This paper points out that a successful numerical simulation is to construct a correct conceptional model which is very dose to the natural condition. A new model, two dimensional coupled three dimensional model (2D -...This paper points out that a successful numerical simulation is to construct a correct conceptional model which is very dose to the natural condition. A new model, two dimensional coupled three dimensional model (2D -3D ) is presented in the Present paper,which is the most suitable one for the dual - structured - aquifer system. An example of Wenyinghu area is shown.By using the 2D-3D model, a satisfied result of the simulated area is achieved.展开更多
In order to research the distribution of thermal field of low temperature discharge from LNG in the ocean, further to formulate reasonable wastewater marine disposal scheme and provide scientific support to the protec...In order to research the distribution of thermal field of low temperature discharge from LNG in the ocean, further to formulate reasonable wastewater marine disposal scheme and provide scientific support to the protection of ocean environment, a two-dimensional hydrodynamic model was used to simulate the tide current field in the radial sand ridge group of shallow sea area of Jiangsu maritime space. This model was based on the tide current characteristics near the LNG project and the seasonal design of the typical hydrological conditions in different seasons. This model was used as the hydrodynamic condition that simulated the transport and diffusion for the heat quantity in the change of time and spatial distribution. Considering the comprehensive heat radiation coefficient of water surface, the 2-D water temperature model was established to predict the spatial distribution and temporal variation of the temperature field in the receiving waters. Finally, results showed that the low temperature drainage less affected in the ocean water environment.展开更多
γ-Aminobutyric acid（GABA）,plays a key role in all stages of life,also is considered the main inhibitory neurotransmitter.GABA activates two kind of membrane receptors known as GABAA and GABAB,the first one is respo...γ-Aminobutyric acid（GABA）,plays a key role in all stages of life,also is considered the main inhibitory neurotransmitter.GABA activates two kind of membrane receptors known as GABAA and GABAB,the first one is responsible to render tonic inhibition by pentameric receptors containing α4-6,β3,δ,or ρ1-3 subunits,they are located at perisynaptic and/or in extrasynaptic regions.The biophysical properties of GABAA tonic inhibition have been related with cellular protection against excitotoxic injury and cell death in presence of excessive excitation.On this basis,GABAA tonic inhibition has been proposed as a potential target for therapeutic intervention of Huntington＇s disease.Huntington＇s disease is a neurodegenerative disorder caused by a genetic mutation of the huntingtin protein.For experimental studies of Huntington＇s disease mouse models have been developed,such as R6/1,R6/2,Hdh Q92,Hdh Q150,as well as YAC128.In all of them,some key experimental reports are focused on neostriatum.The neostriatum is considered as the most important connection between cerebral cortex and basal ganglia structures,its cytology display two pathways called direct and indirect constituted by medium sized spiny neurons expressing dopamine D1 and D2 receptors respectively,they display strong expression of many types of GABAA receptors,including tonic subunits.The studies about of GABAA tonic subunits and Huntington＇s disease into the neostriatum are rising in recent years,suggesting interesting changes in their expression and localization which can be used as a strategy to delay the cellular damage caused by the imbalance between excitation and inhibition,a hallmark of Huntington＇s disease.展开更多
By using the 2-D stratospheric-tropospheric dynamic-radiative-chemical coupled model,some sensitivity experiments have been done,which are interactions among ozone,radiation and temperature,vapor effects,as well as ef...By using the 2-D stratospheric-tropospheric dynamic-radiative-chemical coupled model,some sensitivity experiments have been done,which are interactions among ozone,radiation and temperature,vapor effects,as well as effects of source and sink.The result of temperature experiment shows that feedback interaction among ozone,radiation and temperature,mainly occurs in the upper and middle stratosphere,the maximum of ozone concentration decrease is 1 ppm,the maximum of temperature change is 6 K,and the maximum of total ozone change is 20 DU.From the experiment of water vapor,we can see that the area of the middle and high latitudes of the Northern Hemisphere is sensitive to vapor change.When the maximum difference between both surface sources is in the Antarctic,the maximum of ozone change is also there.Because the character of surface varies with latitude,dry deposition is different in different latitudes.The change of dry deposition makes ozone in boundary layer quite obvious,especially in both poles. The maximum change of total volume ozone in experiments of vapor,source and sink is more than 12 DU.展开更多
This paper focused on the effect of pre-strain on forming limit curves(FLC)of 5754-O aluminum alloy sheet through utilizing biaxial tensile approach.Based on Swift model and Yld2000-2 d yield criterion,the dimensions ...This paper focused on the effect of pre-strain on forming limit curves(FLC)of 5754-O aluminum alloy sheet through utilizing biaxial tensile approach.Based on Swift model and Yld2000-2 d yield criterion,the dimensions of cruciform specimen was optimized through applying finite element method for increasing the strain at specimen center.After that,with the recommended specimen size,the cruciform specimen was tested under various stroke ratios to experimentally characterize the limit strains under different pre-strain levels.Subsequently,the biaxial tensile tests were simulated by Abaqus to obtain the limit strains and validate the material models.It can be observed in both experiments and simulations that the pre-strained uniaxial tension followed by plane tension or equi-biaxial tension can improve the formability of sheet metals.Besides,the strain path change affects the trend of first derivative of strain rate difference between neighboring points with respect to time.An early increase occurred and then fell back to the stable value,the steady evolution continued until to a new increase reaching the critical value.The M–K prediction approach was simulated to verify the influence of pre-strain on FLC.It can be found that the early increase peaks of the major strain incremental ratio rose with the amplitude of pre-strain.Finally,the phenomenon of pseudolocalization caused by the strain path change was explained through evolution of stress state inside the groove.展开更多
文摘This paper points out that a successful numerical simulation is to construct a correct conceptional model which is very dose to the natural condition. A new model, two dimensional coupled three dimensional model (2D -3D ) is presented in the Present paper,which is the most suitable one for the dual - structured - aquifer system. An example of Wenyinghu area is shown.By using the 2D-3D model, a satisfied result of the simulated area is achieved.
文摘In order to research the distribution of thermal field of low temperature discharge from LNG in the ocean, further to formulate reasonable wastewater marine disposal scheme and provide scientific support to the protection of ocean environment, a two-dimensional hydrodynamic model was used to simulate the tide current field in the radial sand ridge group of shallow sea area of Jiangsu maritime space. This model was based on the tide current characteristics near the LNG project and the seasonal design of the typical hydrological conditions in different seasons. This model was used as the hydrodynamic condition that simulated the transport and diffusion for the heat quantity in the change of time and spatial distribution. Considering the comprehensive heat radiation coefficient of water surface, the 2-D water temperature model was established to predict the spatial distribution and temporal variation of the temperature field in the receiving waters. Finally, results showed that the low temperature drainage less affected in the ocean water environment.
基金the programs for the postdoctoral fellowships-Chilean CONICYT-FONDECYT#3140218,Mexican CONACYT#164978 and DID-UACh S-2015-81Sistema Nacional de Investigadores#58512 to Abraham Rosas-Arellano+2 种基金supported by USACH PhD fellowshipsupported with a PhD fellowship from CONACYT(#299627)FONDECYT grants 1151206 and 1110571 to Maite A.Castro
文摘γ-Aminobutyric acid（GABA）,plays a key role in all stages of life,also is considered the main inhibitory neurotransmitter.GABA activates two kind of membrane receptors known as GABAA and GABAB,the first one is responsible to render tonic inhibition by pentameric receptors containing α4-6,β3,δ,or ρ1-3 subunits,they are located at perisynaptic and/or in extrasynaptic regions.The biophysical properties of GABAA tonic inhibition have been related with cellular protection against excitotoxic injury and cell death in presence of excessive excitation.On this basis,GABAA tonic inhibition has been proposed as a potential target for therapeutic intervention of Huntington＇s disease.Huntington＇s disease is a neurodegenerative disorder caused by a genetic mutation of the huntingtin protein.For experimental studies of Huntington＇s disease mouse models have been developed,such as R6/1,R6/2,Hdh Q92,Hdh Q150,as well as YAC128.In all of them,some key experimental reports are focused on neostriatum.The neostriatum is considered as the most important connection between cerebral cortex and basal ganglia structures,its cytology display two pathways called direct and indirect constituted by medium sized spiny neurons expressing dopamine D1 and D2 receptors respectively,they display strong expression of many types of GABAA receptors,including tonic subunits.The studies about of GABAA tonic subunits and Huntington＇s disease into the neostriatum are rising in recent years,suggesting interesting changes in their expression and localization which can be used as a strategy to delay the cellular damage caused by the imbalance between excitation and inhibition,a hallmark of Huntington＇s disease.
文摘By using the 2-D stratospheric-tropospheric dynamic-radiative-chemical coupled model,some sensitivity experiments have been done,which are interactions among ozone,radiation and temperature,vapor effects,as well as effects of source and sink.The result of temperature experiment shows that feedback interaction among ozone,radiation and temperature,mainly occurs in the upper and middle stratosphere,the maximum of ozone concentration decrease is 1 ppm,the maximum of temperature change is 6 K,and the maximum of total ozone change is 20 DU.From the experiment of water vapor,we can see that the area of the middle and high latitudes of the Northern Hemisphere is sensitive to vapor change.When the maximum difference between both surface sources is in the Antarctic,the maximum of ozone change is also there.Because the character of surface varies with latitude,dry deposition is different in different latitudes.The change of dry deposition makes ozone in boundary layer quite obvious,especially in both poles. The maximum change of total volume ozone in experiments of vapor,source and sink is more than 12 DU.
基金supported by the National Natural Science Foundation of China(Grant No.51875027)the China Postdoctoral Science Foundation(No.2018M630058)assistances of the program for the financial support。
文摘This paper focused on the effect of pre-strain on forming limit curves(FLC)of 5754-O aluminum alloy sheet through utilizing biaxial tensile approach.Based on Swift model and Yld2000-2 d yield criterion,the dimensions of cruciform specimen was optimized through applying finite element method for increasing the strain at specimen center.After that,with the recommended specimen size,the cruciform specimen was tested under various stroke ratios to experimentally characterize the limit strains under different pre-strain levels.Subsequently,the biaxial tensile tests were simulated by Abaqus to obtain the limit strains and validate the material models.It can be observed in both experiments and simulations that the pre-strained uniaxial tension followed by plane tension or equi-biaxial tension can improve the formability of sheet metals.Besides,the strain path change affects the trend of first derivative of strain rate difference between neighboring points with respect to time.An early increase occurred and then fell back to the stable value,the steady evolution continued until to a new increase reaching the critical value.The M–K prediction approach was simulated to verify the influence of pre-strain on FLC.It can be found that the early increase peaks of the major strain incremental ratio rose with the amplitude of pre-strain.Finally,the phenomenon of pseudolocalization caused by the strain path change was explained through evolution of stress state inside the groove.
