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Isolation of 2-Chloro-5-methylpyridine from its Isomer 2-Chloro-3-methylpyridine by Formation of its Copper(II) Complex
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作者 RiChengXUAN WeiXiaoHU ZhongYuYANG YaPingLU 《Chinese Chemical Letters》 SCIE CAS CSCD 2004年第2期181-182,共2页
Chloro-5-methylpyridine can be effectively isolated from its isomer 2-chloro-3- methyl-pyridine in the form of Cu2+complex. After hydrolyzing the complex, it can be obtained in more than 99.1% purity.
关键词 ISOLATION 2-chloro-5-methylpyridine.
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The Preparation of 2-Chloro-5-chloromethylpyridine in an Airlift Loop Reactor 被引量:1
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作者 闻建平 王长林 乔萍 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2003年第5期608-610,共3页
A new process for the direct chlorination of 2-chloro-5-methylpyridine to yield 2-chloro-5-chloro-methylpyridine in an airlift loop reactor (ALR) has been studied. Five main reaction conditions including TR, na/ns, cp... A new process for the direct chlorination of 2-chloro-5-methylpyridine to yield 2-chloro-5-chloro-methylpyridine in an airlift loop reactor (ALR) has been studied. Five main reaction conditions including TR, na/ns, cp, Qg and dD/dR were optimized. The average molar yield and purity of 2-chloro-5-chloromethylpyridine obtained were 79% and 98.5% respectively under the optimum operating conditions. Finally, the efficiency for the preparation of 2-chloro-5-chloromethylpyridine with ALR and stirred tank reactor (STR) respectively was compared. 展开更多
关键词 2-chloro-5-chloromethylpyridine 2-chloro-5-methylpyridine direct chlorination airlift loop reactor
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Novel synthesis of 2-butyl-5-chloro-3H-imidazole-4-carbaldehyde:A key intermediate of Losartan 被引量:3
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作者 Hai Bo Sun Guo Jun Zheng +2 位作者 Ya Ping Wang Xiang Jing Wang Wen Sheng Xiang 《Chinese Chemical Letters》 SCIE CAS CSCD 2009年第3期269-270,共2页
A novel method for synthesis of 2-butyl-5 -chloro-3H-imidazole-4-carbaldehyde 2, a key intermediate of Losartan was reported. The compound 2 was synthesized from starting material dimethyl malonate 6 and n-valeronitri... A novel method for synthesis of 2-butyl-5 -chloro-3H-imidazole-4-carbaldehyde 2, a key intermediate of Losartan was reported. The compound 2 was synthesized from starting material dimethyl malonate 6 and n-valeronitrile 8 by six steps with an overall yield of 40%. The key step including the reaction of compound 5 with POCl3/DMF followed by hydrolysis to give compound 2 with the yield of 68%. 展开更多
关键词 LOSARTAN ANTIHYPERTENSIVE Angiotensin II 2-Butyl-5-chloro-3H-imidazole-4-carbaldehyde
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Measurement and Correlation for Solubility of 2-Chloro-5-chloromethylpyridine in Different Solvents 被引量:2
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作者 石晓华 李明 周彩荣 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2010年第4期654-658,共5页
2-Chloro-5-chloromethylpyridine is a crucial intermediate of pesticides.Its solid-liquid equilibrium data will provide essential support for industrial design and further theoretical studies.The solubilities of 2-chlo... 2-Chloro-5-chloromethylpyridine is a crucial intermediate of pesticides.Its solid-liquid equilibrium data will provide essential support for industrial design and further theoretical studies.The solubilities of 2-chloro-5-chloromethylpyridine in water,methanol,ethanol,ethyl acetate,acetone,trichloromethane and toluene at different temperatures were measured using the synthetic method by a laser monitoring observation technique. The solubility data were correlated with the modified Apelblat equation and Wilson equation.The calculated values were in good agreement with the experimental values. 展开更多
关键词 2-chloro-5-CHLOROMETHYLPYRIDINE solid-liquid equilibrium SOLUBILITY
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Coupling Reaction of 4-Chloro-7-H-Pyrrolo[2,3-d]Pyrimidine with 2,3,5-Tri-O-Acetyl-b-D-Ribofuranosyl Chloride 被引量:1
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作者 Yun Long ZHANG Liang Ren ZHANG +5 位作者 Zhen Jun YANG Ji Mei MIN Li He ZHANG Yang LU Ning Bo GONG Qi Tai ZHENG 《Chinese Chemical Letters》 SCIE CAS CSCD 2001年第5期391-394,共4页
Coupling reaction of 4-chloro-7-H-pyrrolo[2,3-d]pyrimidine with 2,3,5-tri-O-acetyl -β-D-ribofuranosyl chloride under the basic condition was investigated. An abnormal coupling reaction, in which the heterocyclic base... Coupling reaction of 4-chloro-7-H-pyrrolo[2,3-d]pyrimidine with 2,3,5-tri-O-acetyl -β-D-ribofuranosyl chloride under the basic condition was investigated. An abnormal coupling reaction, in which the heterocyclic base attacked at the carbon of 1,2-O-methylidene moiety instead of anomeric carbon of ribose was observed and the structure of products 5a, 5b were identified by NMR and X-Ray diffraction. 展开更多
关键词 Chloropyrrolo[2 3-d]pyrimidine 1-chloro-2 3 5-tri-O-acetyl-D-ribofuranose neigh-boring participation effect X-ray diffraction.
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One-step Synthesis of 5-Ethyl-2-methylpyridine from NH4HCO3 and C2H5OH Under Hydrothermal Condition
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作者 TIAN Zhenzhen ZHANG Dong +4 位作者 GUO Biao TIAN Ge LIU Xinxin YUE Huijuan FENG Shouhua 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2015年第2期249-252,共4页
A simple one-pot approach to synthesizing 5-ethyl-2-methylpyridine(EMP) was established using NHaHCO3 and C2H5OH as starting materials and commercial Cu2O as catalyst and oxidant under hydrothermal con- dition. Diff... A simple one-pot approach to synthesizing 5-ethyl-2-methylpyridine(EMP) was established using NHaHCO3 and C2H5OH as starting materials and commercial Cu2O as catalyst and oxidant under hydrothermal con- dition. Different reaction conditions were researched and the optimal ones were achieved by studying the parameters, that could affect the yield of product and by considering the energy and resource saving. The present study provided an eco-friendlv way to obtaining EMP with lower volatility using fewer toxic starting materials. 展开更多
关键词 5-Ethyl-2-methylpyridine Hydrothermal condition NH4HCO3 C2H5OH CU2O
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Approach to synthesis of novel chiral 3-chloro-2(5H)- furanone and its application in asymmetric reactions
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作者 HUANG Hui & CHEN Qinghua1. Department of Chemistry, Tonghua Teacher’s College, Tonghua 134002, China 2. Department of Chemistry, Beijing Normal University, Beijing 100875, China 《Chinese Science Bulletin》 SCIE EI CAS 2000年第8期711-716,共6页
The synthetic method of the novel chiral synthon, 5-/-menthyloxy-3-chloro-2-(5H)-furanone 5a and its application in asymmetric reactions were investigated. 5a is easily obtained in highly optical purity, and acts as a... The synthetic method of the novel chiral synthon, 5-/-menthyloxy-3-chloro-2-(5H)-furanone 5a and its application in asymmetric reactions were investigated. 5a is easily obtained in highly optical purity, and acts as a stable acceptor of Michael addition with oxygen nucleophiles in tandem double Michael addition / internal nucieophilic substitution to offer the spiro-cyclopropane derivative containing four stereogenic centers 8, which it is difficult to obtain by routine methods. The synthetic methods for 5a and 8 are reported in detail and the new compounds are identified on the basis of their analytical data and spectroscopic data, such as UV, IR, H NMR,13 C NMR, MS and elementary analysis. The absolute configuration of the interesting spiro-cyclopropanes, spiro [1-chloro-4-(/-menthyloxy)-5-oxo-6-oxa-biscyclo[3.1.0]hexane-2,3i(4’-/-menthyloxy-5’-/-menthyloxy- butyrolactone)] 8 was established by X-ray crystallography. This result can provide important synthetic strategy in synthesis of some complex 展开更多
关键词 new CHIRAL synthon. 5-l-menthyloxy-3-chloro-2-(5H)-furanone absolute configuration spiro-cyclopropane derivative containing multiple CHIRAL centers.
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A highly enantioselective synthesis of 5- (ι-menthyloxy) -4-substituted-3-chloro-2(5H) -furanones 被引量:1
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作者 耿哲 黄彬 陈庆华 《Chinese Journal of Chemistry》 SCIE CAS CSCD 1999年第2期189-195,共7页
In this paper, stereocontrolled tandem Michael addition-elimination reaction of the novel chiral source, S-(ι-menthyloxy)-3,4-dichloro-2(5H)-furanone, with various thiols and amines has been investigated. A series of... In this paper, stereocontrolled tandem Michael addition-elimination reaction of the novel chiral source, S-(ι-menthyloxy)-3,4-dichloro-2(5H)-furanone, with various thiols and amines has been investigated. A series of new enantiomerically pure compounds, 5-(ι-menthyloxy)-4-substituted-3-cnloro-2(5H)-furanones, were obtained in good yields with d. e.(?)98% under mild conditions. 展开更多
关键词 Tandem Michael addition-elimination reaction 5-(ι-menthyloxy)-3 4-dichloro-2 (5H)-furanone enantiomerically pure compound 5-(ι-menthyloxy)-4-substituted-3-chloro-2(5H)-furanone
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1,3-Dinitro-2-chloro-5-trifluorotoluene and its bridged derivatives Ⅰ.An investigation on the displacement reactions of bidentate nucleophiles towards aromatic rings
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作者 JI,Jing-Shun CHEN,Mei-Jin WANG,Qi-Wen SHENG,Wei Shanghai Institute of Organic Chemistry,Academia Sinica,Shanghai 200032 《Chinese Journal of Chemistry》 SCIE CAS CSCD 1991年第4期343-350,共0页
The reactions of 1,3-dinitro-2-chloro-5-trifluorotoluene(DNCTT)(1)and its bridged com- pounds with bidentate nucleophiles have been investigated.Primary or secondary diamines and diethylene glycol react with 1 and its... The reactions of 1,3-dinitro-2-chloro-5-trifluorotoluene(DNCTT)(1)and its bridged com- pounds with bidentate nucleophiles have been investigated.Primary or secondary diamines and diethylene glycol react with 1 and its bridged derivatives by replacing the substituent grouppara to CF_3, whereas ethanedithiol reacts either by replacing the substituent group para to CF_3 or by displacing both groups and a nitro group.The results have been rationalized in terms of electronic effects and nucleophilicity of the nucleophiles. 展开更多
关键词 An investigation on the displacement reactions of bidentate nucleophiles towards aromatic rings Dinitro-2-chloro-5-trifluorotoluene and its bridged derivatives
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Technological Optimization of the Preparation of Imidacloprid
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作者 闻建平 王长林 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2003年第5期604-607,共4页
In order to reduce the production cost of imidacloprid, the preparation technology for the direct com-bination of 2-chloro-5-chloromethylpyridine and 2-nitryliminoglyoxaline has been optimized in a 10 L stirred tank r... In order to reduce the production cost of imidacloprid, the preparation technology for the direct com-bination of 2-chloro-5-chloromethylpyridine and 2-nitryliminoglyoxaline has been optimized in a 10 L stirred tank reactor with a new solvent, butanone, and a new catalyst, benzyl triethyl-ammonium chloride (BTEAC), which was proved to be more profitable for the production of imidacloprid. Three main affecting factors (the reaction temper-ature, the molar ratio of BTEAC to 2-nitryliminoglyoxaline and the concentration of 2-nitryuminoglyoxaline) for the production of imidacloprid were investigated and the optimum operating conditions were found. Based on the above technological optimization, an industrial process for imidacloprid with a production capacity of 50 tons per year was put in operation using a 2500 L stirred tank reactor under the same operating conditions. Good yield and purity of imidacloprid was also obtained in the industrial production. 展开更多
关键词 IMIDACLOPRID 2-chloro-5-CHLOROMETHYLPYRIDINE 2-nitryliminoglyoxaline technological optimization
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Mild and Efficient Synthesis of 1-(6-Chloroquinoxalin-2-yl)-2- [4-(trifluoromethyl)-2,6-dinitrophenyl] Hydrazine Derivatives by Microwave Irradiation 被引量:2
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作者 MILAD Taheri HANIYEH Alavi HAMIDEH Nazari 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2014年第3期405-408,共4页
Some 1-(6-chloroquinoxalin-2-yl)-2-[4-(trifluoromethyl)-2,6-dinitrophenyl] hydrazine derivatives have been synthesized via both conventional and microwave assisted organic synthesis(MAOS) methods. The MAOS metho... Some 1-(6-chloroquinoxalin-2-yl)-2-[4-(trifluoromethyl)-2,6-dinitrophenyl] hydrazine derivatives have been synthesized via both conventional and microwave assisted organic synthesis(MAOS) methods. The MAOS method is more effective on synthesizing these compounds than the conventional method in regard to the higher chemical yields of products(76%-98%) and the shorter reaction time(1-15 min). 展开更多
关键词 2 6-Dichloroquinoxaline 2-chloro-1-3-dinitro-5-triflouromthylbenzene hydrazine hydrate Methyl hydrazine Microwave assistant organic synthesis(MAOS)
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Fast ethylamine gas sensing based on intermolecular charge-transfer complexation 被引量:1
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作者 Eun Mi Lee Seon Young Gwon +1 位作者 Young A Son Sung Hoon Kim 《Chinese Chemical Letters》 SCIE CAS CSCD 2012年第4期484-487,共4页
We have investigated the fast ethylamine gas sensing of 2-chloro-3,5-dinitrobenzotrifluoride(CDBF) loaded poly(acrylonitrile) nanofiber based on an intermolecular charge-transfer complexation.Reversible response a... We have investigated the fast ethylamine gas sensing of 2-chloro-3,5-dinitrobenzotrifluoride(CDBF) loaded poly(acrylonitrile) nanofiber based on an intermolecular charge-transfer complexation.Reversible response and recovery were achieved using alternating gas exposure.This system shows a fast ethylamine gas sensing within 0.4 s. 展开更多
关键词 Ethylamine gas Fast gas sensing 2-chloro-3 5-dinitrobenzotrifluoride(CDBF) Electrospinning PAN nanofiber Intermolecular charge-transfer(CT) complexation
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