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Mepiquat chloride increases the Cry1Ac protein content of Bt cotton under high temperature and drought stress by regulating carbon and amino acid metabolism
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作者 Dian Jin Yuting Liu +7 位作者 Zhenyu Liu Yuyang Dai Jianing Du Run He Tianfan Wu Yuan Chen Dehua Chen Xiang Zhang 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第12期4032-4045,共14页
The effects of mepiquat chloride(DPC)on the Cry1Ac protein content in Bacillus thuringiensis(Bt)cotton boll shells under high temperature and drought stress were investigated to provide a theoretical reference for Bt ... The effects of mepiquat chloride(DPC)on the Cry1Ac protein content in Bacillus thuringiensis(Bt)cotton boll shells under high temperature and drought stress were investigated to provide a theoretical reference for Bt cotton breeding and high-yield and-efficiency cotton cultivation.This study was conducted using Bt cotton cultivar‘Sikang 3'during the 2020 and 2021 growing seasons at Yangzhou University Farm,Yangzhou,Jiangsu Province,China.Potted cotton plants were exposed to high temperature and drought stress,and sprayed with either 20 mg L^(-1)DPC or water(CK).Seven days after treatment,the Cry1Ac protein content,α-ketoglutarate content,pyruvic acid content,glutamate synthase activity,glutamic oxaloacetic transaminase activity,soluble protein content,and amino acid content were measured,and transcriptome sequencing was performed.DESeq was used for differential gene analysis.Under the DPC treatment,the Cry1Ac protein content increased by 4.7-11.9% compared to CK.Theα-ketoglutarate content,pyruvic acid content,glutamate synthase activity,glutamic oxaloacetic transaminase activity,soluble protein content,and amino acid content all increased.Transcriptome analysis revealed 7,542 upregulated genes and 10,449 downregulated genes for DPC vs.CK.Gene ontology(GO)and Kyoto Encyclopedia of Gene and Genomes(KEGG)analyses showed that the differentially expressed genes were mainly involved in biological processes,such as carbon and amino acid metabolism.For example,genes encoding 6-phosphofructokinase,pyruvate kinase,glutamic pyruvate transaminase,pyruvate dehydrogenase,citrate synthase,isocitrate dehydrogenase,2-oxoglutarate dehydrogenase,glutamate synthase,1-pyrroline-5-carboxylate dehydrogenase,glutamic oxaloacetic transaminase,amino-acid N-acetyltransferase,and acetylornithine deacetylase were all significantly upregulated.The DPC treatment increased pyruvate,α-ketoglutarate,and oxaloacetate by increasing the operational rate of the glycolytic pathway of the citric acid cycle.It also significantly upregulated the genes encoding glutamate synthase,pyrrolidine-5-carboxylic acid dehydrogenase,glutamate oxaloacetate transaminase,and N-acetylglutamate synthetase,while it downregulated the genes encoding glutamine synthetase.Therefore,the synthesis of aspartic acid,glutamic acid,pyruvate,and arginine increased after treatment with DPC,and the Cry1Ac protein content was increased by regulating carbon and amino acid metabolism. 展开更多
关键词 amino acid metabolism Bt cotton carbon metabolism Cry1Ac protein mepiquat chloride
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依达拉奉右莰醇联合丁苯酞氯化钠注射液对急性脑梗死患者血清单核细胞趋化蛋白-1、内皮素-1表达的影响
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作者 杨华英 崔娅晖 +1 位作者 郑连红 王琮民 《中国药业》 CAS 2024年第9期135-138,共4页
目的探讨依达拉奉右莰醇联合丁苯酞氯化钠注射液对急性脑梗死患者血清单核细胞趋化蛋白-1(MCP-1)、内皮素-1(ET-1)表达及动脉粥样硬化斑块的影响。方法选取河北省邯郸市中医院2020年12月至2022年8月收治的急性脑梗死患者140例,按随机数... 目的探讨依达拉奉右莰醇联合丁苯酞氯化钠注射液对急性脑梗死患者血清单核细胞趋化蛋白-1(MCP-1)、内皮素-1(ET-1)表达及动脉粥样硬化斑块的影响。方法选取河北省邯郸市中医院2020年12月至2022年8月收治的急性脑梗死患者140例,按随机数字表法分为联合组和对照组,各70例。两组患者均予丁苯酞氯化钠注射液,联合组患者加用依达拉奉右莰醇注射液,均治疗14 d。结果联合组总有效率为91.43%,显著高于对照组的68.57%(P<0.05)。治疗后,两组患者的颈动脉内中膜厚度、斑块面积、美国国立卫生研究院卒中量表(NIHSS)评分、改良Rankin量表(MRS)评分及血清MCP-1、ET-1、丙二醛、超氧化物歧化酶水平均显著降低(P<0.05),且联合组均显著低于对照组(P<0.05);联合组和对照组患者治疗期间不良反应发生率相当(12.86%比14.29%,P>0.05)。结论依达拉奉右莰醇联合丁苯酞氯化钠注射液治疗急性脑梗死的临床疗效良好,可有效改善患者的神经功能缺损情况、颈动脉粥样硬化斑块稳定性及内皮功能,降低氧化应激水平,提高生活质量,且安全性良好。 展开更多
关键词 急性脑梗死 丁苯酞氯化钠注射液 依达拉奉右莰醇 单核细胞趋化蛋白-1 内皮素-1 氧化应激 动脉粥样硬化斑块
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Synthesis and Crystal Structure of 1D Chloride Bridged Cadmium(Ⅱ) Chain
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作者 欧光川 《湖南科技学院学报》 2005年第5期113-115,共3页
Hydrothermal reaction of 1,10-phenanthroline with CdCl2·2.5H2O in aqueous solution leads to the complex of [Cd(μ-Cl)2(phen)]n (phen = 1-10-phenanthroline). The crystal structure has been determined by X-ray anal... Hydrothermal reaction of 1,10-phenanthroline with CdCl2·2.5H2O in aqueous solution leads to the complex of [Cd(μ-Cl)2(phen)]n (phen = 1-10-phenanthroline). The crystal structure has been determined by X-ray analysis. It crystallizes in monoclinic with space group C2/c, a = 16.947(3), b = 10.529(2), c = 7.235(1) , β = 110.795(3)°, V = 1208.8(3) 3, Z = 4, Dc = 1.997 g.cm-3, μ= 2.22 mm-1, F(000) = 704, R = 0.0231, Rw = 0.0626 for 1194 reflections with I > 2σ (I). In the crystal structure, the [Cd(phen)]2+ units are bridged by chloride ions to form 1D chain. The 1D chains combine through π……π interactions of phen groups to form 2D infinite molecular zipper. 展开更多
关键词 合成反应 晶体结构 氯化镉 钱恩
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Chloride intracellular channel 1 regulates colon cancer cell migration and invasion through ROS/ERK pathway 被引量:6
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作者 Pan Wang Yun Zeng +5 位作者 Tao Liu Chao Zhang Pei-Wu Yu Ying-Xue Hao Hua-Xin Luo Gang Liu 《World Journal of Gastroenterology》 SCIE CAS 2014年第8期2071-2078,共8页
AIM: To investigate the mechanisms of chloride intracellular channel 1 (CLIC1) in the metastasis of colon cancer under hypoxia-reoxygenation (H-R) conditions.
关键词 Colon cancer Intracellular chloride channel 1 HYPOXIA-REOXYGENATION Reactive oxygen species Extracellular signal-regulated kinase Cancer invasion
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An efficient synthesis of 2,2′-arylmethylene bis-(3-hydroxy-5,5-dimethyl-2-cyclohexene-1-one) and 1,8-dioxooctahydroxanthenes using ZnO and ZnO-acetyl chloride 被引量:4
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作者 Malek Taher Maghsoodlou Sayyed Mostafa Habibi-Khorassani +2 位作者 Zahra Shahkarami Nariman Maleki Mohsen Rostamizadeh 《Chinese Chemical Letters》 SCIE CAS CSCD 2010年第6期686-689,共4页
2,2'-Arylmethylene bis(3-hydroxy-5,5-dimethyl-2-cyclohexene-1-one) 4l-s produced from reaction between dimedone with various aldehydes in acetonitrile using ZnO as a catalyst;whereas in the presence of ZnO-acetyl ... 2,2'-Arylmethylene bis(3-hydroxy-5,5-dimethyl-2-cyclohexene-1-one) 4l-s produced from reaction between dimedone with various aldehydes in acetonitrile using ZnO as a catalyst;whereas in the presence of ZnO-acetyl chloride catalysts the reaction is limited to give only 1,8-dioxo-octahydroxanthenes 3a-k in very good yields. 展开更多
关键词 ZNO ZnO-acetyl chloride Dimedone Aldehyde 1 8-Dioxooctahydroxanthene 2 2'-Arylmethylene bis(3-hydroxy-5 5-dimethyl-2-cyclohexene-1-one)
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Function of chloride intracellular channel 1 in gastric cancer cells 被引量:9
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作者 Peng-Fei Ma Jun-Qiang Chen Zhen Wang Jin-Lu Liu Bo-Pei Li 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第24期3070-3080,共11页
AIM:To investigate the effect of chloride intracellular channel 1(CLIC1) on the cell proliferation,apoptosis,migration and invasion of gastric cancer cells.METHODS:CLIC1 expression was evaluated in human gastric cance... AIM:To investigate the effect of chloride intracellular channel 1(CLIC1) on the cell proliferation,apoptosis,migration and invasion of gastric cancer cells.METHODS:CLIC1 expression was evaluated in human gastric cancer cell lines SGC-7901 and MGC-803 by real time polymerase chain reaction(RT-PCR).Four segments of small interference RNA(siRNA) targeting CLIC1 mRNA and a no-sense control segment were designed by bioinformatics technology.CLIC1 siRNA was selected using Lipofectamine 2000 and transfected transiently into human gastric cancer SGC-7901 and MGC-803 cells.The transfected efficiency was observed under fluorescence microscope.After transfection,mRNA expression of CLIC1 was detected with RT-PCR and Western blotting was used to detect the protein expression.Proliferation was examined by methyl thiazolyl tetrazolium and apoptosis was detected with flow cytometry.Polycarbonate membrane transwell chamber and Matrigel were used for the detection of the changes of invasion and migration of the two cell lines.RESULTS:In gastric cancer cell lines SGC-7901 and MGC-803,CLIC1 was obviously expressed and CLIC1 siRNA could effectively suppress the expression of CLIC1 protein and mRNA.Proliferation of cells transfected with CLIC1 siRNA3 was enhanced notably,and the highest proliferation rate was 23.3%(P = 0.002) in SGC-7901 and 35.55%(P = 0.001) in MGC-803 cells at 48 h.The G2/M phase proportion increased,while G0/G1 and S phase proportions decreased.The apoptotic rate of the CLIC1 siRNA3 group obviously decreased in both SGC-7901 cells(62.24%,P = 0.000) and MGC-803 cells(52.67%,P = 0.004).Down-regulation of CLIC1 led to the inhibition of invasion and migration by 54.31%(P = 0.000) and 33.62%(P = 0.001) in SGC-7901 and 40.74%(P = 0.000) and 29.26%(P = 0.002) in MGC-803.However,there was no significant difference between the mock group cells and the negative control group cells. 展开更多
关键词 chloride intracellular channel 1 Gastric car-cinoma Small interference RNA Apoptosis INVASION Migration
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Synthesis of some new bis-3,4-dihydropyrimidin-2(1H)-ones by using silica-supported tin chloride and titanium tetrachloride 被引量:1
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作者 Khodabakhsh Niknam Alireza Hasaninejad Madihe Arman 《Chinese Chemical Letters》 SCIE CAS CSCD 2010年第4期399-402,共4页
Silica-supported tin chloride and titanium tetrachloride were prepared by the reaction of tin chloride and titanium tetrachloride with activated silica gel in refluxing toluene.These solid acids have been employed as ... Silica-supported tin chloride and titanium tetrachloride were prepared by the reaction of tin chloride and titanium tetrachloride with activated silica gel in refluxing toluene.These solid acids have been employed as the catalysts for the synthesis of bisdihydropyrimidin -2(1H)-ones from aromatic dialdehydes,1,3-dicarbonyl compounds and urea at 90℃under solvent-free conditions. 展开更多
关键词 Silica-supported tin chloride Silica-supported titanium tetrachloride Bis-3 4-dihydropyrimidin-2(1H)-one SOLVENT-FREE 1 3-Dicarbonyl compounds
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Alterative Expression and Sequence of Human Elongation Factor-1δ during Malignant Transformation of Human Bronchial Epithelial Cells Induced by Cadmium Chloride 被引量:2
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作者 YI-XIONG LEI MIN WANG +2 位作者 LIAN WEI XI LU HUA-ZHAO LIN 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2010年第2期151-157,共7页
Objective To study the alternative expression and sequence of human elongation factor-1δ (human EF-1δ p31) during malignant transformation of human bronchial epithelial cells induced by cadmium chloride (CdCl2) ... Objective To study the alternative expression and sequence of human elongation factor-1δ (human EF-1δ p31) during malignant transformation of human bronchial epithelial cells induced by cadmium chloride (CdCl2) and its possible mechanism. Methods Total RNA was isolated at different stages of transformed human bronchial epithelial cells (16HBE) induced by CdCl2 at a concentration of 5.0 μM. Special primers and probe for human EF-1δ p31 were designed and expression of human EF-18 mRNA from different cell lines was detected with fluorescent quantitative PCR technique. EF-18 cDNA from different cell lines was purified and cloned into pMD 18-T vector followed by confirming and sequencing analysis. Results The expressions of human EF-1δ p31 at different stages of 16HBE cells transformed by CdCl2 was elevated (P〈0.01 or P〈0.05). Compared with their corresponding non-transformed ceils, the overexpression level of EF-15 p31 was averagely increased 2.9 folds in Cd-pretransformed cells, 4.3 folds in Cd-transformed ceils and 7.2 folds in Cd-tumorigenic cells. No change was found in the sequence of overexpressed EF-1δ p31 at different stages of 16HBE cells transformed by CdCl2. Conclusion Overexpression of human EF-1δ p31 is positively correlated with malignant transformation of 16HBE cells induced by CdCl2, but is not correlated with DNA mutations. 展开更多
关键词 Human elongation factor-1δ Cadmium chloride Human bronchial epithelial cells Cell transformation Sequencing analysis
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Analgesic effect of intrathecal bumetanide is accompanied by changes in spinal sodium-potassium-chloride co-transporter 1 and potassium-chloride co-transporter 2 expression in a rat model of incisional pain 被引量:2
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作者 Yanbing He Shiyuan Xu +1 位作者 Junjie Huang Qingjuan Gong 《Neural Regeneration Research》 SCIE CAS CSCD 2014年第10期1055-1062,共8页
Accumulating evidence has demonstrated that the sodium-potassium-chloride co-transporter 1 and potassium-chloride co-transporter 2 have a role in the modulation of pain transmission at the spinal level through chlorid... Accumulating evidence has demonstrated that the sodium-potassium-chloride co-transporter 1 and potassium-chloride co-transporter 2 have a role in the modulation of pain transmission at the spinal level through chloride regulation in the pain pathway and by effecting neuronal excitability and pain sensitization. The present study aimed to investigate the analgesic effect of the speciifc sodium-potassium-chloride co-transporter 1 inhibitor bumetanide, and the change in spinal sodium-potassium-chloride co-transporter 1 and potassium-chloride co-transporter 2 expression in a rat model of incisional pain. Results showed that intrathecal bumetanide could decrease cumulative pain scores, and could increase thermal and mechanical pain thresholds in a rat model of incisional pain. Sodium-potassium-chloride co-transporter 1 expression in-creased in neurons from dorsal root ganglion and the deep laminae of the ipsilateral dorsal horn following incision. By contrast, potassium-chloride co-transporter 2 expression decreased in neurons of the deep laminae from the ipsilateral dorsal horn. These ifndings suggest that spinal sodium-potassium-chloride co-transporter 1 expression was up-regulated and spinal potassi-um-chloride co-transporter 2 expression was down-regulated following incision. Intrathecal bumetanide has analgesic effects on incisional pain through inhibition of sodium-potassi-um-chloride co-transporter 1. 展开更多
关键词 nerve regeneration sodium-potassium-chloride co-transporter 1 potassium-chloride co-transporter 2 BUMETANIDE spinal cord dorsal root ganglion incision model postoperative pain neural regeneration
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Isobaric Vapor–Liquid Equilibrium for tert-Butyl Alcohol + Water + Propane-1,3-Diol + 1-Ethyl-3-Methylimidazolium Chloride at 101.3 kPa
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作者 Xianbao Cui Qinglong Cheng +5 位作者 Haofei Liu Lexing Xue Jinbo Zhou Ying Zhang Tianyang Feng Kai Zhang 《Transactions of Tianjin University》 EI CAS 2018年第5期424-433,共10页
In this study, we used a mixture of organic liquid propane-1,3-diol and ionic liquid 1-ethyl-3-methylimidazolium chloride([emim]Cl) as the entrainer to separate tert-butyl alcohol(TBA) + water. We measured the isobari... In this study, we used a mixture of organic liquid propane-1,3-diol and ionic liquid 1-ethyl-3-methylimidazolium chloride([emim]Cl) as the entrainer to separate tert-butyl alcohol(TBA) + water. We measured the isobaric vapor–liquid equilibrium(VLE) for the quaternary system TBA + water + propane-1,3-diol + [emim]Cl at 101.3 kPa, and found the VLE data to be well correlated with the nonrandom two-liquid model. These results show that the mixed solvent of propane-1,3-diol + [emim]Cl can increase the relative volatility of TBA to water and break the azeotropic point. We found no notable synergetic effect between them, and observed that the liquid mixed solvent of propane-1,3-diol and [emim]Cl had lower viscosity than [emim]Cl, which makes it a promising entrainer for separating the TBA + water azeotrope in industrial applications. 展开更多
关键词 tert-Butyl alcohol·Water·Propane-1-3-diol·1-Ethyl-3-methylimidazolium chloride·Vapor–liquid EQUILIBRIUM
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Zinc chloride catalyzed synthesis of 5-substituted 1H-tetrazoles under solvent free condition
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作者 Shahnaz Rostamizadeh Hamid Ghaieni +1 位作者 Reza Aryan Ali Amani 《Chinese Chemical Letters》 SCIE CAS CSCD 2009年第11期1311-1314,共4页
Zinc chloride is an efficient and safe catalyst in the [3 + 2] cycloaddition reaction of organic nitriles with sodium azide in solventless condition. The corresponding 5-substituted ^1H tetrazoles were obtained under... Zinc chloride is an efficient and safe catalyst in the [3 + 2] cycloaddition reaction of organic nitriles with sodium azide in solventless condition. The corresponding 5-substituted ^1H tetrazoles were obtained under mild conditions. This method can overcome disadvantages such as: the use of toxic metals and expensive reagents, drastic reaction conditions, water sensitivity and the presence of dangerous hydrazoic acid. 展开更多
关键词 5-Substituted ^1H-tetrazoles Zinc chloride Sodium azide Solvent free
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ELECTROCHEMICAL STUDIES OF TITANIUM(IV)IN 1-METHYL-3-ETHYLIMIDAZOLIUM CHLORIDE
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作者 Bei Long FANG Department of Chemistry.Zhongshan University,Guangzhou.510275 《Chinese Chemical Letters》 SCIE CAS CSCD 1993年第12期1105-1108,共4页
A Titanium tetrachloride-1-methyl-3-ethytimidazolium chloride melt has been prepared.The reduction process of Ti(IV)appears to be diffusion controlled in the composition of 0.4:1 mole ralio of TiCl_4-1-methyl-3-ethyli... A Titanium tetrachloride-1-methyl-3-ethytimidazolium chloride melt has been prepared.The reduction process of Ti(IV)appears to be diffusion controlled in the composition of 0.4:1 mole ralio of TiCl_4-1-methyl-3-ethylimidazolium chloride and the electrochemical behavior of Ti(IV)shows remarkable compositon dependence. 展开更多
关键词 IV)IN 1-METHYL-3-ETHYLIMIDAZOLIUM chloride TI ELECTROCHEMICAL STUDIES OF TITANIUM TIC
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Identification of Herbal Compound Imperatorin with Adverse Effects on ANO1 and CFTR Chloride Channels
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作者 HAO Feng YI Fei +5 位作者 ZHANG Di N1NG Yan SU Wei-heng FENG Xue-chao YANG Hong MA Tong-hui 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2011年第3期461-463,共3页
Calcium-activated chloride channels(CaCCs) are the crucial regulators of transepithelial fluid secretion, smooth muscle contraction and sensory transduction. Recently, compelling evidence has indicated that TMEM16A... Calcium-activated chloride channels(CaCCs) are the crucial regulators of transepithelial fluid secretion, smooth muscle contraction and sensory transduction. Recently, compelling evidence has indicated that TMEM16A(ANO1 or anoctamin-1) is a bona fide calcium-acvtivated chloride channel. A few small molecule CaCCs regulators are available for functional and therapeutic studies. We screened 126 natural compounds from Chinese herbs. Screening was performed with an iodide influx assay in Fischer rat thyroid epithelial cells to coexpress ANO1 and an iodide-sensitive fluorescent indicator(EYFP-H148Q/I152L). Imperatorin, a coumarin compound, was identified to inhibit ANO1-mediated chloride transport activated by multiple calcium-elevating agonists. The inhibitory effect is dose-dependent with IC50~14.63 μmol/L. Interestingly, imperatorin activated CFTR chloride channel with EC50~35.52 μmol/L. The adverse effects of imperatorin on CaCC and CFTR chloride channels will make it useful in pharmacological dissection of chloride transport in airway and intestinal epithelium. Further studies are required to evaluate the therapeutic effects of imperatorin on hypertension, asthma and certain tumors. 展开更多
关键词 Calcium-acvtivated chloride channel(CaCC) ANO1 IMPERATORIN Cystic fibrosis transmembrane conductance regulator(CFTR)
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Synthesis and Characterization of Poly [2,2-( m-phenylene) -5,5-bibenzimidazole] in 1-butyl-3-methylimidazolium Chloride
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作者 白雪君 王彪 +3 位作者 唐艳芳 文志伟 江建明 王华平 《Journal of Donghua University(English Edition)》 EI CAS 2013年第3期239-243,共5页
Poly[ 2, 2-(m.phenylene) -5, 5-bibenzimidazole] (mPBI) were synthesized by mixing 3, 3', 4, 4'-tetraaminobiphenyl and isophthallc acid in 1 -butyl-3 -methyUmidazolinm chloride ( E BMIM] CI). Intrinsic viscosit... Poly[ 2, 2-(m.phenylene) -5, 5-bibenzimidazole] (mPBI) were synthesized by mixing 3, 3', 4, 4'-tetraaminobiphenyl and isophthallc acid in 1 -butyl-3 -methyUmidazolinm chloride ( E BMIM] CI). Intrinsic viscosity of mPBI polymers was 0.67 dL/g which was measured in 96% sulfuric acid. The polymer was characterized by Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance ( 1H-NMR ), and thermogravimetric analysis (TGA). The effects of polymerization conditions on the intrinsic viscosity of mPBI were investigated. It showed that the molecular weight of polymer mainly depended on pre-reaction time and reaction temperature. Comparison of structure and properties of mPBI synthesized in ionic liquids(ILs) and polyphosphoric acid was also reported. It indicates that the ionic liquids are a kind of good solvents in synthesis process of m_PBI and ionic liquids mainly affect molecular weight of mPBL 展开更多
关键词 polybenzimidazole PBI 1-butyl-3-methylimidazolium chloride [ BMIM] C1 ionic liquids(ILs) synthesis
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IR, 1H NMR, Electronic Properties and Conductivity Studies of N1 ,N4-Bis(Diphme)Benzene-l,4-Diamine Chloride Zirconium (IV) [{(Ar)2NC6H5N(Ar)2}ZrCl4] (Ar = C6H5)
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作者 Salem Et. Ashoor 《Journal of Chemistry and Chemical Engineering》 2011年第3期259-263,共5页
A range of new compounds such as N1,N4-bis(diphenylmethlene)benzene-l,4-diamine zirconium (IV) chloride [{(Ar)2NC6HsN(Ar)z}ZrCl4] (Ar = C6H5) complex counting the chelating amine and chloride in position tra... A range of new compounds such as N1,N4-bis(diphenylmethlene)benzene-l,4-diamine zirconium (IV) chloride [{(Ar)2NC6HsN(Ar)z}ZrCl4] (Ar = C6H5) complex counting the chelating amine and chloride in position trans have been prepared. Well-defined NI,N4-bis(diphenylmethlene)benzene-l,4-diamine zirconium (IV) chloride [{(Ar)2NC6H5N(Ar)2}ZrCl4] (Ar = C6H5) was obtained by stoichiometric addition of {(Ar)2NC6H5N(Ar)2} (Ar = C6H5) and {ZrC14} in ethanol at reflex temperature. IR, 1H NMR, electronic properties using hyperchem program study has been improved for this compound such as bond distance, and this compound was also defined as electric conductivity which proves to be useful for conductively compound. 展开更多
关键词 Electronic conductivity NI N4-bis(diphme)benzene-1 4-diamine N1 N4-bis(diphenylmethlene)benzene-1 4-diaminezirconium (IV) chloride.
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Swelling Properties of New Hydrogels Based on the Dimethyl Amino Ethyl Acrylate Methyl Chloride Quaternary Salt with Acrylic Acid and 2-Methylene Butane-1,4-Dioic Acid Monomers in Aqueous Solutions
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作者 Issa Katime Eduardo Mendizábal 《Materials Sciences and Applications》 2010年第3期162-167,共6页
Hydrogels of dimethylaminoethyl acrylate methyl chloride quaternary salt (Q9) have been synthesized with different monomer ratio by copolymerization of this poorly studied monomer either with acrylic acid or with 2-me... Hydrogels of dimethylaminoethyl acrylate methyl chloride quaternary salt (Q9) have been synthesized with different monomer ratio by copolymerization of this poorly studied monomer either with acrylic acid or with 2-methylene bu-tane-1,4-dioic acid. Hydrogel swelling was measured as a function of the composition of the hydrogel and of the crosslinking agent ratio. High values of swelling have been obtained at very high crosslinking values (【14 wt %) and the equilibrium swelling was reached at very low time (less than 15 minutes). The swelling isotherms consisted of a steep initial portion and then levelled off as asymptotically to the equilibrium swelling limit. The experimental data suggest clearly that the swelling process obeys second-order kinetics. According to this, the kinetics rate constant and the equilibrium water content were determined at different comonomer composition and crosslinker concentration. The calculated kinetic constants ranged from 0.48 to 3.76 &#215;10-2 min-1 for poly (acrylic acid-co-Q9) hydrogels and from 0.68 to 4.0 &#215;10-2 min-1 for poly (2-methylene butane-1,4-dioic acid-co-Q9) hydrogels depending on the hydrogels composition. The diffusion process was evaluated for each hydrogel showing a non-Fickian type diffusion. In all cases was observed a considerable increase in diffusion coefficient as Q9 content increases. 展开更多
关键词 DIMETHYL Amino Ethyl Acrylate Methyl chloride QUATERNARY Salt 2-methylene butane-1 4-Dioic ACID Acrylic ACID SWELLING Diffusion Coefficients Kinetic Order
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蛋白激酶C参与调控小鼠脑皮层神经元神经调节蛋白1表达的初步研究
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作者 田佳 陈晶 +2 位作者 陆萍 张越 梁洪宇 《黑龙江八一农垦大学学报》 2023年第5期65-71,共7页
为探索神经活动依赖的神经调节蛋白1(Nrg1)的表达及其机制,在体外培养的小鼠皮层神经元中,通过实时定量聚合酶链反应法发现氯化钾或荷包牡丹碱刺激6 h时,Nrg1和Ⅰ型Nrg1 mRNA表达增加,Ⅱ、Ⅲ型Nrg1表达不变。蛋白激酶C抑制剂bisⅠ可降... 为探索神经活动依赖的神经调节蛋白1(Nrg1)的表达及其机制,在体外培养的小鼠皮层神经元中,通过实时定量聚合酶链反应法发现氯化钾或荷包牡丹碱刺激6 h时,Nrg1和Ⅰ型Nrg1 mRNA表达增加,Ⅱ、Ⅲ型Nrg1表达不变。蛋白激酶C抑制剂bisⅠ可降低氯化钾诱发的Nrg1和Ⅰ型Nrg1 mRNA表达,蛋白激酶C抑制剂bisⅠ、丝裂原活化蛋白激酶抑制剂U0126和Ca^(2+)/钙调蛋白激酶抑制剂KN62,可降低荷包牡丹碱诱发的Nrg1和Ⅰ型Nrg1 mRNA表达。蛋白激酶C参与了氯化钾诱导的Nrg1和Ⅰ型Nrg1 mRNA的表达增加,蛋白激酶C、Ca^(2+)/钙调蛋白激酶和丝裂原活化蛋白激酶参与了荷包牡丹碱诱导的Nrg1和Ⅰ型Nrg1 mRNA的表达增加。 展开更多
关键词 神经调节蛋白1 小鼠 皮层神经元 蛋白激酶C 氯化钾 荷包牡丹碱
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Anomalous expression of chloride transporters in the sclerosed hippocampus of mesial temporal lobe epilepsy patients 被引量:2
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作者 Xiaodong Cai Libai Yang +5 位作者 Jueqian Zhou Dan Zhu Qiang Guo Ziyi Chen Shuda Chen Liemin Zhou 《Neural Regeneration Research》 SCIE CAS CSCD 2013年第6期561-568,共8页
The Na+-K+-CI- cotransporter 1 and K+-CI- cotransporter 2 regulate the levels of intracellular chloride in hippocampal cells. Impaired chloride transport by these proteins is thought to be involved in the pathophys... The Na+-K+-CI- cotransporter 1 and K+-CI- cotransporter 2 regulate the levels of intracellular chloride in hippocampal cells. Impaired chloride transport by these proteins is thought to be involved in the pathophysiological mechanisms of mesial temporal lobe epilepsy. Imbalance in the relative expression of these two proteins can lead to a collapse of CI- homeostasis, resulting in a loss of gamma-aminobutyric acid-ergic inhibition and even epileptiform discharges. In this study, we investigated the expression of Na+-K+-CI- cotransporter 1 and K+-CI- cotransporter 2 in the sclerosed hippocampus of patients with mesial temporal lobe epilepsy, using western blot analysis and immunohistochemistry. Compared with the histologically normal hippocampus, the sclerosed hippocampus showed increased Na+-K+-Cl- cotransporter 1 expression and decreased K+-CI- cotransporter 2 expression, especially in CA2 and the dentate gyrus. The change was more prominent for the Na+-K+-CI- cotransporter 1 than for the K+-CI- cotransporter 2. These experimental findings indicate that the balance between intracellular and extracellular chloride may be disturbed in hippocampal sclerosis, contributing to the hyperexcitability underlying epileptic seizures. Changes in Na+-K+-CI-cotransporter 1 expression seems to be the main contributor. Our study may shed new light on possible therapies for patients with mesial temporal lobe epilepsy with hippocampal sclerosis. 展开更多
关键词 neural regeneration brain injury mesial temporal lobe epilepsy hippocampal sclerosis sodium-potassium chloride cotransporter 1 potassium chloride cotransporter 2 gamma-aminobutyric acid chloride ion dentate gyrus CA2 region human grants-supported paperphotographs-containing paper NEUROREGENERATION
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氯化钙与1-MCP对西州蜜甜瓜采后贮藏品质的影响 被引量:3
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作者 李自芹 李文绮 +2 位作者 贾文婷 李宇辉 刘成江 《新疆农业科学》 CAS CSCD 北大核心 2023年第7期1698-1704,共7页
【目的】研究氯化钙和1-MCP对采后西州蜜甜瓜贮藏品质的影响。【方法】以鲜食西州蜜甜瓜为试材,分别采用1.5%CaCl_(2)、1μL/L的1-甲基环丙烯和1.5%CaCl_(2)、1μL/L1-甲基环丙烯复合处理,以无处理的西州蜜甜瓜作为对照组CK。分析其在... 【目的】研究氯化钙和1-MCP对采后西州蜜甜瓜贮藏品质的影响。【方法】以鲜食西州蜜甜瓜为试材,分别采用1.5%CaCl_(2)、1μL/L的1-甲基环丙烯和1.5%CaCl_(2)、1μL/L1-甲基环丙烯复合处理,以无处理的西州蜜甜瓜作为对照组CK。分析其在贮藏过程中的腐烂率、失重率、呼吸强度、硬度、可溶性固形物、原果胶、POD酶、CAT酶的变化。【结果】氯化钙与1-MCP均能抑制西州蜜甜瓜的呼吸强度、其中氯化钙与1-MCP复合处理还推迟了果实的呼吸跃变,在第28 d,氯化钙与1-MCP复合处理组果实硬度较CK组提高了83.3%,原果胶含量较CK增加了7.5 mg/(g·FW),可溶性固形物含量较CK增加了20.4%,POD酶、CAT酶活性较CK分别降低了42.9%和64.6%。【结论】氯化钙与1-MCP复合处理更好的抑制了果实的呼吸强度、原果胶物质的分解,延缓了西州蜜甜瓜的软化,保持了果实的贮藏品质。 展开更多
关键词 西州蜜甜瓜 氯化钙 1-MCP 贮藏品质
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Evaluation in vinyl chloride monomer-exposed workers and the relationship between liver lesions and gene polymorphisms of metabolic enzymes 被引量:6
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作者 Shou-Min Zhu Xue-Feng Ren Jun-Xiang Wan Zhao-Lin Xia 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第37期5821-5827,共7页
AIM: To analyze occupational health hazards exposure to doses lower than the Chinese occupational health standard in a selected VC polymerization plant in China, and also to elucidate the relationship between genetic... AIM: To analyze occupational health hazards exposure to doses lower than the Chinese occupational health standard in a selected VC polymerization plant in China, and also to elucidate the relationship between genetic polymorphisms and genetic susceptibility on liver lesions of workers exposed to vinyl chloride monomer (VCM). METHODS: In order to explore the mechanism of VCM- related health effects, we used a case-control design to investigate the association between the genetic polymorphisms of metabolic enzymes and liver lesions in workers occupationally exposed to VCM. Genotypes of CYP2E1, GSTT1, GSTM1, ALDH2 and ADH2 were identified using PCR and PCR-RFLP. RESULTS: Even when the concentration of VCM was lower than the current Chinese occupational health standard, neurasthenia, pharyngeal irritation, liver ultrasonography abnormalities and hemoglobin disorders were significantly higher in exposure subjects compared to non-exposure subjects, and the relative risks (RRand 95% C1) were 1.74 (1.06-2.85), 1.97 (1.56-2.48), 10.69 (4.38-26.12), and 2.07 (1.20-3.57). CYP2E1 c1c2/c2c2 genotype was significantly associated with liver damages (OR 3.29, 95% CI 1.51-7.20, P〈0.01). CONCLUSION: The incidences of neurasthenia and liver ultrasonography abnormalities significantly increase when the cumulative exposure dose increases. The genotypes of metabolic enzymes (CYP2E1 c1c2/c2c2, null GSTT1 and ADH2 1-1) play important roles in VCM metabolism. Polymorphisms of CYP 2E1, GSTT1 and ADH2 may be a major reason of genetic susceptibility in VCM-induced hepatic damage. 展开更多
关键词 Vinyl chloride monomer Hepatic lesions Cytochrome p450 2E1 Glutathione S-transferase Aldehyde dehydrogenase-2
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