BACKGROUND The pathophysiology of diabetic kidney disease(DKD)is complex.Interfering with the processes of pyroptosis and fibrosis is an effective strategy for slowing DKD progression.Previous studies have revealed th...BACKGROUND The pathophysiology of diabetic kidney disease(DKD)is complex.Interfering with the processes of pyroptosis and fibrosis is an effective strategy for slowing DKD progression.Previous studies have revealed that nuclear receptor subfamily 4 group A member 1(NR4A1)may serve as a novel pathogenic element in DKD;however,the specific mechanism by which it contributes to pyroptosis and fibrosis in DKD is unknown.AIM To investigate the role of NR4A1 in renal pyroptosis and fibrosis in DKD and possible molecular mechanisms.METHODS Streptozotocin 60 mg/kg was injected intraperitoneally to establish a rat model of DKD.Typically,45 mmol/L glucose[high glucose(HG)]was used to activate HK-2 cells to mimic the DKD model in vitro.HK-2 cells were transfected with NR4A1 siRNA to silence NR4A1.RESULTS NR4A1 was elevated in renal tissues of DKD rats and HG-stimulated HK-2 cells.Concurrently,NOD-like receptor protein 3(NLRP3)and phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)pathways were triggered,and pyroptosis and expression of fibrosis-linked elements was increased in vivo and in vitro.These alterations were significantly reversed via NR4A1 silencing.CONCLUSION Inhibition of NR4A1 mitigated pyroptosis and fibrosis via suppressing NLRP3 activation and the PI3K/AKT pathway in HG-activated HK-2 cells.展开更多
Gravity-1(YL-1) launch vehicle completed its maiden flight from the Yellow Sea near Haiyang City, Shandong Province, on January 11, 2024, this mission successfully launched three Yunyao satellites into their 500 km or...Gravity-1(YL-1) launch vehicle completed its maiden flight from the Yellow Sea near Haiyang City, Shandong Province, on January 11, 2024, this mission successfully launched three Yunyao satellites into their 500 km orbit. The YL-1 has a performance of 4.2 tons for 500 km sun-synchronous orbit and 6.5 tons for low Earth orbit. The success of YL-1 has further enriched China's launch vehicle spectrum, and will facilitate the launch of medium and large satellites and satellite constellations. In this paper, the flight ballistic solution of YL-1 is introduced. The flight trajectory consists of seven flight segments. The trajectory design comprehensively considered the characteristics and safety requirements of the vehicle to achieve effective utilization of the performance. Through comparative analysis of the flight trajectory and the predicted trajectory, the result confirmed that the flight trajectory was consistent with the design results, the design methodology was correct, and the flight test met the expected requirements. Subsequently, the vehicle will be employed for commercial application launch services.展开更多
On January 11, 2024, the Gravity-1 launch vehicle successfully carried out its maiden flight from a mobile sea platform off the coast of Haiyang in Shandong Province, sending three meteorological satellites, Yunyao-1 ...On January 11, 2024, the Gravity-1 launch vehicle successfully carried out its maiden flight from a mobile sea platform off the coast of Haiyang in Shandong Province, sending three meteorological satellites, Yunyao-1 satellite No. 18-20, into an orbit about 500 km above the ground. The successful debut flight of Gravity-1 broke many records such as the world's largest solid launch vehicle, the first sea-launched strap-on launch vehicle in the world, with the maximum carrying capacity of current commercial launch vehicle in China. This flight marked a big step in the field of China's commercial space launch application. A new breakthrough has been made, which is of great significance for further expanding China's diversified and large-scale launch capabilities of medium and low orbit satellites, expanding the spectrum of China's launch vehicle types, and promoting the development of space science.展开更多
文摘目的探讨血清CXC趋化因子受体4(CXC chemokine receptor 4,CXCR4)、趋化因子3(C-C Motif Chemokine3,CCL3)、趋化素样因子-1(chemokine like factor-1,CKLF-1)水平与支气管哮喘患儿肺功能的相关性。方法选取我院2021年6月至2023年6月收治的103例支气管哮喘患儿为观察组,同期103例健康体检儿童为对照组。比较两组入院时血清CXCR4、CCL3、CKLF-1水平及肺功能指标[第1秒用力呼气容积(forced expiratory volume in one second,FEV1)、呼气峰值流速占比预计值百分比(peak expiratory flow,PEF)、第1秒用力呼气容积/用力肺活量(forced expiratory volume in one second/forced vital capacity,FEV1/FVC)、用力肺活量(forced vital capacity,FVC)],采用Pearson分析相关性,采用绘制受试者工作特征(ROC)分析联合诊断价值。结果观察组血清CXCR4、CCL3、CKLF-1水平高于对照组(t_(1)=44.430;t_(2)=22.036;t_(3)=26.314,P<0.05);观察组PEF、FEV_(1)、FVC、FEV_(1)/FVC水平低于对照组(t_(1)=19.329;t_(2)=19.524;t_(3)=11.088;t_(4)=25.812,P<0.05);血清CXCR4、CCL3、CKLF-1水平与PEF、FEV_(1)、FVC、FEV_(1)/FVC均呈负相关(P<0.05);联合诊断最佳敏感度、特异度为92.23%、72.82%。结论血清CXCR4、CCL3、CKLF-1水平与疾病密切相关,可作为临床诊断疾病的重要依据。
基金Supported by Research Fund for Academician Lin He New Medicine,No.JYHL2022FMS02.
文摘BACKGROUND The pathophysiology of diabetic kidney disease(DKD)is complex.Interfering with the processes of pyroptosis and fibrosis is an effective strategy for slowing DKD progression.Previous studies have revealed that nuclear receptor subfamily 4 group A member 1(NR4A1)may serve as a novel pathogenic element in DKD;however,the specific mechanism by which it contributes to pyroptosis and fibrosis in DKD is unknown.AIM To investigate the role of NR4A1 in renal pyroptosis and fibrosis in DKD and possible molecular mechanisms.METHODS Streptozotocin 60 mg/kg was injected intraperitoneally to establish a rat model of DKD.Typically,45 mmol/L glucose[high glucose(HG)]was used to activate HK-2 cells to mimic the DKD model in vitro.HK-2 cells were transfected with NR4A1 siRNA to silence NR4A1.RESULTS NR4A1 was elevated in renal tissues of DKD rats and HG-stimulated HK-2 cells.Concurrently,NOD-like receptor protein 3(NLRP3)and phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)pathways were triggered,and pyroptosis and expression of fibrosis-linked elements was increased in vivo and in vitro.These alterations were significantly reversed via NR4A1 silencing.CONCLUSION Inhibition of NR4A1 mitigated pyroptosis and fibrosis via suppressing NLRP3 activation and the PI3K/AKT pathway in HG-activated HK-2 cells.
文摘Gravity-1(YL-1) launch vehicle completed its maiden flight from the Yellow Sea near Haiyang City, Shandong Province, on January 11, 2024, this mission successfully launched three Yunyao satellites into their 500 km orbit. The YL-1 has a performance of 4.2 tons for 500 km sun-synchronous orbit and 6.5 tons for low Earth orbit. The success of YL-1 has further enriched China's launch vehicle spectrum, and will facilitate the launch of medium and large satellites and satellite constellations. In this paper, the flight ballistic solution of YL-1 is introduced. The flight trajectory consists of seven flight segments. The trajectory design comprehensively considered the characteristics and safety requirements of the vehicle to achieve effective utilization of the performance. Through comparative analysis of the flight trajectory and the predicted trajectory, the result confirmed that the flight trajectory was consistent with the design results, the design methodology was correct, and the flight test met the expected requirements. Subsequently, the vehicle will be employed for commercial application launch services.
文摘On January 11, 2024, the Gravity-1 launch vehicle successfully carried out its maiden flight from a mobile sea platform off the coast of Haiyang in Shandong Province, sending three meteorological satellites, Yunyao-1 satellite No. 18-20, into an orbit about 500 km above the ground. The successful debut flight of Gravity-1 broke many records such as the world's largest solid launch vehicle, the first sea-launched strap-on launch vehicle in the world, with the maximum carrying capacity of current commercial launch vehicle in China. This flight marked a big step in the field of China's commercial space launch application. A new breakthrough has been made, which is of great significance for further expanding China's diversified and large-scale launch capabilities of medium and low orbit satellites, expanding the spectrum of China's launch vehicle types, and promoting the development of space science.
