Synthesis of 2-deoxy-2-chloro-1-amino sugars and evaluation of their cytotoxicity against cancer cells

Using the potent anticancer agent 2-deoxy-2-chloro-1-amino sugar as a lead compound, its analogs were prepared in 6 steps starting from D-glucal. The key step was the synthesis of 2-chloro-1-acetamido sugars using （COCl） 2-AgNO 3-CH 3 CN system in high yields. 2-Deoxy-2-chloro-1-amino sugars were obtained by treating the corresponding acetamido sugars with HCl in MeOH. All the compounds, including the reference compound, displayed almost no cytotoxic activity to the selected cancer cell lines.

Asymmetric total synthesis of (+)-1-deoxy-6-epi-castanospermine

(+)-l-Deoxy-6-epi-castanospermine was asymmetrically synthesized in ten steps from a-furfuryl amine derivative 6 in 2.9% overall yield. The kinetic resolution of a-furfuryl mine derivative 6 and Sharpless AD reaction of 14 were used as key steps.

披针叶茴香果实的化学成分研究

目的研究八角科（Illiciaceae）植物披针叶茴香（Illicium lanceolatum）果实的化学成分。方法应用硅胶、Sephadex LH-20、MCI等各种色谱技术进行分离纯化，根据化合物的理化常数和波谱数据鉴定其结构。结果从披针叶茴香果实的体积分数95％乙醇提取物中分离得到12个化合物，通过渡谱数据和理化常数分别鉴定为2，4-dihydroxy—allylbenzene-2-O-β-D—glucopyranoside（1），（＋）-儿茶素（2），槲皮素-3-O-β-L-鼠李糖苷（3），芦丁（4），异鼠李素-3-D-β-D-芸香糖苷（5），6-deoxy-1-hy—droxy neoanisatin（6），莽草毒素（7），icarisideE3（8），（75，8R）-urolignoside（9），对羟基苯甲酸（10），莽草酸（11），β-谷甾醇（12）。结论化合物1，4～6，8～10为首次从该植物中分离得到。