New 4-imino-4H-Chromeno[2,3-d]Pyrimidin-3(5H)-Amine: Synthesis, Cytotoxic Effects on Tumoral Cell Lines and in Silico ADMET Properties

The synthesis of new 4-imino-4H-chromeno[2,3-d]pyrimidin-3(5H)-amine in four steps including one step under microwave dielectric heating is reported. The structural identity of the synthesized compounds was established according to their spectroscopic analysis, such as FT-IR, NMR and mass spectroscopy. These new compounds were tested for their antiproliferative activities on seven representative human tumoral cell lines (Huh7 D12, Caco2, MDA-MB231, MDA-MB468, HCT116, PC3 and MCF7) and also on fibroblasts. Among them, only the compounds 6c showed micromolar cytotoxic activity on tumor cell lines (1.8 50 50 > 25 μM). Finally, in silico ADMET studies ware performed to investigate the possibility of using of the identified compound 6c as potential anti-tumor compound.

2-D crustal structure of Changbaishan-Tianchi volcanic region determined by seismic traveltime inversion

2-D velocity structure and tectonics of the crust and upper mantle is revealed by inversion of seismic refraction and wide-angle reflection traveltimes acquired along the profile L1 in the Changbaishan-Tianchi volcanic region. It is used in this study that seismic traveltime inversion for simultaneous determination of 2-D velocity and interface structure of the crust and upper mantle. The result shows that, under Changbaishan-Tianchi crater, there exists a low-velocity body in the shape of an inverted triangle, and the crustal reflecting boundaries and Moho all become lower by a varying margin of 2-6 km, forming a crustal root which is assumed to be the Changbaishan-Tianchi volcanic system. Finally, we make a comparison between our 2-D velocity model and the result from the studies by using trial-and-error forward modeling with SEIS83.

SOLVING THE VELOCITY PARAMETER OF THE 2-D WAVE INVERSE PROBLEMS WITH THE INTEGRATION-CHARACTERISTIC METHOD

For the 2-D wave inverse problems introduced from geophysical exploration, in this paper, the author presents integration-characteristic method to solve the velocity parameter, and then applies it to common shotpoint model data, in noise-free case. The accuracy is quite good.

二维地震过障碍观测系统模式及其参数设计

在二维地震勘探中,为了避免因地表障碍物使地震反射剖面出现间断现象,需要改变观测系统设计,跨越障碍物(江河、城镇等),以保证反射同相轴能连续追踪对比。在以往地震勘探中,有时因过障碍观测系统设计不合理,不但增加勘探费用,而且影响采集质量。因此只有科学合理地设计过障碍观测系统模式和参数,才能保证地震测线顺利通过障碍物,得到较好的障碍物下方的地震资料并降低勘探成本。为此本文在调查和研究大量野外实际的过障碍观测系统的基础上,总结归纳成三大类过障碍观测系统模式,并分析其特点和应用范围。采用图解法,推导出主要模式的跨越宽度、最小炮检距及最大炮检距等参数公式。采用这套过障碍观测模式不仅可以得到和障碍区两侧等质量的地震资料,而且可以有效地降低勘探成本。

非线性突变在石龙场油气预测中的应用

研究地震勘探中快速有效地进行油气预测的方法已成为目前十分重要的课题。介绍了利用地震数据沿目的层开时窗提取非线性突变参数进行油气预测的实用技术,此技术具有预测精度高,运算速度快等优点。经石龙场地区的实际资料预测验证,效果良好。

交互闭合差校正方法

在二维地震测网中的每条测线，可能是在不同条件下进行资料采集和处理的，从而在相交测线的地震剖面交点上，导致同一反射层的同相轴间存在着时间和波形的差别，给资料解释和进一步处理带来困难（如二维资料内插成三维资料）。本文根据不同测线的特点，提出了交互闭合差校正方法。该法同时求取不同测线的校正算子，对交点闭合差作时变和空变时间差校正及波形校正。显示功能可随时为用户提供闭合差分布情况，整个交互过程简单、灵活，最后提供的交点闭合差精度可以满足地震资料解释成图的要求。