目的探讨糖尿病视网膜病变(DR)患者餐后2 h血糖(2 h PG)升高对眼底图像中动静脉宽度比(AVR)的影响。方法选取DR患者316例,均行标准75 g口服葡萄糖耐量试验(OGTT)检测空腹血糖(FPG)和餐后2 h PG,根据餐后血糖变化幅度(2 h PG-FPG)将所有...目的探讨糖尿病视网膜病变(DR)患者餐后2 h血糖(2 h PG)升高对眼底图像中动静脉宽度比(AVR)的影响。方法选取DR患者316例,均行标准75 g口服葡萄糖耐量试验(OGTT)检测空腹血糖(FPG)和餐后2 h PG,根据餐后血糖变化幅度(2 h PG-FPG)将所有研究对象按三分位分为3组,低分位组(G1)104例、中分位组(G2)108例及高分位组(G3)104例。测量各组眼底图像中AVR水平,采用Pearson相关性分析和多元线性回归分析DR患者AVR的影响因素。结果 (1)G3组和G2组餐后2 h PG、空腹胰岛素(FIns)、糖化血红蛋白(Hb A1c)及稳态模型评估-胰岛素抵抗指数(HOMA-IR)均高于G1组,且G3组餐后2 h PG和Hb A1c高于G2组;G3组和G2组2 h AVR较G1组降低,G3组较G2组降低(P<0.05),而各组间空腹AVR比较,差异无统计学意义(P>0.05);(2)Pearson相关分析显示,AVR与FPG、餐后2 h PG、Hb A1c、收缩压(SBP)及舒张压(DBP)均呈负相关(P<0.05);(3)多元线性回归分析显示,餐后2 h PG为DR患者AVR的影响因素(P<0.05)。结论餐后2 h PG升高可能会导致AVR降低,对DR患者应动态观察AVR的变化,对判断DR的严重程度具有意义。展开更多
Polygalacturonase (PG) was studied during ripening and senescence of postharvest tomato fruit at pink stage at low and normal temperature. The results showed that the PG activity increased, then decreased during ripen...Polygalacturonase (PG) was studied during ripening and senescence of postharvest tomato fruit at pink stage at low and normal temperature. The results showed that the PG activity increased, then decreased during ripening and senescence of tomato. Low temperature inhibited but ethylene enhanced PG activity. Ethylene also enhanced calmodulin content, which was dependent on Ca 2+concentration in cell. When EGTA(Ca 2+chelator), verapamil(Vp) and LaCl 3(Ca 2+channel blockers), trifluoperazine and chloropromaize (two CaM antagonisms) were used to treat tomato fruit at green mature stage with ethylene, they could reverse ethylene-induced increase in PG activity, but Vp, chloropromaize (CPZ), trifluoperazine (TFP) could not directly influence PG activity, which indirectly indicated that influx of Ca 2+ from the extracellular space including the cell wall via the Ca 2+ channel localized in plasma membrane and CaM were required for ethylene-induced PG activity increase and that ethylene signal transduction may be related to Ca 2+CaM messenger system.展开更多
文摘目的探讨糖尿病视网膜病变(DR)患者餐后2 h血糖(2 h PG)升高对眼底图像中动静脉宽度比(AVR)的影响。方法选取DR患者316例,均行标准75 g口服葡萄糖耐量试验(OGTT)检测空腹血糖(FPG)和餐后2 h PG,根据餐后血糖变化幅度(2 h PG-FPG)将所有研究对象按三分位分为3组,低分位组(G1)104例、中分位组(G2)108例及高分位组(G3)104例。测量各组眼底图像中AVR水平,采用Pearson相关性分析和多元线性回归分析DR患者AVR的影响因素。结果 (1)G3组和G2组餐后2 h PG、空腹胰岛素(FIns)、糖化血红蛋白(Hb A1c)及稳态模型评估-胰岛素抵抗指数(HOMA-IR)均高于G1组,且G3组餐后2 h PG和Hb A1c高于G2组;G3组和G2组2 h AVR较G1组降低,G3组较G2组降低(P<0.05),而各组间空腹AVR比较,差异无统计学意义(P>0.05);(2)Pearson相关分析显示,AVR与FPG、餐后2 h PG、Hb A1c、收缩压(SBP)及舒张压(DBP)均呈负相关(P<0.05);(3)多元线性回归分析显示,餐后2 h PG为DR患者AVR的影响因素(P<0.05)。结论餐后2 h PG升高可能会导致AVR降低,对DR患者应动态观察AVR的变化,对判断DR的严重程度具有意义。
文摘Polygalacturonase (PG) was studied during ripening and senescence of postharvest tomato fruit at pink stage at low and normal temperature. The results showed that the PG activity increased, then decreased during ripening and senescence of tomato. Low temperature inhibited but ethylene enhanced PG activity. Ethylene also enhanced calmodulin content, which was dependent on Ca 2+concentration in cell. When EGTA(Ca 2+chelator), verapamil(Vp) and LaCl 3(Ca 2+channel blockers), trifluoperazine and chloropromaize (two CaM antagonisms) were used to treat tomato fruit at green mature stage with ethylene, they could reverse ethylene-induced increase in PG activity, but Vp, chloropromaize (CPZ), trifluoperazine (TFP) could not directly influence PG activity, which indirectly indicated that influx of Ca 2+ from the extracellular space including the cell wall via the Ca 2+ channel localized in plasma membrane and CaM were required for ethylene-induced PG activity increase and that ethylene signal transduction may be related to Ca 2+CaM messenger system.
