雌酮、17β－雌二醇与17α－乙炔基雌二醇在污水样中的稳定性研究

雌酮(E1)、雌二醇(E2)和炔雌醇(EE2)在ng.L-1的浓度水平即可干扰生物的内分泌系统,在英国即将被限制排放。论文研究了在三种水样保存方式下污水厂进水和尾水中E1,E2和EE2浓度的变化。研究显示:(A)在4℃,避光保存,三种雌激素在进水样中降解率为22%、34%和4%;在尾水样中则分别为14%、26%和2%。(B)在4℃避光及pH=2(英国环保署常规有机污染物保存方法)保存条件下,E1、E2和EE2在2天内在进水样中的损失率为8%、20%和4%;在尾水样中的损失率分别为4%、17%和1%。(C)在水样中加入Cu(NO3)2抑制剂至250mg.L-1并用HCl调节至pH=3在低于10℃避光保存,可保证E1、E2和EE2在15天内损失<3%。采用方式C保存水样有利于提高分析检测E1、E2和EE2的准确度和重现性。

β-17雌二醇对小鼠腹腔巨噬细胞的影响

向小鼠腹部皮下注入20μg β-17雌二醇后,小鼠腹腔巨噬细胞数量增加,吞噬功能及形成EAC花环能力增强。试验结果表明β-17雌二醇具有增强体内单核吞噬细胞系统的功能的特性,妊娠期间小鼠腹腔巨噬细胞(Mφ)增多、功能活跃的现象在某种程度上受雌激素的影响。

Competitive sorption between 17α-ethinyl estradiol and bisphenol A/4-n-nonylphenol by soils

The sorption of 17α-ethinyl estradiol （EE2）, bisphenol A （BPA）, and 4-n-nonylphenol （NP） in single systems and the sorption of EE2 with different initial aqueous concentrations of BPA or NP were examined using three soils. Results showed that all sorption isotherms were nonlinear and fit the Freundlich model. The degree of nonlinearity was in the order BPA （0.537-0.686） 〉 EE2 （0.705-0.858） 〉 NP （0.875-0.0.951） in single systems. The isotherm linearity index of EE2 sorption calculated by the Freundlich model for Loam, Silt Loam and Silt increased from 0.758, 0.705 and 0.858, to 0.889, 0.910 and 0.969, respectively, when BPA concentration increased from 0 to 1000 μg/L, but the effect of NP was comparably minimal. Additionally, EE2 significantly suppressed the sorption of BPA, but insignificantly suppressed that of NE These findings can be attributed to the difference of sorption affinity of EE2, NP and BPA on the hard carbon （e.g., black carbon） of soil organic matter that dominated the sorption in the low equilibrium aqueous concentration range of endocrine-disrupting chemicals （EDCs）. Competitive sorption among EDCs presents new challenges for predicting the transport and fate of EDCs under the influence of co-solutes.

牦牛发情规律及外周血孕酮、17-β雌二醇水平

牦牛发情集中在7月中旬至9月下旬。发情周期平均20.95±5.13d。发情持续时间在24h以内的占69%超过1d的占31%最长可达96h。发情率为66.7%(n=225),其中空怀牛和带犊牛分别为92.1%和50%。未带犊牛发情期17-β雌二醇平均为231±100pg/mL,黄体期孕酮平均为0.43±0.07ng/mL。每日挤乳1次的带犊牛,孕酮及17-β二醇分别为0.26±0.08ng/mL和61±26.0pg/mL。