Effect of electroacupuncture at Jiaji (EX-B2) points on the expression of microRNA-21 and neuronal apoptosis in rats with acute spinal cord injury

Objective:To observe the effect of electroacupuncture at Jiaji (EX-B2) points on the expression of microRNA-21 and neuronal apoptosis in rats with acute spinal cord injury. Methods:SD rats were randomly divided into sham-operated group, model group, electro-acupuncture group and methylprednisolone group. The model of acute spinal cord injury was reproduced by modified Allen's method. Each group was given corresponding intervention treatment 2 hours after modeling. The electroacupuncture group was treated with electro-acupuncture at Jiaji (EX-B2) points in T8 to T12, the methylprednisolone group was given intraperitoneal injection of 30 mg/kg methylprednisolone sodium succinate, and the sham operation group and model group were not treated. After treatment, BBB scores were observed to evaluate the motor function of posterior limb in each group, and the injured spinal cord tissues were taken. The pathological changes of spinal cord neuropathy were observed by Nissl staining. The expression of microRNA-21 was detected by RT-qPCR, and the expression of apoptotic proteins (Bax, Bcl-2 and cleaved-Caspase-3) was detected by Western-Blot. Result:Compared with sham operation group, BBB, neuron survival rate and expression of microRNA-21 were significantly lower, apoptotic rate of neurons was significantly higher, expression of Bax, Bcl-2, cleaved Caspase-3 protein and Bax/Bcl-2 ratio were significantly increased in model group (P< 0.05). Electroacupuncture could significantly increase BBB score, neuron survival rate and expression of microRNA-21, reduce apoptotic rate of neurons and the ratio of Bax/Bcl-2, and inhibit the expression of Bax, Bcl-2 and cleaved Caspase-3 protein in tissues, which were significantly different from those of model group (P< 0.05). Conclusions: Electroacupuncture at Jiaji (EX-B2) points can significantly promote the recovery of neurological function in rats after ASCI, and its mechanism may be closely related to the up-regulation of the expression of microRNA-21 in tissues and the inhibition of the activation of Bax/Bcl-2/cleaved Caspase-3 signaling pathway.

DOUBLE HIGH ORDER S－BREAKING BIFURCATION POINTS AND THEIR NUMERICAL DETERMINATION

We consider double high order S-breaking bifurcation points of two-Parameter dependent nonlinear problems with Z_2×Z_2-symmetry. Because of the underlying symmetry we could propose some regular extended systems to determine double high order S-breaking bifurcation points. and we could also show that there exist two quadratic pitchfork bifurcation point paths passing through the point being considered.

基于多任务学习的非侵入式负荷分解

为解决目前非侵入式负荷分解研究中存在的模型数量多及训练时间长等问题,将多任务学习引入到非侵入式负荷分解研究中,提出一种基于多门多专家模型的非侵入式负荷分解方法,首先通过seq2point模型将用电设备的功率分解转换为总功率序列与用电设备在序列中点时刻功率值的映射关系,其次利用MMoE模型的门控函数及共用的Expert网络组兼顾不同用电设备功率分解任务的独特性和关联性,最终通过单个MMoE模型同时完成多个用电设备的功率分解。在公开数据集上进行验证,测试算例验证了方法的有效性。

汇聚组播:新型MPLS服务质量组播体系结构

为支持新兴网络应用,IP组播(multicast)和MPLS(multi-protocol label switching)技术分别从不同方向扩展了当前的IP路由和交换模式.MPLS和IP组播的结合是当前研究的一个热点,MPLS网络中的服务质量组播面临着标签资源匮乏、组播路由状态的可扩展性以及具体实现上的困难.针对这些问题,提出了基于汇聚方法的新型MPLS服务质量组播体系结构,提出在现有的路由控制平面上叠加一层面向IP组播服务的控制平面,取代组播路由协议并支持组播聚集,形成2层控制平面结构.定义了两平面之间的协作和交互方式,并通过扩展RSVP-TE(resourcereservation protocol-traffic engineering)P2MP(point to multi-point)协议,在新的体系结构中融合了服务质量控制能力.另外,还探讨了汇聚组播中基于距离约束选择汇聚路由器的算法,实现了基于Linux的MPLS组播路由器和IP组播服务控制系统,并组建了实验平台.实验和模拟结果表明,基于汇聚组播的双平面网络控制结构能够适应组播用户和网络拓扑的动态变化,能够有效节省MPLS标签资源,平衡网络中组播流量的分布.

Resolving the Routine Presence of Kyanite, Andalusite and Sillimanite across a Region using Foliation Intersection/Inflection Axes Preserved in Porphyroblasts, Petrographic Observations and Thermobarometry

Constraints from P-T pseudosections （MnNCKFMASH system）, foliation intersection/ inflection axes preserved in porphyroblasts （FIAs）, mineral assemblages and textural relationships for rocks containing all three Al2 SiO5 polymorphs indicate a kyanite→ andalusite→ sillimanite sequential formation at different times rather than stable coexistence at the Al2SiO5 triple point. All three Al2SiO5 polymorphs grew in the Chl, Bt, Ms, Grt, St, Pl and Crd bearing Ordovician Clayhole Schist in Balcooma, northeastern Australia separately along a looped P-T-t-D path that swaps from clockwise to anticlockwise in the tectono-metamorphic history of the region. Kyanite grew during crustal thickening in an Early Silurian Orogenic event followed by decompression/heating, andalusite and fibrolitic sillimanite growth during Early Devonian exhumation.

Effect of transcutaneous electrical nerve stimulation at acupoints on patients with type 2 diabetes mellitus:a randomized controlled trial

OBJECTIVE:To examine whether transcutaneous electric nerve stimulation at acupoints(Acu-TENS)improved the biochemical and physical indices of patients with type 2 diabetes mellitus(T2DM).METHODS:Ninety subjects with T2DM were divided randomly into a control group(n = 30),aerobic exercise group(n- 30),or Acu-TENS group(n = 30).In addition to conventional diabetes drug treatment,patients in the Acu-TENS group received acupoint stimulation,the aerobic exercise group engaged in walking exercises,and the control group was given sham electrical stimulation.All groups were treated for 30 min for each session and five times a week for 2 months.The indices of glycosylated hemoglobin,2 h postprandial glucose,fasting serum insulin,triglyceride,total cholesterol,and body mass index were assessed at pre-treatment,post-treatment,and follow-up,which was 2 months after treatment.RESULTS:The indices of the control group were not changed(P > 0.05) at the three time points.At the pre-treatment measurement,there were significant differences(P > 0.05) in indices among the three groups.At post-treatment,each index of the two groups was lower than that of the control group(P < 0.05),and improved in comparison with the pre-treatment measurement(P < 0.05).In follow-up,each index of the aerobic exercise group and Acu-TENS group increased,but was still decreased compared with the pre-treatment value(P < 0.05),excluding body mass index.CONCLUSION:Acu-TENS could improve the state of patients with T2 DM and be used as a therapy in clinical application.

A New Characterization of Transformations by the Use of Apollonius Points of (2n-1)-gons

In this paper, we give a new characterization of Mobius transformations. To do this, we extend the notion of Apollonius points of a triangle and of a pentagon, to the notion of Apollonius points of an arbitrary （2n-1）-gon.

Clinical observation on acupuncture at Jiaji(EX-B 2) points plus tuina in treating thoracic facet joint disorder

Objective： To observe the clinical effects of acupuncture at Jiaji （EX-B 2） points plus tuina manipulation for thoracic facet joint disorder, and get new clinical evidence for treatment of thoracic facet joint disorder. Methods： Totally 106 patients with thoracic facet joint disorder were randomly allocated into an observation group and a control group based on the random number table. Patients in the control group were treated by tuina manipulation, while those in the observation group were treated by acupuncture at Jiaji （EX-B 2） points before tuina manipulation. Patients in the two groups were treated once a day. The improvements of signs and symptoms and the efficacy were observed after 3 treatments. Results： After treatment, there were intra-group statistical differences in scores of 8 signs and symptoms in both groups （P〈0.01}; the score of each item in the observation group was lower than that in the control group, and there was statistical significance in the inter-group difference （P〈0.05）. The cure rate of the observation group was 50.9%, versus 26.4% in the control group, and there was a significant difference between the two groups （P〈0.05）. Conclusion： In treating thoracic facet joint disorder, acupuncture plus tuina manipulation can restore the biomechanical balance of thoracic vertebrae, fully maximized the combined effect, and significantly improve the clinical efficacy.

Observation on Therapeutic Effects of Electroacupuncture at Jiaji (Ex-B 2) Points plus Herbal Medicine for Herpes Zoster

Objective： To observe the clinical effects of electroacupuncture （EA） at Jiaji （Ex-B 2） points plus herbal medicine for herpes zoster （HZ）. Methods： Sixty-two cases were randomly divided into a treatment group and a control group. The treatment group was treated with EA at Jiaji （Ex-B 2） points plus herbal medicine based upon the pattern differentiation. The control group was treated with oral administration of Aciclovir tablets for resisting virus, and Mecobalamin tablets for nourishing the nerves and Aciclovir cream for skin rash. The therapeutic effects were compared between the two groups, after two-week treatment Results： After 7 d of the treatment, the therapeutic effect was remarkably better in the treatment group than that in the control group （P〈0.01）. After two-week treatment, the therapeutic effects were still different between the two groups （P〈0.05）. Conclusion： The therapeutic effect of EA at Jiaji （Ex-B 2） points plus herbal medicine for HZ is better than that of Western medications in resisting virus and nourishing nerves.

Acupuncture-moxibustion at Jiaji(EX-B 2) points for intervertebral disc herniation: a systematic review

By organizing and classifying the literatures related to acupuncture-moxibustion at Jiaji （EX-B 2） points in treating intervertebral disc herniation （IDH） published before December 32, 2013, to summarize the application status and features of Jiaji （EX-B 2） points. It＇s found that its most favorable indication is IDH. It also further analyzed the action mechanism of acupuncture-moxibustion at Jiaji （EX-B 2） points in treating IDH, and brought up some ideas to highlight the further study.

Photosynthetic features of leaf and silique of 'Qinyou 7' oilseed rape(Brassica napus L.) at reproductive growth stage

Photosynthetic products are mainly produced by leaf and green silique of oil-seed rape （Brassica napus L.） at reproductive growth stage. This study aimed to compare photosynthetic features of leaf and green silique of ‘Qinyou 7’ hybrid oilseed rape variety. Results showed that, during photosynthetic day time, net photosynthetic rate （PN） and sto-matal conductance （gs） of leaf were markedly higher than that of silique. Compared with silique, leaf had signifcant higher PN, gs, light saturated net photosynthetic rate （PNmax）, light saturation point （LSP）, and apparent quantum yield （AQY）, but lower light compensa-tion point （LCP）, CO2 compensation point （Γ） and carboxylation effciency （CE） under var-ious light densities and CO2 concentrations. Carboxylation activities of ribulose-1, 5-bis-phosphate carboxylase/oxygenase （Rubisco）, phosphoenolpyruvate carboxylase （PEPC） and chlorophyll a, b （Chl a, b） of leaf were signifcantly higher than that of silique shell. Our study demonstrated that leaf of oilseed rape at reproductive growth stage had higher photosynthetic capacity than green silique due to its higher carboxylation activity of pho-tosynthetic enzymes as well as higher gs and Chl contents. This study might have good implication in selecting a biological control strategy to enhance seed yield and oil produc-tion of oilseed rape.

急速狂飙赛车游戏

GT赛车4，Burnout2:Point of Impact，F1 2002，车神3，OutRun2。

Intractable post-herpetic neuralgia in the trunk treated with point injection at Jiájǐ(夹脊 EX-B 2)

ABSTRACT Objective To compare the efficacy difference between point injection at Jiiaji （夹脊 EX-B 2） and oral medication in the treatment of intractable post-herpetic neuralgia （PHN） in the trunk. Methods One hundred and thirty cases were randomly divided into an point injection group and an medication group, 65 cases in each one. In point injection group, according to the invasion site of herpes zoster, Jiiaji （夹脊 EX-B 2） of corresponding segments and the meridian points on skin lesion areas, such as Fengchi （风池GB 20）, Tianzhu （天柱 BL 10）, Feishu （肺俞 BL 13） and Geguan （膈关 BL 46） were selected and injected with the mixed solution of compound Betamethasone （administered only in the first injection）, Vitamin B12 and Lidoeaine Carbonate, 2 mL on each point, once per day. In medication group, Diclofenac Sodium sustained release tablets, 75 mg were administered, twice per day. The clinical efficacy was compared 10 days later between two groups. Results The total effective rate in point injection group was 100.0% （65/65）, which was better than 66.1% （43/65） in medication group （P〈0.01）. Conclusion Point injection mainly at Jiiaji （夹脊 EX-B 2） is effective significantly on intractable PHN in the trunk, which is superior to Diclofenac Sodium sustained release tablets.

Generation of meaningful synthetic sensor data—Evaluated with a reliable transferability methodology

As households are equipped with smart meters,supervised Machine Learning(ML)models and especially Non-Intrusive Load Monitoring(NILM)disaggregation algorithms are becoming increasingly important.To be robust,these models require a large amount of data,which is difficult to collect.Consequently,the generation of meaningful synthetic data is becoming more relevant.We use a simulation framework to generate multiple datasets using different techniques and evaluate their quality statistically by measuring the performance of NILM models for transferability.We demonstrate that the method of data generation is crucial to train ML models in a meaningful way.The experiments conducted reveal that adding noise to the synthetic smart meter data is essential to train robust NILM models for transferability.The best results are obtained when this noise is derived from unknown appliances for which no ground truth data is available.Since we observed that NILM models can provide unstable results,we develop a reliable evaluation methodology,based on Cochran’s sample size.Finally,we compare the quality of the generated synthetic data with real data and observe that multiple NILM models trained on synthetic data perform significantly better than those trained on real data.

一种用于非侵入式负荷分解的改进时域卷积网络

非侵入式负载监测(Non-Intrusive Load Monitoring)是通过监测用户电表的总用电量数据并应用负载分解算法,以获取各个电器实时用电量数据。然而,非侵入式负载分解作为一种单通道盲源分离问题,由于其固有的无法识别性导致实现分解困难。深度学习逐渐成为解决NILM问题的主流方法,得益于可用的数据、计算能力和深度网络训练算法模型。其中,序列到点(seq2point)负荷分解模型(Zhang)实现了最先进的预测效果。利用TCN网络架构,使用双向扩张卷积结构代替因果卷积结构,扩大了网络的感受野,并使用非线性激活函数GELU和层标准化(LN)方法,通过残差连接的思想搭建了时域卷积网络模型。最后,在公共数据集UK-DALE上对算法进行了测试,并选择平均绝对误差和F-score作为主要评价指标来评估算法的性能。通过对比两种算法在相同周期数据集上的分解结果,发现基于TCN改进的模型,显著提高了负荷分解的性能指标。

Treatment of 100 Cases of Cervical Spondylotic Radiculopathy by Electroacupuncture of Jiaji(Ex-B2)plus Oblique Needling Ashi Point

Summary： One hundred patients were diagnosed with cervicalspondylotic radiculopathy definitely by symptoms, signs and Xray examination. The therapeutic method was acupuncture of Jiaji（Ex-B 2） on the affected segment and the upper and lower vertebrae close together. After the arrival of qi, the needles were connected to acupuncture therapeutic instrument. Meanwhile, the numb, heavy and uncomfortable area on the shoulder and upper limb, where something like cord could be touched, was selected as Ashi point. The needle was inserted perpendicularly into the skin on the place that the cord was most obvious and inserted obliquely and deeply along the cord. After 3 4 courses of treatment, 90 cases got marked effectiveness and 10 cases got effectiveness.

A symplectic moving horizon estimation algorithm with its application to the Earth-Moon L2 libration point navigation

Accurate state estimations are perquisites of autonomous navigation and orbit maintenance missions.The extended Kalman lter(EKF)and the unscented Kalman lter(UKF),are the most commonly used method.However,the EKF results in poor estimation performance for systems are with high nonlinearity.As for the UKF,irregular sampling instants are required.In addition,both the EKF and the UKF cannot treat constraints.In this paper,a symplectic moving horizon estimation algorithm,where constraints can be considered,for nonlinear systems are developed.The estimation problem to be solved at each sampling instant is seen as a nonlinear constrained optimal control problem.The original nonlinear problem is transferred into a series of linear-quadratic problems and solved iteratively.A symplectic method based on the variational principle is proposed to solve such linear-quadratic problems,where the solution domain is divided into sub-intervals,and state,costate,and parametric variables are locally interpolated with linear approximation.The optimality conditions result in a linear complementarity problem which can be solved by the Lemke's method easily.The developed symplectic moving horizon estimation method is applied to the Earth-Moon L2 libration point navigation.And numerical simulations demonstrate that though more time-consuming,the proposed method results in better estimation performance than the EKF and the UKF.

An Algorithm to Recognize the Target Object Contour Based on 2D Point Clouds by Laser-CCD-Scanning

For a vision measurement system consisted of laser-CCD scanning sensors, an algorithm is proposed to extract and recognize the target object contour. Firstly, the two-dimensional（2D） point cloud that is output by the integrated laser sensor is transformed into a binary image. Secondly, the potential target object contours are segmented and extracted based on the connected domain labeling and adaptive corner detection. Then, the target object contour is recognized by improved Hu invariant moments and BP neural network classifier. Finally, we extract the point data of the target object contour through the reverse transformation from a binary image to a 2D point cloud. The experimental results show that the average recognition rate is 98.5% and the average recognition time is 0.18 s per frame. This algorithm realizes the real-time tracking of the target object in the complex background and the condition of multi-moving objects.

Treatment of 55 Cases of Acute Lumbar Sprain by Puncturing Acupoint Cuanzhu (BL 2)

Treated 55 cases of acute lumbar sprain only with acupuncturing Cuanzhu (BL 2). After three treatments, 53 cases were cured, and 2 cases were improvement. Key Words Lumbar Sprain - Acupuncture Therapy - Point, BL 2 (Cuanzhu) Author: CHEN Hui (1972-), male, attending physicianTranslator: ZHU Zhong-chun

Clinical effect of traditional Chinese spinal orthopedic manipulation in treatment of chondromalacia patellae

OBJECTIVE: To evaluate the clinical effect of traditional Chinese spinal orthopedic manipulation(TCSOM) in treating chondromalacia patellae(CP).METHODS: Sixty cases of CP patients were randomly assigned to a TCSOM group and a Celecoxib group according to the random number table method. All patients in the TCSOM group were treated with a maximum of 10 spinal manipulations and rehabilitation training of quadriceps femoris. The symptoms before and after treatment were assessed with visual analog scale(VAS) and Kujala functional knee scoring system(KFKSS). A symptom improvement rate(SIR) was implemented in order to evaluate the effects of the treatments.RESULTS: The symptoms of 16 patients in the TC-SOM group quickly resolved after the first spinal manipulation and 8 cases were significantly improved. The VAS scores in the TCSOM group after 4weeks of treatment were significantly lower than those in the Celecoxib group. The KFKSS scores in the TCSOM group after 4 weeks of treatment were significantly higher than those in the Celecoxib group. Side effects of the treatment were not reported. Symptom improvement rate based on the VAS in the TCSOM group indicated more significant improvements than the Celecoxib group.CONCLUSION: TCSOM has greater efficacy than Celecoxib capsules for relief of the symptoms of CP.