Transforming growth factor-β1 and vascular endothelial growth factor levels in senile acute myeloid leukemia and correlation with prognosis

BACKGROUND Acute myeloid leukemia(AML)is a disease in which immature hematopoietic cells accumulate in the bone marrow and continuously expand,inhibiting hematopoiesis.The treatment and prognosis of this disease have always been unsatisfactory.AIM To investigate the correlation between vascular endothelial growth factor(VEGF)and transforming growth factor-β1(TGFβ1)expression and prognosis in older adults with AML.METHODS This study enrolled 80 patients with AML(AML group),including 36 with complete response(AML-CR),23 with partial response(AML-PR),and 21 with no response(AML-NR).The expression levels of VEGF and TGFβ1 were detected by reverse transcription polymerase chain reaction in bone marrow mononuclear cells isolated from 56 healthy controls.Kaplan-Meier analysis was performed to assess overall survival(OS)and progression-or disease-free survival(DFS).Prognostic risk factors were analyzed using a Cox proportional hazards model.RESULTS The AML group showed a VEGF level of 2.68±0.16.VEGF expression was lower in patients with AML-CR than those with AML-PR or AML-NR(P<0.05).TGFβ1 expression in the AML group was 0.33±0.05.Patients with AML-CR showed a higher TGFβ1 expression than those with AML-PR or AML-NR(P<0.05).VEGF and TGFβ1 expression in patients with AML was significantly correlated with the counts of leukocytes,platelets,hemoglobin,and peripheral blood immature cells(P<0.05);Kaplan-Meier survival analysis revealed that patients with high TGFβ1 expression had better OS and DFS than those with low TGFβ1 expression(P<0.05),whereas patients with low VEGF levels showed better OS and DFS than those with high VEGF levels(P<0.05).VEGF,TGFβ1,and platelet count were identified by the Cox proportional hazards model as independent risk factors for OS(P<0.05),while VEGF,TGFβ1,and white blood cell count were independent risk factors for DFS(P<0.05).CONCLUSION Decreased VEGF expression and increased TGFβ1 expression in patients with AML provide valuable references for determining and individualizing clinical treatment strategies.

Correlation and Path Analysis for Growth Traits in F_1 Population of Pearl Oyster Pinctada martensii

120 pearl oysters （Pinctada martensii） were randomly sampled from F1 population, and shell length, shell width, shell height, shell weight and total weight of each sample were measured. Correlation and path analysis were conducted on the basis of measurement data. The results showed that shell length, shell width, shell height, shell weight and total weight were significantly correlated （P 〈 0.05）. Total weight was significantly and positively correlated with shell weight （r = 0.8970）, shell height （r = 0.6974）, shell width （r = 0.6521） and shell length （r = 0.5486）. Shell weight, shell height, shell width and shell length had positive and direct effects on total wet weight, with the values of 0.6356, 0.1872, 0.1814 and 0.0599, respectively. The results indicated that growth traits （shell length, shell width, shell height, shell weight and total wet weigh） of the F1 population could be improved by direct or indirect selection.

DNA甲基化转移酶1表达水平与急性髓系白血病临床特征的相关性

目的 探讨DNA甲基化转移酶1(DNMT1)在急性髓系白血病(AML)患者中的表达水平,并分析其与临床特征和分子突变的相关性。方法 本研究纳入34例初诊AML患者和17例复发/难治(R/R)AML患者,另选取同时期50例健康体检的正常受试者作为对照组。通过逆转录聚合酶链反应(RT-PCR)、蛋白质印迹法(WB)和免疫组织化学染色法,检测了样本中DNMT1的表达水平,并评估了其与临床特征及分子突变的关联。结果 初诊AML组、R/R AML组患者组中DNMT1的表达水平显著高于对照组(F=226.385, P<0.05)。DNMT1表达水平与复发状态、年龄、血红蛋白计数、外周血原始细胞比例、DNMT3A突变、RAS突变和NPM1突变呈正相关(β>0),而与白细胞计数、血小板计数、骨髓原始细胞比例、FLT3突变、IDH1突变和TP53突变呈负相关(β<0)。多因素分析显示,复发状态是DNMT1表达水平的独立危险因素(OR=132.497,95%CI=2.053~8 550.566,P=0.022)。结论 DNMT1的表达水平与AML患者的复发状态、临床参数和分子突变密切相关,可作为AML的潜在生物标志物和治疗靶点。

基于1-bit压缩感知非凸算法的平面ECT图像重建

为提高平面电容成像系统的成像质量并提高重建速度,提出了一种基于1-bit压缩感知(1-bit CS)非凸算法的平面ECT图像重建方法。首先,利用离散余弦基(DCT)对灰度值进行稀疏表示;其次,引入极大极小凹惩罚(MCP)作为正则化项,并建立1-bit CS MCP正则化模型;然后,通过MCP非凸算法迭代更新对偶解的近端算子,以求取最优对偶解;最后,根据对偶解求出重建灰度值并进行图像重建。仿真与实验结果表明,相比于Tikhonov算法、Landweber算法及传统压缩感知算法,所提方法得到的重建图像平均相对误差和相关系数分别为0.0496和0.9435,平均重建时间约为0.1723 s,均优于其他3种算法,缺陷还原度及重建速度有明显提升。

ADSL, AMPD1, and ATIC Expression Levels in Muscle and Their Correlations with Muscle Inosine Monophosphate Content in Dapulian and Hybridized Pig Species

We investigated the relationship between muscle inosine monophosphate (IMP) content and mRNA levels of ADSL, AMPD1, and ATIC in Dapulian (DPL), Landrace × Dapulian (LDPL), and Duroc × Landrace × Dapulian (DLDPL) hybridized pigs. Methods: The total RNA in longissimus dorsi was isolated from Dapulian (DPL), Landrace × Dapulian (LDPL) and Duroc × Landrace × Dapulian (DLDPL) hybridized pigs, weighed about 95.0 kg, n = 8/species. The internal genes with highest stability (YWHAZ and RPL4) were chosen from 11 common internal genes using Quantitative real-time PCR (qPCR) and geNorm software. The mRNA levels of ADSL, AMPD1 and ATIC genes were corrected with YWHAZ and RPL4 genes. The muscular IMP content was determined by HPLC. The muscular IMP content in DPL was higher than that in LDPL and DLDPL, 25.00% (p 0.05) and 15.56% (p > 0.05), respectively. The muscular mRNA level of ADSL gene in DPL and LDPL was higher than that in DLDPL, 24.14% and 12.07%, respectively (p 0.05). The muscular mRNA level of ATIC gene in DPL and LDPL was higher than that in DLDPL, 66.67% and 33.33%, respectively (p 0.05). The muscular mRNA level of AMPD1 gene in DPL and LDPL was higher than that in DLDPL, 14.49% and 33.26%, respectively. Furthermore, the IMP content was positively correlated with the mRNA level of ADSL, AMPD1 and ATIC genes, respectively (p 0.05). The mRNA level of ADSL gene was highly related to that of AMPD1 and ATIC gene, respectively (p 0.01), while that of AMPD1 gene was not strongly correlated with that of ATIC gene (p > 0.05). The muscular mRNA level of AMPD1, ADSL and ATIC genes and the muscular IMP content in DPL were highest, followed by those in LDPL and DLDPL. The muscular IMP content was positively correlated with the muscular mRNA level of ADSL, AMPD1 and ATIC genes, respectively.

Study the Biochemical Correlation of Insulin Resistance with HbA1c and Sex Hormones in NIDDM Patients/Meisan-Iraq

Objective: The association between type 2 diabetes mellitus and certain endocrine disorders has the paucity of information and limited data in the province of Meisan (southern of Iraq). Hence, in the present study, an attempt was made to investigate the levels of plasma HbA1c, serum insulin resistance and levels of serum sex hormones in men and women of control and type 2 diabetic patients. Also, the present study aimed to explored the correlation coefficient (r) between insulin resistance and level of HbA1c, FSH, LH, Tt, progesterone and estradiol in men and women patients with NIDDM. Methods: One hundred Iraqi volunteers with abdominal obesity were selected in the present study. Fifty diabetic patients with NIDDM (26 men, and 24 women) aged between (37) and (65) years and 50 healthy individuals (25 men, and 25 women) aged between (36) and (65) years considered as control group. Complete medical history was taken from each subject and complete clinical examinations were performed for all volunteers. Then, the two groups were matched for their fasting blood sugar, BMI, insulin hormone;c-peptide, HbA1c, sex hormones and insulin resistance parameters (HOMA2-IR, HOMA%B and HOMA%S) were calculated using HOMA2 calculator software. Results: We found that insulin resistance demonstrated negative correlations (p 0.05) with levels of serum follicle stimulating hormone (FSH), luteinizing hormone (LH), total testosterone, progesterone and estradiol. While, there was a positive and significant correlation (p 0.01) with value of HbA1c in men and women NIDDM patients. Conclusion: We conclude that an increase in the level of insulin resistance is associated with increased level of blood HbA1c and decreased in level of serum sex hormones (FSH, LH, Tt, E2 and progesterone) in men and women of diabetic group. These behaviors might suggest that insulin resistance can be used as a potential biomarker for predicting dysfunction of sex hygiene in NIDDM patients in addition to glycemic control.

采用1-bit压缩感知的信号识别网络黑盒对抗攻击方法

在无线信号识别的神经网络对抗样本研究中,针对目标网络结构参数与数据集均未知,且查询无法获取识别置信度或识别结果的黑盒攻击场景,提出一种采用1-bit压缩感知的对抗样本生成方法。假设攻击者能够通过查询获取某一批信号样本在待攻击模型下的识别准确率。首先,将模型准确率的梯度视为待感知的稀疏变量,并利用一批样本准确率高于或低于另一批的信息(用1或-1表示)构建1-bit压缩感知模型。其次,通过多次查询并估计梯度,结合0范数约束,使用梯度下降法迭代优化信号扰动,从而生成有效的对抗样本。最后,使用对抗样本攻击目标网络以降低识别准确率。实验结果表明,该方法在公开信号调制识别数据集上能够将识别准确率从79.02%降低至65.39%。相比于现有其他方法,该方法进一步拓展了黑盒攻击的限制条件。

Correlation between the Expression of Aquaporin 1 and Hypoxia-inducible Factor 1 in Breast Cancer Tissues

The correlation between aquaporin 1 （AQP1） and hypoxia-inducible factor 1 （HIF 1） in breast cancer tissues was preliminarily studied. In 155 cases of breast cancer, the expression levels of AQP1 were detected by immunohistochemisty in HIFl-positive group or HIFl-negative group, and the correlation between AQP1 and HIF1 was analyzed. The overexpression of AQP1 and HIF1 were observed in 155 cases of breast cancer tissues. The expression level of AQP1 in HIFl-positive group was significantly higher than that in HIFl-negative group. The positive expression rate of AQP1 was 296.55±24.67 and 168.37±37.53 in HIFl-positive group and HIFl-negative group respectively with the difference being very significant between them （P〈0.001）. It was concluded that AQP1 was overexpressed in the HIFl-positive group and there were some correlations between AQP1 and HIF1, suggesting they interact each other and regulate the oncogenesis of breast cancer.

TESTING OF CORRELATION AND HETEROSCEDASTICITY IN NONLINEAR REGRESSION MODELS WITH DBL(p,q,1) RANDOM ERRORS

Chaos theory has taught us that a system which has both nonlinearity and random input will most likely produce irregular data. If random errors are irregular data, then random error process will raise nonlinearity （Kantz and Schreiber （1997））. Tsai （1986） introduced a composite test for autocorrelation and heteroscedasticity in linear models with AR（1） errors. Liu （2003） introduced a composite test for correlation and heteroscedasticity in nonlinear models with DBL（p, 0, 1） errors. Therefore, the important problems in regression model axe detections of bilinearity, correlation and heteroscedasticity. In this article, the authors discuss more general case of nonlinear models with DBL（p, q, 1） random errors by score test. Several statistics for the test of bilinearity, correlation, and heteroscedasticity are obtained, and expressed in simple matrix formulas. The results of regression models with linear errors are extended to those with bilinear errors. The simulation study is carried out to investigate the powers of the test statistics. All results of this article extend and develop results of Tsai （1986）, Wei, et al （1995）, and Liu, et al （2003）.

Dual-parameter Correlation Analysis of the Fluorescence Data of 1-Methyl-2-formyl-5-substituted Pyrrole(4-nitrophenyl)hydrazones

By using 1-methyl-2-formyl-5 -Y-substituted pyrrole (4-nitrophenyl)hydrazones as a model for nitrogen-containing heterocyclic aromatic compounds, the emission wavelength [lambda(max(em))] values df their fluorescence spectra have been measured. Correlation results show that the Delta E-em values are mainly affected by polar effects, but spin-delocalizatin effects also exist.

No Correlation between <i>AVPR</i>1A Promoter Polymorphisms and Prepulse Inhibition in Patients with Nocturnal Enuresis

Introduction: A correlation between AVPR1A promoter polymorphisms and prepulse inhibition (PPI) of startle reflexes has been described in healthy adults. Many children with nocturnal enuresis (NE) have a reduced PPI and treatment with desamino arginine vasopressin (dDAVP), a ligand of the arginine vasopressin receptor 1A (AVPR1A), and both improve clanical symptoms and significantly increase PPI. Methods: In 17 children (median 9.1 years, range 6.4-17.3) with NE, promoter repeats within the RS1 and RS3 regions of AVPR1A were quantified and correlated to PPI (native and age-adjusted). Results: No direct correlation was found between the number of promoter repeats at RS1 and PPI (correlation coefficient—0.240, p = 0.346) or RS3 and PPI (correlation coefficient—0.0192, p = 0.936), with no change through age-adjustment of PPI. The different RS3 length subgroups did not show differences in PPI, nor did differentiation of NE according to clinical subtype or treatment response to dDAVP show differences in the number of promoter repeats. Conclusion: The missing reproducibility of the correlation between AVPR1A promoter polymorphisms and PPI in a group with wide range of PPI suggests a more complex interaction. Therefore, further investigations are needed to analyze this very plausible interaction. Conditions with a reduced PPI, such as enuresis, schizophrenia or autism, are particularly interesting for this research.

Positive Correlation between PMS2 Deficiency and PD-L1 Expression in Pancreatic Cancer

Background: Pancreatic cancer is one of the most lethal types of cancer, and immunotherapy has become a promising remedy with advancements in tumor immunology. However, predicting the clinical response to immunotherapy in pancreatic cancer remains a dilemma for clinicians. Methods: GEPIA database was used to analyze the differential expression of MMR and PD-L1 genes in 33 common cancer types including pancreatic cancer. The expression levels of MMR and PD-L1 genes were downloaded from the GEPIA and GEO databases to analyze the correlation between MMR genes and PD-L1, and the clinicopathological and survival information were downloaded from the TCGA databases to analyze the relationship between the expression of MMR, PD-L1 and clinicopathological characteristics, prognosis. Meanwhile, the tumor tissue samples of 41 patients with pancreatic cancer were collected, and the protein expression levels of MMR and PD-L1 were detected by immunohistochemical assay. Furthermore, we analyzed the correlation between MMR and PD-L1, and the correlation between the expression of MMR, PD-L1 and clinicopathological characteristics, prognosis of pancreatic cancer patients. Results: Bioinformatics analysis showed that MLH1, MLH3, MSH2, MSH3, and PMS2 were highly expressed in most cancer types including pancreatic cancer (P P = 0.012), clinical stage (I vs II: P = 0.016), MSH2 expression was related to clinical stage (P < 0.05), T stage (T3 vs T4: P = 0.039), and MSH3 expression was related to T stage (P < 0.05). Besides, both MSH2 expression (P P = 0.044) were significantly associated with prognosis. GEPIA data also showed that MSH2 expression was related to prognosis (P = 0.008). The correlation analysis revealed that the expressions MSH2, MLH1, PMS2 had strong correlations with PD-L1 both in GEPIA and GEO databases. Real-world data indicated that of the 41 pancreatic cancer patients, 5 cases had MLH1 deletion, 5 cases had MSH2 deletion, 4 cases had PMS2 deletion, and 12 cases had PD-L1 positive expression. Notably, PMS2 deletion was associated with PD-L1 positive expression (P = 0.035). In addition, MLH1 was related to clinical stage (P = 0.033), age (P = 0.048), and MSH2 was related to clinical stage (P = 0.033). However, MLH1 (P = 0.697), MSH2 (P = 0.956), PMS2 (P = 0.341), and PD-L1 (P = 0.734) appeared to have no impact on overall survival among patients with pancreatic cancer. Conclusion: Both bioinformatics and real-world data showed that there were correlation between PMS2 deletion and PD-L1 expression, and correlation between MLH1, MSH2 and clinical stage.

结直肠腺癌组织PRRX1蛋白表达及其与微卫星不稳定性的关系分析

目的探讨结直肠腺癌组织配对相关同源框1(PRRX1)蛋白表达及其与微卫星不稳定性(MSI)的关系。方法回顾性分析本院2020年10月至2022年12月收治的168例结直肠腺癌患者的临床资料,均于术中留取结直肠腺癌组织与癌旁正常组织(距癌≥5cm)。采用免疫组织化学法检测结直肠腺癌组织和相应癌旁正常组织中PRRX1蛋白表达,并分析PRRX1蛋白表达与临床病理特征的关系。采用PCR法检测结直肠腺癌组织MSI情况,并将其分为微卫星高度不稳定(MSI-H)、微卫星低度不稳定(MSI-L)、微卫星稳定(MSS)3组,比较PRRX1蛋白在3组中.的表达情况。采用Spearman分析结直肠腺癌患者PRRX1蛋白表达与MSI的关系。结果结直肠腺癌组织中PRRX1蛋白阳性表达率高于癌旁正.常组织(P<005)。低分化、临床分期为Ⅲ+Ⅳ期、淋巴结转移患.者的PRRX1蛋白阳性表.达率高于中高分化、临.床分期为Ⅰ+Ⅱ期、无淋巴结转移患者(P<005)。16.8例结直肠腺癌患者中,经检测判定为MSS120例(7143%),MSI-H28例.(1667%).,MSI-L20例(1190%);MSI-H组PRRX1阳性表达率高于MSS组(P<005);经Spearman分析结果显示,PRRX1蛋白表达与MSI呈正相关(r=0568,P=0023)。结论PRRX1蛋白在结直肠腺癌组织中高表达,与患者肿瘤分化程度、临床分期、是否存在淋巴结转移有关,且与患者MSI的发生密切相关。

血清LRG1及FGF-21水平与新生血管性青光眼的相关性

目的:探讨血清富亮氨酸α-2糖蛋白1(LRG1)、成纤维细胞生长因子21(FGF-21)水平与新生血管性青光眼(NVG)的相关性。方法:选取2020-09/2022-09本院眼科收治的110例110眼NVG患者为NVG组(Ⅱ级23例、Ⅲ级44例、Ⅳ级43例),性别、年龄相匹配的白内障患者90例90眼为对照组。ELISA检测血清中LRG1、FGF-21、血管内皮生长因子(VEGF)、色素上皮衍生因子(PEDF)及肿瘤坏死因子-α(TNF-α)水平;Pearson相关性分析血清LRG1、FGF-21水平与Teich分级、VEGF、PEDF、TNF-α水平的相关性。结果:NVG组与对照组相比,血清LRG1、FGF-21、VEGF、PEDF、TNF-α水平显著升高(均P<0.01)。随着Teich分级的增加,NVG患者血清LRG1、FGF-21、VEGF、PEDF、TNF-α水平依次显著升高(均P<0.05)。NVG患者血清中LRG1、FGF-21水平与VEGF、PEDF、TNF-α水平呈正相关(均P<0.05)。结论:NVG患者血清LRG1、FGF-21水平显著升高,与VEGF、PEDF及TNF-α水平正相关,二者可能与NVG的发生有关。

5-羟色胺内皮素-1和炎症因子与卵圆孔未闭相关偏头痛患者临床指标相关性分析

目的:分析5-羟色胺(5-HT),内皮素-1(ET-1)和炎症因子与卵圆孔未闭(PFO)相关偏头痛患者临床指标相关性研究。方法:选取2020年8月至2023年11月在本院接受治疗的120例PFO相关偏头痛患者(PFO组,n=120)。根据偏头痛严重程度分为轻度组(n=62)和重度组(n=58),另选同期在本院健康体检且无PFO偏头痛史的志愿者为对照组(n=60)。收集PFO偏头痛患者的临床资料,比较血清5-HT、ET-1、肿瘤坏死因子-α(TNF-α),降钙素原(PCT),C-反应蛋白(CRP)水平。多因素Logistic回归分析影响PFO相关偏头痛的危险因素。通过受试者工作特征(ROC)曲线来评估血清5-HT、ET-1、TNF-α、PCT、CRP水平对PFO偏头痛患者的预测能力。结果:PFO组血清5-HT水平低于对照组(P<0.05),PFO组血清ET-1、TNF-α、PCT和CRP水平高于对照组(P<0.05)。多因素Logistic回归分析显示,血清ET-1、TNF-α、PCT和CRP水平均影响PFO相关偏头痛的危险因素,5-HT是PFO相关偏头痛的保护因素(P<0.05)。ROC曲线分析结果,血清5HT、ET-1、TNF-α、PCT和CRP诊断PFO相关偏头痛的AUC分别为0.799、0.741、0.751、0.835、0.739(P<0.05)。基于血清5-HT、ET-1、TNF-α、PCT和CRP建立logistic回归模型,logit(P)=-0.087(5-HT)+0.162(ET-1)+0.085(TNF-α)+0.061(PCT)+0.129(CRP)-21.253。联合诊断的AUC为0.934,敏感度为86.21%,特异性为90.32%(P<0.05)。结论:血清5-HT、ET-1、TNF-α、PCT和CRP水平与PFO相关偏头痛的严重程度密切相关,其联合检测能够明显提高诊断准确性,为临床评估和治疗提供重要参考。

Expression of DLK1 protein and its correlation with renal cell carcinoma pathological characteristics

Objective To identify the expression of DLK1 protein in different types of renal cell carcinomas and its correlations with pathological characteristics and metastasis. Methods Immunohistochemistry analysis was performed to evaluate the expression of DLK1 protein in

胃癌组织S1PR1、STING、FBLN5表达水平与病理特征的相关性

目的:分析胃癌组织1-磷酸神经鞘氨醇受体(S1PR1)、干扰素基因刺激因子(STING)、扣针蛋白5(FBLN5)表达水平与病理特征的相关性。方法:回顾性分析2019年6月至2022年6月该院收治的102例胃癌患者的临床资料,采集患者胃癌组织及癌旁组织标本切片,检测S1PR1、STING、FBLN5的阳性率。比较胃癌组织、癌旁组织和不同临床病理特征胃癌患者S1PR1、STING、FBLN5的阳性率。结果:胃癌组织S1PR1、FBLN5阳性率高于癌旁组织,STING阳性率低于癌旁组织,差异均有统计学意义(P<0.05);临床分期Ⅲ~Ⅳ期、低分化程度、淋巴结转移等胃癌患者S1PR1、FBLN5阳性率均高于临床分期Ⅰ~Ⅱ期、中高分化程度、无淋巴结转移胃癌患者,差异有统计学意义(P<0.05);临床分期Ⅲ~Ⅳ期、低分化程度、淋巴结转移胃癌患者STING阳性率均低于临床分期Ⅰ~Ⅱ期、中高分化程度、无淋巴结转移胃癌患者,差异有统计学意义(P<0.05)。结论:胃癌组织S1PR1、FBLN5阳性率高于癌旁组织,STING阳性率低于癌旁组织,三者表达水平均与病理特征密切相关。

1-Bit压缩感知盲重构算法

1-Bit压缩感知(CS)是压缩感知理论的一个重要分支。该领域中二进制迭代硬阈值(BIHT)算法重构精度高且一致性好,是一种有效的重构算法。该文针对BIHT算法重构过程需要信号稀疏度为先验信息的问题,提出一种稀疏度自适应二进制迭代硬阈值算法,简称为SABIHT算法。该算法修正了BIHT算法,首先通过自适应过程自动调节硬阈值参数,然后利用测试条件估计信号的稀疏度,最终实现不需要确切信号稀疏度的1-Bit压缩感知盲重构。理论分析和仿真结果表明,该算法较好地实现了未知信号稀疏度的精确重建,并且与BIHT算法相比重构精度及算法复杂度均相当。

基于阵列域大尺度衰落模型的1-bit大规模MIMO系统性能的分析

该文研究在阵列域大尺度衰落模型下,基站端天线仅仅配备了1-bit精度的模数转换器时大规模MIMO系统的性能。首先给出了系统采用最大比合并接收机时,用户上行可达速率的闭式表达式。然后分析了1-bit系统的功率效率性能,并将该1-bit系统与传统的具有无穷精度模数转换器的系统性能相比较。通过计算机仿真验证了该文的分析结果。该文指出基站端可以安装更多的天线来弥补1-bit精度的模数转换器所造成的性能损失。

基于ICC色彩管理的1-bit TIFF在数码打样中的应用

以胶印印刷样张为仿真打样对象,建立标准ICC Profile文件,推导了印刷系统与数码打样系统之间的色域映射关系,并反馈到数码打样系统中进行修正,重新进行色域匹配和二次验证,确保了印刷样张与数码样张的一致性。结果表明,通过选择性校色对打样ICC Profile特征文件进行编辑校正,能将色差降低到打样的要求,且RIP后打样能模拟出龟纹、补露白等,提高了印刷追样的可行性。