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原发性干燥综合征患者外周血Th17细胞及CXCL13检测及其临床意义 被引量:6
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作者 王柏山 《国际检验医学杂志》 CAS 2018年第14期1705-1707,1711,共4页
目的探讨原发性干燥综合征(pSS)患者外周血Th17细胞和趋化因子CXCL13检测的应用价值及其在疾病发生、发展中的作用机制。方法选取该院73例临床确认原发性干燥综合征患者作为pSS组,40例健康体检者作为对照组。由专科医师对pSS患者进行干... 目的探讨原发性干燥综合征(pSS)患者外周血Th17细胞和趋化因子CXCL13检测的应用价值及其在疾病发生、发展中的作用机制。方法选取该院73例临床确认原发性干燥综合征患者作为pSS组,40例健康体检者作为对照组。由专科医师对pSS患者进行干燥综合征疾病活动指数(ESSDAI)评分。采用流式细胞方法检测Th17细胞,酶联免疫吸附实验法检测CXCL13水平,免疫透射比浊法检测免疫球蛋白(IgG、IgM、IgA)。结果 pSS组患者外周血Th17细胞、CXCL13、IgG、IgM及IgA水平高于对照组,差异有统计学意义(P<0.01)。pSS组中,ESSDAI评分结果与Th17细胞、CXCL13、IgG呈正相关(r=0.58、0.66、0.48),且外周血Th17细胞与CXCL13水平呈正相关,差异有统计学意义(r=0.45,P<0.05)。结论原发性干燥综合征患者血液中Th17细胞、CXCL13水平及IgG检测有助于疾病活动性的判断;Th17细胞、趋化因子CXCL13在pSS的发生发展过程中发挥重要的作用。 展开更多
关键词 原发性干燥综合征 干燥综合征疾病活动指数 th17细胞 趋化因子CXCL13
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Th17细胞、IL-17和MMP-13在过敏性紫癜发病机制中的作用 被引量:12
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作者 侯小芳 夏海龙 《中国实验血液学杂志》 CAS CSCD 北大核心 2018年第5期1502-1506,共5页
目的:通过测定过敏性紫癜(Henoch-Schonlein purpura,HSP)患者急性期外周血中Th17细胞、IL-17、基质金属蛋白酶-13(matrix metalloproteinase-13,MMP-13)的水平以及患者皮损处IL-17的表达,探讨HSP的免疫学发病机制。方法:应用流式细胞术... 目的:通过测定过敏性紫癜(Henoch-Schonlein purpura,HSP)患者急性期外周血中Th17细胞、IL-17、基质金属蛋白酶-13(matrix metalloproteinase-13,MMP-13)的水平以及患者皮损处IL-17的表达,探讨HSP的免疫学发病机制。方法:应用流式细胞术(Flow Cytometry,FCM)检测HSP组和健康对照组外周血中Th17细胞比例;双抗体夹心酶联免疫吸附(ELISA)法检测上述研究对象血浆中IL-17和MMP-13的浓度;免疫组织化学法检测HSP组皮损组织和健康对照组皮肤组织IL-17的表达情况。结果:HSP组急性期外周血中Th17细胞比例为(1.21±0.59)%,明显高于对照组的(0.71±0.26)%(t=4.907,P <0.01);HSP组急性期血浆中IL-17和MMP-13浓度分别为(64.58±36.21)pg/ml和(17.57±5.40)ng/ml,均明显高于对照组的(26.16±14.90)pg/ml和(11.55±4.40)ng/ml(t=6.183,P <0.01和t=5.022,P <0.01);HSP组皮损组织中IL-17的免疫组织化学积分光密度值为(7.26±2.34),非常显著高于对照组的(4.61±1.82)(t=2.877,P <0.01)。结论:Th17细胞、IL-17以及MMP-13有可能参与过敏性紫癜的发病过程。 展开更多
关键词 过敏性紫癜 th17细胞 IL-17 MMP-13
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Ubc13对胶原诱导性关节炎小鼠体内Treg/Th17平衡的影响研究 被引量:1
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作者 任路路 韩蓉 +2 位作者 郭音 范阔海 姜俊兵 《中国免疫学杂志》 CAS CSCD 北大核心 2019年第11期1300-1304,共5页
目的:研究重组泛素结合酶2N(Ubc13)蛋白对胶原诱导性关节炎(CIA)模型小鼠体内调节性T细胞(Treg)和辅助性T细胞17(Th17)平衡的影响。方法:小鼠随机分为空白对照组(空白组),CIA模型对照组(模型组),CIA+5 μg Ubc13组(低剂量组),CIA+25 μg... 目的:研究重组泛素结合酶2N(Ubc13)蛋白对胶原诱导性关节炎(CIA)模型小鼠体内调节性T细胞(Treg)和辅助性T细胞17(Th17)平衡的影响。方法:小鼠随机分为空白对照组(空白组),CIA模型对照组(模型组),CIA+5 μg Ubc13组(低剂量组),CIA+25 μg Ubc13组(中剂量组),CIA+50 μg Ubc13组(高剂量组)。模型组与Ubc13各剂量组小鼠第0天尾根部皮下注射胶原,第21天加强免疫,建立CIA模型。第21天开始Ubc13各剂量组分别每天皮下注射Ubc13重组蛋白,模型组注射等体积生理盐水。二次免疫56 d后,剖解小鼠,取小鼠脾淋巴细胞,流式细胞术检测Treg细胞和Th17细胞数目,实时定量PCR(qRT-PCR)检测小鼠脾脏维甲酸相关受体c(RORc)、白介素23(IL-23)、叉头转录因子p3(Foxp3)和白介素17(IL-17)mRNA水平,HE染色鉴定小鼠关节病理特征。结果: Ubc13能显著提高小鼠Treg细胞在Th细胞中的比率( P <0.05),并改善关节炎症。与模型组相比,Ubc13各剂量组脾脏中IL-23、IL-17和RORγt的表达量显著降低( P <0.05),HE染色显示Ubc13各组小鼠关节损伤均显著减轻。结论:皮下注射Ubc13可通过增加CIA模型小鼠体内Treg的数量,降低Th17细胞相关基因的表达,改善CIA小鼠关节炎。 展开更多
关键词 Ubc13 CIA小鼠 外周T淋巴细胞 Treg/th17平衡 流式细胞术
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丹酚酸B通过抑制IL-13/STAT6通路和恢复Th17/Treg平衡阻滞大鼠慢性阻塞性肺病研究 被引量:3
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作者 张莉 何达 席俊峰 《广西医科大学学报》 CAS 2021年第10期1893-1899,共7页
目的:探究丹酚酸B对慢性阻塞性肺病的作用及其可能的机制。方法:将40只SD大鼠随机分为对照组、模型组、丹酚酸B组和阳性对照组,每组10只。除对照组外,其余组大鼠采用烟熏联合气管内滴注脂多糖法建立慢阻肺大鼠模型。丹酚酸B组和阳性对... 目的:探究丹酚酸B对慢性阻塞性肺病的作用及其可能的机制。方法:将40只SD大鼠随机分为对照组、模型组、丹酚酸B组和阳性对照组,每组10只。除对照组外,其余组大鼠采用烟熏联合气管内滴注脂多糖法建立慢阻肺大鼠模型。丹酚酸B组和阳性对照组腹腔注射丹酚酸B(50 mg/kg)和地塞米松(0.2 mg/kg),其余组注射生理盐水。AniRes2005动物肺功能分析系统检测各大鼠肺功能改变;大鼠肺水肿情况使用大鼠肺组织湿/干重比(W/D)检测;HE染色检测大鼠肺组织病理学变化;AB-PAS染色检测各组大鼠肺组织杯状细胞增生;免疫组化检测大鼠肺组织MUC5AC表达;Western blotting检测大鼠肺组织MUC5AC、RORγt、Foxp3和IL-13/STAT6通路中IL-13蛋白和STAT6(p-STAT6/STAT6)磷酸化水平;ELISA检测肺泡灌洗液(BALF)中TNF-α、TGF-β、IL-6、IL-10和IL-17A水平。结果:与对照组相比,模型组、丹酚酸B组和阳性对照组大鼠肺功能明显降低(P<0.05),W/D比值、肺组织病理学评分、AB/PAS阳性率明显升高(P<0.05),MUC5AC、RORγt、IL-13和p-STAT6/STAT6表达明显升高(P<0.05),肺泡灌洗液(BALF)中TNF-α、TGF-β、IL-6和IL-17A水平明显升高(P<0.05),Foxp3表达和IL-10水平明显降低(P<0.05);而与模型组相比,丹酚酸B组和阳性对照组大鼠肺功能明显改善(P<0.05),W/D比值、肺组织病理学评分、AB/PAS阳性率显著下降(P<0.05),MUC5AC、RORγt、IL-13和p-STAT6/STAT6表达明显降低(P<0.05),TNF-α、TGF-β、IL-6和IL-17A水平明显降低,Foxp3表达和IL-10水平明显升高(P<0.05)。结论:丹酚酸B可能通过抑制IL-13/STAT6通路和恢复Th17/Treg平衡对慢阻肺大鼠发挥保护作用。 展开更多
关键词 丹酚酸B 大鼠慢性阻塞性肺病 IL-13/STAT6通路 th17/Treg平衡
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类风湿关节炎患者血清IL-13水平表达及对外周血单个核细胞中Th17细胞亚群分化的影响 被引量:5
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作者 李长超 柴艳梅 +3 位作者 刘丹 周成 陈蓉 黄文峰 《陕西医学杂志》 CAS 2021年第2期197-200,共4页
目的:探讨类风湿关节炎(RA)患者血清IL-13表达及对RA患者外周血单个核细胞(PBMC)中Th17细胞亚群分化的影响。方法:通过酶联免疫吸附试验(ELISA)检测活动期RA患者(活动组,n=30)、稳定期RA患者(稳定组,n=30)和健康体检者(正常组,n=30)外... 目的:探讨类风湿关节炎(RA)患者血清IL-13表达及对RA患者外周血单个核细胞(PBMC)中Th17细胞亚群分化的影响。方法:通过酶联免疫吸附试验(ELISA)检测活动期RA患者(活动组,n=30)、稳定期RA患者(稳定组,n=30)和健康体检者(正常组,n=30)外周血血清白细胞介素-13(IL-13)表达水平,分析血清IL-13水平与RA疾病活动评分(DAS-28)、红细胞沉降率(ESR)及C反应蛋白(CRP)的相关性;提取RA患者和健康体检者PBMC(设为对照组),分离纯化人CD4^+T细胞并用IL-13分组干预,采用ELISA和RT-PCR方法检测其上清和细胞中IL-17A表达水平。结果:①相比正常组,RA患者血清IL-13表达显著升高(P<0.001),其表达水平与DAS28评分、ESR和CRP呈正相关(均P<0.001);②RA患者CD4^+T细胞经重组人白细胞介素13(rhIL-13)刺激后其上清中IL-17A蛋白及mRNA表达均显著降低(均P<0.001)。结论:IL-13表达水平与RA患者疾病严重程度和免疫炎性反应密切相关,可能通过抑制RA患者CD4^+T细胞向Th17分化减少IL-17A分泌而控制RA发展。 展开更多
关键词 类风湿关节炎 th17细胞 白细胞介素-13 疾病严重程度 免疫炎性反应 相关性
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UBC13对支气管哮喘模型小鼠Th2、Th17型细胞极化的影响
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作者 郭音 孟维金 +1 位作者 孙健康 姜俊兵 《中国畜牧兽医》 CAS 北大核心 2020年第4期1148-1155,共8页
试验旨在探究UBC13蛋白对支气管哮喘小鼠体内Th2、Th17细胞极化的影响。18只BALB/c小鼠随机均分为3组:PBS组、哮喘模型(OVA)组和UBC13蛋白(UBC13)组,OVA组和UBC13组采用卵清蛋白(OVA)和脂多糖(LPS)进行致敏和雾化建立哮喘模型,其中UBC1... 试验旨在探究UBC13蛋白对支气管哮喘小鼠体内Th2、Th17细胞极化的影响。18只BALB/c小鼠随机均分为3组:PBS组、哮喘模型(OVA)组和UBC13蛋白(UBC13)组,OVA组和UBC13组采用卵清蛋白(OVA)和脂多糖(LPS)进行致敏和雾化建立哮喘模型,其中UBC13组于每次雾化前0.5 h腹腔注射100μg UBC13蛋白。末次雾化激发24 h后处死小鼠,采集样品,通过HE染色观察肺脏切片病理学变化、PAS染色观察气道黏液的分泌,ELISA法检测血清IgE浓度和肺支气管肺泡灌洗液(BALF)上清中IL-4、IL-5和IL-17A的水平,实时荧光定量PCR法检测肺脏Th2型相关因子IL-4、IL-5、IL-13、IFN-γmRNA和Th17型细胞因子IL-1β、IL-6、IL-17A、IL-23 mRNA的相对表达量。结果显示,试验成功建立了哮喘模型,与PBS组相比,OVA组IgE浓度极显著上升(P<0.01),肺脏病理切片炎性细胞浸润和中性黏液分泌现象明显,肺脏中IL-1β、IL-4、IL-6、IL-13和IL-17A mRNA相对表达量均极显著升高(P<0.01),IL-5和IL-23 mRNA相对表达量显著升高(P<0.05),IFN-γmRNA相对表达量极显著下降(P<0.01),BALF中IL-4、IL-5和IL-17A的水平极显著上升(P<0.01);与OVA组相比,UBC13组IgE浓度显著降低(P<0.05),病理切片炎性细胞浸润现象减轻、黏液分泌减少,肺脏IL-1β、IL-4、IL-17A、IL-13和IL-23 mRNA相对表达量均显著下降(P<0.05),IFN-γmRNA相对表达量显著升高(P<0.05);IL-6 mRNA相对表达量极显著下降(P<0.01),BALF中IL-5的水平极显著下降(P<0.01),IL-4的水平显著下降(P<0.05),IL-17A的水平无显著差异(P>0.05)。由此可见,UBC13蛋白能下调Th2和Th17型细胞因子的表达量,影响哮喘模型Th2和Th17细胞的极化。 展开更多
关键词 UBC13 支气管哮喘 th2型细胞 th17型细胞
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Study on Objectives and Strategies for Energy Conservation and Emission Reduction in Transportation Industry during the 13th Five-Year Plan Period in Beijing
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作者 Ying Liu Xiaoyi Li Jun Yang 《Journal of Transportation Technologies》 2017年第3期304-317,共14页
Facing increasing passenger and cargo transport demand and limited re-source in the 13th Five-Year period, how to make a breakthrough and substantial progress has become a key issue on planning and the Top-level Desig... Facing increasing passenger and cargo transport demand and limited re-source in the 13th Five-Year period, how to make a breakthrough and substantial progress has become a key issue on planning and the Top-level Design. In this paper we judged and analyzed the current development and potential demand of the energy saving and emission reduction in Beijing traffic industry. Through application of energy and emission prediction model which based on the vehicle activity data, the development goals of “one drop, double control, and triple upgrade” have been put forward. In order to achieve the goal, “5 + 1” development strategies should be implemented, and we also proposed the thinking and recommendations on sustainable development of transportation. 展开更多
关键词 Transport Energy SAVING and EMISSION Reduction 13th Five-Year PLAN Prediction Model Development Goals and Strategy
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Small Town Construction in the 13th Five-Year Plan Period: A Case Study of Shangrao City
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作者 Kun YANG Xifeng SHENG 《Asian Agricultural Research》 2016年第10期101-104,共4页
The 12 th Five-Year Plan period was unusual five years in the development of China. Under the dual pressure of complex international environment and arduous domestic reform task,China made outstanding achievements in ... The 12 th Five-Year Plan period was unusual five years in the development of China. Under the dual pressure of complex international environment and arduous domestic reform task,China made outstanding achievements in economic development,which lays a solid foundation for building a moderately prosperous society in all respects in the 13 th Five-Year Plan period. The key and difficult points of building a moderately prosperous society in all respects lie in solving issues concerning agriculture,farmers,and rural areas. The 18 th National Congress of the CPC stated that integrated urban and rural development is the fundamental approach for solving issues concerning agriculture,farmers,and rural areas. As a transitional form from rural areas to urban areas,small town play an important role in integrated urban and rural development. In the 13 th Five-Year Plan period,China should take a new road of characteristic urbanization,energetically develop key towns,central towns,and characteristic towns,use points to drive areas,and promote coordinated progress of urbanization construction and new countryside construction. Focusing on the objective of building a moderately prosperous society in all respects and taking Shangrao City as an example,we analyzed construction of small town,in order to provide scientific theoretical reference for urbanization development,plan preparation,and policy formulation of Shangrao City. 展开更多
关键词 13th Five-Year Plan period Small town construction Shangrao City
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CCPIT Briefed Press about the 13th China-LAC Business Summit
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《China's Foreign Trade》 2019年第3期2-3,共2页
CCPIT Chairperson Gao Yan said,the 13th China-LAC Business Summit will be held from December 9 to 11 in Panama City.The summit will focus on Belt and Road cooperation between China and Latin America.With the theme of... CCPIT Chairperson Gao Yan said,the 13th China-LAC Business Summit will be held from December 9 to 11 in Panama City.The summit will focus on Belt and Road cooperation between China and Latin America.With the theme of“Deepening Belt and Road Cooperation Between China-LAC for Common Development and Prosperity”.The forum will explore more opportunities for China-LAC cooperation in the areas of infrastructure,finance,trade,services and the development of SMEs,and promote steady development and prosperity of the two sides. 展开更多
关键词 China LAC CCPIT Briefed PRESS ABOUT the 13th China-LAC BUSINESS SUMMIT
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Basic Ideas and Principles for the Development of Graduate Education During "the 13th Five-Year Plan"
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作者 Yiying Liu 《Review of Educational Theory》 2018年第2期40-43,共4页
"The 13th Five-Year Plan", referring to the period from 2016 to 2020, marks a decisive stage in building moderately prosperous society of China. During "the 13th Five-Year Plan", the demand of Chin... "The 13th Five-Year Plan", referring to the period from 2016 to 2020, marks a decisive stage in building moderately prosperous society of China. During "the 13th Five-Year Plan", the demand of China's graduate education is increasing. Therefore, the development of graduate education during "the 13th Five-Year Plan" must meet the needs of the development of China's economy. By strictly adhering to the basic principle of steady development and deepening reform, improve the integral level of graduate education across the board to better provide high-level talents for the development of China's socialism. This paper, starting from the general situation of graduate education during "the 12th Five-year Plan", discusses basic ideas and principles for the development of graduate education during "the 13th Five-Year Plan" for reference only. 展开更多
关键词 "the 13th Five-Year Plan" GRADUATE education Basic ideas and PRINCIPLES
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The 13th China-ASEAN Business and Investment Summit Opened in Nanning
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《China's Foreign Trade》 2016年第5期2-,共1页
The China ASEAN Business and Investment Summit opened in Nanning,capital city of China’s southern Guangxi Zhuang autonomous region on September 11,along with the 13th China-ASEAN Expo.Chinese Vice-Premier Zhang Gaoli... The China ASEAN Business and Investment Summit opened in Nanning,capital city of China’s southern Guangxi Zhuang autonomous region on September 11,along with the 13th China-ASEAN Expo.Chinese Vice-Premier Zhang Gaoli delivered a keynote speech at the opening ceremony of the summit.He said,the ASEAN-China dialogue relations. 展开更多
关键词 ASEAN the 13th China-ASEAN Business and Investment Summit Opened in Nanning
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Western China Development During 13th Five-Year Plan Period:Poverty Alleviation and Green Development
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《Ecological Economy》 2016年第4期384-385,共2页
The 12th Annual Conference of the Consortium for Western China Development Studies July,2017Gui-An New District,CHINABackground Since its establishment in 2004,the Consortium for Western China Development Studies(CWCD... The 12th Annual Conference of the Consortium for Western China Development Studies July,2017Gui-An New District,CHINABackground Since its establishment in 2004,the Consortium for Western China Development Studies(CWCDS)has organized nine conferences on vari- 展开更多
关键词 Office TEL Western China Development During 13th Five-Year Plan Period
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Address by the UN High Commissioner for Human Rights Ms. Louise Arbour at the Opening Ceremony of the 13th Annual Workshop of the Framework on Regional Cooperation for the Promotion and Protection of Human Rights in the Asia-Pacific Region 被引量:1
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作者 Louise Arbour 《The Journal of Human Rights》 2005年第6期4-6,共3页
关键词 Louise Arbour at the Opening Ceremony of the 13th Annual Workshop of the Framework on Regional Cooperation for the Promotion and Protection of Human Rights in the Asia-Pacific Region Address by the UN High Commissioner for Human Rights Ms Asia UN
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Eight Highlights in 13th China (Humen) International Fashion Fair
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《China Textile》 2008年第11期42-43,共2页
Currently, it has been learned from the Humen Fashion Fair Organizing Committee that the 13th China (Humen) International Fashion Fair (hereafter referred to the Fair for short) to be held from Nov.
关键词 International Fashion Fair Eight Highlights in 13th China Humen MMS
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The 13th China International MMF Conference: How to be more environmental-friendly?
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作者 Wang Ting 《China Textile》 2007年第10期8-9,共2页
On September 13-14th, the 13th China International Man-made Fiber Conference (Ke Qiao 2007) was held in the county of Ke Qiao, Shaoxing County, Zhejiang Province of China,
关键词 MMF the 13th China International MMF Conference How to be more environmental-friendly MORE
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The 13th Humen International Fashion Fair The View of a Gorgeous Back
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《China Textile》 2008年第12期44-45,共2页
Cheerful songs and passionate dance bring out the best of all. In a sea of harvest celebration, the 13th Humen International Fashion Fair concluded with a complete success.During only 5 days from Nov. 21 to 25, the fa... Cheerful songs and passionate dance bring out the best of all. In a sea of harvest celebration, the 13th Humen International Fashion Fair concluded with a complete success.During only 5 days from Nov. 21 to 25, the famous fashion city Humen became a 展开更多
关键词 OVER the 13th Humen International Fashion Fair the View of a Gorgeous Back VIEW
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13-14世纪的丝路与布料文化——以“纳石失”为主要考察对象
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作者 邱栋容 《湖州师范学院学报》 2023年第11期28-36,共9页
13—14世纪可谓“蒙古治世”(pax mongolica)。在此时期,丝绸之路上各国的物质往来呈现出空前的繁荣,东西方文化的互动与碰撞也日益频繁。蒙古作为当时的权力中心,其喜好与倾向更是具有世界性的影响。布料自汉代以来便是在丝路上的珍贵... 13—14世纪可谓“蒙古治世”(pax mongolica)。在此时期,丝绸之路上各国的物质往来呈现出空前的繁荣,东西方文化的互动与碰撞也日益频繁。蒙古作为当时的权力中心,其喜好与倾向更是具有世界性的影响。布料自汉代以来便是在丝路上的珍贵通货。沿丝路传入中国西域的波斯布料“纳石失”,在13—14世纪备受元代蒙古贵族喜爱。“纳石失”在中国境内的风靡,使其于14世纪又被意大利的商人、旅行家携至欧洲,成为皇家、贵族、教会中精英人士的流行服饰。 展开更多
关键词 13—14世纪 丝绸之路 纳石失 鞑靼布
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肝硬化患者血清Th1/Th2细胞因子水平变化及临床意义
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作者 张佳豪 吴佩玲 +2 位作者 兰宇航 万苹 李娅琳 《转化医学杂志》 2023年第4期175-179,共5页
目的探讨Th1/Th2细胞因子在肝硬化发生、发展及早期筛查中的作用和临床意义。方法收集2019年9月—2020年3月收治的25例肝硬化作为病例组,同时选取31例健康人作为对照组,比较2组血清Th1型细胞因子白细胞介素-2、干扰素-γ(IFN-γ)、肿瘤... 目的探讨Th1/Th2细胞因子在肝硬化发生、发展及早期筛查中的作用和临床意义。方法收集2019年9月—2020年3月收治的25例肝硬化作为病例组,同时选取31例健康人作为对照组,比较2组血清Th1型细胞因子白细胞介素-2、干扰素-γ(IFN-γ)、肿瘤坏死因子-α水平,以及Th2型细胞因子白细胞介素-4、白细胞介素-6(IL-6)、白细胞介素-10和白细胞介素-13(IL-13)水平差异,并分析细胞因子与肝功能指标的相关性,采用多因素Logistic回归分析探讨细胞因子对肝硬化发生的影响,采用受试者工作特征(ROC)曲线分析细胞因子对肝硬化的诊断价值和保护效能。结果病例组血清天冬氨酸转氨酶(AST)、γ-谷氨酰转肽酶(GGT)、总胆红素(TBIL)、IFN-γ、IL-6水平高于对照组,血清白蛋白(ALB)、IL-13水平低于对照组(P<0.05,P<0.01)。肝硬化患者血清IFN-γ与GGT呈负相关(P<0.05);血清IL-13与TBIL呈正相关(P<0.01);血清IL-6与ALB呈负相关,而与Child-Pugh分级评分呈正相关(P<0.05,P<0.01)。IFN-γ是肝硬化发生的独立危险因素,而IL-13是保护因素(P<0.01)。血清IFN-γ对肝硬化诊断价值的曲线下面积(AUC)为0.750,血清IL-13对肝硬化保护效能的AUC为0.794。结论肝硬化患者血清IFN-γ、IL-6水平升高及IL-13水平降低与肝功能损伤相关,对肝硬化的临床诊断和治疗有指导意义。 展开更多
关键词 肝硬化 th1细胞 th2细胞 白细胞介素-2 干扰素-Γ 白细胞介素-6 白细胞介素-13 诊断
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The Reincarnation of the 13th Dalai Lama
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《China's Tibet》 1995年第S1期26-28,共3页
TheReincarnationofthe13thDalaiLama¥OnMay17,1995,thespokesmanoftheStateCouncilissuedastatementthattheDalai'sc... TheReincarnationofthe13thDalaiLama¥OnMay17,1995,thespokesmanoftheStateCouncilissuedastatementthattheDalai'schoiceofthereincar... 展开更多
关键词 the Reincarnation of the 13th Dalai Lama
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An Inference of the Temperature in the 13th Century of China
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作者 张德二 《中国气象科学研究院年报》 1994年第0期100-102,共3页
ANINFERENCEOFTHETEMPERATUREINTHE13THCENTURYOFCHINAZhangDe’e(张德二)CenterforClimaticResearchEXTENDEDABSTRACTSin... ANINFERENCEOFTHETEMPERATUREINTHE13THCENTURYOFCHINAZhangDe’e(张德二)CenterforClimaticResearchEXTENDEDABSTRACTSincethethermaloptim... 展开更多
关键词 An Inference of the Temperature in the 13th Century of China
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