The microstructure of the 18R-type long period stacking ordered （LPSO） phase in Mg 97 Y 2 Zn 1 alloy was investigated by the first principles calculation. The arrangement rule of Zn and Y atoms in the LPSO structure...The microstructure of the 18R-type long period stacking ordered （LPSO） phase in Mg 97 Y 2 Zn 1 alloy was investigated by the first principles calculation. The arrangement rule of Zn and Y atoms in the LPSO structure is determined theoretically. The calculation results reveal that the additive atoms are firstly located in the fault layers at the two ends of the 18R-type LPSO structure, and then extend to fault layers in the interior, which is in good agreement with the experimental observations. This feature also implies the microstructural relationship between 18R and other LPSO structures. The cohesive energy and the formation heat indicate the dependence of the stability of 18R LPSO structure on contents of Y and Zn atoms. The calculated electronic structures reveal the underlying mechanism of microstructure and the stability of 18R LPSO structure.展开更多
The microstructural evolution of a 18R single phase （S 18） alloy during annealing at 773 K for 100 h was investigated in order to reveal the formation mechanism of 14H phase. The results showed that the as-cast S 18...The microstructural evolution of a 18R single phase （S 18） alloy during annealing at 773 K for 100 h was investigated in order to reveal the formation mechanism of 14H phase. The results showed that the as-cast S 18 alloy was composed of 18R phase （its volume fraction exceeds 93%）, W particles and α-Mg phase. The 18R phase in S18 alloy was thermally stable and was not transformed into 14H long period stacking ordered （LPSO） phase during annealing. However, 14H lamellas formed within tiny α-Mg slices, and their average size and volume fraction increased with prolonging annealing time. Moreover, the 14H phase is nucleated within α-Mg independently on the basis of basal stacking faults （SFs）. The broadening growth of 14H lamellas is an interface-controlled process which involves ledges on basal planes, while the lengthening growth is a diffusion-controlled process and is associated with diffusion of solute atoms. The formation mechanism of 14H phase in this alloy could be explained as α-Mg＇→α-Mg＋14H.展开更多
The motion of intervariant intedeces under the action of applied stress in the internally faulted 18R martensite in a Cu-Zn-Al shape memory alloy has been studied. Transmission electron microscopy in situ observations...The motion of intervariant intedeces under the action of applied stress in the internally faulted 18R martensite in a Cu-Zn-Al shape memory alloy has been studied. Transmission electron microscopy in situ observations show that the interfaces between 24 martensite variants have different reaction to applied stress. The A/C type and A/B type interfaces have good mobil-ity, the A/D type interface has bad mobiIity, and the different-group-intervariant interfaces are basically immobile.展开更多
AIM To investigate the antitumor effects and underlying mechanisms of(17 R,18 R)-2-(1-hexyloxyethyl)-2-devinyl chlorine E6 trisodium salt(YLG-1)-induced photodynamic therapy(PDT) on pancreatic cancer in vitro and in v...AIM To investigate the antitumor effects and underlying mechanisms of(17 R,18 R)-2-(1-hexyloxyethyl)-2-devinyl chlorine E6 trisodium salt(YLG-1)-induced photodynamic therapy(PDT) on pancreatic cancer in vitro and in vivo.METHODS YLG-1 is a novel photosensitizer extracted from spirulina. Its phototoxicity, cellular uptake and localization, as well as its effect on reactive oxygen species(ROS) production, apoptosis, and expression of apoptosis-associated proteins were detected in vitro. An in vivo imaging system(IVIS), the Lumina K imaging system, and mouse models of subcutaneous Panc-1-bearing tumors were exploited to evaluate the drug delivery pathway and pancreatic cancer growth in vivo.RESULTS YLG-1 was localized to the mitochondria, and the appropriate incubation time was 6 h. Under 650 nm light irradiation, YLG-1-PDT exerted a potent cytotoxic effect on pancreatic cancer cells in vitro, which could be abolished by the ROS scavenger N-acetyl-L-cysteine(NAC). The death mode caused by YLG-1-PDT was apoptosis, accompanied by upregulated Bax and cleaved Caspase-3 and decreased Bcl-2 expression. The results from the IVIS images suggested that the optimal administration route was intratumoral(IT) injection and that the best time to conduct YLG-1-PDT was 2 h post-IT injection. Consistent with the results in vitro, YLG-1-PDT showed great growth inhibition effects on pancreatic cancer cells in a mouse model.CONCLUSION YLG-1 is a potential photosensitizer for pancreatic cancer PDT via IT injection, the mechanisms of which are associated with inducing ROS and promoting apoptosis.展开更多
Detailed crystallographic analysis has been undertaken on the various combinations Of 24 martensite variants in the 18R martensite of a Cu-Zn-Al shape memory alloy. Based upon the calculated crystallographic data, the...Detailed crystallographic analysis has been undertaken on the various combinations Of 24 martensite variants in the 18R martensite of a Cu-Zn-Al shape memory alloy. Based upon the calculated crystallographic data, the interface energy of different twin interfaces was calculated using a lowangle-grain-interface model. For the variant/variant pairs in a self-accommodating group. the A/C type and A/B type interfaces have low interface energy, and A/D type interface is an intermediate one. In contrast, the intervariant interfaces that belong to different plate groups have high intrface energy. The calculated results are consiStent with the previous observations of the mobility of intervariant interfaces.展开更多
To reduce distribution transformer losses and carbon dioxide emissions, in recent years, the major countries in the world have issued mandatory standards for high-energy efficiency in distribution transformers. In 201...To reduce distribution transformer losses and carbon dioxide emissions, in recent years, the major countries in the world have issued mandatory standards for high-energy efficiency in distribution transformers. In 2013,China has carried out a new standard GB 20052-2013. To meet the update of the standard and energy efficiency,it is important to enhance the magnetic properties of core materials. The new products B18R065 and B20R070 which are developed by Baosteel, are successfully used for grade 1 energy efficiency distribution transformers. And Baosteel becomes one of the companies which can supply both the 0.20 mm and the 0.18 mm gauge grain oriented electrical steels （GOES） in the world. The development principle, material properties, and transformer performance of B18R065 and B20R070 were introduced,which were expected to be a useful reference for materials selection by transformer manufacturers.展开更多
本文采用高性能的Discovery Studio 2021(DS2018R2)大分子计算模拟软件,在RCSB PDB数据库中调用蛋白质文件建立其立体结构,应用ZDOCK程序算法探究IL-18亚基(AB亚基或B亚基)与IL-18R相互作用的空间结构与构象变化,计算找到了相互作用界...本文采用高性能的Discovery Studio 2021(DS2018R2)大分子计算模拟软件,在RCSB PDB数据库中调用蛋白质文件建立其立体结构,应用ZDOCK程序算法探究IL-18亚基(AB亚基或B亚基)与IL-18R相互作用的空间结构与构象变化,计算找到了相互作用界面的氨基酸的一级序列与二级结构以及它们之间的相互作用力,并用拉氏图评估对接构象,研究发现B亚基在IL-18与IL-18R的结合中起主要作用。该计算方法与实验方法比较,可快速找到蛋白-蛋白相互作用的构象空间,优化膜蛋白相互作用的精度,其能从原子与量子水平探究细胞因子与膜蛋白受体的相互作用,其数据精确定量,有助于更深入解析分子机理。本文应用ZDOCK算法建立了通过计算模拟膜蛋白生物大分子相互作用的新领域,为细胞因子与化学因子的多肽类药物开发提供新的思路,为细菌病毒感染/肿瘤疾病的防治提供科学理论依据,在分子识别、神经元网络深度学习、生物信息处理领域具有广泛的应用。展开更多
基金Projects(50861002,51071053)supported by the National Natural Science Foundation of ChinaProject(0991051)supported by NaturalScience Foundation of Guangxi Province,China+1 种基金Project(KF0803)supported by Open Project of Key Laboratory of Materials Design and Preparation Technology of Hunan Province,ChinaProject(X071117)supported by Scientific Research Foundation of Guangxi University,China
文摘The microstructure of the 18R-type long period stacking ordered （LPSO） phase in Mg 97 Y 2 Zn 1 alloy was investigated by the first principles calculation. The arrangement rule of Zn and Y atoms in the LPSO structure is determined theoretically. The calculation results reveal that the additive atoms are firstly located in the fault layers at the two ends of the 18R-type LPSO structure, and then extend to fault layers in the interior, which is in good agreement with the experimental observations. This feature also implies the microstructural relationship between 18R and other LPSO structures. The cohesive energy and the formation heat indicate the dependence of the stability of 18R LPSO structure on contents of Y and Zn atoms. The calculated electronic structures reveal the underlying mechanism of microstructure and the stability of 18R LPSO structure.
基金Project(BK20160869)supported by the Natural Science Foundation of Jiangsu Province,ChinaProject(GY12015009)supported by the Nantong Science and Technology Program,China+1 种基金Project(2015B01314)supported by the Fundamental Research Funds for the Central Universities,ChinaProject(51501039)supported by the National Natural Science Foundation of China
文摘The microstructural evolution of a 18R single phase （S 18） alloy during annealing at 773 K for 100 h was investigated in order to reveal the formation mechanism of 14H phase. The results showed that the as-cast S 18 alloy was composed of 18R phase （its volume fraction exceeds 93%）, W particles and α-Mg phase. The 18R phase in S18 alloy was thermally stable and was not transformed into 14H long period stacking ordered （LPSO） phase during annealing. However, 14H lamellas formed within tiny α-Mg slices, and their average size and volume fraction increased with prolonging annealing time. Moreover, the 14H phase is nucleated within α-Mg independently on the basis of basal stacking faults （SFs）. The broadening growth of 14H lamellas is an interface-controlled process which involves ledges on basal planes, while the lengthening growth is a diffusion-controlled process and is associated with diffusion of solute atoms. The formation mechanism of 14H phase in this alloy could be explained as α-Mg＇→α-Mg＋14H.
基金supported by Chongqing Talent Plan:Leading Talents in Innovation and Entrepreneurship,China(No.CQYC201903051)University Innovation Research Group of Chongqing,China(No.CXQT20023)+4 种基金Qingnian Project of Science and Technology Research Program of Chongqing Municipal Education Commission,China(No.KJQN202001106)China Postdoctoral Science Foundation(No.2021M700556)Natural Science Foundation of Chongqing,China(No.cstc2021jcyj-bsh X0114)Natural Science Foundation of China(Nos.U20A20234,51874062)Chongqing Foundation and Advanced Research Project,China(No.cstc2019jcyj-zdxm X0010)。
文摘The motion of intervariant intedeces under the action of applied stress in the internally faulted 18R martensite in a Cu-Zn-Al shape memory alloy has been studied. Transmission electron microscopy in situ observations show that the interfaces between 24 martensite variants have different reaction to applied stress. The A/C type and A/B type interfaces have good mobil-ity, the A/D type interface has bad mobiIity, and the different-group-intervariant interfaces are basically immobile.
基金Supported by National Natural Science Foundation of China,No.81472844
文摘AIM To investigate the antitumor effects and underlying mechanisms of(17 R,18 R)-2-(1-hexyloxyethyl)-2-devinyl chlorine E6 trisodium salt(YLG-1)-induced photodynamic therapy(PDT) on pancreatic cancer in vitro and in vivo.METHODS YLG-1 is a novel photosensitizer extracted from spirulina. Its phototoxicity, cellular uptake and localization, as well as its effect on reactive oxygen species(ROS) production, apoptosis, and expression of apoptosis-associated proteins were detected in vitro. An in vivo imaging system(IVIS), the Lumina K imaging system, and mouse models of subcutaneous Panc-1-bearing tumors were exploited to evaluate the drug delivery pathway and pancreatic cancer growth in vivo.RESULTS YLG-1 was localized to the mitochondria, and the appropriate incubation time was 6 h. Under 650 nm light irradiation, YLG-1-PDT exerted a potent cytotoxic effect on pancreatic cancer cells in vitro, which could be abolished by the ROS scavenger N-acetyl-L-cysteine(NAC). The death mode caused by YLG-1-PDT was apoptosis, accompanied by upregulated Bax and cleaved Caspase-3 and decreased Bcl-2 expression. The results from the IVIS images suggested that the optimal administration route was intratumoral(IT) injection and that the best time to conduct YLG-1-PDT was 2 h post-IT injection. Consistent with the results in vitro, YLG-1-PDT showed great growth inhibition effects on pancreatic cancer cells in a mouse model.CONCLUSION YLG-1 is a potential photosensitizer for pancreatic cancer PDT via IT injection, the mechanisms of which are associated with inducing ROS and promoting apoptosis.
文摘Detailed crystallographic analysis has been undertaken on the various combinations Of 24 martensite variants in the 18R martensite of a Cu-Zn-Al shape memory alloy. Based upon the calculated crystallographic data, the interface energy of different twin interfaces was calculated using a lowangle-grain-interface model. For the variant/variant pairs in a self-accommodating group. the A/C type and A/B type interfaces have low interface energy, and A/D type interface is an intermediate one. In contrast, the intervariant interfaces that belong to different plate groups have high intrface energy. The calculated results are consiStent with the previous observations of the mobility of intervariant interfaces.
文摘To reduce distribution transformer losses and carbon dioxide emissions, in recent years, the major countries in the world have issued mandatory standards for high-energy efficiency in distribution transformers. In 2013,China has carried out a new standard GB 20052-2013. To meet the update of the standard and energy efficiency,it is important to enhance the magnetic properties of core materials. The new products B18R065 and B20R070 which are developed by Baosteel, are successfully used for grade 1 energy efficiency distribution transformers. And Baosteel becomes one of the companies which can supply both the 0.20 mm and the 0.18 mm gauge grain oriented electrical steels （GOES） in the world. The development principle, material properties, and transformer performance of B18R065 and B20R070 were introduced,which were expected to be a useful reference for materials selection by transformer manufacturers.
文摘本文采用高性能的Discovery Studio 2021(DS2018R2)大分子计算模拟软件,在RCSB PDB数据库中调用蛋白质文件建立其立体结构,应用ZDOCK程序算法探究IL-18亚基(AB亚基或B亚基)与IL-18R相互作用的空间结构与构象变化,计算找到了相互作用界面的氨基酸的一级序列与二级结构以及它们之间的相互作用力,并用拉氏图评估对接构象,研究发现B亚基在IL-18与IL-18R的结合中起主要作用。该计算方法与实验方法比较,可快速找到蛋白-蛋白相互作用的构象空间,优化膜蛋白相互作用的精度,其能从原子与量子水平探究细胞因子与膜蛋白受体的相互作用,其数据精确定量,有助于更深入解析分子机理。本文应用ZDOCK算法建立了通过计算模拟膜蛋白生物大分子相互作用的新领域,为细胞因子与化学因子的多肽类药物开发提供新的思路,为细菌病毒感染/肿瘤疾病的防治提供科学理论依据,在分子识别、神经元网络深度学习、生物信息处理领域具有广泛的应用。
