This paper points out that a successful numerical simulation is to construct a correct conceptional model which is very dose to the natural condition. A new model, two dimensional coupled three dimensional model (2D -...This paper points out that a successful numerical simulation is to construct a correct conceptional model which is very dose to the natural condition. A new model, two dimensional coupled three dimensional model (2D -3D ) is presented in the Present paper,which is the most suitable one for the dual - structured - aquifer system. An example of Wenyinghu area is shown.By using the 2D-3D model, a satisfied result of the simulated area is achieved.展开更多
A convective and stratiform cloud classification method for weather radar is proposed based on the density-based spatial clustering of applications with noise(DBSCAN)algorithm.To identify convective and stratiform clo...A convective and stratiform cloud classification method for weather radar is proposed based on the density-based spatial clustering of applications with noise(DBSCAN)algorithm.To identify convective and stratiform clouds in different developmental phases,two-dimensional(2D)and three-dimensional(3D)models are proposed by applying reflectivity factors at 0.5°and at 0.5°,1.5°,and 2.4°elevation angles,respectively.According to the thresholds of the algorithm,which include echo intensity,the echo top height of 35 dBZ(ET),density threshold,andεneighborhood,cloud clusters can be marked into four types:deep-convective cloud(DCC),shallow-convective cloud(SCC),hybrid convective-stratiform cloud(HCS),and stratiform cloud(SFC)types.Each cloud cluster type is further identified as a core area and boundary area,which can provide more abundant cloud structure information.The algorithm is verified using the volume scan data observed with new-generation S-band weather radars in Nanjing,Xuzhou,and Qingdao.The results show that cloud clusters can be intuitively identified as core and boundary points,which change in area continuously during the process of convective evolution,by the improved DBSCAN algorithm.Therefore,the occurrence and disappearance of convective weather can be estimated in advance by observing the changes of the classification.Because density thresholds are different and multiple elevations are utilized in the 3D model,the identified echo types and areas are dissimilar between the 2D and 3D models.The 3D model identifies larger convective and stratiform clouds than the 2D model.However,the developing convective clouds of small areas at lower heights cannot be identified with the 3D model because they are covered by thick stratiform clouds.In addition,the 3D model can avoid the influence of the melting layer and better suggest convective clouds in the developmental stage.展开更多
γ-Aminobutyric acid（GABA）,plays a key role in all stages of life,also is considered the main inhibitory neurotransmitter.GABA activates two kind of membrane receptors known as GABAA and GABAB,the first one is respo...γ-Aminobutyric acid（GABA）,plays a key role in all stages of life,also is considered the main inhibitory neurotransmitter.GABA activates two kind of membrane receptors known as GABAA and GABAB,the first one is responsible to render tonic inhibition by pentameric receptors containing α4-6,β3,δ,or ρ1-3 subunits,they are located at perisynaptic and/or in extrasynaptic regions.The biophysical properties of GABAA tonic inhibition have been related with cellular protection against excitotoxic injury and cell death in presence of excessive excitation.On this basis,GABAA tonic inhibition has been proposed as a potential target for therapeutic intervention of Huntington＇s disease.Huntington＇s disease is a neurodegenerative disorder caused by a genetic mutation of the huntingtin protein.For experimental studies of Huntington＇s disease mouse models have been developed,such as R6/1,R6/2,Hdh Q92,Hdh Q150,as well as YAC128.In all of them,some key experimental reports are focused on neostriatum.The neostriatum is considered as the most important connection between cerebral cortex and basal ganglia structures,its cytology display two pathways called direct and indirect constituted by medium sized spiny neurons expressing dopamine D1 and D2 receptors respectively,they display strong expression of many types of GABAA receptors,including tonic subunits.The studies about of GABAA tonic subunits and Huntington＇s disease into the neostriatum are rising in recent years,suggesting interesting changes in their expression and localization which can be used as a strategy to delay the cellular damage caused by the imbalance between excitation and inhibition,a hallmark of Huntington＇s disease.展开更多
This paper focused on the effect of pre-strain on forming limit curves(FLC)of 5754-O aluminum alloy sheet through utilizing biaxial tensile approach.Based on Swift model and Yld2000-2 d yield criterion,the dimensions ...This paper focused on the effect of pre-strain on forming limit curves(FLC)of 5754-O aluminum alloy sheet through utilizing biaxial tensile approach.Based on Swift model and Yld2000-2 d yield criterion,the dimensions of cruciform specimen was optimized through applying finite element method for increasing the strain at specimen center.After that,with the recommended specimen size,the cruciform specimen was tested under various stroke ratios to experimentally characterize the limit strains under different pre-strain levels.Subsequently,the biaxial tensile tests were simulated by Abaqus to obtain the limit strains and validate the material models.It can be observed in both experiments and simulations that the pre-strained uniaxial tension followed by plane tension or equi-biaxial tension can improve the formability of sheet metals.Besides,the strain path change affects the trend of first derivative of strain rate difference between neighboring points with respect to time.An early increase occurred and then fell back to the stable value,the steady evolution continued until to a new increase reaching the critical value.The M–K prediction approach was simulated to verify the influence of pre-strain on FLC.It can be found that the early increase peaks of the major strain incremental ratio rose with the amplitude of pre-strain.Finally,the phenomenon of pseudolocalization caused by the strain path change was explained through evolution of stress state inside the groove.展开更多
文摘This paper points out that a successful numerical simulation is to construct a correct conceptional model which is very dose to the natural condition. A new model, two dimensional coupled three dimensional model (2D -3D ) is presented in the Present paper,which is the most suitable one for the dual - structured - aquifer system. An example of Wenyinghu area is shown.By using the 2D-3D model, a satisfied result of the simulated area is achieved.
基金funded by the Key-Area Research and Development Program of Guangdong Province(Grant No.2020B1111200001)the Key project of monitoring,early warning and prevention of major natural disasters of China(Grant No.2019YFC1510304)+1 种基金the S&T Program of Hebei(Grant No.19275408D)the Scientific Research Projects of Weather Modification in Northwest China(Grant No.RYSY201905).
文摘A convective and stratiform cloud classification method for weather radar is proposed based on the density-based spatial clustering of applications with noise(DBSCAN)algorithm.To identify convective and stratiform clouds in different developmental phases,two-dimensional(2D)and three-dimensional(3D)models are proposed by applying reflectivity factors at 0.5°and at 0.5°,1.5°,and 2.4°elevation angles,respectively.According to the thresholds of the algorithm,which include echo intensity,the echo top height of 35 dBZ(ET),density threshold,andεneighborhood,cloud clusters can be marked into four types:deep-convective cloud(DCC),shallow-convective cloud(SCC),hybrid convective-stratiform cloud(HCS),and stratiform cloud(SFC)types.Each cloud cluster type is further identified as a core area and boundary area,which can provide more abundant cloud structure information.The algorithm is verified using the volume scan data observed with new-generation S-band weather radars in Nanjing,Xuzhou,and Qingdao.The results show that cloud clusters can be intuitively identified as core and boundary points,which change in area continuously during the process of convective evolution,by the improved DBSCAN algorithm.Therefore,the occurrence and disappearance of convective weather can be estimated in advance by observing the changes of the classification.Because density thresholds are different and multiple elevations are utilized in the 3D model,the identified echo types and areas are dissimilar between the 2D and 3D models.The 3D model identifies larger convective and stratiform clouds than the 2D model.However,the developing convective clouds of small areas at lower heights cannot be identified with the 3D model because they are covered by thick stratiform clouds.In addition,the 3D model can avoid the influence of the melting layer and better suggest convective clouds in the developmental stage.
基金the programs for the postdoctoral fellowships-Chilean CONICYT-FONDECYT#3140218,Mexican CONACYT#164978 and DID-UACh S-2015-81Sistema Nacional de Investigadores#58512 to Abraham Rosas-Arellano+2 种基金supported by USACH PhD fellowshipsupported with a PhD fellowship from CONACYT(#299627)FONDECYT grants 1151206 and 1110571 to Maite A.Castro
文摘γ-Aminobutyric acid（GABA）,plays a key role in all stages of life,also is considered the main inhibitory neurotransmitter.GABA activates two kind of membrane receptors known as GABAA and GABAB,the first one is responsible to render tonic inhibition by pentameric receptors containing α4-6,β3,δ,or ρ1-3 subunits,they are located at perisynaptic and/or in extrasynaptic regions.The biophysical properties of GABAA tonic inhibition have been related with cellular protection against excitotoxic injury and cell death in presence of excessive excitation.On this basis,GABAA tonic inhibition has been proposed as a potential target for therapeutic intervention of Huntington＇s disease.Huntington＇s disease is a neurodegenerative disorder caused by a genetic mutation of the huntingtin protein.For experimental studies of Huntington＇s disease mouse models have been developed,such as R6/1,R6/2,Hdh Q92,Hdh Q150,as well as YAC128.In all of them,some key experimental reports are focused on neostriatum.The neostriatum is considered as the most important connection between cerebral cortex and basal ganglia structures,its cytology display two pathways called direct and indirect constituted by medium sized spiny neurons expressing dopamine D1 and D2 receptors respectively,they display strong expression of many types of GABAA receptors,including tonic subunits.The studies about of GABAA tonic subunits and Huntington＇s disease into the neostriatum are rising in recent years,suggesting interesting changes in their expression and localization which can be used as a strategy to delay the cellular damage caused by the imbalance between excitation and inhibition,a hallmark of Huntington＇s disease.
基金supported by the National Natural Science Foundation of China(Grant No.51875027)the China Postdoctoral Science Foundation(No.2018M630058)assistances of the program for the financial support。
文摘This paper focused on the effect of pre-strain on forming limit curves(FLC)of 5754-O aluminum alloy sheet through utilizing biaxial tensile approach.Based on Swift model and Yld2000-2 d yield criterion,the dimensions of cruciform specimen was optimized through applying finite element method for increasing the strain at specimen center.After that,with the recommended specimen size,the cruciform specimen was tested under various stroke ratios to experimentally characterize the limit strains under different pre-strain levels.Subsequently,the biaxial tensile tests were simulated by Abaqus to obtain the limit strains and validate the material models.It can be observed in both experiments and simulations that the pre-strained uniaxial tension followed by plane tension or equi-biaxial tension can improve the formability of sheet metals.Besides,the strain path change affects the trend of first derivative of strain rate difference between neighboring points with respect to time.An early increase occurred and then fell back to the stable value,the steady evolution continued until to a new increase reaching the critical value.The M–K prediction approach was simulated to verify the influence of pre-strain on FLC.It can be found that the early increase peaks of the major strain incremental ratio rose with the amplitude of pre-strain.Finally,the phenomenon of pseudolocalization caused by the strain path change was explained through evolution of stress state inside the groove.
