285(4),c = 27.2561(16),β=106.9950(10)°,V=0.38212(4)nm3,Z=8,Dc =1.236 Mg/m3,μ=0.085 mm-1,F(000)=1520,S=1.053,R=0.0574,wR=0.1732.
