目的探讨老年初诊2型糖尿病(T2DM)病人血清淀粉样蛋白A(SAA)、摄食抑制因子-1(Nesfatin-1)、25-羟维生素-D3[25(OH)D3)]水平变化及其与糖脂代谢、胰岛素抵抗的关系。方法选取2017年8月至2019年10月石家庄市第三医院老年初诊T2DM病人106...目的探讨老年初诊2型糖尿病(T2DM)病人血清淀粉样蛋白A(SAA)、摄食抑制因子-1(Nesfatin-1)、25-羟维生素-D3[25(OH)D3)]水平变化及其与糖脂代谢、胰岛素抵抗的关系。方法选取2017年8月至2019年10月石家庄市第三医院老年初诊T2DM病人106例为T2DM组,按1∶1比例选取同期106例健康体检者为健康对照组。对比两组血清SAA、Nesfatin-1、25(OH)D3水平、血糖指标[餐后2 h血糖(2 h PG)、空腹血糖(FBG)]、血脂指标[总胆固醇(TC)、三酰甘油(TG)]、胰岛素敏感性指数(ISI)、胰岛素抵抗指数(HOMA-IR)、餐后2 h胰岛素水平(2 h INS)水平,Pearson相关系数分析老年初诊T2DM病人血清SAA、Nesfatin-1、25(OH)D3水平与糖脂代谢、胰岛素抵抗的相关性。结果 T2DM组血清SAA(564.86±102.53)μg/L、Nesfatin-1(3.06±1.12)μg/L、2 h PG(17.49±3.67)mmol/L、FBG(9.64±2.52)mmol/L、2 h INS(40.29±4.57)mU/L、TC(5.83±1.49)mmol/L、TG(2.92±0.56)mmol/L水平高于健康对照组(496.28±94.42)μg/L、(1.04±0.47)μg/L、(9.58±2.46)mmol/L、(5.31±1.27)mmol/L、(35.63±3.47)mU/L、(4.68±1.26)mmol/L、(1.49±0.47)mmol/L,血清25(OH)D3水平(35.72±5.41)nmol/L低于健康对照组(50.69±6.42)nmol/L(P<0.05);T2DM组ISI(0.46±0.17)低于健康对照组(0.59±0.20),HOMA-IR(5.59±1.04)高于健康对照组(1.69±0.49)(P<0.05);T2DM病人血清SAA、Nesfatin-1水平与2 h PG、FBG、TC、TG、HOMA-IR水平呈正相关,与血清ISI水平呈负相关,血清25(OH)D3水平与2 h PG、FBG、TC、TG、HOMA-IR水平呈负相关,与ISI水平呈正相关(P<0.05)。结论血清SAA、Nesfatin-1在老年初诊T2DM病人中呈高表达,血清25(OH)D3呈低表达,且表达与病人糖脂代谢、胰岛素抵抗关系密切,可作为病情程度评估因子。展开更多
The crystal structure of the title compound 1-（4-fluorophenyl） -2-hexylthio-benzo [4,5]furo[3,2-d]-1,2,4-triazolo[1,5-a]pyrimidin-5（1H） -one（C23H21FN4O2S,Mr = 436.5） has been prepared and determined by single-cr...The crystal structure of the title compound 1-（4-fluorophenyl） -2-hexylthio-benzo [4,5]furo[3,2-d]-1,2,4-triazolo[1,5-a]pyrimidin-5（1H） -one（C23H21FN4O2S,Mr = 436.5） has been prepared and determined by single-crystal X-ray diffraction. The crystal is of monoclinic,space group P21/n with a = 13.9854（3） ,b = 17.2678（4） ,c = 18.1828（5）A,β = 99.364（2） °,V = 4332.58（18） A^3,Z = 4,Dc = 1.338,F（000） =1824,μ = 0.185 mm^-1,MoKa radiation（λ = 0.71073） ,R = 0.0538 and wR = 0.1162 for 4728 observed reflections with I 〉 2σ（I） . X-ray diffraction analysis reveals the fused rings of benzo[4,5]furo[3,2-d]-1,2,4-triazolo[1,5-a] pyrimidin-5（1H） -one system are nearly coplanar. The crystal packing is mainly stabilized by weak intermolecular C-H···O hydrogen bond and π-π interactions.展开更多
Coupling reaction of 4-chloro-7-H-pyrrolo[2,3-d]pyrimidine with 2,3,5-tri-O-acetyl -β-D-ribofuranosyl chloride under the basic condition was investigated. An abnormal coupling reaction, in which the heterocyclic base...Coupling reaction of 4-chloro-7-H-pyrrolo[2,3-d]pyrimidine with 2,3,5-tri-O-acetyl -β-D-ribofuranosyl chloride under the basic condition was investigated. An abnormal coupling reaction, in which the heterocyclic base attacked at the carbon of 1,2-O-methylidene moiety instead of anomeric carbon of ribose was observed and the structure of products 5a, 5b were identified by NMR and X-Ray diffraction.展开更多
The crystal structure of the title compound ethyl 3-（4-chlorophenyl）-3,4-dihydro-6- methyl-4-oxo-2-（pyrrolidin-1-yl）furo[2,3-d]pyrimidine-5-carboxylate （C20H20ClN3O4, Mr= 401.84） has been prepared and determined...The crystal structure of the title compound ethyl 3-（4-chlorophenyl）-3,4-dihydro-6- methyl-4-oxo-2-（pyrrolidin-1-yl）furo[2,3-d]pyrimidine-5-carboxylate （C20H20ClN3O4, Mr= 401.84） has been prepared and determined by single-crystal X-ray diffraction. The crystal is of monoclinic, space group P21/n with a = 20.6215（9）, b = 8.5311（4）, c = 21.6886（9） A^°, β = 91.607（1）°, V = 3814.0（3）A^°^3, Z = 8, Dc = 1.400 g/cm^3, F（000） = 1680, μ = 0.233 mm^-1, R = 0.0718 and wR = 0.1545 for 6717 observed reflections with I 〉 2σ（I）. X-ray diffraction analysis reveals two crystallographically independent molecules in the asymmetric unit.展开更多
文摘目的探讨老年初诊2型糖尿病(T2DM)病人血清淀粉样蛋白A(SAA)、摄食抑制因子-1(Nesfatin-1)、25-羟维生素-D3[25(OH)D3)]水平变化及其与糖脂代谢、胰岛素抵抗的关系。方法选取2017年8月至2019年10月石家庄市第三医院老年初诊T2DM病人106例为T2DM组,按1∶1比例选取同期106例健康体检者为健康对照组。对比两组血清SAA、Nesfatin-1、25(OH)D3水平、血糖指标[餐后2 h血糖(2 h PG)、空腹血糖(FBG)]、血脂指标[总胆固醇(TC)、三酰甘油(TG)]、胰岛素敏感性指数(ISI)、胰岛素抵抗指数(HOMA-IR)、餐后2 h胰岛素水平(2 h INS)水平,Pearson相关系数分析老年初诊T2DM病人血清SAA、Nesfatin-1、25(OH)D3水平与糖脂代谢、胰岛素抵抗的相关性。结果 T2DM组血清SAA(564.86±102.53)μg/L、Nesfatin-1(3.06±1.12)μg/L、2 h PG(17.49±3.67)mmol/L、FBG(9.64±2.52)mmol/L、2 h INS(40.29±4.57)mU/L、TC(5.83±1.49)mmol/L、TG(2.92±0.56)mmol/L水平高于健康对照组(496.28±94.42)μg/L、(1.04±0.47)μg/L、(9.58±2.46)mmol/L、(5.31±1.27)mmol/L、(35.63±3.47)mU/L、(4.68±1.26)mmol/L、(1.49±0.47)mmol/L,血清25(OH)D3水平(35.72±5.41)nmol/L低于健康对照组(50.69±6.42)nmol/L(P<0.05);T2DM组ISI(0.46±0.17)低于健康对照组(0.59±0.20),HOMA-IR(5.59±1.04)高于健康对照组(1.69±0.49)(P<0.05);T2DM病人血清SAA、Nesfatin-1水平与2 h PG、FBG、TC、TG、HOMA-IR水平呈正相关,与血清ISI水平呈负相关,血清25(OH)D3水平与2 h PG、FBG、TC、TG、HOMA-IR水平呈负相关,与ISI水平呈正相关(P<0.05)。结论血清SAA、Nesfatin-1在老年初诊T2DM病人中呈高表达,血清25(OH)D3呈低表达,且表达与病人糖脂代谢、胰岛素抵抗关系密切,可作为病情程度评估因子。
基金Supported by the Natural Science Foundation of Hubei Province (2006ABB016)Key Science Research Project of Hubei Provincial Department of Education (No.D200724001)the Science Research Project of Yunyang Medical College (No.2008CXG01)
文摘The crystal structure of the title compound 1-（4-fluorophenyl） -2-hexylthio-benzo [4,5]furo[3,2-d]-1,2,4-triazolo[1,5-a]pyrimidin-5（1H） -one（C23H21FN4O2S,Mr = 436.5） has been prepared and determined by single-crystal X-ray diffraction. The crystal is of monoclinic,space group P21/n with a = 13.9854（3） ,b = 17.2678（4） ,c = 18.1828（5）A,β = 99.364（2） °,V = 4332.58（18） A^3,Z = 4,Dc = 1.338,F（000） =1824,μ = 0.185 mm^-1,MoKa radiation（λ = 0.71073） ,R = 0.0538 and wR = 0.1162 for 4728 observed reflections with I 〉 2σ（I） . X-ray diffraction analysis reveals the fused rings of benzo[4,5]furo[3,2-d]-1,2,4-triazolo[1,5-a] pyrimidin-5（1H） -one system are nearly coplanar. The crystal packing is mainly stabilized by weak intermolecular C-H···O hydrogen bond and π-π interactions.
基金This work was supported by the National Natural Science Foundation of China.
文摘Coupling reaction of 4-chloro-7-H-pyrrolo[2,3-d]pyrimidine with 2,3,5-tri-O-acetyl -β-D-ribofuranosyl chloride under the basic condition was investigated. An abnormal coupling reaction, in which the heterocyclic base attacked at the carbon of 1,2-O-methylidene moiety instead of anomeric carbon of ribose was observed and the structure of products 5a, 5b were identified by NMR and X-Ray diffraction.
基金supported by the Natural Science Foundation of Hubei Province (2006ABB016)Key Science Research Project of Hubei Provincial Department of Education (No.D200724001) the Science Research Project of Yunyang Medical College (No. 2006QDJ16)
文摘The crystal structure of the title compound ethyl 3-（4-chlorophenyl）-3,4-dihydro-6- methyl-4-oxo-2-（pyrrolidin-1-yl）furo[2,3-d]pyrimidine-5-carboxylate （C20H20ClN3O4, Mr= 401.84） has been prepared and determined by single-crystal X-ray diffraction. The crystal is of monoclinic, space group P21/n with a = 20.6215（9）, b = 8.5311（4）, c = 21.6886（9） A^°, β = 91.607（1）°, V = 3814.0（3）A^°^3, Z = 8, Dc = 1.400 g/cm^3, F（000） = 1680, μ = 0.233 mm^-1, R = 0.0718 and wR = 0.1545 for 6717 observed reflections with I 〉 2σ（I）. X-ray diffraction analysis reveals two crystallographically independent molecules in the asymmetric unit.
