Since the Dongfeng-2 missile, full-vehicle modal testing has been established as an indispensable part of the development and testing of rocket and missile models. However, as rockets have been developed larger, the c...Since the Dongfeng-2 missile, full-vehicle modal testing has been established as an indispensable part of the development and testing of rocket and missile models. However, as rockets have been developed larger, the cost and duration of such tests have significantly increased, magnifying their impact on model development. This article follows the process of the modal testing practice of the Gravity-1 rocket, reviewing and summarizing the design process of the rocket's dynamic characteristics. Initially, the article introduces common modeling techniques for launch rockets, including the mass-beam model and the hybrid element model. It then discusses the relationship between the structural dynamics model of the launch rocket and modal testing, aiming to reduce testing costs through refined structural dynamics modeling methods. Subsequently, the article describes the dynamic characteristics design process of the Gravity-1 carrier rocket, categorizes structural parameters, and studies how the selection of structural parameters affects the predicted dynamic characteristics of the rocket. Finally, it elaborates on the design of the modal testing scheme and the dynamic characteristics design based on the test data.展开更多
目的探讨(1-3)-β-D葡聚糖联合降钙素原(procalcitonin,PCT)、CD4^(+)T淋巴细胞多指标在艾滋病患者马尔尼菲篮状菌感染早期诊断临床研究。方法回顾性选取我院2020年1月—2022年6月住院的120例艾滋病患者为研究对象。依据实验室结果,将...目的探讨(1-3)-β-D葡聚糖联合降钙素原(procalcitonin,PCT)、CD4^(+)T淋巴细胞多指标在艾滋病患者马尔尼菲篮状菌感染早期诊断临床研究。方法回顾性选取我院2020年1月—2022年6月住院的120例艾滋病患者为研究对象。依据实验室结果,将其分为马尔尼菲篮状菌感染确诊组(血或组织液培育养出马尔尼菲篮状菌),简称A组(62例),及马尔尼菲篮状菌感染临床诊断组[根据临床症状、体征、血常规及(1-3)-β-D葡聚糖、PCT、CD4^(+)T淋巴细胞多指标诊断],简称B组(58例)。检测患者(1-3)-β-D葡聚糖、PCT、CD4^(+)T淋巴细胞的表达水平,采用受试者工作特征(receiver-operating characteristic,ROC)曲线下面积(area under the curve,AUC)评估上述指标联合检测对艾滋病患者感染马尔尼菲篮状菌的诊断效能。结果A组的(1-3)-β-D葡聚糖和PCT水平均高于B组,CD4^(+)T淋巴细胞个数低于B组(P<0.05);(1-3)-β-D葡聚糖、PCT、CD4^(+)T淋巴细胞联合检测的AUC为0.933,(1-3)-β-D葡聚糖单独检测的AUC是0.812,PCT单独检测的AUC为0.883,CD4^(+)T淋巴细胞单独检测的AUC是0.810,(1-3)-β-D葡聚糖、PCT和CD4^(+)T淋巴细胞联合检测的AUC皆优于三项单独检测,表明(1-3)-β-D葡聚糖、PCT和CD4^(+)T淋巴细胞联合检测的诊断价值皆优于单一指标诊断,且联合检测的特异度、约登指数分别为92.43%和0.580,均高于三项单独检测。结论(1-3)-β-D葡聚糖联合PCT和CD4^(+)T淋巴细胞多指标对艾滋病马尔尼菲篮状菌感染具有非常高的临床诊断价值,能够帮助医生分析出高危风险患者,及时制定治疗方案,同时也承担预后效果的判断依据,对治疗艾滋病马尔尼菲篮状菌感染具有非常重要的研究价值。展开更多
Twenty-seven oxadiazolino[5,4-d][1,5]benzodiheteropine derivatives have been synthesized by the 1,3-dipolar cycloaddition of benzodiheteropines with nitrile oxide 1,3-dipoles,their conformations and the characteristic...Twenty-seven oxadiazolino[5,4-d][1,5]benzodiheteropine derivatives have been synthesized by the 1,3-dipolar cycloaddition of benzodiheteropines with nitrile oxide 1,3-dipoles,their conformations and the characteristics of the newly formed oxadiazoline fused on them have been studied.It has also been found that the mass spectra show characteristic fragmentation patterns.展开更多
With the development of genome-wide sequencing technology, 195 types of functional, long non-coding RNAs(lnc RNAs) have been identified so far, and their cellular roles are gradually being revealed. Lnc RNAs have now ...With the development of genome-wide sequencing technology, 195 types of functional, long non-coding RNAs(lnc RNAs) have been identified so far, and their cellular roles are gradually being revealed. Lnc RNAs have now become a hotspot in the field of life sciences. These small molecules exist in almost all higher eukaryotes and play very important regulatory roles in these organisms. This review briefly summarizes the recent progress in research on plasmacytoma variant translocation 1 gene(PVT1), an lnc RNA.展开更多
文摘Since the Dongfeng-2 missile, full-vehicle modal testing has been established as an indispensable part of the development and testing of rocket and missile models. However, as rockets have been developed larger, the cost and duration of such tests have significantly increased, magnifying their impact on model development. This article follows the process of the modal testing practice of the Gravity-1 rocket, reviewing and summarizing the design process of the rocket's dynamic characteristics. Initially, the article introduces common modeling techniques for launch rockets, including the mass-beam model and the hybrid element model. It then discusses the relationship between the structural dynamics model of the launch rocket and modal testing, aiming to reduce testing costs through refined structural dynamics modeling methods. Subsequently, the article describes the dynamic characteristics design process of the Gravity-1 carrier rocket, categorizes structural parameters, and studies how the selection of structural parameters affects the predicted dynamic characteristics of the rocket. Finally, it elaborates on the design of the modal testing scheme and the dynamic characteristics design based on the test data.
文摘目的探讨(1-3)-β-D葡聚糖联合降钙素原(procalcitonin,PCT)、CD4^(+)T淋巴细胞多指标在艾滋病患者马尔尼菲篮状菌感染早期诊断临床研究。方法回顾性选取我院2020年1月—2022年6月住院的120例艾滋病患者为研究对象。依据实验室结果,将其分为马尔尼菲篮状菌感染确诊组(血或组织液培育养出马尔尼菲篮状菌),简称A组(62例),及马尔尼菲篮状菌感染临床诊断组[根据临床症状、体征、血常规及(1-3)-β-D葡聚糖、PCT、CD4^(+)T淋巴细胞多指标诊断],简称B组(58例)。检测患者(1-3)-β-D葡聚糖、PCT、CD4^(+)T淋巴细胞的表达水平,采用受试者工作特征(receiver-operating characteristic,ROC)曲线下面积(area under the curve,AUC)评估上述指标联合检测对艾滋病患者感染马尔尼菲篮状菌的诊断效能。结果A组的(1-3)-β-D葡聚糖和PCT水平均高于B组,CD4^(+)T淋巴细胞个数低于B组(P<0.05);(1-3)-β-D葡聚糖、PCT、CD4^(+)T淋巴细胞联合检测的AUC为0.933,(1-3)-β-D葡聚糖单独检测的AUC是0.812,PCT单独检测的AUC为0.883,CD4^(+)T淋巴细胞单独检测的AUC是0.810,(1-3)-β-D葡聚糖、PCT和CD4^(+)T淋巴细胞联合检测的AUC皆优于三项单独检测,表明(1-3)-β-D葡聚糖、PCT和CD4^(+)T淋巴细胞联合检测的诊断价值皆优于单一指标诊断,且联合检测的特异度、约登指数分别为92.43%和0.580,均高于三项单独检测。结论(1-3)-β-D葡聚糖联合PCT和CD4^(+)T淋巴细胞多指标对艾滋病马尔尼菲篮状菌感染具有非常高的临床诊断价值,能够帮助医生分析出高危风险患者,及时制定治疗方案,同时也承担预后效果的判断依据,对治疗艾滋病马尔尼菲篮状菌感染具有非常重要的研究价值。
文摘Twenty-seven oxadiazolino[5,4-d][1,5]benzodiheteropine derivatives have been synthesized by the 1,3-dipolar cycloaddition of benzodiheteropines with nitrile oxide 1,3-dipoles,their conformations and the characteristics of the newly formed oxadiazoline fused on them have been studied.It has also been found that the mass spectra show characteristic fragmentation patterns.
基金Supported by Science and Technology Plan of Guangdong Provincial Department of Science and Technology(2011B031800012)
文摘With the development of genome-wide sequencing technology, 195 types of functional, long non-coding RNAs(lnc RNAs) have been identified so far, and their cellular roles are gradually being revealed. Lnc RNAs have now become a hotspot in the field of life sciences. These small molecules exist in almost all higher eukaryotes and play very important regulatory roles in these organisms. This review briefly summarizes the recent progress in research on plasmacytoma variant translocation 1 gene(PVT1), an lnc RNA.
