The title compound C18H16N4O3 （Mr = 336.35） has been synthesized and characterized by elemental analysis and single-crystal X-ray diffraction. The Schiff base compound is a derivative of 4-aminoantipyrine. As expect...The title compound C18H16N4O3 （Mr = 336.35） has been synthesized and characterized by elemental analysis and single-crystal X-ray diffraction. The Schiff base compound is a derivative of 4-aminoantipyrine. As expected, the molecular structure adopts a trans configuration about the central C=N double bond. It crystallizes in orthorhombic, space group P2dc with a = 7.632（1）, b = 7.816（1）, c = 28.082（5） A,β = 96.18（1）°, V= 1665.48（51） A^3, Z= 4, Dc = 1.341 g/cm^3, F（000） = 704,μ = 0.094 mm^-1, the final R = 0.0448 and wR = 0.1058. Of the total 3748 collections, 3105 were unique. In the molecule there exist two different planes of pyrazoline and C（11）-C（16） phenyl ring, which are approximately coplanar （r.m.s. de deviation from the combined mean plane is 0.03 A） with the dihedral angle between them of 9.8%.展开更多
Sodium silicate（NazSiO3） was used to improve the elution of super heavy oil from weathered soil on an ultrasound-enhanced elution system by the solution containing 0-6000 mg/L surfactant Triton X-100. The removal ex...Sodium silicate（NazSiO3） was used to improve the elution of super heavy oil from weathered soil on an ultrasound-enhanced elution system by the solution containing 0-6000 mg/L surfactant Triton X-100. The removal extent of three markers[C26-34 17a 25-norhopanes, C26-28triaromatic steroids（TAS）, and C27-29methyl triaromatic steroids（MTAS）] was monitored. The average elution percentages of C26-34 norhopanes, C26-28 TAS, and C27-29 MTAS by Triton X-100/Na2SiO3 solutions were increased by 11%-13%, 9%-11% and 8%-13% with increasing Triton X-100 concentrations from 150 mg/L to 6000 mg/L. All the concentrations of Triton X-100 improved the elu- tion of TAS homologs containing fewer carbon atoms, whereas high concentrations improved the elution of larger 17a 25-norhopane and MTAS species. Addition of Na2SiO3 produced a noticeable increase in elution, particularly for lower-weight species. Scanning electron microscope（SEM） images and energy spectroscopy data reveal that surfac- rant solution of 6000 mg/L Triton X-100 and 4000 mg/L Na2SiO3 produced the greatest improvement in the elution of super heavy oil aggregates encapsulating the soil surface and the emulsification of particle dispersions. That is to say mixed solutions of Triton X-100 and Na2SiO3 in combination with ultrasound are a potential means of removing super heavy oil from weathered soils.展开更多
Cotton(Gossypium hirsutum L.) fibers,one of the most important natural raw materials for the textile industry,are highly elongated trichomes from epidermal cells of cotton ovules.Among the longest plant cells ever cha...Cotton(Gossypium hirsutum L.) fibers,one of the most important natural raw materials for the textile industry,are highly elongated trichomes from epidermal cells of cotton ovules.Among the longest plant cells ever characterized,cotton fiber is an ideal system for studying plant cell elongation.展开更多
Novel fluorine substituted α-amino phosphonic acids containing 1,2,4-triazin- 5-one (6a-f) have been obtained from fluoroacylation of 6-(2′-amino-5′-nitrophenyl)-3-thioxo-1,2,4-triazin-5(4H)-one (...Novel fluorine substituted α-amino phosphonic acids containing 1,2,4-triazin- 5-one (6a-f) have been obtained from fluoroacylation of 6-(2′-amino-5′-nitrophenyl)-3-thioxo-1,2,4-triazin-5(4H)-one (1) followed by ammonilysis to give the corresponding 3-amino-derivative 3. Condensation of compound 3 with nitro/halogenated aromatic aldehydes yielded the Schiff bases 4. The simple addition of diethyl phosphonate to compound 4 produced the α-amino phosphonates 5. Acidic hydrolysis of compound 5 produced the fluorine substituted α-amino acids derivatives 6. Structures of the new compounds have been established with the help of elemental analysis and spectral measurements. Also, the products evaluated as antioxidants, where the fluorinated α-amino phosphonic acids 6 are more active than the other synthesized systems.展开更多
The title complex, （1S）-1,1＇-bis{[N-ethyl-N-（1-methylethyl）-amino]carbonyl}-2- （hydroxyldiphenylmethyl）-ferrocene （[Fe（C24H22NO2）（C11H16NO）]2·H2O, Mr = 1207.13）, was synthesized via （-）-Sparteine-m...The title complex, （1S）-1,1＇-bis{[N-ethyl-N-（1-methylethyl）-amino]carbonyl}-2- （hydroxyldiphenylmethyl）-ferrocene （[Fe（C24H22NO2）（C11H16NO）]2·H2O, Mr = 1207.13）, was synthesized via （-）-Sparteine-mediated enantioselective directed ortho-lithiation of 1,1‘-bis{[N- ethyl-N-（1-methylethyl）-amino]carbonyl}-2-（hydroxydiphenylmethyl）-ferrocene. The structure of the rifle compound was determined by X-ray single-crystal diffraction. The crystal belongs to the orthorhombic system, space group P212121, with a = 10.266（2）, b = 17.676（4）, c = 34.097（7）A, V = 6187（2）A3, Z = 4, C70H86Fe2N4O7, Dc = 1.296 g/cm^3,μ = 0.527 mm^-1, T= 113（2） K, F（000） = 2568, the final R = 0.0469 and wR = 0.0984 for 13940 observed reflections with I 〉 2σ（I）. The neighboring ferrocene derivatives are joined into dimers via O-H…O=C intermolecular hydrogen bonding by a water molecule. Besides, the dimers form neat rows along the a axis.展开更多
The title compound （C16H15N3O2, Mr= 281.31） has been synthesized and characterized by elemental analysis and single-crystal X-ray diffraction. The Schiff base compound is a derivative of 4-aminoantipyrine. As expect...The title compound （C16H15N3O2, Mr= 281.31） has been synthesized and characterized by elemental analysis and single-crystal X-ray diffraction. The Schiff base compound is a derivative of 4-aminoantipyrine. As expected, the molecular structure adopts a trans configuration about the C=N double bond. It crystallizes in the monoclinic system, space group P2 1/c with a = 11.150（3）, b = 9.906（3）, c = 13.624（4） A, β = 106.360（4）°, V= 1443.9（7） ,A^3, Z = 4, Dc = 1.294 g/cm^3, F（000） = 592,μ（MoKa） = 0.088 mm ^-1, R = 0.0577 and wR = 0.1214. Of the 5766 total reflections, 2540 were unique. In the molecule there exist two different planes of pyrazoline and O（2）-C（10） phenyl ring, which are approximately coplanar （r.m.s. de deviation from the combined mean plane is 0026 A） with the dihedral angle between them of 6.3°.展开更多
目的探讨肾炎康复片联合舒洛地特治疗肾病综合征合并类固醇糖尿病的疗效及对β2-MG、CRP、HCY水平影响。方法选取医院治疗的84例肾病综合征合并类固醇糖尿病炎患者,随机分为两组各42例。对照组患者给予舒洛地特,治疗组在对照组基础上口...目的探讨肾炎康复片联合舒洛地特治疗肾病综合征合并类固醇糖尿病的疗效及对β2-MG、CRP、HCY水平影响。方法选取医院治疗的84例肾病综合征合并类固醇糖尿病炎患者,随机分为两组各42例。对照组患者给予舒洛地特,治疗组在对照组基础上口服肾炎康复片,两组患者均持续治疗6个月。对比两组患者的临床疗效、中医症候积分、Scr、ALB、BUN、24 h UPE水平、2 h PG、FBG、HbA1c和FINS水平、β2-MG、CRP、HCY水平、补体C3、IgG和CD^(+)_(4)/CD^(+)_(8)水平。结果治疗后,治疗组总有效率较高(P<0.05);两组患者治疗前中医证候积分差异无统计学意义(P>0.05);两组患者治疗后腰脊酸痛、疲倦乏力、面浮肢肿、肢体困重等证候评分显著降低(P<0.05);并且治疗组腰脊酸痛、疲倦乏力、面浮肢肿、肢体困重评分明显低于对照组(P<0.05);两组患者治疗前Scr、ALB、BUN、24 h UPE水平差异无统计学意义(P>0.05);两组患者治疗后Scr、BUN、24 h UPE显著降低,ALB水平明显升高(P<0.05);并且治疗组改善较多(P<0.05);两组患者治疗前2 h PG、FBG、HbA1c和FINS水平差异无统计学意义(P>0.05);两组患者治疗后2 h PG、FBG、HbA1c和FINS水平显著降低(P<0.05);并且治疗组2 h PG、FBG、HbA1c明显低于对照组(P<0.05),治疗组患者FINS水平低于对照组,但但差异无统计学意义(P>0.05);两组患者治疗前β2-MG、CRP、HCY水平差异无统计学意义(P>0.05);治疗后两组患者β2-MG、CRP、HCY水平显著降低(P<0.05);并且治疗组降低较多(P<0.05);两组患者治疗前补体C3、IgG和CD^(+)_(4)/CD^(+)_(8)水平差异无统计学意义(P>0.05);对照组患者治疗前后补体C3、IgG和CD^(+)_(4)/CD^(+)_(8)水平变化无统计学意义(P>0.05);治疗组患者治疗后补体C3、IgG和CD^(+)_(4)/CD^(+)_(8)水平高于对照组,但差异无统计学意义(P>0.05)。结论采用肾炎康复片联合舒洛地特治疗肾病综合征合并类固醇糖尿病具有较好的治疗效果,能够改善血清β2-MG、CRP、HCY水平,安全性较高,值得在临床上推广应用。展开更多
目的探讨类固醇5α-还原酶2型缺乏症(SRD5A2)的临床特点、基因突变特征。方法回顾分析1例以外阴异常为初诊表现的SRD5A2患儿的临床资料。结果患儿,2岁5个月,社会性别为女性。基础促黄体生成素(LH)0.07 m IU/mL、促卵泡激素(FSH)0.39 m I...目的探讨类固醇5α-还原酶2型缺乏症(SRD5A2)的临床特点、基因突变特征。方法回顾分析1例以外阴异常为初诊表现的SRD5A2患儿的临床资料。结果患儿,2岁5个月,社会性别为女性。基础促黄体生成素(LH)0.07 m IU/mL、促卵泡激素(FSH)0.39 m IU/mL;人绒毛膜促性腺激素(HCG)刺激试验前后,睾酮分别是0.06 ng/mL、3.65ng/mL,双氢睾酮(DHT)分别是19.67 pg/mL、68.25 pg/mL;17-羟孕酮(17-OHP)1.20 ng/mL,雄烯二酮(A 2)0.07 ng/mL;HCG试验后T/DHT为51.72、T/A 2为14.70;抗苗勒管激素(AMH)22.97 ng/mL,抑制素B(INH-B)274.4 pg/mL。盆腔超声和磁共振均未探及子宫及卵巢。染色体为46,XY;性别决定(SRY)基因检测无异常;雄激素受体(AR)基因结果阴性。患儿及父母外周血均检测到2型5α-还原酶(SRD5A2)基因的致病性突变。应用2.5%DHT凝胶涂抹阴茎4个月后阴茎增长2 cm。结论 SRD5A2的诊断以HCG试验后T/DHT增高为主要依据,检测到致病性的SRD5A2基因突变可确诊。展开更多
文摘The title compound C18H16N4O3 （Mr = 336.35） has been synthesized and characterized by elemental analysis and single-crystal X-ray diffraction. The Schiff base compound is a derivative of 4-aminoantipyrine. As expected, the molecular structure adopts a trans configuration about the central C=N double bond. It crystallizes in orthorhombic, space group P2dc with a = 7.632（1）, b = 7.816（1）, c = 28.082（5） A,β = 96.18（1）°, V= 1665.48（51） A^3, Z= 4, Dc = 1.341 g/cm^3, F（000） = 704,μ = 0.094 mm^-1, the final R = 0.0448 and wR = 0.1058. Of the total 3748 collections, 3105 were unique. In the molecule there exist two different planes of pyrazoline and C（11）-C（16） phenyl ring, which are approximately coplanar （r.m.s. de deviation from the combined mean plane is 0.03 A） with the dihedral angle between them of 9.8%.
基金Supported by the National Natural Science Foundation of China(Nos.51179001 and 40772146)the Fok Ying Tung Education Foundation,China(No.122041)
文摘Sodium silicate（NazSiO3） was used to improve the elution of super heavy oil from weathered soil on an ultrasound-enhanced elution system by the solution containing 0-6000 mg/L surfactant Triton X-100. The removal extent of three markers[C26-34 17a 25-norhopanes, C26-28triaromatic steroids（TAS）, and C27-29methyl triaromatic steroids（MTAS）] was monitored. The average elution percentages of C26-34 norhopanes, C26-28 TAS, and C27-29 MTAS by Triton X-100/Na2SiO3 solutions were increased by 11%-13%, 9%-11% and 8%-13% with increasing Triton X-100 concentrations from 150 mg/L to 6000 mg/L. All the concentrations of Triton X-100 improved the elu- tion of TAS homologs containing fewer carbon atoms, whereas high concentrations improved the elution of larger 17a 25-norhopane and MTAS species. Addition of Na2SiO3 produced a noticeable increase in elution, particularly for lower-weight species. Scanning electron microscope（SEM） images and energy spectroscopy data reveal that surfac- rant solution of 6000 mg/L Triton X-100 and 4000 mg/L Na2SiO3 produced the greatest improvement in the elution of super heavy oil aggregates encapsulating the soil surface and the emulsification of particle dispersions. That is to say mixed solutions of Triton X-100 and Na2SiO3 in combination with ultrasound are a potential means of removing super heavy oil from weathered soils.
文摘Cotton(Gossypium hirsutum L.) fibers,one of the most important natural raw materials for the textile industry,are highly elongated trichomes from epidermal cells of cotton ovules.Among the longest plant cells ever characterized,cotton fiber is an ideal system for studying plant cell elongation.
文摘Novel fluorine substituted α-amino phosphonic acids containing 1,2,4-triazin- 5-one (6a-f) have been obtained from fluoroacylation of 6-(2′-amino-5′-nitrophenyl)-3-thioxo-1,2,4-triazin-5(4H)-one (1) followed by ammonilysis to give the corresponding 3-amino-derivative 3. Condensation of compound 3 with nitro/halogenated aromatic aldehydes yielded the Schiff bases 4. The simple addition of diethyl phosphonate to compound 4 produced the α-amino phosphonates 5. Acidic hydrolysis of compound 5 produced the fluorine substituted α-amino acids derivatives 6. Structures of the new compounds have been established with the help of elemental analysis and spectral measurements. Also, the products evaluated as antioxidants, where the fluorinated α-amino phosphonic acids 6 are more active than the other synthesized systems.
基金supported by the Major Program of National Natural Science Foundation of China (200572009)Beijing Natural Science Foundation Program and Scientific Research Key Program of Beijing Municipal Commission of Education (KZ200610011006)
文摘The title complex, （1S）-1,1＇-bis{[N-ethyl-N-（1-methylethyl）-amino]carbonyl}-2- （hydroxyldiphenylmethyl）-ferrocene （[Fe（C24H22NO2）（C11H16NO）]2·H2O, Mr = 1207.13）, was synthesized via （-）-Sparteine-mediated enantioselective directed ortho-lithiation of 1,1‘-bis{[N- ethyl-N-（1-methylethyl）-amino]carbonyl}-2-（hydroxydiphenylmethyl）-ferrocene. The structure of the rifle compound was determined by X-ray single-crystal diffraction. The crystal belongs to the orthorhombic system, space group P212121, with a = 10.266（2）, b = 17.676（4）, c = 34.097（7）A, V = 6187（2）A3, Z = 4, C70H86Fe2N4O7, Dc = 1.296 g/cm^3,μ = 0.527 mm^-1, T= 113（2） K, F（000） = 2568, the final R = 0.0469 and wR = 0.0984 for 13940 observed reflections with I 〉 2σ（I）. The neighboring ferrocene derivatives are joined into dimers via O-H…O=C intermolecular hydrogen bonding by a water molecule. Besides, the dimers form neat rows along the a axis.
基金This work was supported by the Phytochemistry Key Laboratory of Shaanxi Province (No. 02js40)
文摘The title compound （C16H15N3O2, Mr= 281.31） has been synthesized and characterized by elemental analysis and single-crystal X-ray diffraction. The Schiff base compound is a derivative of 4-aminoantipyrine. As expected, the molecular structure adopts a trans configuration about the C=N double bond. It crystallizes in the monoclinic system, space group P2 1/c with a = 11.150（3）, b = 9.906（3）, c = 13.624（4） A, β = 106.360（4）°, V= 1443.9（7） ,A^3, Z = 4, Dc = 1.294 g/cm^3, F（000） = 592,μ（MoKa） = 0.088 mm ^-1, R = 0.0577 and wR = 0.1214. Of the 5766 total reflections, 2540 were unique. In the molecule there exist two different planes of pyrazoline and O（2）-C（10） phenyl ring, which are approximately coplanar （r.m.s. de deviation from the combined mean plane is 0026 A） with the dihedral angle between them of 6.3°.
文摘目的探讨肾炎康复片联合舒洛地特治疗肾病综合征合并类固醇糖尿病的疗效及对β2-MG、CRP、HCY水平影响。方法选取医院治疗的84例肾病综合征合并类固醇糖尿病炎患者,随机分为两组各42例。对照组患者给予舒洛地特,治疗组在对照组基础上口服肾炎康复片,两组患者均持续治疗6个月。对比两组患者的临床疗效、中医症候积分、Scr、ALB、BUN、24 h UPE水平、2 h PG、FBG、HbA1c和FINS水平、β2-MG、CRP、HCY水平、补体C3、IgG和CD^(+)_(4)/CD^(+)_(8)水平。结果治疗后,治疗组总有效率较高(P<0.05);两组患者治疗前中医证候积分差异无统计学意义(P>0.05);两组患者治疗后腰脊酸痛、疲倦乏力、面浮肢肿、肢体困重等证候评分显著降低(P<0.05);并且治疗组腰脊酸痛、疲倦乏力、面浮肢肿、肢体困重评分明显低于对照组(P<0.05);两组患者治疗前Scr、ALB、BUN、24 h UPE水平差异无统计学意义(P>0.05);两组患者治疗后Scr、BUN、24 h UPE显著降低,ALB水平明显升高(P<0.05);并且治疗组改善较多(P<0.05);两组患者治疗前2 h PG、FBG、HbA1c和FINS水平差异无统计学意义(P>0.05);两组患者治疗后2 h PG、FBG、HbA1c和FINS水平显著降低(P<0.05);并且治疗组2 h PG、FBG、HbA1c明显低于对照组(P<0.05),治疗组患者FINS水平低于对照组,但但差异无统计学意义(P>0.05);两组患者治疗前β2-MG、CRP、HCY水平差异无统计学意义(P>0.05);治疗后两组患者β2-MG、CRP、HCY水平显著降低(P<0.05);并且治疗组降低较多(P<0.05);两组患者治疗前补体C3、IgG和CD^(+)_(4)/CD^(+)_(8)水平差异无统计学意义(P>0.05);对照组患者治疗前后补体C3、IgG和CD^(+)_(4)/CD^(+)_(8)水平变化无统计学意义(P>0.05);治疗组患者治疗后补体C3、IgG和CD^(+)_(4)/CD^(+)_(8)水平高于对照组,但差异无统计学意义(P>0.05)。结论采用肾炎康复片联合舒洛地特治疗肾病综合征合并类固醇糖尿病具有较好的治疗效果,能够改善血清β2-MG、CRP、HCY水平,安全性较高,值得在临床上推广应用。
