2-Phenylfuran-3,4-dicarboxylic acid anhydride reacted with seven aromatic compounds, of which five gave keto acids in yields of 94%-63%. The structure of the keto acid was elucidated by reducing it to hydroxy acid and...2-Phenylfuran-3,4-dicarboxylic acid anhydride reacted with seven aromatic compounds, of which five gave keto acids in yields of 94%-63%. The structure of the keto acid was elucidated by reducing it to hydroxy acid and analyzing with NMR technique.展开更多
Dialkyl 2-phenylfuran (and 2-phenyltetrahydrofuran)-3,4-dicarboxylates (1, 2, 5-7), which are potential precursors of the synthesis of furofuran and tetrahydrofurofuran lignans, can be selectively hydrolyzed to monoac...Dialkyl 2-phenylfuran (and 2-phenyltetrahydrofuran)-3,4-dicarboxylates (1, 2, 5-7), which are potential precursors of the synthesis of furofuran and tetrahydrofurofuran lignans, can be selectively hydrolyzed to monoacid (3, 8) by potassium hydroxide. The regioselective hydrolysis was affected significantly by the 2-phenyl group of the furan or tetrahydrofuran skeleton. The geometric structures of 3, 8 and related compounds were elucidated and verified by NMR spectra.展开更多
3-Carboxy-2-pyrazinehydroxamic acid was prepared by a one pot reaction starting from pyrazine-2,3-dicarboxylic anhydride with a high yield, and characterized by IR, Mass spectrum, 1H NMR and 13C NMR spectra and single...3-Carboxy-2-pyrazinehydroxamic acid was prepared by a one pot reaction starting from pyrazine-2,3-dicarboxylic anhydride with a high yield, and characterized by IR, Mass spectrum, 1H NMR and 13C NMR spectra and single-crystal X-ray diffraction. It crystallizes in triclinic, space group Pī with a=4.8659（10）, b=7.4233（15）, c=11.602（2）, α=96.904（2）, β=92.422（3）, γ=107.454（2）°, V=395.51（14）3 , Z=2, Dc=1.689g/cm3 , F（000）=208, μ（MoKα）=0.149 mm-1 , the final R=0.0473 and wR=0.1306 for 2853 observed reflections （I〉2σ （I））. A three-dimensional framework was assembled through intermolecular hydrogen bonding between water and 3-carboxy-2-pyrazine-carbohydroxamic acid molecules.展开更多
文摘2-Phenylfuran-3,4-dicarboxylic acid anhydride reacted with seven aromatic compounds, of which five gave keto acids in yields of 94%-63%. The structure of the keto acid was elucidated by reducing it to hydroxy acid and analyzing with NMR technique.
文摘Dialkyl 2-phenylfuran (and 2-phenyltetrahydrofuran)-3,4-dicarboxylates (1, 2, 5-7), which are potential precursors of the synthesis of furofuran and tetrahydrofurofuran lignans, can be selectively hydrolyzed to monoacid (3, 8) by potassium hydroxide. The regioselective hydrolysis was affected significantly by the 2-phenyl group of the furan or tetrahydrofuran skeleton. The geometric structures of 3, 8 and related compounds were elucidated and verified by NMR spectra.
基金supported by the National Natural Science Foundation of China (No. 20861007)Science Foundation of State Key Laboratory of Structural Chemistry (No. 20100009)Science and Technology Research Projects in Department of Education of Jiangxi Province (No. GJJ08026)
文摘3-Carboxy-2-pyrazinehydroxamic acid was prepared by a one pot reaction starting from pyrazine-2,3-dicarboxylic anhydride with a high yield, and characterized by IR, Mass spectrum, 1H NMR and 13C NMR spectra and single-crystal X-ray diffraction. It crystallizes in triclinic, space group Pī with a=4.8659（10）, b=7.4233（15）, c=11.602（2）, α=96.904（2）, β=92.422（3）, γ=107.454（2）°, V=395.51（14）3 , Z=2, Dc=1.689g/cm3 , F（000）=208, μ（MoKα）=0.149 mm-1 , the final R=0.0473 and wR=0.1306 for 2853 observed reflections （I〉2σ （I））. A three-dimensional framework was assembled through intermolecular hydrogen bonding between water and 3-carboxy-2-pyrazine-carbohydroxamic acid molecules.
